DE69232552D1 - Tetrapeptide Derivat - Google Patents

Tetrapeptide Derivat

Info

Publication number
DE69232552D1
DE69232552D1 DE69232552T DE69232552T DE69232552D1 DE 69232552 D1 DE69232552 D1 DE 69232552D1 DE 69232552 T DE69232552 T DE 69232552T DE 69232552 T DE69232552 T DE 69232552T DE 69232552 D1 DE69232552 D1 DE 69232552D1
Authority
DE
Germany
Prior art keywords
chem
tetrapeptide derivative
tetrapeptide
derivative
dolastatin
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69232552T
Other languages
English (en)
Other versions
DE69232552T2 (de
Inventor
Kyoichi Sakakibara
Masaaki Gondo
Koichi Miyazaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Aska Pharmaceutical Co Ltd
Original Assignee
Teikoku Hormone Manufacturing Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=26525532&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69232552(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Teikoku Hormone Manufacturing Co Ltd filed Critical Teikoku Hormone Manufacturing Co Ltd
Application granted granted Critical
Publication of DE69232552D1 publication Critical patent/DE69232552D1/de
Publication of DE69232552T2 publication Critical patent/DE69232552T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/02—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link
    • C07K5/0205—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing at least one abnormal peptide link containing the structure -NH-(X)3-C(=0)-, e.g. statine or derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/02—Linear peptides containing at least one abnormal peptide link
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
DE69232552T 1991-08-09 1992-08-06 Tetrapeptide Derivat Expired - Fee Related DE69232552T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP22353491 1991-08-09
JP22539191 1991-08-12

Publications (2)

Publication Number Publication Date
DE69232552D1 true DE69232552D1 (de) 2002-05-16
DE69232552T2 DE69232552T2 (de) 2002-10-31

Family

ID=26525532

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69230824T Expired - Lifetime DE69230824T2 (de) 1991-08-09 1992-08-06 Neue tetrapeptidderivate
DE69232552T Expired - Fee Related DE69232552T2 (de) 1991-08-09 1992-08-06 Tetrapeptide Derivat

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69230824T Expired - Lifetime DE69230824T2 (de) 1991-08-09 1992-08-06 Neue tetrapeptidderivate

Country Status (13)

Country Link
US (2) US6004934A (de)
EP (2) EP0934950B1 (de)
JP (1) JP2618597B2 (de)
KR (2) KR0185440B1 (de)
AT (2) ATE190983T1 (de)
AU (2) AU662551B2 (de)
CA (1) CA2115355C (de)
DE (2) DE69230824T2 (de)
DK (2) DK0934950T3 (de)
ES (2) ES2172069T3 (de)
GR (1) GR3033397T3 (de)
SG (1) SG87056A1 (de)
WO (1) WO1993003054A1 (de)

Families Citing this family (55)

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Publication number Priority date Publication date Assignee Title
US5831002A (en) * 1992-05-20 1998-11-03 Basf Aktiengesellschaft Antitumor peptides
DK0642530T3 (da) * 1992-05-20 1998-10-26 Basf Ag Dolastatinderivater
WO1994013695A1 (en) * 1992-12-16 1994-06-23 Basf Aktiengesellschaft Dolostatin analog
KR100332254B1 (ko) * 1993-10-01 2002-09-27 데이꼬꾸 조끼 세이야꾸 가부시키가이샤 신규인펩티드유도체
US5599902A (en) * 1994-11-10 1997-02-04 Arizona Board Of Regents Acting On Behalf Of Arizona State University Cancer inhibitory peptides
US5663149A (en) * 1994-12-13 1997-09-02 Arizona Board Of Regents Acting On Behalf Of Arizona State University Human cancer inhibitory pentapeptide heterocyclic and halophenyl amides
CN1113066C (zh) * 1995-04-21 2003-07-02 帝国脏器制药株式会社 新型肽衍生物
US5807984A (en) * 1995-11-09 1998-09-15 Basf Aktienegesellschaft Oligopeptides, the preparation and use thereof
US20010009901A1 (en) 1996-12-11 2001-07-26 Basf Aktiengesellschaft Germany Antineoplastic peptides
US5939527A (en) * 1996-07-30 1999-08-17 Basf Aktiengesellschaft Tetrapeptides as antitumor agents
US5741892A (en) * 1996-07-30 1998-04-21 Basf Aktiengesellschaft Pentapeptides as antitumor agents
US5965537A (en) * 1997-03-10 1999-10-12 Basf Aktiengesellschaft Dolastatin 15 derivatives with carbonyl and heterocyclic functionalities at the C-terminus
US6103698A (en) 1997-03-13 2000-08-15 Basf Aktiengesellschaft Dolastatin-15 derivatives in combination with taxanes
US6143721A (en) 1997-07-18 2000-11-07 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6686445B1 (en) 1997-09-24 2004-02-03 Arizona Board Of Regents, Acting For And On Behalf Of Arizona State University Synthetic antineoplastic agents derived from dolastatin 15 and methods of making same
DE69829881T2 (de) * 1997-09-24 2006-03-09 Arizona Board Of Regents, Tempe Synthetische antineoplastische wirkstoffe abgeleitet von dolastatin 15 sowie verfahren zu ihrer herstellung
US6015790A (en) * 1997-10-06 2000-01-18 Basf Aktiengesellschaft Methods and compositions for treating rheumatoid arthritis
US5985837A (en) * 1998-07-08 1999-11-16 Basf Aktiengesellschaft Dolastatin 15 derivatives
US6323315B1 (en) * 1999-09-10 2001-11-27 Basf Aktiengesellschaft Dolastatin peptides
EP2289549A3 (de) 1999-10-01 2011-06-15 Immunogen, Inc. Immunokonjugate für Krebsbehandlung
AU1730701A (en) * 1999-12-07 2001-06-18 Santen Pharmaceutical Co. Ltd. Rheumatism remedy containing tetrapeptide derivative as active ingredient
US7256257B2 (en) 2001-04-30 2007-08-14 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
US6884869B2 (en) * 2001-04-30 2005-04-26 Seattle Genetics, Inc. Pentapeptide compounds and uses related thereto
KR20010079252A (ko) * 2001-06-27 2001-08-22 홍진의 주름형 드럼을 갖는 드럼 필터
EP1428530B1 (de) * 2001-09-20 2008-08-20 Teikoku Hormone Mfg. Co., Ltd. Tetrapeptid-derivat-kristalle
JP4741838B2 (ja) 2002-07-31 2011-08-10 シアトル ジェネティクス，インコーポレーテッド 癌、自己免疫疾患または感染症を治療するための薬物結合体およびその使用
PT2489364E (pt) * 2003-11-06 2015-04-16 Seattle Genetics Inc Compostos de monometilvalina conjugados com anticorpos
ES2715776T3 (es) * 2004-11-12 2019-06-06 Seattle Genetics Inc Auristatinas que tienen una unidad de ácido aminobenzoico en el extremo N
WO2006122408A1 (en) 2005-05-18 2006-11-23 Aegera Therapeutics Inc. Bir domain binding compounds
WO2007008848A2 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine carboxy modifications at the c-terminus
WO2007008603A1 (en) 2005-07-07 2007-01-18 Seattle Genetics, Inc. Monomethylvaline compounds having phenylalanine side-chain modifications at the c-terminus
US7750116B1 (en) 2006-02-18 2010-07-06 Seattle Genetics, Inc. Antibody drug conjugate metabolites
BRPI0711591A2 (pt) 2006-05-16 2011-11-16 Aegera Therapeutics Inc composto de ligação de domìnio bir da iap
PT2474557E (pt) 2007-07-16 2014-12-03 Genentech Inc Anticorpos e imunoconjugados anti-cd79b e métodos de utilização
BRPI0813514A2 (pt) 2007-07-16 2019-09-24 Genentech Inc anticorpos anti-cd79b humanizados e imunoconjugados e métodos de uso
US20090035848A1 (en) * 2007-08-03 2009-02-05 Robert Hickey Moving bed biofilm reactor (mbbr) system for conversion of syngas components to liquid products
SI2247620T1 (sl) 2008-01-31 2016-09-30 Genentech, Inc. Protitelesa proti CD79b in imunokonjugati in postopki za uporabo
CA2718942A1 (en) 2008-03-18 2009-09-24 Seattle Genetics, Inc. Auristatin drug linker conjugates
CN102985439B9 (zh) 2010-02-12 2016-08-03 制药科学股份有限公司 Iap bir结构域结合化合物
AR088694A1 (es) 2011-11-17 2014-06-25 Pfizer Peptidos citotoxicos y conjugados de anticuerpo-farmaco de los mismos
ES2604766T3 (es) * 2012-09-20 2017-03-09 Celltrion, Inc. Derivado de dolastatina-10, procedimiento de producción del mismo y composición de fármaco anticanceroso que contiene el mismo
AU2012395148B2 (en) 2012-11-24 2016-10-27 Hangzhou Dac Biotech Co., Ltd. Hydrophilic linkers and their uses for conjugation of drugs to cell binding molecules
EP3753578A1 (de) 2013-12-17 2020-12-23 Novartis AG Zytotoxische peptide und konjugate davon
FI3122757T3 (fi) 2014-02-28 2023-10-10 Hangzhou Dac Biotech Co Ltd Varautuneita linkkereitä ja niiden konjugointikäyttötapoja
SG11201609739UA (en) * 2014-05-28 2016-12-29 Agensys Inc Derivatives of dolaproine-dolaisoleuine peptides
WO2015189791A1 (en) 2014-06-13 2015-12-17 Novartis Ag Auristatin derivatives and conjugates thereof
AU2015320678B2 (en) 2014-09-23 2021-07-22 Genentech, Inc. Method of using anti-CD79b immunoconjugates
WO2015151081A2 (en) 2015-07-12 2015-10-08 Suzhou M-Conj Biotech Co., Ltd Bridge linkers for conjugation of a cell-binding molecule
US9839687B2 (en) 2015-07-15 2017-12-12 Suzhou M-Conj Biotech Co., Ltd. Acetylenedicarboxyl linkers and their uses in specific conjugation of a cell-binding molecule
WO2017019489A1 (en) 2015-07-24 2017-02-02 George Robert Pettit Quinstatin compounds
WO2017058808A1 (en) * 2015-10-02 2017-04-06 Sirenas Llc Anti-cancer compounds and conjugates thereof
ES2948846T3 (es) * 2016-03-29 2023-09-20 Toray Industries Derivado peptídico y uso del mismo
KR102459468B1 (ko) 2016-11-14 2022-10-26 항저우 디에이씨 바이오테크 씨오, 엘티디 결합 링커, 그러한 결합 링커를 함유하는 세포 결합 분자-약물 결합체, 링커를 갖는 그러한 결합체의 제조 및 사용
US20230000995A1 (en) * 2019-10-28 2023-01-05 Ariel Scientific Innovations Ltd. Dolastatin 10 analog
CA3230737A1 (en) 2021-09-03 2023-03-09 Toray Industries, Inc. Pharmaceutical composition for cancer treatment and/or prevention

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5017691A (en) * 1986-07-03 1991-05-21 Schering Corporation Mammalian interleukin-4
US4816444A (en) * 1987-07-10 1989-03-28 Arizona Board Of Regents, Arizona State University Cell growth inhibitory substance
US4978744A (en) * 1989-01-27 1990-12-18 Arizona Board Of Regents Synthesis of dolastatin 10
US6034065A (en) * 1992-12-03 2000-03-07 Arizona Board Of Regents Elucidation and synthesis of antineoplastic tetrapeptide phenethylamides of dolastatin 10
US5635483A (en) * 1992-12-03 1997-06-03 Arizona Board Of Regents Acting On Behalf Of Arizona State University Tumor inhibiting tetrapeptide bearing modified phenethyl amides

Also Published As

Publication number Publication date
DK0934950T3 (da) 2002-07-29
WO1993003054A1 (en) 1993-02-18
GR3033397T3 (en) 2000-09-29
AU2001095A (en) 1995-07-20
EP0598129A4 (en) 1995-10-25
JP2618597B2 (ja) 1997-06-11
DE69232552T2 (de) 2002-10-31
CA2115355A1 (en) 1993-02-18
AU2415292A (en) 1993-03-02
ES2172069T3 (es) 2002-09-16
SG87056A1 (en) 2002-03-19
AU673487B2 (en) 1996-11-07
DK0598129T3 (da) 2000-07-03
CA2115355C (en) 2007-09-11
US6004934A (en) 1999-12-21
KR100202474B1 (en) 1999-06-15
KR0185440B1 (ko) 1999-04-01
EP0598129B1 (de) 2000-03-22
ATE215962T1 (de) 2002-04-15
EP0934950A1 (de) 1999-08-11
DE69230824D1 (de) 2000-04-27
AU662551B2 (en) 1995-09-07
EP0934950B1 (de) 2002-04-10
ATE190983T1 (de) 2000-04-15
EP0598129A1 (de) 1994-05-25
ES2144421T3 (es) 2000-06-16
US5654399A (en) 1997-08-05
DE69230824T2 (de) 2000-07-27

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee