DE69304076D1 - N-cyano-n'-pyridylguanidine als serotoninantagonisten - Google Patents
N-cyano-n'-pyridylguanidine als serotoninantagonistenInfo
- Publication number
- DE69304076D1 DE69304076D1 DE69304076T DE69304076T DE69304076D1 DE 69304076 D1 DE69304076 D1 DE 69304076D1 DE 69304076 T DE69304076 T DE 69304076T DE 69304076 T DE69304076 T DE 69304076T DE 69304076 D1 DE69304076 D1 DE 69304076D1
- Authority
- DE
- Germany
- Prior art keywords
- pct
- stands
- hydroxy
- halogen
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/75—Amino or imino radicals, acylated by carboxylic or carbonic acids, or by sulfur or nitrogen analogues thereof, e.g. carbamates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Psychiatry (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB929219472A GB9219472D0 (en) | 1992-09-15 | 1992-09-15 | Chemical compounds |
PCT/DK1993/000291 WO1994006770A1 (en) | 1992-09-15 | 1993-09-13 | N-cyano-n'-pyridylguanidines as serotonin antagonists |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69304076D1 true DE69304076D1 (de) | 1996-09-19 |
DE69304076T2 DE69304076T2 (de) | 1997-04-03 |
Family
ID=10721912
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69304076T Expired - Lifetime DE69304076T2 (de) | 1992-09-15 | 1993-09-13 | N-cyano-n'-pyridylguanidine als serotoninantagonisten |
Country Status (16)
Country | Link |
---|---|
US (1) | US5563160A (de) |
EP (1) | EP0660823B1 (de) |
JP (1) | JP3485567B2 (de) |
KR (1) | KR100292592B1 (de) |
AT (1) | ATE141262T1 (de) |
AU (1) | AU670816B2 (de) |
CA (1) | CA2143756C (de) |
DE (1) | DE69304076T2 (de) |
DK (1) | DK0660823T3 (de) |
ES (1) | ES2092835T3 (de) |
FI (1) | FI109118B (de) |
GB (1) | GB9219472D0 (de) |
GR (1) | GR3021015T3 (de) |
NZ (1) | NZ255330A (de) |
RU (1) | RU2141951C1 (de) |
WO (1) | WO1994006770A1 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5696140A (en) * | 1992-09-15 | 1997-12-09 | Leo Pharmaceutical Products Ltd. | N-cyano-N'-pyridylguanidines as serotonin antagonists |
US5869497A (en) * | 1996-03-15 | 1999-02-09 | Eli Lilly And Company | Method of treating or ameliorating the symptoms of common cold or allergic rhinitis |
EP0795328A1 (de) * | 1996-03-15 | 1997-09-17 | Pfizer Inc. | Verwendung von Naphthalenderivate zur Behandlung von Lungenkrebs |
GB9711126D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Cyanoamidines |
GB9711127D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
GB9711124D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
GB9711119D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
GB9711122D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
GB9711123D0 (en) | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
GB9711125D0 (en) * | 1997-05-29 | 1997-07-23 | Leo Pharm Prod Ltd | Novel cyanoguanidines |
CA2335038A1 (en) * | 1998-06-15 | 1999-12-23 | Arch Development Corporation | Combination of radiotherapy and anti-angiogenic factors |
AU4080300A (en) * | 1999-04-09 | 2000-11-14 | Shionogi Bioresearch Corp. | Cyanoguanidine compounds |
AU4841700A (en) | 1999-05-12 | 2000-11-21 | Nitromed, Inc. | Nitrosated and nitrosylated potassium channel activators, compositions and methods of use |
AU1494702A (en) | 2000-11-21 | 2002-06-03 | Leo Pharma As | Cyanoguanidine prodrugs |
BR0209930A (pt) * | 2001-05-24 | 2004-03-30 | Leo Pharma As | Composto, composição farmacêutica, método para tratar doenças proliferativas, e, uso de um composto |
US20030045515A1 (en) * | 2001-05-24 | 2003-03-06 | Lise Binderup | Combination medicament for treatment of neoplastic diseases |
GB0217920D0 (en) * | 2002-04-23 | 2002-09-11 | Aventis Pharm Prod Inc | Interleukin-4 Gene Expression inhibitors |
US7253193B2 (en) | 2002-05-17 | 2007-08-07 | Leo Pharma A/S | Cyanoguanidine prodrugs |
JP4935073B2 (ja) | 2003-10-14 | 2012-05-23 | 味の素株式会社 | エーテル誘導体 |
DE102004008141A1 (de) * | 2004-02-19 | 2005-09-01 | Abbott Gmbh & Co. Kg | Guanidinverbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren |
JP5189367B2 (ja) | 2004-12-22 | 2013-04-24 | レオ ファーマ アクティーゼルスカブ | 新規シアノグアニジン化合物 |
WO2007022964A2 (de) | 2005-08-24 | 2007-03-01 | Abbott Gmbh & Co. Kg | Hetaryl substituierte guanidinverbindungen und ihre verwendung als bindungspartner für 5-ht5-rezeptoren |
EP2197443A4 (de) | 2007-09-26 | 2014-01-01 | Gemin X Pharmaceuticals Canada Inc | Zusammensetzungen und verfahren zur herbeiführung von nad+-spiegeln mithilfe eines nicotinamid-phosphoribosyl-transferase-hemmers |
US8173677B2 (en) | 2007-09-26 | 2012-05-08 | Gemin X Pharmaceuticals Canada Inc. | Compositions and methods for effecting NAD+ levels using a nicotinamide phosphoribosyl transferase inhibitor |
AU2010210248B2 (en) | 2009-02-06 | 2012-08-16 | Tianjin Hemay Bio-Tech Co., Ltd. | Pharmaceutical compositions comprising pyridyl cyanoguanidine, process for preparing the same and use thereof |
US8912184B1 (en) | 2010-03-01 | 2014-12-16 | Alzheimer's Institute Of America, Inc. | Therapeutic and diagnostic methods |
KR20140020823A (ko) * | 2010-09-03 | 2014-02-19 | 포르마 티엠, 엘엘씨. | Nampt의 억제를 위한 구아니딘 화합물 및 조성물 |
WO2012055346A1 (zh) | 2010-10-26 | 2012-05-03 | 天津和美生物技术有限公司 | N-(6-(4-氯苯氧基)己基)-n'-氰基-n''-(4-吡啶基)胍的多晶型物及其制备和应用 |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1489879A (en) * | 1974-12-20 | 1977-10-26 | Leo Pharm Prod Ltd | N'-cyano-n'-3-pyridylguanidines |
GB2242628A (en) * | 1990-04-06 | 1991-10-09 | Sandoz Ltd | Asthma prophylactic use of K+ channel activators |
-
1992
- 1992-09-15 GB GB929219472A patent/GB9219472D0/en active Pending
-
1993
- 1993-09-13 NZ NZ255330A patent/NZ255330A/en not_active IP Right Cessation
- 1993-09-13 JP JP50770994A patent/JP3485567B2/ja not_active Expired - Lifetime
- 1993-09-13 RU RU95105437A patent/RU2141951C1/ru active
- 1993-09-13 US US08/397,266 patent/US5563160A/en not_active Expired - Lifetime
- 1993-09-13 KR KR1019950700625A patent/KR100292592B1/ko not_active IP Right Cessation
- 1993-09-13 CA CA002143756A patent/CA2143756C/en not_active Expired - Lifetime
- 1993-09-13 EP EP93919045A patent/EP0660823B1/de not_active Expired - Lifetime
- 1993-09-13 WO PCT/DK1993/000291 patent/WO1994006770A1/en active IP Right Grant
- 1993-09-13 DK DK93919045.0T patent/DK0660823T3/da active
- 1993-09-13 ES ES93919045T patent/ES2092835T3/es not_active Expired - Lifetime
- 1993-09-13 AT AT93919045T patent/ATE141262T1/de active
- 1993-09-13 AU AU49456/93A patent/AU670816B2/en not_active Expired
- 1993-09-13 DE DE69304076T patent/DE69304076T2/de not_active Expired - Lifetime
-
1995
- 1995-03-14 FI FI951189A patent/FI109118B/fi not_active IP Right Cessation
-
1996
- 1996-09-12 GR GR960402367T patent/GR3021015T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
WO1994006770A1 (en) | 1994-03-31 |
AU670816B2 (en) | 1996-08-01 |
JPH08501539A (ja) | 1996-02-20 |
CA2143756C (en) | 2003-11-11 |
JP3485567B2 (ja) | 2004-01-13 |
EP0660823A1 (de) | 1995-07-05 |
RU2141951C1 (ru) | 1999-11-27 |
ATE141262T1 (de) | 1996-08-15 |
DK0660823T3 (da) | 1996-09-23 |
EP0660823B1 (de) | 1996-08-14 |
AU4945693A (en) | 1994-04-12 |
FI951189A (fi) | 1995-03-14 |
DE69304076T2 (de) | 1997-04-03 |
US5563160A (en) | 1996-10-08 |
GB9219472D0 (en) | 1992-10-28 |
FI951189A0 (fi) | 1995-03-14 |
KR950702964A (ko) | 1995-08-23 |
GR3021015T3 (en) | 1996-12-31 |
FI109118B (fi) | 2002-05-31 |
CA2143756A1 (en) | 1994-03-31 |
ES2092835T3 (es) | 1996-12-01 |
NZ255330A (en) | 1997-06-24 |
KR100292592B1 (ko) | 2001-09-17 |
RU95105437A (ru) | 1996-10-27 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8327 | Change in the person/name/address of the patent owner |
Owner name: LEO PHARMA A/S ZWEITNAME: LEO PHARMACEUTICAL PRODU |