DE69223952D1 - Entwurf, Konstruktion und Expression von chimärischen Proteinen zur Entwicklung von Impfstoffen und diagnostischen Reagenzien - Google Patents

Entwurf, Konstruktion und Expression von chimärischen Proteinen zur Entwicklung von Impfstoffen und diagnostischen Reagenzien

Info

Publication number
DE69223952D1
DE69223952D1 DE69223952T DE69223952T DE69223952D1 DE 69223952 D1 DE69223952 D1 DE 69223952D1 DE 69223952 T DE69223952 T DE 69223952T DE 69223952 T DE69223952 T DE 69223952T DE 69223952 D1 DE69223952 D1 DE 69223952D1
Authority
DE
Germany
Prior art keywords
vaccines
expression
development
construction
design
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69223952T
Other languages
English (en)
Other versions
DE69223952T2 (de
Inventor
Chil-Yong Kang
Lizhong Luo
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Green Cross Vaccine Corp
Original Assignee
Korea Green Cross Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Korea Green Cross Corp filed Critical Korea Green Cross Corp
Publication of DE69223952D1 publication Critical patent/DE69223952D1/de
Application granted granted Critical
Publication of DE69223952T2 publication Critical patent/DE69223952T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • C07K14/08—RNA viruses
    • C07K14/15—Retroviridae, e.g. bovine leukaemia virus, feline leukaemia virus human T-cell leukaemia-lymphoma virus
    • C07K14/155—Lentiviridae, e.g. human immunodeficiency virus [HIV], visna-maedi virus or equine infectious anaemia virus
    • C07K14/16—HIV-1 ; HIV-2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
    • C12N2740/16122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2740/00—Reverse transcribing RNA viruses
    • C12N2740/00011—Details
    • C12N2740/10011—Retroviridae
    • C12N2740/16011—Human Immunodeficiency Virus, HIV
    • C12N2740/16211—Human Immunodeficiency Virus, HIV concerning HIV gagpol
    • C12N2740/16222—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/82—Proteins from microorganisms
    • Y10S530/826—Viruses

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • AIDS & HIV (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Hematology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE69223952T 1992-06-17 1992-11-02 Entwurf, Konstruktion und Expression von chimärischen Proteinen zur Entwicklung von Impfstoffen und diagnostischen Reagenzien Expired - Lifetime DE69223952T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
KR1019920010493A KR0172970B1 (ko) 1992-06-17 1992-06-17 Aids백신에 유용한 키메릭 단백 및 그의 제조방법

Publications (2)

Publication Number Publication Date
DE69223952D1 true DE69223952D1 (de) 1998-02-12
DE69223952T2 DE69223952T2 (de) 1998-08-13

Family

ID=19334799

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69223952T Expired - Lifetime DE69223952T2 (de) 1992-06-17 1992-11-02 Entwurf, Konstruktion und Expression von chimärischen Proteinen zur Entwicklung von Impfstoffen und diagnostischen Reagenzien

Country Status (5)

Country Link
US (1) US5443828A (de)
EP (1) EP0577894B1 (de)
JP (1) JPH06321997A (de)
KR (1) KR0172970B1 (de)
DE (1) DE69223952T2 (de)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BR9406821A (pt) * 1993-06-09 1996-03-26 Connaught Lab Peptideo sintético composiçao imunogenica kit de diagnostico útil para dectar anticorpos especificos de hiv em amostra de teste kit de diagnostico para detectar antigenos de hiv em amostra de teste codificaçao de molécula de ácido nucléico e anticorpo
CA2269097C (en) 1996-11-08 2007-01-09 The Government Of The United States Of America, Represented By The Secretary, Department Of Health And Human Services Synthesis and purification of hepatitis c virus-like particles
US6271354B1 (en) 1997-04-03 2001-08-07 Thomas Jefferson University Chimeric viral proteins
CA2418091A1 (en) * 2000-08-08 2002-02-14 The Kitasato Institute Virus-like particles and process for producing the same
US7943146B2 (en) * 2001-12-21 2011-05-17 Myrexis, Inc. Immunizing compositions comprising HIV-1 proviral constructs with an inactive p6 gag TSG101 UEV binding domain capable of producing budding-defective viral particles that remain tethered to the cell surface
KR100466382B1 (ko) * 2002-01-08 2005-01-14 주식회사 엘지생명과학 인간 면역 결핍 바이러스-1, -2 타입의 단백질이 융합된 재조합 콤보 단백질, 이의 생산방법, 이를 포함하는 벡터, 형질전환된 대장균 및 진단키트
FR2844519A1 (fr) * 2002-09-17 2004-03-19 Bio Merieux Proteine recombinante chimerique et diagnostic in vitro
GB0225788D0 (en) 2002-11-05 2002-12-11 Glaxo Group Ltd Vaccine
GB0225786D0 (en) * 2002-11-05 2002-12-11 Glaxo Group Ltd Vaccine
US7556814B2 (en) * 2003-10-23 2009-07-07 Karp Nelson M Immunogenic compositions comprising UV-irradiated, psoralen-inactivated, desialated human immunodeficiency virus (HIV) devoid of CD55 and CD59 in the viral membrane
GB0417494D0 (en) 2004-08-05 2004-09-08 Glaxosmithkline Biolog Sa Vaccine
ZA200803883B (en) * 2005-11-08 2009-07-29 South African Medical Research Council Chimaeric HIV-1 subtype C Gag-virus-like particles
EP2025762A3 (de) 2006-01-17 2009-09-30 Health Research Inc. Heteroduplex-Trackingassay
WO2011160177A1 (en) * 2010-06-23 2011-12-29 Monash University Constrained immunogenic compositions and uses therefor
CN111704657B (zh) * 2020-06-16 2021-11-09 四川安可瑞新材料技术有限公司 Hiv-2重组抗原及其制备方法、用途

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4808536A (en) * 1986-02-27 1989-02-28 Centocor, Inc. Immunochemical method for detection of antibody against HTLV-III core protein based upon recombinant HTLV-III gag gene encoded protein
US4925784A (en) * 1986-04-04 1990-05-15 Hoffmann-La Roche Inc. Expression and purification of an HTLV-III gag/env gene protein

Also Published As

Publication number Publication date
EP0577894B1 (de) 1998-01-07
US5443828A (en) 1995-08-22
KR940000577A (ko) 1994-01-03
EP0577894A1 (de) 1994-01-12
KR0172970B1 (ko) 1999-02-01
DE69223952T2 (de) 1998-08-13
JPH06321997A (ja) 1994-11-22

Similar Documents

Publication Publication Date Title
DE69223952T2 (de) Entwurf, Konstruktion und Expression von chimärischen Proteinen zur Entwicklung von Impfstoffen und diagnostischen Reagenzien
DE69033032T2 (de) Integriertes zellkultur-proteinreinigungssystem zur automatisierten herstellung und reinigung von zellkulturprodukten
DE69434942D1 (de) Mehrzweckreagenzsystem zur schnellen lysierung von vollblutproben
DE69502829D1 (de) System zur positionsbestimmung und identifizierung von luftfahrzeugen
DE69534568D1 (de) Säugetier-telomerase
DK110885D0 (da) Nucleinsyre-proteinkonjugater, disses anvendelse samt fremgangsmaade til fremstilling heraf
DE3689123T2 (de) Modulare einheit von antikörpergenen, daraus hergestellte antikörper und verwendung.
DE240975T1 (de) Menschliches gamma-interferon-spezifisches rezeptorprotein, antikoerper gegen dieses protein, verfahren zur herstellung dieses proteins und dieses antikoerpers und dieses protein und diesen antikoerper enthaltende zusammensetzungen.
DE3861132D1 (de) Dismulgierendes und reinigungsmittel, verwendbar zur trennung von erdoel-wasser-gemischen, gegebenenfalls emulsionen und anwendungen dieses mittels.
DE68909179T2 (de) Verschlusselement zur Kontrolle von Ileokolostomie.
DE69022819D1 (de) Verbindungen und Reagenzien zur Bestimmung von Retikulozyten.
IT7925568A0 (it) Composizione adatta al controllo di tessuti e/o liquidi biologici emetodo impiegante la stessa.
DE69531958D1 (de) (1-3)-beta-d-glukon-bindungsprotein, antikörper der dieses protein erkennt undverwendung des proteins und antikörper
DE3668168D1 (de) Desmosinderivate und reagenz zur herstellung artifizieller antigene.
DK41590A (da) Forbedrede protein c-molekyler samt fremgangsmaade til fremstilling og aktivering af samme
DE3788852T2 (de) Proteine mit Glutathion-S-Transferase-Aktivität, DNA-Sequenzen, Antikörper, Poxviren und Arzneimittel zur Prävention von Schistosomiasis.
DE3689948D1 (de) Monoklonale antikörper und testverfahren.
DE3852625D1 (de) Vektoren und Verbindungen zur Expression von Zymogen-Formen von menschlichem Protein C.
DK105886A (da) Monoklone anti-alfa-amylaseantistoffer, fremgangsmaade til fremstilling heraf samt laegemidler indeholdende disse antistoffer
DE68908764T2 (de) Pufferlösungssysteme und Elektrolyten zur Eichung von Analysegeräten.
DE3580482D1 (de) Monoklonale antikoerper und immunisierung damit.
DE3880486D1 (de) Aspirator zur aufnahme von koerperfluessigkeiten.
DE3768306D1 (de) Verfahren zur fabrikation von n-(sulfonylmethyl)-formamiden und von sulfonylmethylisocyaniden.
DK120687A (da) Hoej-produktiv bakterie-fermentation samt fremgangsmaade til fremstilling af proteinmateriale
DE69001376T2 (de) Navigationshilfsvorrichtung und terrestrisches navigationssystem.

Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: GREEN CROSS VACCINE CORP., KYONGKI-DO, KR