DE69230614D1 - Protein-s polypeptide und deren verwendungen - Google Patents

Protein-s polypeptide und deren verwendungen

Info

Publication number
DE69230614D1
DE69230614D1 DE69230614T DE69230614T DE69230614D1 DE 69230614 D1 DE69230614 D1 DE 69230614D1 DE 69230614 T DE69230614 T DE 69230614T DE 69230614 T DE69230614 T DE 69230614T DE 69230614 D1 DE69230614 D1 DE 69230614D1
Authority
DE
Germany
Prior art keywords
polypeptides
protein
useful
antibodies
c4bp
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69230614T
Other languages
English (en)
Other versions
DE69230614T2 (de
Inventor
H Griffin
A Fernandez
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/907,190 external-priority patent/US5321123A/en
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Publication of DE69230614D1 publication Critical patent/DE69230614D1/de
Application granted granted Critical
Publication of DE69230614T2 publication Critical patent/DE69230614T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745—Blood coagulation or fibrinolysis factors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE69230614T 1991-07-02 1992-07-02 Protein-s polypeptide und deren verwendungen Expired - Fee Related DE69230614T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72474691A 1991-07-02 1991-07-02
US07/907,190 US5321123A (en) 1991-07-02 1992-07-01 Protein S polypeptides and anti-peptide antibodies that inhibit protein S binding to C4B binding protein, diagnostic systems and therapeutic methods
PCT/US1992/005599 WO1993001209A1 (en) 1991-07-02 1992-07-02 Proteins s polypeptides and uses thereof

Publications (2)

Publication Number Publication Date
DE69230614D1 true DE69230614D1 (de) 2000-03-02
DE69230614T2 DE69230614T2 (de) 2000-06-21

Family

ID=27111033

Family Applications (2)

Application Number Title Priority Date Filing Date
DE69233673T Expired - Fee Related DE69233673T2 (de) 1991-07-02 1992-07-02 Protein S polypeptide und deren Verwendungen
DE69230614T Expired - Fee Related DE69230614T2 (de) 1991-07-02 1992-07-02 Protein-s polypeptide und deren verwendungen

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE69233673T Expired - Fee Related DE69233673T2 (de) 1991-07-02 1992-07-02 Protein S polypeptide und deren Verwendungen

Country Status (10)

Country Link
EP (2) EP0592600B1 (de)
AT (2) ATE350398T1 (de)
AU (1) AU674496B2 (de)
CA (1) CA2112701C (de)
DE (2) DE69233673T2 (de)
DK (2) DK0972781T3 (de)
ES (2) ES2142317T3 (de)
GR (1) GR3033242T3 (de)
PT (1) PT592600E (de)
WO (1) WO1993001209A1 (de)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5863896A (en) * 1995-11-09 1999-01-26 Immuno Ag Evaluation of substances for altering and for increasing APC response
SE9604378D0 (sv) * 1996-11-27 1996-11-27 Tac Ab Methods and reagents for determining protein S
US6379975B1 (en) 1996-11-27 2002-04-30 T.A.C. Thrombosis And Coagulation Aktiebolag Methods and reagents for determining protein S
JP2006524496A (ja) * 2003-04-18 2006-11-02 ノバルティス アクチエンゲゼルシャフト 骨関節炎の診断および処置のためのチロシンキナーゼを標的化する方法および組成物
FR2863616A1 (fr) * 2003-12-12 2005-06-17 Stago Diagnostica Dosage de la proteine s libre non clivee par le facteur xa et utilisation de ce dosage pour l'evaluation du potentiel de coagulation
US20080161425A1 (en) * 2005-07-29 2008-07-03 Universiteit Van Maastricht Regulation of Tissue Factor Activity by Protein S and Tissue Factor Pathway Inhibitor

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0271810B1 (de) * 1986-12-15 1994-03-09 Teijin Limited Immunologische Bestimmung von freiem menschlichem Protein-S und c4bp-Protein-S-Komplex
EP0315447A3 (de) * 1987-11-06 1990-07-18 Teijin Limited Verfahren zur immunologischen Bestimmung von humanem Protein S sowie Reagens und Kit dafür
JPH01231893A (ja) * 1988-03-14 1989-09-18 Fuji Yakuhin Kogyo Kk 抗ヒトプロテインｓモノクローナル抗体およびその利用

Also Published As

Publication number Publication date
ES2279598T3 (es) 2007-08-16
DE69233673T2 (de) 2007-10-04
EP0592600B1 (de) 2000-01-26
DE69233673D1 (de) 2007-02-15
CA2112701C (en) 2007-09-25
AU674496B2 (en) 1997-01-02
DK0972781T3 (da) 2007-03-05
EP0592600A1 (de) 1994-04-20
ATE189232T1 (de) 2000-02-15
ATE350398T1 (de) 2007-01-15
AU2323092A (en) 1993-02-11
ES2142317T3 (es) 2000-04-16
EP0592600A4 (de) 1994-10-12
EP0524737A3 (en) 1994-10-05
PT592600E (pt) 2000-05-31
WO1993001209A1 (en) 1993-01-21
DK0592600T3 (da) 2000-04-17
DE69230614T2 (de) 2000-06-21
EP0524737A2 (de) 1993-01-27
CA2112701A1 (en) 1993-01-21
GR3033242T3 (en) 2000-09-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee