DE69225075T2 - Stereoselektive synthese von 2-arylpropionsäuren hoher optischer reinheit unter verwendung von chiralen oxazolinen - Google Patents

Stereoselektive synthese von 2-arylpropionsäuren hoher optischer reinheit unter verwendung von chiralen oxazolinen

Info

Publication number
DE69225075T2
DE69225075T2 DE69225075T DE69225075T DE69225075T2 DE 69225075 T2 DE69225075 T2 DE 69225075T2 DE 69225075 T DE69225075 T DE 69225075T DE 69225075 T DE69225075 T DE 69225075T DE 69225075 T2 DE69225075 T2 DE 69225075T2
Authority
DE
Germany
Prior art keywords
pureity
high optical
stereoselective synthesis
arylpropionic acids
acids high
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69225075T
Other languages
English (en)
Other versions
DE69225075D1 (de
Inventor
Henrich Paradies
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
CHEMISCH BIOTECHNOLOGISCHE LAB
Original Assignee
CHEMISCH BIOTECHNOLOGISCHE LAB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by CHEMISCH BIOTECHNOLOGISCHE LAB filed Critical CHEMISCH BIOTECHNOLOGISCHE LAB
Publication of DE69225075D1 publication Critical patent/DE69225075D1/de
Application granted granted Critical
Publication of DE69225075T2 publication Critical patent/DE69225075T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C33/00—Unsaturated compounds having hydroxy or O-metal groups bound to acyclic carbon atoms
    • C07C33/18—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part
    • C07C33/20—Monohydroxylic alcohols containing only six-membered aromatic rings as cyclic part monocyclic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C51/00—Preparation of carboxylic acids or their salts, halides or anhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/08—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member
    • C07D263/10—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D263/14—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having one double bond between ring members or between a ring member and a non-ring member with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with radicals substituted by oxygen atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
DE69225075T 1991-12-27 1992-12-28 Stereoselektive synthese von 2-arylpropionsäuren hoher optischer reinheit unter verwendung von chiralen oxazolinen Expired - Fee Related DE69225075T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/815,057 US5248815A (en) 1991-12-27 1991-12-27 Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines
PCT/US1992/011236 WO1993013046A1 (en) 1991-12-27 1992-12-28 Stereo-selective synthesis of 2-aryl-propionic acids of high optical purity by using chiral oxazolines

Publications (2)

Publication Number Publication Date
DE69225075D1 DE69225075D1 (de) 1998-05-14
DE69225075T2 true DE69225075T2 (de) 1998-07-30

Family

ID=25216733

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69225075T Expired - Fee Related DE69225075T2 (de) 1991-12-27 1992-12-28 Stereoselektive synthese von 2-arylpropionsäuren hoher optischer reinheit unter verwendung von chiralen oxazolinen

Country Status (6)

Country Link
US (1) US5248815A (de)
EP (1) EP0641304B1 (de)
JP (1) JP2694386B2 (de)
AU (1) AU3423193A (de)
DE (1) DE69225075T2 (de)
WO (1) WO1993013046A1 (de)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6867310B1 (en) 1997-11-20 2005-03-15 Massachusetts Institute Of Technology Arylation and vinylation of activated carbons
US6552078B2 (en) 1999-10-27 2003-04-22 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
US6436990B1 (en) 1999-10-27 2002-08-20 Nobex Corporation 6-methoxy-2-naphthylacetic acid prodrugs
TWI262791B (en) 1999-10-27 2006-10-01 Nobex Corp 6-methoxy-2-naphthylacetic acid prodrugs
JP4496770B2 (ja) * 2003-12-15 2010-07-07 Ｄｉｃ株式会社 １−ハロゲノ−２−アルコキシナフタレン誘導体およびその製造方法
JP6504530B2 (ja) * 2015-09-30 2019-04-24 大正製薬株式会社 光学活性な２−（２−フルオロビフェニル−４−イル）プロパン酸の製造法
CN113135870B (zh) * 2020-01-20 2022-04-19 浙江师范大学 一种制备手性α-芳基羰基化合物的方法及产品

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1051442B (it) * 1975-05-22 1981-04-21 Ind Chimica Prodotti Francis S Procedimento per la preparazione di derivati dell acido para isobutil fenilacetico
US4209638A (en) * 1977-03-08 1980-06-24 The Boots Company Limited Preparation of therapeutic agents
US4912254A (en) * 1981-12-11 1990-03-27 Syntex Pharmaceutical International Limited Preparation of α-arylalkanoic acids
US4723033A (en) * 1982-11-24 1988-02-02 Syntex Pharmaceuticals International Ltd. Manufacture of optically active α-arylalkanoic acids and precursors thereof
KR930003864B1 (ko) * 1990-10-19 1993-05-14 한국과학기술연구원 d-2-(6-메톡시-2-나프틸)-프로피온산의 제조방법
JPH0758641A (ja) * 1993-06-30 1995-03-03 Natl Sci Council チョッパー安定化シグマデルタ型アナログデジタル変換器

Also Published As

Publication number Publication date
EP0641304B1 (de) 1998-04-08
DE69225075D1 (de) 1998-05-14
EP0641304A4 (de) 1994-12-13
JP2694386B2 (ja) 1997-12-24
AU3423193A (en) 1993-07-28
WO1993013046A1 (en) 1993-07-08
EP0641304A1 (de) 1995-03-08
US5248815A (en) 1993-09-28
JPH07506808A (ja) 1995-07-27

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