ATE159727T1 - Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers - Google Patents

Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers

Info

Publication number
ATE159727T1
ATE159727T1 AT92908820T AT92908820T ATE159727T1 AT E159727 T1 ATE159727 T1 AT E159727T1 AT 92908820 T AT92908820 T AT 92908820T AT 92908820 T AT92908820 T AT 92908820T AT E159727 T1 ATE159727 T1 AT E159727T1
Authority
AT
Austria
Prior art keywords
mucin
pct
pem
monoclonal antibodies
recognition unit
Prior art date
Application number
AT92908820T
Other languages
English (en)
Inventor
Nigel Stephen Courtenay-Luck
Original Assignee
Cancer Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Therapeutics Limited filed Critical Cancer Therapeutics Limited
Application granted granted Critical
Publication of ATE159727T1 publication Critical patent/ATE159727T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT92908820T 1991-04-23 1992-04-23 Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers ATE159727T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919108652A GB9108652D0 (en) 1991-04-23 1991-04-23 Immunoreactive compounds

Publications (1)

Publication Number Publication Date
ATE159727T1 true ATE159727T1 (de) 1997-11-15

Family

ID=10693760

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92908820T ATE159727T1 (de) 1991-04-23 1992-04-23 Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers

Country Status (10)

Country Link
US (4) US5591593A (de)
EP (1) EP0672063B1 (de)
JP (1) JP3280966B2 (de)
AT (1) ATE159727T1 (de)
DE (1) DE69222956T2 (de)
DK (1) DK0672063T3 (de)
ES (1) ES2111066T3 (de)
GB (2) GB9108652D0 (de)
GR (1) GR3025982T3 (de)
WO (1) WO1992018534A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds
US5827498A (en) 1994-06-07 1998-10-27 Nihon Medi-Physics Co., Ltd. Tumor affinity peptide, and radioactive diagnostic agent and radioactive therapeutic agent containing the peptide
CA2165228A1 (en) * 1994-12-27 1996-06-28 Yoshitoshi Itaya Metal chelate forming peptides and use thereof
GR1002903B (el) * 1995-11-21 1998-05-12 Antisoma Limited Πεπτιδιο συγγενες με ογκο και ραδιενεργος διαγνωστικος παραγοντας και ραδιενεργος θεραπευτικος παραγοντας που περιεχει το πεπτιδιο.
AU2937597A (en) * 1996-05-10 1997-12-05 Biogen, Inc. Common gamma chain blocking agents
US8038994B2 (en) * 1996-05-15 2011-10-18 Quest Pharmatech Inc. Combination therapy for treating disease
WO1997042973A1 (en) * 1996-05-15 1997-11-20 Altarex, Corp. Method and composition for reconforming multi-epitopic antigens to initiate an immune response
US7318921B2 (en) * 1996-05-15 2008-01-15 Altarex Medical Corp. Therapeutic compositions that alter the immune response
US20060159688A1 (en) * 1996-05-15 2006-07-20 Ragupathy Madiyalakan Method for diagnosing efficacy of xenotypic antibody therapy
US7361346B1 (en) * 1996-05-15 2008-04-22 Altarex Corp. Therapeutic compositions that produce an immune response
US5952294A (en) * 1996-07-31 1999-09-14 University Of Pittsburgh Of The Commonwealth System Of Higher Education Peptidyl prodrugs and methods of making and using the same
US20040077826A1 (en) * 1997-08-28 2004-04-22 R. Rao Koganty Randomly generated glycopeptide combinatorial libraries
AU5382200A (en) * 1999-06-15 2001-01-02 University Health Network Muc1 ligands
US6801270B2 (en) * 2000-06-26 2004-10-05 Reveo, Inc. Backlight for a liquid crystal display having high light-recycling efficiency
CZ20031262A3 (en) * 2000-10-16 2004-03-17 Neopharm, Inc. Liposomal formulation of mitoxantrone
US20040143101A1 (en) * 2001-04-02 2004-07-22 Soltis Daniel A. Immunoglobulin construct containing anti-mucin variable domain sequences for eliciting an anti-idiotype anti-tumor response
US20050069549A1 (en) 2002-01-14 2005-03-31 William Herman Targeted ligands
HRP20041037A2 (en) * 2002-04-11 2005-06-30 Altarex Medical Corporation Binding agents and their use in targeting tumor cells
SI2066351T1 (sl) 2006-10-02 2016-02-29 E.R. Squibb & Sons, L.L.C. Humana protitelesa, ki vežejo cxcr4 in njihova uporaba
CA2987970A1 (en) * 2006-11-21 2008-05-29 Abbvie Inc. Neutralizing monoclonal antibodies against the nogo-66 receptor (ngr) and uses thereof
SG177168A1 (en) 2006-12-01 2012-01-30 Medarex Inc Human antibodies that bind cd22 and uses thereof
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
US20100150950A1 (en) 2006-12-14 2010-06-17 Medarex, Inc. Human antibodies that bind cd70 and uses thereof
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
BR112013015001B1 (pt) * 2010-12-14 2021-10-13 Recepta Biopharma S.A. Peptídeo antitumor isolado ou sintético, composição farmacêutica, e, usos de um peptídeo
EP3252076B1 (de) 2011-01-14 2019-09-04 The Regents Of The University Of California Diagnostische verwendung von antikörpern gegen das protein ror-1
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
CN107550864B (zh) * 2017-08-23 2020-12-18 科笛生物医药(上海)有限公司 Eppt多肽-聚乙二醇-磷脂复合膜材料、其制备方法及主动靶向脂质体递药系统和应用
TWI754157B (zh) 2018-07-25 2022-02-01 大陸商信達生物製藥（蘇州）有限公司 抗ｔｉｇｉｔ抗體及其用途
CN109762067B (zh) 2019-01-17 2020-02-28 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途
US10570210B1 (en) 2019-03-04 2020-02-25 Beijing Mabworks Biotech Co.Ltd Antibodies binding CD40 and uses thereof
CN119708230A (zh) 2020-02-27 2025-03-28 正大天晴药业集团股份有限公司 结合il4r的抗体及其用途
CN121914272A (zh) 2020-05-12 2026-04-24 正大天晴药业集团股份有限公司 St2抗原结合蛋白
CN118159286A (zh) 2021-11-25 2024-06-07 正大天晴药业集团股份有限公司 抗Siglec-15抗体及其应用
AU2022446336A1 (en) 2022-03-18 2024-09-19 Beijing Mabworks Biotech Co., Ltd B7-h3-binding antibody and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ219024A (en) * 1986-01-22 1990-04-26 Pasteur Institut Hiv-2 retrovirus protein and nucleic acid sequences and detection methods
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5077220A (en) * 1988-08-26 1991-12-31 John Muir Cancer & Aging Institute Monoclonal antibody specific to a novel glycoprotein antigen on human carcinoma cells
EP0442926A1 (de) * 1988-11-10 1991-08-28 Imperial Cancer Research Technology Limited Polypeptide
CA2003211A1 (en) * 1988-11-17 1990-05-17 Pei-Xiang Xing Monoclonal antibodies
EP0483247A4 (en) * 1989-07-21 1992-12-09 Washington University Recombinantly produced human membrane cofactor protein (mcp)
CA1341094C (en) * 1989-09-25 2000-09-05 Ronald G. Worton Diagnosis for malignant hyperthermia
WO1992010518A1 (en) * 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds

Also Published As

Publication number Publication date
DK0672063T3 (da) 1998-05-18
WO1992018534A1 (en) 1992-10-29
EP0672063B1 (de) 1997-10-29
JP3280966B2 (ja) 2002-05-13
US5833943A (en) 1998-11-10
ES2111066T3 (es) 1998-03-01
JPH06506927A (ja) 1994-08-04
GB2270078A (en) 1994-03-02
DE69222956D1 (de) 1997-12-04
EP0672063A1 (de) 1995-09-20
US6174691B1 (en) 2001-01-16
US5591593A (en) 1997-01-07
GB9108652D0 (en) 1991-06-12
GB2270078B (en) 1995-07-12
GB9319300D0 (en) 1993-12-22
GR3025982T3 (en) 1998-04-30
US6107469A (en) 2000-08-22
DE69222956T2 (de) 1998-04-09

Similar Documents

Publication Publication Date Title
DE69222956D1 (de) Kleinste erkennungseinheit eines pem-mucin-"tandem repeat"-spezifischen monoklonalen antikoerpers
Michaelsen et al. Primary structure of the" hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit.
KR950032279A (ko) 인체의 프로그램된 세포 사멸과 관련 있는 펩티드 및 이를 암호하는 디엔에이(dna)
NZ330897A (en) Human trk receptors and neurotropic factor inhibitors
SG96535A1 (en) Pharmaceutical composition for the treatment or prevention of a malignant tumor
DE69130506D1 (de) Nukleotidsequenzen kodierend für ein humanes protein mit angiogenetisch-regulatorischen eigenschaften
KR900013979A (ko) 사람 유두종비루스형 16의 e7 단백질상의 면역원성 영역
DE69227041D1 (de) Expression und reinigung von rekombinantem, löslichem gewebefaktor
ES2129487T3 (es) Peptidos sinteticos, anticuerpos dirigidos contra ellos y su utilizacion.
NO940736D0 (no) DNA sekvenser som koder for gelonin polypeptid
AU7565991A (en) Variant cd44 surface proteins, dna sequences coding them, antibodies against these proteins and their use in diagnosis and therapy
ATE410514T1 (de) Calciumbindende rekombinante antikörper gegen protein c
ATE282634T1 (de) Chaperonin 10
EA201001190A1 (ru) Выделенное антитело, специфически связанное с полипептидом, состоящее из последовательности аминокислотных остатков
DK0580672T3 (da) Syntetisk CDw52-(CAMPATH-1)-peptidantigen
PT93178A (pt) Agente proteico anticanceroso
EP0369816A3 (de) Gegen menschliches polymorphes epitheliales Muzin spezifische monoklonale Antikörper
ATE247164T1 (de) Insulinartigen wachstumsfaktor bindendes protein
DE69634757D1 (de) Vektor zur expression von n-terminal verlängerten proteinen in hefezellen
GB1294771A (en) Thyrocalcitonin derivative
DK0876610T3 (da) Fremgangsmåde og anvendelse af polypeptid i sædcelle-æg-binding til at foröge eller mindske fertilitet
KR850002285A (ko) 면역 인터페론의 제조방법
DE69635457D1 (de) Deprenyl induziertes protein
NZ606260A (en) Novel polypeptides involved in immune response

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee