DE69226187D1 - (-)-(s)-2,8-dimethyl-3-methylen-1-oxa-8-azaspiro(4,5)decan l-tartrat - Google Patents
(-)-(s)-2,8-dimethyl-3-methylen-1-oxa-8-azaspiro(4,5)decan l-tartratInfo
- Publication number
- DE69226187D1 DE69226187D1 DE69226187T DE69226187T DE69226187D1 DE 69226187 D1 DE69226187 D1 DE 69226187D1 DE 69226187 T DE69226187 T DE 69226187T DE 69226187 T DE69226187 T DE 69226187T DE 69226187 D1 DE69226187 D1 DE 69226187D1
- Authority
- DE
- Germany
- Prior art keywords
- azaspiro
- oxa
- tartrate
- methylene
- dimethyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP13961991 | 1991-05-15 | ||
PCT/JP1992/000548 WO1992020683A1 (en) | 1991-05-15 | 1992-04-27 | (-)-(s)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4,5]decane l-tartrate |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69226187D1 true DE69226187D1 (de) | 1998-08-13 |
DE69226187T2 DE69226187T2 (de) | 1998-10-22 |
Family
ID=15249510
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69226187T Expired - Fee Related DE69226187T2 (de) | 1991-05-15 | 1992-04-27 | (-)-(s)-2,8-dimethyl-3-methylen-1-oxa-8-azaspiro(4,5)decan l-tartrat |
Country Status (11)
Country | Link |
---|---|
US (1) | US5403931A (de) |
EP (1) | EP0590150B1 (de) |
AT (1) | ATE168114T1 (de) |
AU (1) | AU1666392A (de) |
CA (1) | CA2109117A1 (de) |
DE (1) | DE69226187T2 (de) |
DK (1) | DK0590150T3 (de) |
ES (1) | ES2118814T3 (de) |
GR (1) | GR3027686T3 (de) |
RU (1) | RU2057132C1 (de) |
WO (1) | WO1992020683A1 (de) |
Families Citing this family (16)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE187735T1 (de) * | 1993-08-19 | 2000-01-15 | Merck & Co Inc | Thermodynamisch stabile kristallform von 4''- deoxy-4''-epi-methylamino avermectin bia/bib benzoesauresalz und verfahren zu seiner herstellung |
US6521608B1 (en) * | 1998-03-27 | 2003-02-18 | Oregon Health & Science University | Vitamin D and its analogs in the treatment of tumors and other hyperproliferative disorders |
JP2003063964A (ja) * | 2001-08-28 | 2003-03-05 | Senju Pharmaceut Co Ltd | ドライアイまたはドライアイを伴なう疾病の予防治療剤 |
US7491725B2 (en) | 2004-02-06 | 2009-02-17 | Bristol-Myers Squibb Company | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
WO2007013661A1 (ja) * | 2005-07-26 | 2007-02-01 | Senju Pharmaceutical Co., Ltd. | 眼科用経皮吸収型製剤 |
EP2275095A3 (de) * | 2005-08-26 | 2011-08-17 | Braincells, Inc. | Neurogenese durch modulation des Muscarinrezeptors |
EP2258359A3 (de) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenese durch Modulation des Muscarinrezeptors mit Sabcomelin |
EP2377530A3 (de) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation von Neurogenese durch PDE-Hemmung |
EP2314289A1 (de) | 2005-10-31 | 2011-04-27 | Braincells, Inc. | Gaba-rezeptor-vermittelte modulation von neurogenese |
US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
CA2651813A1 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
WO2007134077A2 (en) | 2006-05-09 | 2007-11-22 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
AU2007292848A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
KR20150116466A (ko) * | 2009-01-26 | 2015-10-15 | 이스라엘 인스티튜트 포 바이올로지컬 리서치 | 이환형 헤테로사이클릭 스피로 화합물 |
US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2074441T3 (es) * | 1987-10-05 | 1995-09-16 | Yamanouchi Pharma Co Ltd | Compuestos espiro heterociclicos y su preparacion. |
US5075317A (en) * | 1989-06-21 | 1991-12-24 | Fisons Corporation | Spirofurane derivatives |
-
1992
- 1992-04-27 DK DK92909279T patent/DK0590150T3/da active
- 1992-04-27 US US08/146,133 patent/US5403931A/en not_active Expired - Fee Related
- 1992-04-27 WO PCT/JP1992/000548 patent/WO1992020683A1/ja active IP Right Grant
- 1992-04-27 ES ES92909279T patent/ES2118814T3/es not_active Expired - Lifetime
- 1992-04-27 CA CA002109117A patent/CA2109117A1/en not_active Abandoned
- 1992-04-27 AT AT92909279T patent/ATE168114T1/de not_active IP Right Cessation
- 1992-04-27 RU RU9293058306A patent/RU2057132C1/ru active
- 1992-04-27 DE DE69226187T patent/DE69226187T2/de not_active Expired - Fee Related
- 1992-04-27 EP EP92909279A patent/EP0590150B1/de not_active Expired - Lifetime
- 1992-04-27 AU AU16663/92A patent/AU1666392A/en not_active Abandoned
-
1998
- 1998-08-20 GR GR980401862T patent/GR3027686T3/el unknown
Also Published As
Publication number | Publication date |
---|---|
US5403931A (en) | 1995-04-04 |
RU2057132C1 (ru) | 1996-03-27 |
DK0590150T3 (da) | 1999-04-19 |
CA2109117A1 (en) | 1992-11-16 |
GR3027686T3 (en) | 1998-11-30 |
EP0590150A1 (de) | 1994-04-06 |
AU1666392A (en) | 1992-12-30 |
DE69226187T2 (de) | 1998-10-22 |
ATE168114T1 (de) | 1998-07-15 |
ES2118814T3 (es) | 1998-10-01 |
WO1992020683A1 (en) | 1992-11-26 |
EP0590150A4 (en) | 1994-06-29 |
EP0590150B1 (de) | 1998-07-08 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |