DE69229151T2 - Pseudopeptide und Dipeptide, die durch eine substituierte Methylketoneinheit am C-Terminus gekennzeichnet sind als Inhibitoren von Thiol-Proteasen - Google Patents

Pseudopeptide und Dipeptide, die durch eine substituierte Methylketoneinheit am C-Terminus gekennzeichnet sind als Inhibitoren von Thiol-Proteasen

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Publication number
DE69229151T2
DE69229151T2 DE69229151T DE69229151T DE69229151T2 DE 69229151 T2 DE69229151 T2 DE 69229151T2 DE 69229151 T DE69229151 T DE 69229151T DE 69229151 T DE69229151 T DE 69229151T DE 69229151 T2 DE69229151 T2 DE 69229151T2
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Prior art keywords
pseudopeptides
dipeptides
cathepsin
terminus
inhibitors
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Expired - Fee Related
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DE69229151T
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English (en)
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DE69229151D1 (de
Inventor
Ryoichi Ando
Naoko Ando
Hirokazu Masuda
Yasuhiro Morinaka
Chizuko Takahashi
Yoshikuni Tamao
Akihiro Tobe
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Mitsubishi Chemical Corp
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Mitsubishi Chemical Corp
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Publication of DE69229151T2 publication Critical patent/DE69229151T2/de
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    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/16—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06043—Leu-amino acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/06—Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08—Systems containing only non-condensed rings with a five-membered ring the ring being saturated
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
    • C07C2601/14—The ring being saturated

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DE69229151T 1991-07-01 1992-07-01 Pseudopeptide und Dipeptide, die durch eine substituierte Methylketoneinheit am C-Terminus gekennzeichnet sind als Inhibitoren von Thiol-Proteasen Expired - Fee Related DE69229151T2 (de)

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EP0525420B1 (de) 1999-05-12
EP0525420A1 (de) 1993-02-03
DK0525420T3 (da) 1999-11-01
ATE179974T1 (de) 1999-05-15
TW239144B (de) 1995-01-21
DE69229151D1 (de) 1999-06-17
JPH05246968A (ja) 1993-09-24
US5834508A (en) 1998-11-10
US5639783A (en) 1997-06-17
ES2132096T3 (es) 1999-08-16
KR100228505B1 (ko) 1999-11-01
GR3030837T3 (en) 1999-11-30
JP3190431B2 (ja) 2001-07-23
KR930002335A (ko) 1993-02-23
CA2072834A1 (en) 1993-01-02

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