DE69222956D1 - Kleinste erkennungseinheit eines pem-mucin-"tandem repeat"-spezifischen monoklonalen antikoerpers - Google Patents

Kleinste erkennungseinheit eines pem-mucin-"tandem repeat"-spezifischen monoklonalen antikoerpers

Info

Publication number
DE69222956D1
DE69222956D1 DE69222956T DE69222956T DE69222956D1 DE 69222956 D1 DE69222956 D1 DE 69222956D1 DE 69222956 T DE69222956 T DE 69222956T DE 69222956 T DE69222956 T DE 69222956T DE 69222956 D1 DE69222956 D1 DE 69222956D1
Authority
DE
Germany
Prior art keywords
mucin
pct
pem
detection unit
monoclonal antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69222956T
Other languages
English (en)
Other versions
DE69222956T2 (de
Inventor
Nigel Stephen Courtenay-Luck
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Cancer Therapeutics Ltd
Original Assignee
Cancer Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Therapeutics Ltd filed Critical Cancer Therapeutics Ltd
Application granted granted Critical
Publication of DE69222956D1 publication Critical patent/DE69222956D1/de
Publication of DE69222956T2 publication Critical patent/DE69222956T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69222956T 1991-04-23 1992-04-23 Kleinste erkennungseinheit eines pem-mucin-"tandem repeat"-spezifischen monoklonalen antikoerpers Expired - Fee Related DE69222956T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB919108652A GB9108652D0 (en) 1991-04-23 1991-04-23 Immunoreactive compounds
PCT/GB1992/000746 WO1992018534A1 (en) 1991-04-23 1992-04-23 Minimum recognition unit of a pem mucin tandem repeat specific monoclonal antibody

Publications (2)

Publication Number Publication Date
DE69222956D1 true DE69222956D1 (de) 1997-12-04
DE69222956T2 DE69222956T2 (de) 1998-04-09

Family

ID=10693760

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69222956T Expired - Fee Related DE69222956T2 (de) 1991-04-23 1992-04-23 Kleinste erkennungseinheit eines pem-mucin-"tandem repeat"-spezifischen monoklonalen antikoerpers

Country Status (10)

Country Link
US (4) US5591593A (de)
EP (1) EP0672063B1 (de)
JP (1) JP3280966B2 (de)
AT (1) ATE159727T1 (de)
DE (1) DE69222956T2 (de)
DK (1) DK0672063T3 (de)
ES (1) ES2111066T3 (de)
GB (2) GB9108652D0 (de)
GR (1) GR3025982T3 (de)
WO (1) WO1992018534A1 (de)

Families Citing this family (33)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds
AU684348B2 (en) * 1994-06-07 1997-12-11 Nihon Medi-Physics Co., Ltd. Tumor affinity peptide, and radioactive diagnostic agent and adioactive therapeutic agent containing the peptide
CA2165228A1 (en) * 1994-12-27 1996-06-28 Yoshitoshi Itaya Metal chelate forming peptides and use thereof
GR950100415A (en) * 1995-11-21 1997-07-30 Antisoma Ltd Tumor affinity peptide, and radioactive diagnostic agent and radioactive therapeutic agent containing the peptide
WO1997043416A1 (en) 1996-05-10 1997-11-20 Biogen, Inc. Common gamma chain blocking agents
EP0910407B1 (de) * 1996-05-15 2003-02-26 Altarex Corp. Verfahren und zusammensetzung zur umgestaltung multi-epitopischer antigene um die immunantwort einzuleiten
US7361346B1 (en) * 1996-05-15 2008-04-22 Altarex Corp. Therapeutic compositions that produce an immune response
US8038994B2 (en) * 1996-05-15 2011-10-18 Quest Pharmatech Inc. Combination therapy for treating disease
US20060159688A1 (en) * 1996-05-15 2006-07-20 Ragupathy Madiyalakan Method for diagnosing efficacy of xenotypic antibody therapy
US7318921B2 (en) * 1996-05-15 2008-01-15 Altarex Medical Corp. Therapeutic compositions that alter the immune response
US5952294A (en) * 1996-07-31 1999-09-14 University Of Pittsburgh Of The Commonwealth System Of Higher Education Peptidyl prodrugs and methods of making and using the same
DE69835679T2 (de) * 1997-08-28 2007-08-23 Biomira, Inc., Edmonton Zufälligverteilt erzeugte kombinatorische peptidbibliotheken
WO2000077031A2 (en) * 1999-06-15 2000-12-21 University Health Network Muc1 ligands
US6801270B2 (en) * 2000-06-26 2004-10-05 Reveo, Inc. Backlight for a liquid crystal display having high light-recycling efficiency
MXPA03003401A (es) * 2000-10-16 2004-06-30 Neopharm Inc Formulacion liposomica de mitoxantrona.
US20040143101A1 (en) * 2001-04-02 2004-07-22 Soltis Daniel A. Immunoglobulin construct containing anti-mucin variable domain sequences for eliciting an anti-idiotype anti-tumor response
US20050069549A1 (en) 2002-01-14 2005-03-31 William Herman Targeted ligands
US20050260208A1 (en) * 2002-04-11 2005-11-24 Altarex Medical Corp. Binding agents and their use in targeting tumor cells
AU2007320024B2 (en) 2006-10-02 2012-11-08 E. R. Squibb & Sons, L.L.C. Human antibodies that bind CXCR4 and uses thereof
CN105111310B (zh) 2006-11-21 2019-07-26 雅培制药有限公司 抗nogo-66受体(ngr)的中和单克隆抗体及其用途
SG177168A1 (en) 2006-12-01 2012-01-30 Medarex Inc Human antibodies that bind cd22 and uses thereof
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
NZ578354A (en) 2006-12-14 2012-01-12 Medarex Inc Antibody-partner molecule conjugates that bind cd70 and uses thereof
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
US9193797B2 (en) * 2010-12-14 2015-11-24 Recepta Biopharma S.A. Antitumor peptide derived from a complementarity determining region of a humanized monoclonal antibody to NaPi2B transporter
EP3252076B1 (de) 2011-01-14 2019-09-04 The Regents Of The University Of California Diagnostische verwendung von antikörpern gegen das protein ror-1
UY34887A (es) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
CN107550864B (zh) * 2017-08-23 2020-12-18 科笛生物医药(上海)有限公司 Eppt多肽-聚乙二醇-磷脂复合膜材料、其制备方法及主动靶向脂质体递药系统和应用
TWI754157B (zh) 2018-07-25 2022-02-01 大陸商信達生物製藥（蘇州）有限公司 抗ｔｉｇｉｔ抗體及其用途
CN109762067B (zh) 2019-01-17 2020-02-28 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途
EP4110816A1 (de) 2020-02-27 2023-01-04 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. Il4r-bindende antikörper und verwendungen davon
KR20230010691A (ko) 2020-05-12 2023-01-19 치아타이 티안큉 파마수티컬 그룹 주식회사 St2 항원 결합 단백질

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2150897T3 (es) * 1986-01-22 2000-12-16 Pasteur Institut Procedimiento de fabricacion recombinante de las proteinas derivadas de hiv-2 y cultivo celular que expresa proteinas de hiv-2.
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5077220A (en) * 1988-08-26 1991-12-31 John Muir Cancer & Aging Institute Monoclonal antibody specific to a novel glycoprotein antigen on human carcinoma cells
WO1990005142A1 (en) * 1988-11-10 1990-05-17 Imperial Cancer Research Technology Ltd. Polypeptides
EP0369816A3 (de) * 1988-11-17 1990-09-12 The University Of Melbourne Gegen menschliches polymorphes epitheliales Muzin spezifische monoklonale Antikörper
WO1991002002A1 (en) * 1989-07-21 1991-02-21 Washington University Recombinantly produced human membrane cofactor protein (mcp)
CA1341094C (en) * 1989-09-25 2000-09-05 Ronald G. Worton Diagnosis for malignant hyperthermia
WO1992010518A1 (en) * 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds

Also Published As

Publication number Publication date
GB2270078A (en) 1994-03-02
JPH06506927A (ja) 1994-08-04
US6107469A (en) 2000-08-22
US5833943A (en) 1998-11-10
GB2270078B (en) 1995-07-12
US5591593A (en) 1997-01-07
GB9108652D0 (en) 1991-06-12
US6174691B1 (en) 2001-01-16
GR3025982T3 (en) 1998-04-30
ES2111066T3 (es) 1998-03-01
DE69222956T2 (de) 1998-04-09
JP3280966B2 (ja) 2002-05-13
EP0672063B1 (de) 1997-10-29
ATE159727T1 (de) 1997-11-15
DK0672063T3 (da) 1998-05-18
WO1992018534A1 (en) 1992-10-29
GB9319300D0 (en) 1993-12-22
EP0672063A1 (de) 1995-09-20

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee