DE69302109T2 - Oximderivate als 5-Lipoxygenase-Hemmer - Google Patents
Oximderivate als 5-Lipoxygenase-HemmerInfo
- Publication number
- DE69302109T2 DE69302109T2 DE69302109T DE69302109T DE69302109T2 DE 69302109 T2 DE69302109 T2 DE 69302109T2 DE 69302109 T DE69302109 T DE 69302109T DE 69302109 T DE69302109 T DE 69302109T DE 69302109 T2 DE69302109 T2 DE 69302109T2
- Authority
- DE
- Germany
- Prior art keywords
- alkyl
- lipoxygenase inhibitors
- oxime derivatives
- sulphinyl
- sulphonyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
- C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
- C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D307/20—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
- C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
- C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D309/10—Oxygen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
- C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
- C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
- C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
- C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
- C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
- C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
- C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Immunology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Peptides Or Proteins (AREA)
- Pyrane Compounds (AREA)
- Furan Compounds (AREA)
- Cephalosporin Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP92400318 | 1992-02-07 | ||
EP92402764 | 1992-10-09 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69302109D1 DE69302109D1 (de) | 1996-05-15 |
DE69302109T2 true DE69302109T2 (de) | 1996-10-17 |
Family
ID=26132332
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69302109T Expired - Fee Related DE69302109T2 (de) | 1992-02-07 | 1993-02-03 | Oximderivate als 5-Lipoxygenase-Hemmer |
Country Status (20)
Country | Link |
---|---|
US (2) | US5332757A (de) |
EP (1) | EP0555068B1 (de) |
JP (1) | JPH05286957A (de) |
AT (1) | ATE136546T1 (de) |
AU (1) | AU658964B2 (de) |
CA (1) | CA2088864A1 (de) |
CZ (1) | CZ13393A3 (de) |
DE (1) | DE69302109T2 (de) |
ES (1) | ES2086878T3 (de) |
FI (1) | FI930475A (de) |
GB (1) | GB9300894D0 (de) |
GR (1) | GR3019634T3 (de) |
HU (1) | HUT63840A (de) |
IL (1) | IL104624A0 (de) |
NO (1) | NO930411L (de) |
NZ (1) | NZ245772A (de) |
PL (1) | PL297666A1 (de) |
SK (1) | SK6993A3 (de) |
TW (1) | TW224094B (de) |
ZW (1) | ZW1293A1 (de) |
Families Citing this family (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IL108187A0 (en) * | 1993-01-28 | 1994-04-12 | Zenecca Limited | Oxime derivatives |
ZA945250B (en) * | 1993-07-27 | 1995-01-27 | Zeneca Ltd | Thiazole derivatives |
WO1995030668A1 (en) * | 1994-05-06 | 1995-11-16 | Zeneca Limited | Cyclic ether derivatives and pharmaceutical composition containing them |
US5668159A (en) * | 1996-05-08 | 1997-09-16 | The Dupont Merck Pharmaceutical Company | 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists |
WO1998003496A1 (en) * | 1996-07-19 | 1998-01-29 | Centaur Pharmaceuticals, Inc. | Furan nitrone compounds |
CN1136212C (zh) * | 1998-01-16 | 2004-01-28 | 桑道药品有限公司 | 噻吩硝酮化合物 |
CN1291980A (zh) * | 1998-01-16 | 2001-04-18 | 桑道药品有限公司 | 硫醚呋喃硝酮化合物 |
JP2006527207A (ja) * | 2003-06-11 | 2006-11-30 | メルク フロスト カナダ リミテツド | 7−(1,3−チアゾール−2−イル)チオ−クマリン誘導体およびそれのロイコトリエン生合成阻害薬としての使用 |
KR20100072090A (ko) * | 2007-11-26 | 2010-06-29 | 화이자 인코포레이티드 | 5-lo 억제제로서의 피라졸 유도체 |
CN104447658A (zh) * | 2014-12-04 | 2015-03-25 | 杭州杜易科技有限公司 | 一种卤代4-色满酮衍生物的制备方法 |
US20220235013A1 (en) | 2017-03-21 | 2022-07-28 | Bayer Pharma Aktiengesellschaft | 2-methyl-quinazolines |
CA3097231A1 (en) | 2018-04-18 | 2019-10-24 | Bayer Pharma Aktiengesellschaft | 2-methyl-aza-quinazolines |
BR112021008900A2 (pt) | 2018-11-08 | 2021-08-10 | Unilever Ip Holdings B.V. | processo para a síntese de lactama |
CN112969762A (zh) * | 2018-11-08 | 2021-06-15 | 联合利华知识产权控股有限公司 | 表面处理方法 |
KR20220020243A (ko) * | 2019-06-11 | 2022-02-18 | 가부시키가이샤 아데카 | 카르바모일옥심 화합물 그리고 상기 화합물을 함유하는 중합 개시제 및 중합성 조성물 |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
IE56702B1 (en) * | 1982-12-01 | 1991-11-06 | Usv Pharma Corp | Antiinflammatory antiallergic compounds |
US4794188A (en) * | 1982-12-01 | 1988-12-27 | Usv Pharmaceutical Corporation | Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity |
US4567184A (en) * | 1982-12-01 | 1986-01-28 | Usv Pharmaceutical Corporation | Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies |
NO174506B (no) * | 1984-10-30 | 1994-02-07 | Usv Pharma Corp | Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser |
US4625034A (en) * | 1985-02-04 | 1986-11-25 | Usv Pharmaceutical Corp. | 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives |
US4661596A (en) * | 1985-02-21 | 1987-04-28 | American Home Products Corporation | Quinolinyl (or pyridinyl) methoxy substituted naphthalene compounds as antiallergic agents |
US4631287A (en) * | 1985-04-16 | 1986-12-23 | Usv Pharmaceutical Corp. | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4725619A (en) * | 1985-04-16 | 1988-02-16 | Usv Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4728668A (en) * | 1985-04-16 | 1988-03-01 | Usv Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4839369A (en) * | 1985-04-16 | 1989-06-13 | Rorer Pharmaceutical Corporation | Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments |
US4876346A (en) * | 1985-05-02 | 1989-10-24 | American Home Products Corporation | Quinoline compounds |
DE3617183A1 (de) * | 1985-11-16 | 1987-05-27 | Bayer Ag | Substituierte benzylether |
US4681940A (en) * | 1985-11-19 | 1987-07-21 | American Home Products Corporation | 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles |
US4868193A (en) * | 1986-09-24 | 1989-09-19 | Rorer Pharmaceutical Corporation | Styryl tetrazoles and anti-allergic use thereof |
IL92620A0 (en) * | 1988-12-23 | 1990-08-31 | Ici Pharma | Cycloalkane derivatives |
GB8926981D0 (en) * | 1988-12-23 | 1990-01-17 | Ici Plc | Heterocyclic derivatives |
GB8927287D0 (en) * | 1988-12-23 | 1990-01-31 | Ici Plc | Cyclic ether derivatives |
US5134148A (en) * | 1989-02-28 | 1992-07-28 | Imperial Chemical Industries Plc | Heterocycles for use as inhibitors of leukotrienes |
IE70521B1 (en) * | 1989-02-28 | 1996-12-11 | Zeneca Pharma Sa | Heterocycles with inhibitory activity of 5-lipoxygenase |
IL93344A0 (en) * | 1989-02-28 | 1990-11-29 | Ici Plc | Heterocyclic cyclic ethers |
IE902113A1 (en) * | 1989-07-18 | 1991-06-19 | Ici Plc | Diaryl ether cyclic ethers |
IE64358B1 (en) * | 1989-07-18 | 1995-07-26 | Ici Plc | Diaryl ether heterocycles |
DE69117355T2 (de) * | 1990-06-21 | 1996-08-08 | Zeneca Ltd | Bizyklische Pyran-Derivate und ihre Verwendung als 5-Lipoxygenasehemmer |
IE911853A1 (en) * | 1990-06-21 | 1992-01-01 | Ici Plc | Heterocyclene derivatives |
IE913866A1 (en) * | 1990-11-28 | 1992-06-03 | Ici Plc | Aryl derivatives |
-
1993
- 1993-01-18 GB GB939300894A patent/GB9300894D0/en active Pending
- 1993-01-21 ZW ZW12/93A patent/ZW1293A1/xx unknown
- 1993-01-22 AU AU31972/93A patent/AU658964B2/en not_active Ceased
- 1993-01-27 NZ NZ245772A patent/NZ245772A/en unknown
- 1993-02-03 ES ES93300782T patent/ES2086878T3/es not_active Expired - Lifetime
- 1993-02-03 HU HU9300272A patent/HUT63840A/hu unknown
- 1993-02-03 AT AT93300782T patent/ATE136546T1/de not_active IP Right Cessation
- 1993-02-03 FI FI930475A patent/FI930475A/fi not_active Application Discontinuation
- 1993-02-03 DE DE69302109T patent/DE69302109T2/de not_active Expired - Fee Related
- 1993-02-03 EP EP93300782A patent/EP0555068B1/de not_active Expired - Lifetime
- 1993-02-04 IL IL104624A patent/IL104624A0/xx unknown
- 1993-02-04 CZ CZ93133A patent/CZ13393A3/cs unknown
- 1993-02-05 CA CA002088864A patent/CA2088864A1/en not_active Abandoned
- 1993-02-05 TW TW082100795A patent/TW224094B/zh active
- 1993-02-05 NO NO93930411A patent/NO930411L/no unknown
- 1993-02-05 JP JP5018574A patent/JPH05286957A/ja active Pending
- 1993-02-05 PL PL29766693A patent/PL297666A1/xx unknown
- 1993-02-05 SK SK6993A patent/SK6993A3/sk unknown
- 1993-02-08 US US08/014,564 patent/US5332757A/en not_active Expired - Fee Related
-
1994
- 1994-06-13 US US08/240,464 patent/US5482966A/en not_active Expired - Fee Related
-
1996
- 1996-04-11 GR GR960400829T patent/GR3019634T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
AU3197293A (en) | 1993-08-12 |
NZ245772A (en) | 1995-05-26 |
DE69302109D1 (de) | 1996-05-15 |
CA2088864A1 (en) | 1993-08-08 |
HU9300272D0 (en) | 1993-04-28 |
US5482966A (en) | 1996-01-09 |
GB9300894D0 (en) | 1993-03-10 |
AU658964B2 (en) | 1995-05-04 |
PL297666A1 (en) | 1993-10-18 |
TW224094B (de) | 1994-05-21 |
ZW1293A1 (en) | 1993-09-29 |
FI930475A0 (fi) | 1993-02-03 |
IL104624A0 (en) | 1993-06-10 |
JPH05286957A (ja) | 1993-11-02 |
NO930411D0 (no) | 1993-02-05 |
US5332757A (en) | 1994-07-26 |
EP0555068B1 (de) | 1996-04-10 |
HUT63840A (en) | 1993-10-28 |
GR3019634T3 (en) | 1996-07-31 |
FI930475A (fi) | 1993-08-08 |
NO930411L (no) | 1993-08-09 |
CZ13393A3 (en) | 1993-10-13 |
EP0555068A1 (de) | 1993-08-11 |
ATE136546T1 (de) | 1996-04-15 |
ES2086878T3 (es) | 1996-07-01 |
SK6993A3 (en) | 1993-09-09 |
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NO903185D0 (no) | Fremgangsmaate for fremstilling av diaryleter-heterocykliske forbindelser. | |
MY106366A (en) | Bicyclic heterocyclic pryan derivatives and their use as inhibitors of 5-lipoxygenase | |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |