ATE159727T1 - Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers - Google Patents

Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers

Info

Publication number
ATE159727T1
ATE159727T1 AT92908820T AT92908820T ATE159727T1 AT E159727 T1 ATE159727 T1 AT E159727T1 AT 92908820 T AT92908820 T AT 92908820T AT 92908820 T AT92908820 T AT 92908820T AT E159727 T1 ATE159727 T1 AT E159727T1
Authority
AT
Austria
Prior art keywords
mucin
pct
pem
monoclonal antibodies
recognition unit
Prior art date
Application number
AT92908820T
Other languages
English (en)
Inventor
Nigel Stephen Courtenay-Luck
Original Assignee
Cancer Therapeutics Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cancer Therapeutics Limited filed Critical Cancer Therapeutics Limited
Application granted granted Critical
Publication of ATE159727T1 publication Critical patent/ATE159727T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4727—Mucins, e.g. human intestinal mucin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/10—Tetrapeptides
    • C07K5/1021—Tetrapeptides with the first amino acid being acidic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Cell Biology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Veterinary Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
AT92908820T 1991-04-23 1992-04-23 Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers ATE159727T1 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GB919108652A GB9108652D0 (en) 1991-04-23 1991-04-23 Immunoreactive compounds

Publications (1)

Publication Number Publication Date
ATE159727T1 true ATE159727T1 (de) 1997-11-15

Family

ID=10693760

Family Applications (1)

Application Number Title Priority Date Filing Date
AT92908820T ATE159727T1 (de) 1991-04-23 1992-04-23 Kleinste erkennungseinheit eines pem-mucin- ''tandem repeat''-spezifischen monoklonalen antikoerpers

Country Status (10)

Country Link
US (4) US5591593A (de)
EP (1) EP0672063B1 (de)
JP (1) JP3280966B2 (de)
AT (1) ATE159727T1 (de)
DE (1) DE69222956T2 (de)
DK (1) DK0672063T3 (de)
ES (1) ES2111066T3 (de)
GB (2) GB9108652D0 (de)
GR (1) GR3025982T3 (de)
WO (1) WO1992018534A1 (de)

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US5443815A (en) * 1991-11-27 1995-08-22 Diatech, Inc. Technetium-99m labeled peptides for imaging
GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds
AU684348B2 (en) * 1994-06-07 1997-12-11 Nihon Medi-Physics Co., Ltd. Tumor affinity peptide, and radioactive diagnostic agent and adioactive therapeutic agent containing the peptide
CA2165228A1 (en) * 1994-12-27 1996-06-28 Yoshitoshi Itaya Metal chelate forming peptides and use thereof
GR950100415A (en) * 1995-11-21 1997-07-30 Antisoma Ltd Tumor affinity peptide, and radioactive diagnostic agent and radioactive therapeutic agent containing the peptide
WO1997043416A1 (en) 1996-05-10 1997-11-20 Biogen, Inc. Common gamma chain blocking agents
US20060159688A1 (en) * 1996-05-15 2006-07-20 Ragupathy Madiyalakan Method for diagnosing efficacy of xenotypic antibody therapy
US7361346B1 (en) * 1996-05-15 2008-04-22 Altarex Corp. Therapeutic compositions that produce an immune response
ATE233102T1 (de) * 1996-05-15 2003-03-15 Altarex Inc Verfahren und zusammensetzung zur umgestaltung multi-epitopischer antigene um die immunantwort einzuleiten
US7318921B2 (en) * 1996-05-15 2008-01-15 Altarex Medical Corp. Therapeutic compositions that alter the immune response
US8038994B2 (en) * 1996-05-15 2011-10-18 Quest Pharmatech Inc. Combination therapy for treating disease
US5952294A (en) * 1996-07-31 1999-09-14 University Of Pittsburgh Of The Commonwealth System Of Higher Education Peptidyl prodrugs and methods of making and using the same
EP1007541B1 (de) * 1997-08-28 2006-08-23 Biomira, Inc. Zufälligverteilt erzeugte kombinatorische peptidbibliotheken
AU5382200A (en) * 1999-06-15 2001-01-02 University Health Network Muc1 ligands
US6801270B2 (en) * 2000-06-26 2004-10-05 Reveo, Inc. Backlight for a liquid crystal display having high light-recycling efficiency
IL155291A0 (en) * 2000-10-16 2003-11-23 Neopharm Inc Liposomal formulation of mitoxantrone
AU2002307064A1 (en) * 2001-04-02 2002-10-15 Purdue Pharma L.P. Immunoglobulin construct containing anti-mucin variable domain sequences for eliciting an anti-idiotype anti-tumor response
EP2075256A2 (de) 2002-01-14 2009-07-01 William Herman Gezielte Liganden
WO2003086041A2 (en) * 2002-04-11 2003-10-23 Altarex Medical Corporation Binding agents and their use in targeting tumor cells
EP2486941B1 (de) 2006-10-02 2017-03-15 E. R. Squibb & Sons, L.L.C. CXCR4-bindende humane Antikörper und deren Verwendungen
CN101969999B (zh) * 2006-11-21 2017-03-22 雅培制药有限公司 抗nogo‑66受体(ngr)的中和单克隆抗体及其用途
NZ578064A (en) 2006-12-01 2012-01-12 Medarex Inc Human antibodies that bind cd22 and uses thereof
CL2007003622A1 (es) 2006-12-13 2009-08-07 Medarex Inc Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales.
WO2008074004A2 (en) 2006-12-14 2008-06-19 Medarex, Inc. Human antibodies that bind cd70 and uses thereof
AR072999A1 (es) 2008-08-11 2010-10-06 Medarex Inc Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos
WO2012080822A2 (en) * 2010-12-14 2012-06-21 Recepta Biopharma S.A. Antitumor peptide derived from a complementarity determining region of a humanized monoclonal antibody to napi2b transporter
ES2634098T3 (es) 2011-01-14 2017-09-26 The Regents Of The University Of California Anticuerpos terapéuticos contra la proteína ROR-1 y procedimientos para el uso de los mismos.
UY34887A (es) 2012-07-02 2013-12-31 Bristol Myers Squibb Company Una Corporacion Del Estado De Delaware Optimización de anticuerpos que se fijan al gen de activación de linfocitos 3 (lag-3) y sus usos
CN107550864B (zh) * 2017-08-23 2020-12-18 科笛生物医药(上海)有限公司 Eppt多肽-聚乙二醇-磷脂复合膜材料、其制备方法及主动靶向脂质体递药系统和应用
CN112135626B (zh) 2018-07-25 2023-05-23 信达生物制药(苏州)有限公司 抗tigit抗体及其用途
CN109762067B (zh) 2019-01-17 2020-02-28 北京天广实生物技术股份有限公司 结合人Claudin 18.2的抗体及其用途
US10570210B1 (en) 2019-03-04 2020-02-25 Beijing Mabworks Biotech Co.Ltd Antibodies binding CD40 and uses thereof
KR20220147642A (ko) 2020-02-27 2022-11-03 치아타이 티안큉 파마수티컬 그룹 주식회사 Il4r에 결합하는 항체 및 이의 용도
EP4151654A4 (de) 2020-05-12 2024-11-27 Chia Tai Tianqing Pharmaceutical Group Co., Ltd. St2-antigenbindendes protein
CN118159286A (zh) 2021-11-25 2024-06-07 正大天晴药业集团股份有限公司 抗Siglec-15抗体及其应用
CN118900847A (zh) 2022-03-18 2024-11-05 北京天广实生物技术股份有限公司 结合b7-h3的抗体及其用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3752319T2 (de) * 1986-01-22 2001-03-15 Pasteur Institut Prozess zur rekombinanten Herstellung von HIV-2 - Proteinen sowie Zellen, die HIV-2 - Proteine exprimiert
GB8607679D0 (en) * 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US5077220A (en) * 1988-08-26 1991-12-31 John Muir Cancer & Aging Institute Monoclonal antibody specific to a novel glycoprotein antigen on human carcinoma cells
JPH04501719A (ja) * 1988-11-10 1992-03-26 インペリアル・キヤンサー・リサーチ・テクノロジー・リミテツド ポリペプチド
EP0369816A3 (de) * 1988-11-17 1990-09-12 The University Of Melbourne Gegen menschliches polymorphes epitheliales Muzin spezifische monoklonale Antikörper
JP2750220B2 (ja) * 1989-07-21 1998-05-13 ワシントン ユニバーシティ 組換え産生したヒト細胞膜補助因子タンパク（ｍｃｐ）
CA1341094C (en) * 1989-09-25 2000-09-05 Ronald G. Worton Diagnosis for malignant hyperthermia
WO1992010518A1 (en) * 1990-12-07 1992-06-25 Yale University Purified slit protein and sequence elements thereof
GB9108652D0 (en) * 1991-04-23 1991-06-12 Antisoma Ltd Immunoreactive compounds

Also Published As

Publication number Publication date
ES2111066T3 (es) 1998-03-01
JP3280966B2 (ja) 2002-05-13
GB9108652D0 (en) 1991-06-12
US5833943A (en) 1998-11-10
EP0672063B1 (de) 1997-10-29
GB2270078A (en) 1994-03-02
EP0672063A1 (de) 1995-09-20
GR3025982T3 (en) 1998-04-30
US6107469A (en) 2000-08-22
DE69222956T2 (de) 1998-04-09
GB9319300D0 (en) 1993-12-22
WO1992018534A1 (en) 1992-10-29
US6174691B1 (en) 2001-01-16
JPH06506927A (ja) 1994-08-04
GB2270078B (en) 1995-07-12
US5591593A (en) 1997-01-07
DK0672063T3 (da) 1998-05-18
DE69222956D1 (de) 1997-12-04

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Legal Events

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UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee