ATE136546T1 - Oximderivate als 5-lipoxygenase-hemmer - Google Patents

Oximderivate als 5-lipoxygenase-hemmer

Info

Publication number
ATE136546T1
ATE136546T1 AT93300782T AT93300782T ATE136546T1 AT E136546 T1 ATE136546 T1 AT E136546T1 AT 93300782 T AT93300782 T AT 93300782T AT 93300782 T AT93300782 T AT 93300782T AT E136546 T1 ATE136546 T1 AT E136546T1
Authority
AT
Austria
Prior art keywords
alkyl
lipoxygenase inhibitors
oxime derivatives
sulphinyl
sulphonyl
Prior art date
Application number
AT93300782T
Other languages
English (en)
Inventor
Thomas Geoffrey Colerick Bird
Patrick Ple
Original Assignee
Zeneca Ltd
Zeneca Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zeneca Ltd, Zeneca Pharma Sa filed Critical Zeneca Ltd
Application granted granted Critical
Publication of ATE136546T1 publication Critical patent/ATE136546T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/04—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D307/18—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/20—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D309/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings
    • C07D309/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D309/08—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only ring hetero atom, not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D309/10—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D317/00—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms
    • C07D317/08—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3
    • C07D317/10—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings
    • C07D317/14—Heterocyclic compounds containing five-membered rings having two oxygen atoms as the only ring hetero atoms having the hetero atoms in positions 1 and 3 not condensed with other rings with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D317/18—Radicals substituted by singly bound oxygen or sulfur atoms
    • C07D317/22—Radicals substituted by singly bound oxygen or sulfur atoms etherified
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pulmonology (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Indole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Peptides Or Proteins (AREA)
  • Pyrane Compounds (AREA)
  • Furan Compounds (AREA)
  • Cephalosporin Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
AT93300782T 1992-02-07 1993-02-03 Oximderivate als 5-lipoxygenase-hemmer ATE136546T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP92400318 1992-02-07
EP92402764 1992-10-09

Publications (1)

Publication Number Publication Date
ATE136546T1 true ATE136546T1 (de) 1996-04-15

Family

ID=26132332

Family Applications (1)

Application Number Title Priority Date Filing Date
AT93300782T ATE136546T1 (de) 1992-02-07 1993-02-03 Oximderivate als 5-lipoxygenase-hemmer

Country Status (20)

Country Link
US (2) US5332757A (de)
EP (1) EP0555068B1 (de)
JP (1) JPH05286957A (de)
AT (1) ATE136546T1 (de)
AU (1) AU658964B2 (de)
CA (1) CA2088864A1 (de)
CZ (1) CZ13393A3 (de)
DE (1) DE69302109T2 (de)
ES (1) ES2086878T3 (de)
FI (1) FI930475A (de)
GB (1) GB9300894D0 (de)
GR (1) GR3019634T3 (de)
HU (1) HUT63840A (de)
IL (1) IL104624A0 (de)
NO (1) NO930411L (de)
NZ (1) NZ245772A (de)
PL (1) PL297666A1 (de)
SK (1) SK6993A3 (de)
TW (1) TW224094B (de)
ZW (1) ZW1293A1 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL108187A0 (en) * 1993-01-28 1994-04-12 Zenecca Limited Oxime derivatives
ZA945250B (en) * 1993-07-27 1995-01-27 Zeneca Ltd Thiazole derivatives
WO1995030668A1 (en) * 1994-05-06 1995-11-16 Zeneca Limited Cyclic ether derivatives and pharmaceutical composition containing them
US5668159A (en) * 1996-05-08 1997-09-16 The Dupont Merck Pharmaceutical Company 1,3,4-thiadiazoles and 1,3,4-oxadiazoles as IIb/IIIa antagonists
WO1998003496A1 (en) * 1996-07-19 1998-01-29 Centaur Pharmaceuticals, Inc. Furan nitrone compounds
CN1136212C (zh) * 1998-01-16 2004-01-28 桑道药品有限公司 噻吩硝酮化合物
CN1291980A (zh) * 1998-01-16 2001-04-18 桑道药品有限公司 硫醚呋喃硝酮化合物
JP2006527207A (ja) * 2003-06-11 2006-11-30 メルク フロスト カナダ リミテツド ７−（１，３−チアゾール−２−イル）チオ−クマリン誘導体およびそれのロイコトリエン生合成阻害薬としての使用
KR20100072090A (ko) * 2007-11-26 2010-06-29 화이자 인코포레이티드 5-ｌｏ 억제제로서의 피라졸 유도체
CN104447658A (zh) * 2014-12-04 2015-03-25 杭州杜易科技有限公司 一种卤代4-色满酮衍生物的制备方法
US20220235013A1 (en) 2017-03-21 2022-07-28 Bayer Pharma Aktiengesellschaft 2-methyl-quinazolines
CA3097231A1 (en) 2018-04-18 2019-10-24 Bayer Pharma Aktiengesellschaft 2-methyl-aza-quinazolines
BR112021008900A2 (pt) 2018-11-08 2021-08-10 Unilever Ip Holdings B.V. processo para a síntese de lactama
CN112969762A (zh) * 2018-11-08 2021-06-15 联合利华知识产权控股有限公司 表面处理方法
KR20220020243A (ko) * 2019-06-11 2022-02-18 가부시키가이샤 아데카 카르바모일옥심 화합물 그리고 상기 화합물을 함유하는 중합 개시제 및 중합성 조성물

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IE56702B1 (en) * 1982-12-01 1991-11-06 Usv Pharma Corp Antiinflammatory antiallergic compounds
US4794188A (en) * 1982-12-01 1988-12-27 Usv Pharmaceutical Corporation Certain unsymmetrical quinolinyl ethers having anti-inflammatory and anti-allergic activity
US4567184A (en) * 1982-12-01 1986-01-28 Usv Pharmaceutical Corporation Certain aryl or hetero-aryl derivatives of 1-hydroxy-pentane or 1-hydroxy-hexane which are useful for treating inflammation and allergies
NO174506B (no) * 1984-10-30 1994-02-07 Usv Pharma Corp Analogifremgangsmaate ved fremstilling av terapeutisk aktive forbindelser
US4625034A (en) * 1985-02-04 1986-11-25 Usv Pharmaceutical Corp. 1,2-Dihydro; 1,2,3,4-tetrahydro; 5,8 dihydro; and 5,6,7,8-tetrahydroquinoline derivatives
US4661596A (en) * 1985-02-21 1987-04-28 American Home Products Corporation Quinolinyl (or pyridinyl) methoxy substituted naphthalene compounds as antiallergic agents
US4631287A (en) * 1985-04-16 1986-12-23 Usv Pharmaceutical Corp. Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4725619A (en) * 1985-04-16 1988-02-16 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4728668A (en) * 1985-04-16 1988-03-01 Usv Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4839369A (en) * 1985-04-16 1989-06-13 Rorer Pharmaceutical Corporation Aryl and heteroaryl ethers as agents for the treatment of hypersensitive ailments
US4876346A (en) * 1985-05-02 1989-10-24 American Home Products Corporation Quinoline compounds
DE3617183A1 (de) * 1985-11-16 1987-05-27 Bayer Ag Substituierte benzylether
US4681940A (en) * 1985-11-19 1987-07-21 American Home Products Corporation 5-[3-[[2-quinolyl]methoxy]phenyl]-1,3-oxazoles
US4868193A (en) * 1986-09-24 1989-09-19 Rorer Pharmaceutical Corporation Styryl tetrazoles and anti-allergic use thereof
IL92620A0 (en) * 1988-12-23 1990-08-31 Ici Pharma Cycloalkane derivatives
GB8926981D0 (en) * 1988-12-23 1990-01-17 Ici Plc Heterocyclic derivatives
GB8927287D0 (en) * 1988-12-23 1990-01-31 Ici Plc Cyclic ether derivatives
US5134148A (en) * 1989-02-28 1992-07-28 Imperial Chemical Industries Plc Heterocycles for use as inhibitors of leukotrienes
IE70521B1 (en) * 1989-02-28 1996-12-11 Zeneca Pharma Sa Heterocycles with inhibitory activity of 5-lipoxygenase
IL93344A0 (en) * 1989-02-28 1990-11-29 Ici Plc Heterocyclic cyclic ethers
IE902113A1 (en) * 1989-07-18 1991-06-19 Ici Plc Diaryl ether cyclic ethers
IE64358B1 (en) * 1989-07-18 1995-07-26 Ici Plc Diaryl ether heterocycles
DE69117355T2 (de) * 1990-06-21 1996-08-08 Zeneca Ltd Bizyklische Pyran-Derivate und ihre Verwendung als 5-Lipoxygenasehemmer
IE911853A1 (en) * 1990-06-21 1992-01-01 Ici Plc Heterocyclene derivatives
IE913866A1 (en) * 1990-11-28 1992-06-03 Ici Plc Aryl derivatives

Also Published As

Publication number Publication date
AU3197293A (en) 1993-08-12
NZ245772A (en) 1995-05-26
DE69302109D1 (de) 1996-05-15
CA2088864A1 (en) 1993-08-08
HU9300272D0 (en) 1993-04-28
US5482966A (en) 1996-01-09
GB9300894D0 (en) 1993-03-10
AU658964B2 (en) 1995-05-04
PL297666A1 (en) 1993-10-18
TW224094B (de) 1994-05-21
ZW1293A1 (en) 1993-09-29
FI930475A0 (fi) 1993-02-03
DE69302109T2 (de) 1996-10-17
IL104624A0 (en) 1993-06-10
JPH05286957A (ja) 1993-11-02
NO930411D0 (no) 1993-02-05
US5332757A (en) 1994-07-26
EP0555068B1 (de) 1996-04-10
HUT63840A (en) 1993-10-28
GR3019634T3 (en) 1996-07-31
FI930475A (fi) 1993-08-08
NO930411L (no) 1993-08-09
CZ13393A3 (en) 1993-10-13
EP0555068A1 (de) 1993-08-11
ES2086878T3 (es) 1996-07-01
SK6993A3 (en) 1993-09-09

Similar Documents

Publication Publication Date Title
DE69302109D1 (de) Oximderivate als 5-Lipoxygenase-Hemmer
HUT61999A (en) Process for producing thioxo compounds and pharmaceutical compositions comprising same as active ingredient
NO903185D0 (no) Fremgangsmaate for fremstilling av diaryleter-heterocykliske forbindelser.
MY106366A (en) Bicyclic heterocyclic pryan derivatives and their use as inhibitors of 5-lipoxygenase
GB2264946B (en) Anti-tumour compounds
IL109615A0 (en) Polypeptide derivatives, processes for the preparation thereof and pharmaceutical compositions containing the same
DE69430128D1 (en) Cyclodepsipeptide
DE69003616D1 (en) Diarylcycloalkanether.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties