RU93058306A - Моногидрат l-тартрата(-)-(s)-2,8-диметил-3-метилен-1-окса-8-азаспиро-(4,5)-декана - Google Patents
Моногидрат l-тартрата(-)-(s)-2,8-диметил-3-метилен-1-окса-8-азаспиро-(4,5)-деканаInfo
- Publication number
- RU93058306A RU93058306A RU93058306/04A RU93058306A RU93058306A RU 93058306 A RU93058306 A RU 93058306A RU 93058306/04 A RU93058306/04 A RU 93058306/04A RU 93058306 A RU93058306 A RU 93058306A RU 93058306 A RU93058306 A RU 93058306A
- Authority
- RU
- Russia
- Prior art keywords
- azaspiro
- oxa
- decane
- methylene
- dimethyl
- Prior art date
Links
- -1 (-) - (S) -2,8-dimethyl-3-methylene-1-oxa-8-azaspiro- (4,5) -decane monohydrate Chemical compound 0.000 title 1
- 239000003814 drug Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
Claims (1)
- (-)-(S)-2,8-Диметил-3-метилен-1-окса-8-азаспиро [4,5]-декан-L-тартрат, обладающий стабильностью при хранении выше таковой других солей и применимый в медицине.
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP3-139619 | 1991-05-15 | ||
| JP3139619 | 1991-05-15 | ||
| JP13961991 | 1991-05-15 | ||
| PCT/JP1992/000548 WO1992020683A1 (en) | 1991-05-15 | 1992-04-27 | (-)-(s)-2,8-dimethyl-3-methylene-1-oxa-8-azaspiro[4,5]decane l-tartrate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2057132C1 RU2057132C1 (ru) | 1996-03-27 |
| RU93058306A true RU93058306A (ru) | 1996-12-27 |
Family
ID=15249510
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU9293058306A RU2057132C1 (ru) | 1991-05-15 | 1992-04-27 | Моногидрат (-)-(s)-2,8-диметил-3-метилен-1-окса-8-азаспиро[4,5]-декана l-тартрата и способ его получения |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5403931A (ru) |
| EP (1) | EP0590150B1 (ru) |
| AT (1) | ATE168114T1 (ru) |
| AU (1) | AU1666392A (ru) |
| CA (1) | CA2109117A1 (ru) |
| DE (1) | DE69226187T2 (ru) |
| DK (1) | DK0590150T3 (ru) |
| ES (1) | ES2118814T3 (ru) |
| GR (1) | GR3027686T3 (ru) |
| RU (1) | RU2057132C1 (ru) |
| WO (1) | WO1992020683A1 (ru) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE187735T1 (de) * | 1993-08-19 | 2000-01-15 | Merck & Co Inc | Thermodynamisch stabile kristallform von 4''- deoxy-4''-epi-methylamino avermectin bia/bib benzoesauresalz und verfahren zu seiner herstellung |
| CA2326117A1 (en) * | 1998-03-27 | 1999-10-07 | Oregon Health Sciences University | Vitamin d and its analogs in the treatment of tumors and other hyperproliferative disorders |
| JP2003063964A (ja) * | 2001-08-28 | 2003-03-05 | Senju Pharmaceut Co Ltd | ドライアイまたはドライアイを伴なう疾病の予防治療剤 |
| US7491725B2 (en) | 2004-02-06 | 2009-02-17 | Bristol-Myers Squibb Company | Process for preparing 2-aminothiazole-5-aromatic carboxamides as kinase inhibitors |
| US20090082381A1 (en) * | 2005-07-26 | 2009-03-26 | Akiharu Isowaki | Percutaneously Absorbable Ophthalmic Preparation |
| EP2258359A3 (en) | 2005-08-26 | 2011-04-06 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation with sabcomelin |
| CA2620333A1 (en) * | 2005-08-26 | 2007-03-01 | Braincells, Inc. | Neurogenesis by muscarinic receptor modulation |
| EP2377530A3 (en) | 2005-10-21 | 2012-06-20 | Braincells, Inc. | Modulation of neurogenesis by PDE inhibition |
| WO2007053596A1 (en) | 2005-10-31 | 2007-05-10 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| JP2009536669A (ja) | 2006-05-09 | 2009-10-15 | ブレインセルス，インコーポレイティド | アンジオテンシン調節による神経新生 |
| EP2026813A2 (en) | 2006-05-09 | 2009-02-25 | Braincells, Inc. | 5 ht receptor mediated neurogenesis |
| KR20090064418A (ko) | 2006-09-08 | 2009-06-18 | 브레인셀즈 인코퍼레이션 | 4-아실아미노피리딘 유도체 포함 조합물 |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| BRPI1007350B8 (pt) * | 2009-01-26 | 2021-05-25 | Israel Institute For Biological Res | compostos espiro heterocíclicos bicíclicos |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE122353T1 (de) * | 1987-10-05 | 1995-05-15 | Yamanouchi Pharma Co Ltd | Heterozyklische spiroverbindungen und ihre herstellung. |
| US5075317A (en) * | 1989-06-21 | 1991-12-24 | Fisons Corporation | Spirofurane derivatives |
-
1992
- 1992-04-27 RU RU9293058306A patent/RU2057132C1/ru active
- 1992-04-27 WO PCT/JP1992/000548 patent/WO1992020683A1/ja active IP Right Grant
- 1992-04-27 CA CA002109117A patent/CA2109117A1/en not_active Abandoned
- 1992-04-27 AT AT92909279T patent/ATE168114T1/de not_active IP Right Cessation
- 1992-04-27 DK DK92909279T patent/DK0590150T3/da active
- 1992-04-27 DE DE69226187T patent/DE69226187T2/de not_active Expired - Fee Related
- 1992-04-27 ES ES92909279T patent/ES2118814T3/es not_active Expired - Lifetime
- 1992-04-27 AU AU16663/92A patent/AU1666392A/en not_active Abandoned
- 1992-04-27 EP EP92909279A patent/EP0590150B1/en not_active Expired - Lifetime
- 1992-04-27 US US08/146,133 patent/US5403931A/en not_active Expired - Fee Related
-
1998
- 1998-08-20 GR GR980401862T patent/GR3027686T3/el unknown
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