DE69315307T2 - Chimuclidine Derivate als Squalen synthetase Inhibitoren - Google Patents

Chimuclidine Derivate als Squalen synthetase Inhibitoren

Info

Publication number
DE69315307T2
DE69315307T2 DE69315307T DE69315307T DE69315307T2 DE 69315307 T2 DE69315307 T2 DE 69315307T2 DE 69315307 T DE69315307 T DE 69315307T DE 69315307 T DE69315307 T DE 69315307T DE 69315307 T2 DE69315307 T2 DE 69315307T2
Authority
DE
Germany
Prior art keywords
formula
compound
alkyl
hydroxy
hydrogen
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69315307T
Other languages
German (de)
English (en)
Other versions
DE69315307D1 (de
Inventor
Keith Mallion
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Syngenta Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Publication of DE69315307D1 publication Critical patent/DE69315307D1/de
Application granted granted Critical
Publication of DE69315307T2 publication Critical patent/DE69315307T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
DE69315307T 1992-06-04 1993-06-02 Chimuclidine Derivate als Squalen synthetase Inhibitoren Expired - Fee Related DE69315307T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB929211796A GB9211796D0 (en) 1992-06-04 1992-06-04 Heterocyclic derivatives
PCT/GB1993/001165 WO1993024486A1 (en) 1992-06-04 1993-06-02 Quinuclidine derivatives as squalene synthetase inhibitors

Publications (2)

Publication Number Publication Date
DE69315307D1 DE69315307D1 (de) 1998-01-02
DE69315307T2 true DE69315307T2 (de) 1998-03-12

Family

ID=10716501

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69315307T Expired - Fee Related DE69315307T2 (de) 1992-06-04 1993-06-02 Chimuclidine Derivate als Squalen synthetase Inhibitoren

Country Status (14)

Country Link
US (1) US5554613A (enExample)
EP (1) EP0598093B1 (enExample)
JP (1) JPH06509590A (enExample)
AT (1) ATE160348T1 (enExample)
AU (1) AU670295B2 (enExample)
CA (1) CA2097671A1 (enExample)
DE (1) DE69315307T2 (enExample)
FI (1) FI940503A0 (enExample)
GB (2) GB9211796D0 (enExample)
IL (1) IL105882A0 (enExample)
NZ (1) NZ253230A (enExample)
TW (1) TW276252B (enExample)
WO (1) WO1993024486A1 (enExample)
ZA (1) ZA933644B (enExample)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9218334D0 (en) * 1992-08-28 1992-10-14 Ici Plc Heterocyclic compounds
WO1994014803A1 (en) * 1992-12-21 1994-07-07 Zeneca Limited Quinuclidine derivatives as squalene synthase inhibitors
US5556990A (en) * 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
US20040186071A1 (en) 1998-04-13 2004-09-23 Bennett C. Frank Antisense modulation of CD40 expression
US7321828B2 (en) 1998-04-13 2008-01-22 Isis Pharmaceuticals, Inc. System of components for preparing oligonucleotides
JP2008526781A (ja) * 2005-02-22 2008-07-24 テバ ファーマシューティカル インダストリーズ リミティド ロスバスタチンの製造
EP2222851B1 (en) 2007-11-20 2017-06-28 Ionis Pharmaceuticals, Inc. Modulation of cd40 expression

Family Cites Families (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3405134A (en) * 1965-08-17 1968-10-08 Colgate Palmolive Co Quinuclidyl esters of aromatic acids
NL6715600A (enExample) * 1966-12-02 1968-06-04
US3534053A (en) * 1967-05-24 1970-10-13 American Home Prod Quinuclidine derivatives
US3763168A (en) * 1968-09-09 1973-10-02 Sterling Drug Inc N-(3-quinuclidinyl) acylanilides
US3655675A (en) * 1968-09-09 1972-04-11 Sterling Drug Inc N-(n-heteryl)-acylanilides
US3725410A (en) * 1970-07-15 1973-04-03 American Home Prod 3-aminomethyl-3-quinuclidinols
US3679690A (en) * 1971-03-18 1972-07-25 Sterling Drug Inc Certain n-(pyridyl) propionanilides
FR2183565B1 (enExample) * 1972-05-10 1975-12-26 Cerm Cent Europ Rech Mauvernay
CA1014958A (en) * 1973-10-05 1977-08-02 Jacques Moleyre .alpha.-QUINUCLIDYLMETHYL PHENYL KETONES
US4038402A (en) * 1974-03-05 1977-07-26 Mikhail Emmanuilovich Kaminka Method of effecting antihistaminic, antiserotonin and antiallergic actions
SU495310A1 (ru) * 1974-03-05 1975-12-15 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
FR2414044A1 (fr) * 1978-01-10 1979-08-03 Pharmindustrie Nouveaux derives d'aza-1 bicyclo(2,2,2) octane, utilisables comme medicaments
US4599344A (en) * 1984-10-31 1986-07-08 Schering A.G. Quinuclidines and quinuclidinium salts as antiarrhythmic agents
CH667657A5 (de) * 1985-01-07 1988-10-31 Sandoz Ag Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
NZ225999A (en) * 1987-09-10 1992-04-28 Merck Sharp & Dohme Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions
IE63906B1 (en) * 1987-11-13 1995-06-14 Novo Nordisk As Azabicyclic compounds and their preparation and use
EP0322182A3 (en) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclic compounds, process for their preparation and pharmaceutical compositions containing them
DK730588A (da) * 1988-02-03 1989-08-04 Asta Pharma Ag Anvendelse af pyridin-2-ethere eller pyridin-2-thioethere med en nitrogenholdig cycloalifatisk ring som antidepressivt laegemiddel
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
US5242914A (en) * 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
FI91258C (fi) * 1988-04-01 1994-06-10 Sankyo Co Menetelmä lääkeaineina käyttökelpoisten 2-(heterosyklyylitio)karbapeneemijohdannaisten valmistamiseksi
US5286864A (en) * 1988-11-22 1994-02-15 Boehringer Ingelheim Kg Quinuclidines, their use as medicaments and processes for their preparation
DE8817121U1 (de) * 1988-11-22 1993-02-04 Boehringer Ingelheim Kg, 55218 Ingelheim Neue Quinuclidine
GB8918061D0 (en) * 1989-08-08 1989-09-20 Merck Sharp & Dohme Therapeutic agents
DE4116582A1 (de) * 1990-05-19 1991-11-21 Boehringer Ingelheim Kg Bicyclische 1-aza-cycloalkane
YU84791A (sh) * 1990-05-19 1994-06-10 Boehringer Ingelheim Kg. Biciklicni 1-aza-cikloalkalni
ZA92278B (en) * 1991-02-01 1992-10-28 Akzo Nv 3-quinuclidine derivatives
US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
CA2105655A1 (en) * 1991-03-08 1992-09-09 Kent Neuenschwander Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
US5135935A (en) * 1991-05-17 1992-08-04 Merck & Co., Inc. Squalene synthetase inhibitors
GB9122988D0 (en) * 1991-10-30 1991-12-18 Ici Plc Heterocyclic compounds
GB9201749D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Plc Medicaments
GB9202443D0 (en) * 1992-02-05 1992-03-18 Fujisawa Pharmaceutical Co A novel substituted-acetamide compound and a process for the preparation thereof

Also Published As

Publication number Publication date
JPH06509590A (ja) 1994-10-27
AU670295B2 (en) 1996-07-11
DE69315307D1 (de) 1998-01-02
WO1993024486A1 (en) 1993-12-09
ATE160348T1 (de) 1997-12-15
CA2097671A1 (en) 1993-12-05
IL105882A0 (en) 1993-10-20
FI940503A7 (fi) 1994-02-03
EP0598093B1 (en) 1997-11-19
AU4339893A (en) 1993-12-30
NZ253230A (en) 1996-06-25
GB9211796D0 (en) 1992-07-15
FI940503A0 (fi) 1994-02-03
ZA933644B (en) 1993-12-06
EP0598093A1 (en) 1994-05-25
GB9310418D0 (en) 1993-07-07
TW276252B (enExample) 1996-05-21
US5554613A (en) 1996-09-10

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee