DE69315307D1 - Chimuclidine Derivate als Squalen synthetase Inhibitoren - Google Patents
Chimuclidine Derivate als Squalen synthetase InhibitorenInfo
- Publication number
- DE69315307D1 DE69315307D1 DE69315307T DE69315307T DE69315307D1 DE 69315307 D1 DE69315307 D1 DE 69315307D1 DE 69315307 T DE69315307 T DE 69315307T DE 69315307 T DE69315307 T DE 69315307T DE 69315307 D1 DE69315307 D1 DE 69315307D1
- Authority
- DE
- Germany
- Prior art keywords
- derivatives
- pct
- treating
- date
- alkylcarbamoyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/06—Antihyperlipidemics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929211796A GB9211796D0 (en) | 1992-06-04 | 1992-06-04 | Heterocyclic derivatives |
PCT/GB1993/001165 WO1993024486A1 (en) | 1992-06-04 | 1993-06-02 | Quinuclidine derivatives as squalene synthetase inhibitors |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69315307D1 true DE69315307D1 (de) | 1998-01-02 |
DE69315307T2 DE69315307T2 (de) | 1998-03-12 |
Family
ID=10716501
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69315307T Expired - Fee Related DE69315307T2 (de) | 1992-06-04 | 1993-06-02 | Chimuclidine Derivate als Squalen synthetase Inhibitoren |
Country Status (14)
Country | Link |
---|---|
US (1) | US5554613A (de) |
EP (1) | EP0598093B1 (de) |
JP (1) | JPH06509590A (de) |
AT (1) | ATE160348T1 (de) |
AU (1) | AU670295B2 (de) |
CA (1) | CA2097671A1 (de) |
DE (1) | DE69315307T2 (de) |
FI (1) | FI940503A (de) |
GB (2) | GB9211796D0 (de) |
IL (1) | IL105882A0 (de) |
NZ (1) | NZ253230A (de) |
TW (1) | TW276252B (de) |
WO (1) | WO1993024486A1 (de) |
ZA (1) | ZA933644B (de) |
Families Citing this family (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9122988D0 (en) * | 1991-10-30 | 1991-12-18 | Ici Plc | Heterocyclic compounds |
GB9218334D0 (en) * | 1992-08-28 | 1992-10-14 | Ici Plc | Heterocyclic compounds |
DE69330069D1 (en) * | 1992-12-21 | 2001-05-03 | Syngenta Ltd | Chinuclidin derivate als squalen synthase inhibitoren |
US5556990A (en) * | 1994-12-16 | 1996-09-17 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Polyarylcarbamoylaza- and -carbamoylalkanedioic acids |
US20040186071A1 (en) | 1998-04-13 | 2004-09-23 | Bennett C. Frank | Antisense modulation of CD40 expression |
TWI353981B (en) * | 2005-02-22 | 2011-12-11 | Teva Pharma | Preparation of rosuvastatin |
US8916531B2 (en) | 2007-11-20 | 2014-12-23 | Isis Pharmaceuticals, Inc. | Modulation of CD40 expression |
Family Cites Families (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3405134A (en) * | 1965-08-17 | 1968-10-08 | Colgate Palmolive Co | Quinuclidyl esters of aromatic acids |
NL6715600A (de) * | 1966-12-02 | 1968-06-04 | ||
US3534053A (en) * | 1967-05-24 | 1970-10-13 | American Home Prod | Quinuclidine derivatives |
US3763168A (en) * | 1968-09-09 | 1973-10-02 | Sterling Drug Inc | N-(3-quinuclidinyl) acylanilides |
US3655675A (en) * | 1968-09-09 | 1972-04-11 | Sterling Drug Inc | N-(n-heteryl)-acylanilides |
US3725410A (en) * | 1970-07-15 | 1973-04-03 | American Home Prod | 3-aminomethyl-3-quinuclidinols |
US3679690A (en) * | 1971-03-18 | 1972-07-25 | Sterling Drug Inc | Certain n-(pyridyl) propionanilides |
FR2183565B1 (de) * | 1972-05-10 | 1975-12-26 | Cerm Cent Europ Rech Mauvernay | |
CA1014958A (en) * | 1973-10-05 | 1977-08-02 | Jacques Moleyre | .alpha.-QUINUCLIDYLMETHYL PHENYL KETONES |
US4038402A (en) * | 1974-03-05 | 1977-07-26 | Mikhail Emmanuilovich Kaminka | Method of effecting antihistaminic, antiserotonin and antiallergic actions |
SU495310A1 (ru) * | 1974-03-05 | 1975-12-15 | Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе | Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени |
FR2414044A1 (fr) * | 1978-01-10 | 1979-08-03 | Pharmindustrie | Nouveaux derives d'aza-1 bicyclo(2,2,2) octane, utilisables comme medicaments |
US4599344A (en) * | 1984-10-31 | 1986-07-08 | Schering A.G. | Quinuclidines and quinuclidinium salts as antiarrhythmic agents |
CH667657A5 (de) * | 1985-01-07 | 1988-10-31 | Sandoz Ag | Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine. |
NZ225999A (en) * | 1987-09-10 | 1992-04-28 | Merck Sharp & Dohme | Azacyclic- or azabicyclic-substituted thiadiazole derivatives and pharmaceutical compositions |
IL88156A (en) * | 1987-11-13 | 1997-02-18 | Novo Nordisk As | Azacyclic compounds their preparation and pharmaceutical compositions containing them |
EP0322182A3 (de) * | 1987-12-22 | 1992-01-02 | Beecham Group Plc | Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen |
DK730588A (da) * | 1988-02-03 | 1989-08-04 | Asta Pharma Ag | Anvendelse af pyridin-2-ethere eller pyridin-2-thioethere med en nitrogenholdig cycloalifatisk ring som antidepressivt laegemiddel |
NZ227841A (en) * | 1988-02-12 | 1991-08-27 | Merck Sharp & Dohme | Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions |
IE950607L (en) * | 1988-04-01 | 1989-10-01 | Sankyo Co | 2-(heterocyclylthio) carbapenem derivatives, their¹preparation and their use as antibiotics |
US5242914A (en) * | 1988-04-01 | 1993-09-07 | Sankyo Company, Limited | 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics |
DE8817121U1 (de) * | 1988-11-22 | 1993-02-04 | Boehringer Ingelheim Kg, 6507 Ingelheim, De | |
US5286864A (en) * | 1988-11-22 | 1994-02-15 | Boehringer Ingelheim Kg | Quinuclidines, their use as medicaments and processes for their preparation |
GB8918061D0 (en) * | 1989-08-08 | 1989-09-20 | Merck Sharp & Dohme | Therapeutic agents |
DE4116582A1 (de) * | 1990-05-19 | 1991-11-21 | Boehringer Ingelheim Kg | Bicyclische 1-aza-cycloalkane |
YU84791A (sh) * | 1990-05-19 | 1994-06-10 | Boehringer Ingelheim Kg. | Biciklicni 1-aza-cikloalkalni |
ZA92278B (en) * | 1991-02-01 | 1992-10-28 | Akzo Nv | 3-quinuclidine derivatives |
JPH06506467A (ja) * | 1991-03-08 | 1994-07-21 | ローヌ−プーラン ローラー インターナショナル(ホウルディングス) インコーポレイテッド | 多環式三級アミンポリ芳香族スクアレンシンセターゼインヒビター |
US5385912A (en) * | 1991-03-08 | 1995-01-31 | Rhone-Poulenc Rorer Pharmaceuticals Inc. | Multicyclic tertiary amine polyaromatic squalene synthase inhibitors |
US5135935A (en) * | 1991-05-17 | 1992-08-04 | Merck & Co., Inc. | Squalene synthetase inhibitors |
GB9122988D0 (en) * | 1991-10-30 | 1991-12-18 | Ici Plc | Heterocyclic compounds |
GB9201749D0 (en) * | 1992-01-28 | 1992-03-11 | Smithkline Beecham Plc | Medicaments |
GB9202443D0 (en) * | 1992-02-05 | 1992-03-18 | Fujisawa Pharmaceutical Co | A novel substituted-acetamide compound and a process for the preparation thereof |
-
1992
- 1992-06-04 GB GB929211796A patent/GB9211796D0/en active Pending
-
1993
- 1993-05-20 GB GB939310418A patent/GB9310418D0/en active Pending
- 1993-05-25 ZA ZA933644A patent/ZA933644B/xx unknown
- 1993-05-28 TW TW082104245A patent/TW276252B/zh active
- 1993-06-02 NZ NZ253230A patent/NZ253230A/en unknown
- 1993-06-02 IL IL105882A patent/IL105882A0/xx unknown
- 1993-06-02 WO PCT/GB1993/001165 patent/WO1993024486A1/en active IP Right Grant
- 1993-06-02 AT AT93913270T patent/ATE160348T1/de not_active IP Right Cessation
- 1993-06-02 DE DE69315307T patent/DE69315307T2/de not_active Expired - Fee Related
- 1993-06-02 EP EP93913270A patent/EP0598093B1/de not_active Expired - Lifetime
- 1993-06-02 AU AU43398/93A patent/AU670295B2/en not_active Ceased
- 1993-06-02 JP JP6500358A patent/JPH06509590A/ja active Pending
- 1993-06-02 US US08/190,073 patent/US5554613A/en not_active Expired - Fee Related
- 1993-06-03 CA CA002097671A patent/CA2097671A1/en not_active Abandoned
-
1994
- 1994-02-03 FI FI940503A patent/FI940503A/fi unknown
Also Published As
Publication number | Publication date |
---|---|
GB9211796D0 (en) | 1992-07-15 |
ATE160348T1 (de) | 1997-12-15 |
TW276252B (de) | 1996-05-21 |
GB9310418D0 (en) | 1993-07-07 |
ZA933644B (en) | 1993-12-06 |
CA2097671A1 (en) | 1993-12-05 |
FI940503A0 (fi) | 1994-02-03 |
EP0598093A1 (de) | 1994-05-25 |
IL105882A0 (en) | 1993-10-20 |
NZ253230A (en) | 1996-06-25 |
WO1993024486A1 (en) | 1993-12-09 |
FI940503A (fi) | 1994-02-03 |
EP0598093B1 (de) | 1997-11-19 |
DE69315307T2 (de) | 1998-03-12 |
US5554613A (en) | 1996-09-10 |
JPH06509590A (ja) | 1994-10-27 |
AU4339893A (en) | 1993-12-30 |
AU670295B2 (en) | 1996-07-11 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69316224D1 (de) | Chinuclidine derivate als squalen synthase inhibitoren | |
AU1729097A (en) | Quinazoline derivatives as vegf inhibitors | |
CA2263319A1 (en) | Quinazoline derivatives and pharmaceutical compositions containing them | |
ATE160348T1 (de) | Chimuclidine derivate als squalen synthetase inhibitoren | |
IL116526A (en) | Piperazinediones their preparation and pharmaceutical and veterinary compositions containing them | |
ATE159255T1 (de) | Chinuclidine derivate als squalen synthase inhibitoren | |
DE69320911D1 (de) | Chinuclidine derivate als squalen synthase inhibitore | |
DE69223769T2 (de) | Diphenylylchinuclidine als squalen-synthetase-inhibitoren | |
GB9226577D0 (en) | Heterocyclic derivatives | |
NO950756L (no) | Kinuklidinderivater som squalensyntetase-inhibitorer | |
NO940360L (no) | Heterocykliske derivater |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |