DE69223769T2 - Diphenylylchinuclidine als squalen-synthetase-inhibitoren - Google Patents

Diphenylylchinuclidine als squalen-synthetase-inhibitoren

Info

Publication number
DE69223769T2
DE69223769T2 DE69223769T DE69223769T DE69223769T2 DE 69223769 T2 DE69223769 T2 DE 69223769T2 DE 69223769 T DE69223769 T DE 69223769T DE 69223769 T DE69223769 T DE 69223769T DE 69223769 T2 DE69223769 T2 DE 69223769T2
Authority
DE
Germany
Prior art keywords
alkyl
compounds
carbamoyl
pct
halogeno
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69223769T
Other languages
English (en)
Other versions
DE69223769D1 (en
Inventor
George Robert Brown
Keith Blakeney Mallion
Peter Harrison
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
AstraZeneca UK Ltd
Original Assignee
Zeneca Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd filed Critical Zeneca Ltd
Application granted granted Critical
Publication of DE69223769D1 publication Critical patent/DE69223769D1/de
Publication of DE69223769T2 publication Critical patent/DE69223769T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
    • C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Cardiology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Obesity (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Detergent Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DE69223769T 1991-10-30 1992-10-27 Diphenylylchinuclidine als squalen-synthetase-inhibitoren Expired - Fee Related DE69223769T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919122988A GB9122988D0 (en) 1991-10-30 1991-10-30 Heterocyclic compounds
PCT/GB1992/001968 WO1993009115A1 (en) 1991-10-30 1992-10-27 Biphenylylquinuclidines, useful as squalene synthetase inhibitors

Publications (2)

Publication Number Publication Date
DE69223769D1 DE69223769D1 (en) 1998-02-05
DE69223769T2 true DE69223769T2 (de) 1998-05-07

Family

ID=10703745

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69223769T Expired - Fee Related DE69223769T2 (de) 1991-10-30 1992-10-27 Diphenylylchinuclidine als squalen-synthetase-inhibitoren

Country Status (16)

Country Link
US (1) US5792777A (de)
EP (1) EP0569564B1 (de)
JP (1) JPH06504069A (de)
AT (1) ATE161534T1 (de)
AU (1) AU658458B2 (de)
CA (1) CA2081674A1 (de)
CZ (1) CZ127293A3 (de)
DE (1) DE69223769T2 (de)
FI (1) FI932996A (de)
GB (1) GB9122988D0 (de)
HU (1) HUT64063A (de)
IL (1) IL103587A (de)
NO (1) NO932382D0 (de)
NZ (1) NZ244962A (de)
WO (1) WO1993009115A1 (de)
ZA (1) ZA928428B (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives
DE69330069D1 (en) * 1992-12-21 2001-05-03 Syngenta Ltd Chinuclidin derivate als squalen synthase inhibitoren
US5451596A (en) * 1992-12-29 1995-09-19 Rhone Poulenc Rorer Pharmaceuticals Inc. Cycloalkyl amine bis-aryl squalene synthase inhibitors
US5455260A (en) * 1993-05-21 1995-10-03 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aliphatic amino bis-aryl squalene synthase inhibitors
US5395846A (en) * 1993-06-25 1995-03-07 Rhone-Poulenc Rorer Pharmaceuticals Inc. Amino Bi- and tri-carbocyclic aklane bis-aryl squalene synthase inhibitors
US5556990A (en) * 1994-12-16 1996-09-17 Rhone-Poulenc Rorer Pharmaceuticals Inc. Polyarylcarbamoylaza- and -carbamoylalkanedioic acids
US5561143A (en) * 1995-01-25 1996-10-01 Rhone-Poulenc Rorer Pharmaceuticals Inc. Aliphatic amino bis-aryl squalene synthase inhibitors

Family Cites Families (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3405134A (en) * 1965-08-17 1968-10-08 Colgate Palmolive Co Quinuclidyl esters of aromatic acids
NL6715600A (de) * 1966-12-02 1968-06-04
US3534053A (en) * 1967-05-24 1970-10-13 American Home Prod Quinuclidine derivatives
US3655675A (en) * 1968-09-09 1972-04-11 Sterling Drug Inc N-(n-heteryl)-acylanilides
US3763168A (en) * 1968-09-09 1973-10-02 Sterling Drug Inc N-(3-quinuclidinyl) acylanilides
US3725410A (en) * 1970-07-15 1973-04-03 American Home Prod 3-aminomethyl-3-quinuclidinols
US3679690A (en) * 1971-03-18 1972-07-25 Sterling Drug Inc Certain n-(pyridyl) propionanilides
FR2183565B1 (de) * 1972-05-10 1975-12-26 Cerm Cent Europ Rech Mauvernay
CA1014958A (en) * 1973-10-05 1977-08-02 Jacques Moleyre .alpha.-QUINUCLIDYLMETHYL PHENYL KETONES
SU495310A1 (ru) * 1974-03-05 1975-12-15 Всесоюзный Научно-Исследовательский Химико-Фармацевтический Институт Им.С.Орджоникидзе Хинуклидил-3-диарал(гетерил) карбинолы, про вл ющие антигистаминную, антисеротониновую и антиаллергическую активность и способ их получени
US4038402A (en) * 1974-03-05 1977-07-26 Mikhail Emmanuilovich Kaminka Method of effecting antihistaminic, antiserotonin and antiallergic actions
FR2414044A1 (fr) * 1978-01-10 1979-08-03 Pharmindustrie Nouveaux derives d'aza-1 bicyclo(2,2,2) octane, utilisables comme medicaments
US4599344A (en) * 1984-10-31 1986-07-08 Schering A.G. Quinuclidines and quinuclidinium salts as antiarrhythmic agents
CH667657A5 (de) * 1985-01-07 1988-10-31 Sandoz Ag Carbocyclische und heterocyclische carbonylmethylen- und methylpiperidine und -pyrrolidine.
IL88156A (en) * 1987-11-13 1997-02-18 Novo Nordisk As Azacyclic compounds their preparation and pharmaceutical compositions containing them
EP0322182A3 (de) * 1987-12-22 1992-01-02 Beecham Group Plc Azabicyclische-Verbindungen, Verfahren zu ihrer Herstellung und diese enthaltende pharmazeutische Zubereitungen
DK730588A (da) * 1988-02-03 1989-08-04 Asta Pharma Ag Anvendelse af pyridin-2-ethere eller pyridin-2-thioethere med en nitrogenholdig cycloalifatisk ring som antidepressivt laegemiddel
NZ227841A (en) * 1988-02-12 1991-08-27 Merck Sharp & Dohme Heterocyclic compounds with at least two non-condensed five membered rings and pharmaceutical compositions
US5242914A (en) * 1988-04-01 1993-09-07 Sankyo Company, Limited 2-(heterocyclylthio) carbapenem derivatives, their preparation and their use as antibiotics
NO168304C (no) * 1988-04-01 1992-02-05 Sankyo Co Analogifremgangsmaate til fremstilling av terapeutisk aktive 2-(heterocyklyltio)karbapenemderivater
US5286864A (en) * 1988-11-22 1994-02-15 Boehringer Ingelheim Kg Quinuclidines, their use as medicaments and processes for their preparation
DE8817121U1 (de) * 1988-11-22 1993-02-04 Boehringer Ingelheim Kg, 6507 Ingelheim, De
GB8918061D0 (en) * 1989-08-08 1989-09-20 Merck Sharp & Dohme Therapeutic agents
DE4116582A1 (de) * 1990-05-19 1991-11-21 Boehringer Ingelheim Kg Bicyclische 1-aza-cycloalkane
YU84791A (sh) * 1990-05-19 1994-06-10 Boehringer Ingelheim Kg. Biciklicni 1-aza-cikloalkalni
ZA92278B (en) * 1991-02-01 1992-10-28 Akzo Nv 3-quinuclidine derivatives
AU1752792A (en) * 1991-03-08 1992-10-06 Rhone-Poulenc Rorer International (Holdings) Inc. Multicyclic tertiary amine polyaromatic squalene synthetase inhibitors
US5385912A (en) * 1991-03-08 1995-01-31 Rhone-Poulenc Rorer Pharmaceuticals Inc. Multicyclic tertiary amine polyaromatic squalene synthase inhibitors
US5135935A (en) * 1991-05-17 1992-08-04 Merck & Co., Inc. Squalene synthetase inhibitors
GB9201749D0 (en) * 1992-01-28 1992-03-11 Smithkline Beecham Plc Medicaments
GB9202443D0 (en) * 1992-02-05 1992-03-18 Fujisawa Pharmaceutical Co A novel substituted-acetamide compound and a process for the preparation thereof
GB9211796D0 (en) * 1992-06-04 1992-07-15 Ici Plc Heterocyclic derivatives

Also Published As

Publication number Publication date
CZ127293A3 (en) 1994-02-16
JPH06504069A (ja) 1994-05-12
NO932382L (no) 1993-06-29
US5792777A (en) 1998-08-11
AU658458B2 (en) 1995-04-13
NZ244962A (en) 1995-04-27
GB9122988D0 (en) 1991-12-18
IL103587A (en) 1996-10-31
EP0569564A1 (de) 1993-11-18
NO932382D0 (no) 1993-06-29
HU9301846D0 (en) 1993-10-28
IL103587A0 (en) 1993-03-15
DE69223769D1 (en) 1998-02-05
ATE161534T1 (de) 1998-01-15
CA2081674A1 (en) 1993-05-01
EP0569564B1 (de) 1997-12-29
AU2783392A (en) 1993-06-07
FI932996A0 (fi) 1993-06-29
WO1993009115A1 (en) 1993-05-13
FI932996A (fi) 1993-06-29
ZA928428B (en) 1993-05-03
HUT64063A (en) 1993-11-29

Similar Documents

Publication Publication Date Title
NZ335363A (en) Naphthyridine derivatives
DE69316224D1 (de) Chinuclidine derivate als squalen synthase inhibitoren
AU1729097A (en) Quinazoline derivatives as vegf inhibitors
YU59602A (sh) Aril fuzionisana azapoliciklična jedinjenja
HUT66971A (en) 4-amino-naphthyridine derivatives pharmaceutical compositions containing the same and process for the production of thereof
TW375615B (en) Galanthamine derivatives and their use as medicaments
DE69223769T2 (de) Diphenylylchinuclidine als squalen-synthetase-inhibitoren
ATE159255T1 (de) Chinuclidine derivate als squalen synthase inhibitoren
DE59304311D1 (de) N-substituierte 3-azabicyclo[3.2.0]heptan-derivate als neuroleptika
DE69315307D1 (de) Chimuclidine Derivate als Squalen synthetase Inhibitoren
AU2134995A (en) 2,4-diphosphonoglutaric acid derivatives, methods of preparing such compounds and drugs containing them

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee
8327 Change in the person/name/address of the patent owner

Owner name: ASTRAZENECA UK LTD., LONDON, GB