DE69224507T2 - Beta-Oxo-Beta-Benzenepropanthioamidderivate - Google Patents

Beta-Oxo-Beta-Benzenepropanthioamidderivate

Info

Publication number
DE69224507T2
DE69224507T2 DE69224507T DE69224507T DE69224507T2 DE 69224507 T2 DE69224507 T2 DE 69224507T2 DE 69224507 T DE69224507 T DE 69224507T DE 69224507 T DE69224507 T DE 69224507T DE 69224507 T2 DE69224507 T2 DE 69224507T2
Authority
DE
Germany
Prior art keywords
group
hydrogen atom
atom
membered
compound according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69224507T
Other languages
German (de)
English (en)
Other versions
DE69224507D1 (de
Inventor
Junko Hayashi
Tatsuo Nagano
Asami Seino
Tetsuo Sekiya
Tetsuro Shimpuku
Mikio Tsutsui
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Mitsubishi Chemical Corp filed Critical Mitsubishi Chemical Corp
Application granted granted Critical
Publication of DE69224507D1 publication Critical patent/DE69224507D1/de
Publication of DE69224507T2 publication Critical patent/DE69224507T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/02Monothiocarboxylic acids
    • C07C327/04Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/12Monothiocarboxylic acids having carbon atoms of thiocarboxyl groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton containing rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/38Amides of thiocarboxylic acids
    • C07C327/46Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/08Vasodilators for multiple indications
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00Drugs for disorders of the cardiovascular system
    • A61P9/12Antihypertensives
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C327/00Thiocarboxylic acids
    • C07C327/38Amides of thiocarboxylic acids
    • C07C327/40Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C327/44Amides of thiocarboxylic acids having carbon atoms of thiocarboxamide groups bound to hydrogen atoms or to acyclic carbon atoms to carbon atoms of an unsaturated carbon skeleton
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/02Systems containing only non-condensed rings with a three-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/04Systems containing only non-condensed rings with a four-membered ring
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07CACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00Systems containing only non-condensed rings
    • C07C2601/06Systems containing only non-condensed rings with a five-membered ring
    • C07C2601/08Systems containing only non-condensed rings with a five-membered ring the ring being saturated

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Pulmonology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Pyrrole Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
DE69224507T 1991-12-26 1992-12-09 Beta-Oxo-Beta-Benzenepropanthioamidderivate Expired - Fee Related DE69224507T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
JP34565791 1991-12-26

Publications (2)

Publication Number Publication Date
DE69224507D1 DE69224507D1 (de) 1998-04-02
DE69224507T2 true DE69224507T2 (de) 1998-08-20

Family

ID=18378084

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69224507T Expired - Fee Related DE69224507T2 (de) 1991-12-26 1992-12-09 Beta-Oxo-Beta-Benzenepropanthioamidderivate

Country Status (11)

Country Link
US (2) US5332833A (el)
EP (1) EP0548680B1 (el)
JP (1) JP2707936B2 (el)
KR (1) KR930012698A (el)
AT (1) ATE163410T1 (el)
CA (1) CA2086210A1 (el)
DE (1) DE69224507T2 (el)
DK (1) DK0548680T3 (el)
ES (1) ES2113399T3 (el)
GR (1) GR3026240T3 (el)
TW (1) TW242138B (el)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0548680B1 (en) * 1991-12-26 1998-02-25 Mitsubishi Chemical Corporation Beta-oxo-beta-benzenepropanethioamide derivatives
WO1996022086A1 (fr) * 1995-01-17 1996-07-25 Mitsubishi Chemical Corporation MEDICAMENT CONTENANT UN DERIVE DE β-OXO-β-BENZENEPROPANE-THIOAMIDE
CN1162151C (zh) * 1998-01-14 2004-08-18 日本新药株式会社 钾通道激活剂
JP4073786B2 (ja) * 2001-04-16 2008-04-09 田辺三菱製薬株式会社 高コンダクタンス型カルシウム感受性kチャネル開口薬
EP1465869B1 (en) 2001-12-21 2013-05-15 Exelixis Patent Company LLC Modulators of lxr
US7482366B2 (en) 2001-12-21 2009-01-27 X-Ceptor Therapeutics, Inc. Modulators of LXR
DK1928454T3 (da) 2005-05-10 2014-11-03 Intermune Inc Pyridonderivater til modulering af stress-aktiveret proteinkinasesystem
JP5627574B2 (ja) 2008-06-03 2014-11-19 インターミューン, インコーポレイテッド 炎症性および線維性疾患を治療するための化合物および方法
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
RU2692485C2 (ru) 2014-04-02 2019-06-25 Интермьюн, Инк. Противофиброзные пиридиноны
WO2016144936A1 (en) 2015-03-09 2016-09-15 Bristol-Myers Squibb Company Lactams as inhibitors of rock
KR102512548B1 (ko) 2017-12-22 2023-03-22 삼성디스플레이 주식회사 유기 전계 발광 소자 및 유기 전계 발광 소자용 함질소 화합물

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2460909C2 (de) * 1974-12-21 1986-02-27 Bayer Ag, 5090 Leverkusen Verfahren zur Herstellung von alpha- Oxothiodimethylamiden
JPS5444660A (en) * 1977-08-29 1979-04-09 Yamanouchi Pharmaceut Co Ltd Heterocyclic compound and its preparation
US4299845A (en) * 1980-04-14 1981-11-10 Schering Corporation Dermatological compositions and methods of use therefor
GB8530015D0 (en) * 1985-12-05 1986-01-15 Ici Plc Biologically active amide derivatives
US4851526A (en) * 1987-09-04 1989-07-25 Schering A.G. 1-(4-Substituted phenyl)-1H-imidazoles compounds
US5185375A (en) * 1987-12-18 1993-02-09 May & Baker Limited Thioformamide derivatives
EP0548680B1 (en) * 1991-12-26 1998-02-25 Mitsubishi Chemical Corporation Beta-oxo-beta-benzenepropanethioamide derivatives

Also Published As

Publication number Publication date
US5332833A (en) 1994-07-26
EP0548680B1 (en) 1998-02-25
US5439927A (en) 1995-08-08
DK0548680T3 (da) 1998-09-23
ES2113399T3 (es) 1998-05-01
ATE163410T1 (de) 1998-03-15
KR930012698A (ko) 1993-07-21
JP2707936B2 (ja) 1998-02-04
GR3026240T3 (en) 1998-05-29
CA2086210A1 (en) 1993-06-27
DE69224507D1 (de) 1998-04-02
TW242138B (el) 1995-03-01
JPH05246980A (ja) 1993-09-24
EP0548680A1 (en) 1993-06-30

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee