DE69224496D1 - Humaner monoklonaler Antikörper, spezifisch gegen ein Oberflächenantigen der Krebszell-Membran - Google Patents
Humaner monoklonaler Antikörper, spezifisch gegen ein Oberflächenantigen der Krebszell-MembranInfo
- Publication number
- DE69224496D1 DE69224496D1 DE69224496T DE69224496T DE69224496D1 DE 69224496 D1 DE69224496 D1 DE 69224496D1 DE 69224496 T DE69224496 T DE 69224496T DE 69224496 T DE69224496 T DE 69224496T DE 69224496 D1 DE69224496 D1 DE 69224496D1
- Authority
- DE
- Germany
- Prior art keywords
- monoclonal antibody
- cancer cell
- cell membrane
- human monoclonal
- surface antigen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
- A61K47/6905—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion
- A61K47/6911—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome
- A61K47/6913—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a colloid or an emulsion the form being a liposome the liposome being modified on its surface by an antibody
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6863—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from stomach or intestines cancer cell
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
- A61K9/1271—Non-conventional liposomes, e.g. PEGylated liposomes, liposomes coated with polymers
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B82—NANOTECHNOLOGY
- B82Y—SPECIFIC USES OR APPLICATIONS OF NANOSTRUCTURES; MEASUREMENT OR ANALYSIS OF NANOSTRUCTURES; MANUFACTURE OR TREATMENT OF NANOSTRUCTURES
- B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/812—Liposome comprising an antibody, antibody fragment, antigen, or other specific or nonspecific immunoeffector
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
- Y10S530/809—Fused cells, e.g. hybridoma
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/863—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgM
- Y10S530/864—Monoclonal
- Y10S530/865—Human
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/866—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody fragment, e.g. fab', fab, fv, fc, heavy chain or light chain
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/867—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving immunoglobulin or antibody produced via recombinant dna technology
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Pharmacology & Pharmacy (AREA)
- Cell Biology (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Dispersion Chemistry (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Nanotechnology (AREA)
- Molecular Biology (AREA)
- Medical Informatics (AREA)
- General Engineering & Computer Science (AREA)
- Crystallography & Structural Chemistry (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP15886091 | 1991-06-28 | ||
JP15885991 | 1991-06-28 | ||
JP15886191 | 1991-06-28 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69224496D1 true DE69224496D1 (de) | 1998-04-02 |
DE69224496T2 DE69224496T2 (de) | 1998-07-09 |
Family
ID=27321422
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69224496T Expired - Fee Related DE69224496T2 (de) | 1991-06-28 | 1992-06-26 | Humaner monoklonaler Antikörper, spezifisch gegen ein Oberflächenantigen der Krebszell-Membran |
Country Status (5)
Country | Link |
---|---|
US (5) | US5767246A (de) |
EP (1) | EP0520499B1 (de) |
CA (1) | CA2072249C (de) |
DE (1) | DE69224496T2 (de) |
ES (1) | ES2115626T3 (de) |
Families Citing this family (59)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3220180B2 (ja) * | 1991-05-23 | 2001-10-22 | 三菱化学株式会社 | 薬剤含有タンパク質結合リポソーム |
CA2072249C (en) * | 1991-06-28 | 2003-06-17 | Saiko Hosokawa | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane |
ATE191853T1 (de) * | 1992-07-27 | 2000-05-15 | Us Health | Zielgerichte liposome zur blut-hirne schranke |
JP3351476B2 (ja) * | 1993-01-22 | 2002-11-25 | 三菱化学株式会社 | リン脂質誘導体及びそれを含有するリポソーム |
FR2706486B1 (fr) * | 1993-06-16 | 1995-09-01 | Rhone Poulenc Rorer Sa | Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques. |
US6825320B1 (en) | 1995-03-29 | 2004-11-30 | Millenium Pharmaceuticals, Inc. | FOHY03 polypeptides |
US6251597B1 (en) | 1996-03-29 | 2001-06-26 | Millennium Pharmaceuticals, Inc. | Methods for detecting fohy030 |
US5633161A (en) * | 1995-03-29 | 1997-05-27 | Millennium Pharmaceuticals, Inc. | Murine gene fomy030 coding for tumor progression inhibitor |
US6794185B1 (en) | 1995-03-29 | 2004-09-21 | Millennium Pharmaceuticals, Inc. | fohy030 nucleic acid molecules |
US6312909B1 (en) * | 1996-03-29 | 2001-11-06 | Millennium Pharmaceuticals, Inc. | Compositions and methods for the diagnosis prevention and treatment of tumor progression |
KR19990029749A (ko) * | 1997-09-17 | 1999-04-26 | 미우라 아끼라 | 2가 반응성 수용성 고분자 유도체 및 이들을 함유하는 복합체 |
GB9814383D0 (en) * | 1998-07-02 | 1998-09-02 | Cambridge Antibody Tech | Improvements relating to antibodies |
CN101088561A (zh) | 1998-07-21 | 2007-12-19 | 展马博联合股份有限公司 | 抗丙型肝炎病毒抗体及其用途 |
AU3191100A (en) * | 1999-03-17 | 2000-10-04 | Mitsubishi Chemical Corporation | Ligand-bonded complex |
AU3673500A (en) * | 1999-04-08 | 2000-11-14 | Mitsubishi Chemical Corporation | Fine particles targeting cells and process for producing the same |
WO2000064413A1 (fr) * | 1999-04-23 | 2000-11-02 | Mitsubishi Chemical Corporation | Anticorps et liposome lie a un polyalkylene-glycol |
CA2402038C (en) * | 2000-03-17 | 2011-03-15 | The University Of Tennessee Research Corporation | Lpa receptor agonists and antagonists and methods of use |
ES2192426B1 (es) * | 2000-05-11 | 2005-02-16 | Universidad De Vigo | Anticuerpo monoclonal humano sm50/20 que reconoce leucocitos humanos, y su uso en terapia. |
PL364932A1 (en) * | 2000-11-27 | 2004-12-27 | Rmf Dictagene S.A. | Process for folding chemically synthesized polypeptides |
EP1377314B1 (de) * | 2001-01-26 | 2011-09-14 | Inhibitex, Inc. | Monoklonale antikörper gegen das clfa-protein und verfahren zur verwendung bei der behandlung bzw. pr vention von infektionen |
US20050037061A1 (en) * | 2001-07-25 | 2005-02-17 | Saiko Hosokawa | Remedies for mammary cancer |
US20050032132A1 (en) * | 2001-07-25 | 2005-02-10 | Hisae Niki | Cancer diagnostics |
US7282205B2 (en) * | 2001-11-07 | 2007-10-16 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Anti-hepatitis A virus antibodies |
AU2002354363A1 (en) * | 2001-12-04 | 2003-06-17 | Mitsubishi Pharma Corporation | Method of activating protein |
JP4866006B2 (ja) | 2002-10-04 | 2012-02-01 | 田辺三菱製薬株式会社 | 抗体認識抗原 |
CA2511228A1 (en) * | 2002-12-20 | 2004-07-08 | Mitsubishi Pharma Corporation | Method of protecting thiol group of protein |
ES2367430T3 (es) * | 2002-12-23 | 2011-11-03 | Wyeth Llc | Anticuerpos contra pd-1 y sus usos. |
PE20040942A1 (es) | 2003-01-24 | 2004-12-28 | Elan Pharm Inc | Preparacion y tratamiento para las enfermedades desmielinizantes y paralisis mediante la aplicacion de agentes remielinizantes |
AU2005213324B2 (en) | 2004-02-06 | 2011-06-09 | Biogen Idec Ma Inc. | Methods and compositions for treating tumors and metastatic disease |
US20080069867A1 (en) * | 2004-09-16 | 2008-03-20 | Mitsubishi Pharma Corporation | Diagnostic and/or Remedy for Ovarian Cancer |
ES2272178B1 (es) * | 2005-09-19 | 2008-03-16 | Daniel Serrano Gil | Una composicion para ser administrada a un mamifero o a un ser humano. |
CA2523032A1 (en) * | 2005-10-07 | 2007-04-07 | Immunovaccine Technologies Inc. | Vaccines for cancer therapy |
GB0607798D0 (en) * | 2006-04-20 | 2006-05-31 | Alligator Bioscience Ab | Novel polypeptides and use thereof |
ES2558928T3 (es) | 2007-01-31 | 2016-02-09 | Dana-Farber Cancer Institute, Inc. | Péptidos p53 estabilizados y usos de los mismos |
US8592377B2 (en) | 2007-03-28 | 2013-11-26 | President And Fellows Of Harvard College | Stitched polypeptides |
US9498493B2 (en) | 2007-09-27 | 2016-11-22 | Immunovaccine Technologies Inc. | Use of liposomes in a carrier comprising a continuous hydrophobic phase for delivery of polynucleotides in vivo |
CN102056622B (zh) | 2008-06-05 | 2016-04-06 | 免疫疫苗技术有限公司 | 包含脂质体、抗原、多核苷酸和含疏水物质的连续相的载体的组合物 |
GB0905790D0 (en) | 2009-04-03 | 2009-05-20 | Alligator Bioscience Ab | Novel polypeptides and use thereof |
US9724337B2 (en) * | 2009-04-21 | 2017-08-08 | University Of Kentucky Research Foundation | AG-205 for the treatment of breast cancer |
US20130072439A1 (en) | 2009-09-22 | 2013-03-21 | Huw M. Nash | Peptidomimetic macrocycles |
WO2012021144A1 (en) | 2010-08-12 | 2012-02-16 | New York University | Oligooxopiperazines and methods of making and using them |
JP2013535514A (ja) | 2010-08-13 | 2013-09-12 | エイルロン セラピューティクス,インコーポレイテッド | ペプチド模倣大環状分子 |
SE535296C2 (sv) | 2010-09-08 | 2012-06-19 | Anara Ab | Mognad av mag-tarmkanalen |
GB2490655A (en) | 2011-04-28 | 2012-11-14 | Univ Aston | Modulators of tissue transglutaminase |
WO2013049941A1 (en) | 2011-10-06 | 2013-04-11 | Immunovaccine Technologies Inc. | Liposome compositions comprising an adjuvant that activates or increases the activity of tlr2 and uses thereof |
TW201806968A (zh) | 2011-10-18 | 2018-03-01 | 艾利倫治療公司 | 擬肽巨環化合物 |
WO2013123267A1 (en) | 2012-02-15 | 2013-08-22 | Aileron Therapeutics, Inc. | Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles |
CN104159595A (zh) | 2012-02-15 | 2014-11-19 | 爱勒让治疗公司 | 拟肽大环化合物 |
US9255086B2 (en) | 2012-02-16 | 2016-02-09 | New York University | Control of hypoxia-inducible gene expression with oligooxopiperazine nonpeptidic helix mimetics |
MX2015005244A (es) | 2012-11-01 | 2015-07-14 | Aileron Therapeutics Inc | Aminoacidos disustituidos y metodos de preparacion y el uso de los mismos. |
GB201219678D0 (en) | 2012-11-01 | 2012-12-12 | Benf Ab | Ketone body inhibitors and uses thereof |
WO2015123654A1 (en) | 2014-02-17 | 2015-08-20 | The Cleveland Clinic Foundation | Amine passivated nanoparticles for cancer treatment and imaging |
JP2018503595A (ja) | 2014-09-24 | 2018-02-08 | エルロン・セラピューティクス・インコーポレイテッドAileron Therapeutics,Inc. | ペプチド模倣大環状分子およびその製剤 |
AU2015320549A1 (en) | 2014-09-24 | 2017-04-13 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles and uses thereof |
BR112017019738A2 (pt) | 2015-03-20 | 2018-05-29 | Aileron Therapeutics Inc | macrociclos peptidomiméticos e usos dos mesmos |
US10059741B2 (en) | 2015-07-01 | 2018-08-28 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles |
US10023613B2 (en) | 2015-09-10 | 2018-07-17 | Aileron Therapeutics, Inc. | Peptidomimetic macrocycles as modulators of MCL-1 |
US11273151B2 (en) | 2015-11-04 | 2022-03-15 | Icahn School Of Medicine At Mount Sinai | Methods of treating tumors and cancer, and identifying candidate subjects for such treatment |
EP3448881B1 (de) | 2016-04-26 | 2023-06-07 | Icahn School of Medicine at Mount Sinai | Behandlung von hippo-pfad-mutanten tumoren und verfahren zur identifizierung von probanden als kandidaten für die behandlung |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4761377A (en) * | 1984-10-15 | 1988-08-02 | The Regents Of The University Of California | Human-human hybrid cell lines that produce antibodies against antigenic determinants on cancer cells |
EP0218158A3 (de) * | 1985-09-30 | 1988-12-07 | Asahi Kasei Kogyo Kabushiki Kaisha | Menschlicher monoklonaler Antikörper, B-Zell-Linie für die Herstellung dieses Antikörpers und Verfahren zur Herstellung dieser B-Zell-Linie und Antikörper. |
EP0232871A3 (de) * | 1986-02-07 | 1989-03-15 | Yoshitomi Pharmaceutical Industries, Ltd. | Menschlicher monoklonaler Antikörper, Hybridoma zu seiner Herstellung und seine Verwendung |
JPH0798000B2 (ja) * | 1987-05-23 | 1995-10-25 | 萩原 義秀 | ガン関連抗原特異的ヒト免疫グロブリン |
US5145773A (en) * | 1989-05-25 | 1992-09-08 | Sloan-Kettering Institute For Cancer Research | Method to detect sensitivity to alpha-interferon therapy |
CA2069439A1 (en) * | 1989-12-15 | 1991-06-16 | Susumu Iwasa | Monoclonal antibodies, their production and use |
ZA912490B (en) * | 1990-04-19 | 1992-12-30 | Res Dev Foundation | Antibody conjugates for treatment of neoplastic disease |
US5419904A (en) * | 1990-11-05 | 1995-05-30 | The Regents Of The University Of California | Human B-lymphoblastoid cell line secreting anti-ganglioside antibody |
JP3220180B2 (ja) * | 1991-05-23 | 2001-10-22 | 三菱化学株式会社 | 薬剤含有タンパク質結合リポソーム |
CA2072249C (en) * | 1991-06-28 | 2003-06-17 | Saiko Hosokawa | Human monoclonal antibody specifically binding to surface antigen of cancer cell membrane |
-
1992
- 1992-06-24 CA CA002072249A patent/CA2072249C/en not_active Expired - Fee Related
- 1992-06-26 DE DE69224496T patent/DE69224496T2/de not_active Expired - Fee Related
- 1992-06-26 ES ES92110841T patent/ES2115626T3/es not_active Expired - Lifetime
- 1992-06-26 EP EP92110841A patent/EP0520499B1/de not_active Expired - Lifetime
-
1994
- 1994-12-20 US US08/360,125 patent/US5767246A/en not_active Expired - Fee Related
-
1995
- 1995-05-25 US US08/450,578 patent/US5837845A/en not_active Expired - Fee Related
- 1995-05-25 US US08/450,363 patent/US6139869A/en not_active Expired - Fee Related
-
1998
- 1998-01-28 US US09/014,880 patent/US5990297A/en not_active Expired - Fee Related
- 1998-02-02 US US09/017,628 patent/US5990287A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
ES2115626T3 (es) | 1998-07-01 |
CA2072249A1 (en) | 1992-12-29 |
US5990287A (en) | 1999-11-23 |
DE69224496T2 (de) | 1998-07-09 |
US6139869A (en) | 2000-10-31 |
CA2072249C (en) | 2003-06-17 |
EP0520499A1 (de) | 1992-12-30 |
US5837845A (en) | 1998-11-17 |
US5990297A (en) | 1999-11-23 |
EP0520499B1 (de) | 1998-02-25 |
US5767246A (en) | 1998-06-16 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DE69224496T2 (de) | Humaner monoklonaler Antikörper, spezifisch gegen ein Oberflächenantigen der Krebszell-Membran | |
DE3574730D1 (de) | Monoklonaler antikoerper gegen ein humanes tumor-karzinom-assoziiertes antigen. | |
DE69029327T2 (de) | Neue antikörper reaktiv gegen menschliche karzinome | |
DE3854502T2 (de) | Gegen hiv-antigene spezifischer monoklonaler antikörper. | |
DK666389D0 (da) | Monoklonalt antistof | |
DE68914244D1 (de) | Monoklonaler Antikörper. | |
DE69111930D1 (de) | Künstlicher Antikörper. | |
DE4192335T1 (de) | T-Zell-Epitope | |
NO920523L (no) | Ige-reseptor-antistoff | |
DE69223606D1 (de) | Humaner monoklonaler antikörper gegen glycoprotein-iib/iiia | |
DE606516T1 (de) | Gegen menschlichen Ceruloplasmin monoklonaler Antikörper. | |
DE3584280D1 (de) | Monoklonaler antikoerper gegen menschlichen krebs. | |
DE3684857D1 (de) | Spezifischer monoklonaler antikoerper gegen menschliches lungenadenokarzinom. | |
DK474189A (da) | Monoklonalt antistof | |
DE69129582T2 (de) | Antikörper gegen menschlichen plasmin-alpha 2-plasmininhibitor-komplex, hybridoma und immunoassay | |
DE68912772T2 (de) | Monoklonaler antikörper gegen entero-viren. | |
NO890116D0 (no) | Monoklonale antistoffer. | |
DE3687542D1 (de) | Monoklonaler antikoerper gegen humanes protein c. | |
DE3851855T2 (de) | Gegen die Gamma-Kette des T-Zell-Rezeptors gerichteter monoklonaler Antikörper. | |
DE69023717D1 (de) | Monoklonaler Antikörper. | |
IT8821702A0 (it) | Nuovo anticorpo monoclonale. | |
DE69020315D1 (de) | Monoklonaler antikörper gegen c-reaktives protein. | |
DE69427850D1 (de) | Monoklonaler antikörper gegen mucoglykoprotein | |
DE68913601T2 (de) | Monoklonaler Antikörper gegen menschliches Lungenadenokarzinom. | |
DE3787416D1 (de) | Monoklonaler Antikörper gegen Laforakörper. |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |