ATE159727T1 - Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers - Google Patents

Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers

Info

Publication number
ATE159727T1
ATE159727T1 AT92908820T AT92908820T ATE159727T1 AT E159727 T1 ATE159727 T1 AT E159727T1 AT 92908820 T AT92908820 T AT 92908820T AT 92908820 T AT92908820 T AT 92908820T AT E159727 T1 ATE159727 T1 AT E159727T1
Authority
AT
Austria
Prior art keywords
mucin
pct
pem
monoclonal antibodies
recognition unit
Prior art date
Application number
AT92908820T
Other languages
English (en)
Inventor
Nigel Stephen Courtenay-Luck
Original Assignee
Cancer Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Therapeutics Limited filed Critical Cancer Therapeutics Limited
Application granted granted Critical
Publication of ATE159727T1 publication Critical patent/ATE159727T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Cell Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT92908820T 1991-04-23 1992-04-23 Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers ATE159727T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919108652A GB9108652D0 (en) 1991-04-23 1991-04-23 Immunoreactive compounds

Publications (1)

Publication Number Publication Date
ATE159727T1 true ATE159727T1 (de) 1997-11-15

Family

ID=10693760

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92908820T ATE159727T1 (de) 1991-04-23 1992-04-23 Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers

Country Status (10)

Country Link
US (4) US5591593A (de)
EP (1) EP0672063B1 (de)
JP (1) JP3280966B2 (de)
AT (1) ATE159727T1 (de)
DE (1) DE69222956T2 (de)
DK (1) DK0672063T3 (de)
ES (1) ES2111066T3 (de)
GB (2) GB9108652D0 (de)
GR (1) GR3025982T3 (de)
WO (1) WO1992018534A1 (de)

Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds
AU684348B2 (en) 1994-06-07 1997-12-11 Nihon Medi-Physics Co., Ltd. Tumor affinity peptide, and radioactive diagnostic agent and adioactive therapeutic agent containing the peptide
CA2165228A1 (en) * 1994-12-27 1996-06-28 Yoshitoshi Itaya Metal chelate forming peptides and use thereof
GR950100415A (en) * 1995-11-21 1997-07-30 Antisoma Ltd Tumor affinity peptide, and radioactive diagnostic agent and radioactive therapeutic agent containing the peptide
WO1997043416A1 (en) * 1996-05-10 1997-11-20 Biogen, Inc. Common gamma chain blocking agents
NZ332588A (en) * 1996-05-15 2000-11-24 Altarex Inc Cancer antigens CA125 (multiple epitote) recognised by OC125, M11, B43.13, B27.1, where B43.13 is used as a binding agent to elicit host immune response as a vaccination method against cancer
US8038994B2 (en) * 1996-05-15 2011-10-18 Quest Pharmatech Inc. Combination therapy for treating disease
US7361346B1 (en) * 1996-05-15 2008-04-22 Altarex Corp. Therapeutic compositions that produce an immune response
US20060159688A1 (en) * 1996-05-15 2006-07-20 Ragupathy Madiyalakan Method for diagnosing efficacy of xenotypic antibody therapy
US7318921B2 (en) * 1996-05-15 2008-01-15 Altarex Medical Corp. Therapeutic compositions that alter the immune response
US5952294A (en) * 1996-07-31 1999-09-14 University Of Pittsburgh Of The Commonwealth System Of Higher Education Peptidyl prodrugs and methods of making and using the same
DE69835679T2 (de) * 1997-08-28 2007-08-23 Biomira, Inc., Edmonton Zufälligverteilt erzeugte kombinatorische peptidbibliotheken
AU5382200A (en) * 1999-06-15 2001-01-02 University Health Network Muc1 ligands
WO2003002908A1 (en) * 2000-06-26 2003-01-09 Reveo, Inc. Backlight for a liquid crystal display having high light-recycling efficiency
AU2002214649A1 (en) * 2000-10-16 2002-04-29 Neopharm, Inc. Liposomal formulation of mitoxantrone
AU2002307064A1 (en) * 2001-04-02 2002-10-15 Purdue Pharma L.P. Immunoglobulin construct containing anti-mucin variable domain sequences for eliciting an anti-idiotype anti-tumor response
EP2075256A2 (de) 2002-01-14 2009-07-01 William Herman Gezielte Liganden
EP1492566A4 (de) * 2002-04-11 2005-11-23 Altarex Medical Corp Bindemittel und ihre verwendung zum targeting von tumorzellen
HUE033630T2 (en) 2006-10-02 2017-12-28 Squibb & Sons Llc CXCR4 binding human antibodies and their use
CA2670368C (en) 2006-11-21 2018-05-29 Abbott Laboratories Neutralizing monoclonal antibodies against the nogo-66 receptor (ngr) and uses thereof
JP5398538B2 (ja) 2006-12-01 2014-01-29 メダレックス・リミテッド・ライアビリティ・カンパニー Ｃｄ２２に結合するヒト抗体およびその使用
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
EP2097534A4 (de) 2006-12-14 2010-05-12 Medarex Inc Cd70-bindende antikörper und ihre verwendungen
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
ES2804476T3 (es) 2010-12-14 2021-02-08 Recepta Biopharma S A Péptido antitumoral derivado de una región determinante de complementariedad de un anticuerpo monoclonal humanizado contra el transportador NaPI2B
DK3604339T3 (da) 2011-01-14 2021-04-12 Univ California Terapeutiske antistoffer mod ror-1-protein og fremgangsmåder til anvendelse af samme
AR091649A1 (es) 2012-07-02 2015-02-18 Bristol Myers Squibb Co Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos
CN107550864B (zh) * 2017-08-23 2020-12-18 科笛生物医药(上海)有限公司 Eppt多肽-聚乙二醇-磷脂复合膜材料、其制备方法及主动靶向脂质体递药系统和应用
KR20210040827A (ko) 2018-07-25 2021-04-14 이노벤트 바이오로직스 (쑤저우) 컴퍼니, 리미티드 항 tigit 항체 및 그 용도
CN109762067B (zh) 2019-01-17 2020-02-28 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途
US10570210B1 (en) 2019-03-04 2020-02-25 Beijing Mabworks Biotech Co.Ltd Antibodies binding CD40 and uses thereof
CN119708230A (zh) 2020-02-27 2025-03-28 正大天晴药业集团股份有限公司 结合il4r的抗体及其用途
EP4151654A4 (de) 2020-05-12 2024-11-27 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. St2-antigenbindendes protein
CN118159286A (zh) 2021-11-25 2024-06-07 正大天晴药业集团股份有限公司 抗Siglec-15抗体及其应用
AU2022446336A1 (en) 2022-03-18 2024-09-19 Beijing Mabworks Biotech Co., Ltd B7-h3-binding antibody and use thereof

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1987004459A1 (fr) * 1986-01-22 1987-07-30 Institut Pasteur Retrovirus du type hiv-2 susceptible de provoquer le sida, et ses constituants antigeniques et nucleiques
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5077220A (en) * 1988-08-26 1991-12-31 John Muir Cancer & Aging Institute Monoclonal antibody specific to a novel glycoprotein antigen on human carcinoma cells
WO1990005142A1 (en) * 1988-11-10 1990-05-17 Imperial Cancer Research Technology Ltd. Polypeptides
EP0369816A3 (de) * 1988-11-17 1990-09-12 The University Of Melbourne Gegen menschliches polymorphes epitheliales Muzin spezifische monoklonale Antikörper
CA2062969C (en) * 1989-07-21 2000-10-10 John P. Atkinson Recombinantly produced human membrane cofactor protein (mcp)
CA1341094C (en) * 1989-09-25 2000-09-05 Ronald G. Worton Diagnosis for malignant hyperthermia
WO1992010518A1 (en) * 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds

Also Published As

Publication number Publication date
US6107469A (en) 2000-08-22
GB9108652D0 (en) 1991-06-12
DK0672063T3 (da) 1998-05-18
EP0672063A1 (de) 1995-09-20
US5833943A (en) 1998-11-10
US5591593A (en) 1997-01-07
EP0672063B1 (de) 1997-10-29
DE69222956T2 (de) 1998-04-09
DE69222956D1 (de) 1997-12-04
GB2270078B (en) 1995-07-12
JP3280966B2 (ja) 2002-05-13
GB9319300D0 (en) 1993-12-22
WO1992018534A1 (en) 1992-10-29
US6174691B1 (en) 2001-01-16
GB2270078A (en) 1994-03-02
GR3025982T3 (en) 1998-04-30
ES2111066T3 (es) 1998-03-01
JPH06506927A (ja) 1994-08-04

Similar Documents

Publication Publication Date Title
ATE159727T1 (de) Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers
Michaelsen et al. Primary structure of the" hinge" region of human IgG3. Probable quadruplication of a 15-amino acid residue basic unit.
KR950032279A (ko) 인체의 프로그램된 세포 사멸과 관련 있는 펩티드 및 이를 암호하는 디엔에이(dna)
NZ330897A (en) Human trk receptors and neurotropic factor inhibitors
SG96535A1 (en) Pharmaceutical composition for the treatment or prevention of a malignant tumor
DE69130506D1 (de) Nukleotidsequenzen kodierend für ein humanes protein mit angiogenetisch-regulatorischen eigenschaften
KR900013979A (ko) 사람 유두종비루스형 16의 e7 단백질상의 면역원성 영역
DE69227041D1 (de) Expression und reinigung von rekombinantem, löslichem gewebefaktor
ES2129487T3 (es) Peptidos sinteticos, anticuerpos dirigidos contra ellos y su utilizacion.
AU7565991A (en) Variant cd44 surface proteins, dna sequences coding them, antibodies against these proteins and their use in diagnosis and therapy
NO940736L (no) DNA sekvenser som koder for gelonin polypeptid
ATE410514T1 (de) Calciumbindende rekombinante antikörper gegen protein c
PT731811E (pt) Chaperonina 10
EA201001190A1 (ru) Выделенное антитело, специфически связанное с полипептидом, состоящее из последовательности аминокислотных остатков
FR2677653B1 (de)
DK0580672T3 (da) Syntetisk CDw52-(CAMPATH-1)-peptidantigen
PT93178A (pt) Agente proteico anticanceroso
ATE247164T1 (de) Insulinartigen wachstumsfaktor bindendes protein
DK0876610T3 (da) Fremgangsmåde og anvendelse af polypeptid i sædcelle-æg-binding til at foröge eller mindske fertilitet
KR850002285A (ko) 면역 인터페론의 제조방법
DE69635457D1 (de) Deprenyl induziertes protein
WO2003044159A9 (en) Zinc finger proteins, polynucleotides encoding same and antibodies thereto
NZ606260A (en) Novel polypeptides involved in immune response

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee