DE69222956T2 - Kleinste erkennungseinheit eines pem-mucin-"tandem repeat"-spezifischen monoklonalen antikoerpers - Google Patents
Kleinste erkennungseinheit eines pem-mucin-"tandem repeat"-spezifischen monoklonalen antikoerpersInfo
- Publication number
- DE69222956T2 DE69222956T2 DE69222956T DE69222956T DE69222956T2 DE 69222956 T2 DE69222956 T2 DE 69222956T2 DE 69222956 T DE69222956 T DE 69222956T DE 69222956 T DE69222956 T DE 69222956T DE 69222956 T2 DE69222956 T2 DE 69222956T2
- Authority
- DE
- Germany
- Prior art keywords
- mucin
- pct
- pem
- detection unit
- monoclonal antibody
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
- C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
- C07K14/4727—Mucins, e.g. human intestinal mucin
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/10—Tetrapeptides
- C07K5/1021—Tetrapeptides with the first amino acid being acidic
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Toxicology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB919108652A GB9108652D0 (en) | 1991-04-23 | 1991-04-23 | Immunoreactive compounds |
PCT/GB1992/000746 WO1992018534A1 (en) | 1991-04-23 | 1992-04-23 | Minimum recognition unit of a pem mucin tandem repeat specific monoclonal antibody |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69222956D1 DE69222956D1 (de) | 1997-12-04 |
DE69222956T2 true DE69222956T2 (de) | 1998-04-09 |
Family
ID=10693760
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69222956T Expired - Fee Related DE69222956T2 (de) | 1991-04-23 | 1992-04-23 | Kleinste erkennungseinheit eines pem-mucin-"tandem repeat"-spezifischen monoklonalen antikoerpers |
Country Status (10)
Country | Link |
---|---|
US (4) | US5591593A (de) |
EP (1) | EP0672063B1 (de) |
JP (1) | JP3280966B2 (de) |
AT (1) | ATE159727T1 (de) |
DE (1) | DE69222956T2 (de) |
DK (1) | DK0672063T3 (de) |
ES (1) | ES2111066T3 (de) |
GB (2) | GB9108652D0 (de) |
GR (1) | GR3025982T3 (de) |
WO (1) | WO1992018534A1 (de) |
Families Citing this family (33)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5443815A (en) * | 1991-11-27 | 1995-08-22 | Diatech, Inc. | Technetium-99m labeled peptides for imaging |
GB9108652D0 (en) * | 1991-04-23 | 1991-06-12 | Antisoma Ltd | Immunoreactive compounds |
AU684348B2 (en) | 1994-06-07 | 1997-12-11 | Nihon Medi-Physics Co., Ltd. | Tumor affinity peptide, and radioactive diagnostic agent and adioactive therapeutic agent containing the peptide |
CA2165228A1 (en) * | 1994-12-27 | 1996-06-28 | Yoshitoshi Itaya | Metal chelate forming peptides and use thereof |
GR1002903B (el) * | 1995-11-21 | 1998-05-12 | Antisoma Limited | Πεπτιδιο συγγενες με ογκο και ραδιενεργος διαγνωστικος παραγοντας και ραδιενεργος θεραπευτικος παραγοντας που περιεχει το πεπτιδιο. |
CA2253942A1 (en) * | 1996-05-10 | 1997-11-20 | Biogen, Inc. | Common gamma chain blocking agents |
CA2253602A1 (en) * | 1996-05-15 | 1997-11-20 | Altarex Corp. | Method and composition for reconforming multi-epitopic antigens to initiate an immune response |
US7361346B1 (en) * | 1996-05-15 | 2008-04-22 | Altarex Corp. | Therapeutic compositions that produce an immune response |
US20060159688A1 (en) * | 1996-05-15 | 2006-07-20 | Ragupathy Madiyalakan | Method for diagnosing efficacy of xenotypic antibody therapy |
US7318921B2 (en) * | 1996-05-15 | 2008-01-15 | Altarex Medical Corp. | Therapeutic compositions that alter the immune response |
US8038994B2 (en) * | 1996-05-15 | 2011-10-18 | Quest Pharmatech Inc. | Combination therapy for treating disease |
US5952294A (en) * | 1996-07-31 | 1999-09-14 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Peptidyl prodrugs and methods of making and using the same |
DE69835679T2 (de) * | 1997-08-28 | 2007-08-23 | Biomira, Inc., Edmonton | Zufälligverteilt erzeugte kombinatorische peptidbibliotheken |
AU5382200A (en) * | 1999-06-15 | 2001-01-02 | University Health Network | Muc1 ligands |
US6801270B2 (en) * | 2000-06-26 | 2004-10-05 | Reveo, Inc. | Backlight for a liquid crystal display having high light-recycling efficiency |
CZ20031262A3 (en) * | 2000-10-16 | 2004-03-17 | Neopharm, Inc. | Liposomal formulation of mitoxantrone |
AU2002307064A1 (en) * | 2001-04-02 | 2002-10-15 | Purdue Pharma L.P. | Immunoglobulin construct containing anti-mucin variable domain sequences for eliciting an anti-idiotype anti-tumor response |
US20050069549A1 (en) | 2002-01-14 | 2005-03-31 | William Herman | Targeted ligands |
JP2005522483A (ja) * | 2002-04-11 | 2005-07-28 | アルタレックス メディカル コーポレーション | 結合剤及び腫瘍細胞をターゲティングする際のそれらの使用 |
PL2066351T3 (pl) | 2006-10-02 | 2016-02-29 | Squibb & Sons Llc | Przeciwciała ludzkie wiążące CXCR4 i ich wykorzystanie |
ES2609924T3 (es) | 2006-11-21 | 2017-04-25 | Abbott Laboratories | Anticuerpos monoclonales neutralizantes contra el receptor de Nogo-66 (NGR) y usos de los mismos |
SG177168A1 (en) | 2006-12-01 | 2012-01-30 | Medarex Inc | Human antibodies that bind cd22 and uses thereof |
CL2007003622A1 (es) | 2006-12-13 | 2009-08-07 | Medarex Inc | Anticuerpo monoclonal humano anti-cd19; composicion que lo comprende; y metodo de inhibicion del crecimiento de celulas tumorales. |
NZ578354A (en) | 2006-12-14 | 2012-01-12 | Medarex Inc | Antibody-partner molecule conjugates that bind cd70 and uses thereof |
AR072999A1 (es) | 2008-08-11 | 2010-10-06 | Medarex Inc | Anticuerpos humanos que se unen al gen 3 de activacion linfocitaria (lag-3) y los usos de estos |
WO2012080822A2 (en) * | 2010-12-14 | 2012-06-21 | Recepta Biopharma S.A. | Antitumor peptide derived from a complementarity determining region of a humanized monoclonal antibody to napi2b transporter |
ES2634098T3 (es) | 2011-01-14 | 2017-09-26 | The Regents Of The University Of California | Anticuerpos terapéuticos contra la proteína ROR-1 y procedimientos para el uso de los mismos. |
AR091649A1 (es) | 2012-07-02 | 2015-02-18 | Bristol Myers Squibb Co | Optimizacion de anticuerpos que se fijan al gen de activacion de linfocitos 3 (lag-3) y sus usos |
CN107550864B (zh) * | 2017-08-23 | 2020-12-18 | 科笛生物医药(上海)有限公司 | Eppt多肽-聚乙二醇-磷脂复合膜材料、其制备方法及主动靶向脂质体递药系统和应用 |
SG11202100746WA (en) | 2018-07-25 | 2021-03-30 | Innovent Biologics Suzhou Co Ltd | Anti-tigit antibody and use thereof |
CN109762067B (zh) | 2019-01-17 | 2020-02-28 | 北京天广实生物技术股份有限公司 | 结合人Claudin 18.2的抗体及其用途 |
BR112022017174A2 (pt) | 2020-02-27 | 2022-10-18 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Anticorpo monoclonal isolado, ou uma porção de ligação ao antígeno do mesmo, nucleotídeo, vetor de expressão, célula hospedeira, composição farmacêutica e métodos de tratamento de uma doença alérgica e de um tumor |
BR112022022852A2 (pt) | 2020-05-12 | 2022-12-20 | Chia Tai Tianqing Pharmaceutical Group Co Ltd | Anticorpo st2 isolado ou um fragmento de ligação ao antígeno deste, molécula de ácido nucleico isolada, vetor de expressão, célula hospedeira, fusão polipeptídica ou molécula multiespecífica, vetor viral, composição farmacêutica, métodos para determinar um nível de expressão de st2 em uma amostra de um sujeito e para uso no tratamento ou melhoria de doenças e condições relacionadas mediadas por il33/st2 em um sujeito que necessite |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AR243931A1 (es) * | 1986-01-22 | 1993-09-30 | Pasteur Institut | Antigeno purificado,conjunto de reactivos para la deteccion de anticuerpos anti-hiv-2 en un fluido biologico que comprende dichos antigenos,anticuerpos,hibridomas y procedimientos. |
GB8607679D0 (en) * | 1986-03-27 | 1986-04-30 | Winter G P | Recombinant dna product |
US5077220A (en) * | 1988-08-26 | 1991-12-31 | John Muir Cancer & Aging Institute | Monoclonal antibody specific to a novel glycoprotein antigen on human carcinoma cells |
EP0442926A1 (de) * | 1988-11-10 | 1991-08-28 | Imperial Cancer Research Technology Limited | Polypeptide |
EP0369816A3 (de) * | 1988-11-17 | 1990-09-12 | The University Of Melbourne | Gegen menschliches polymorphes epitheliales Muzin spezifische monoklonale Antikörper |
AU651068B2 (en) * | 1989-07-21 | 1994-07-14 | Washington University | Recombinantly produced human membrane cofactor protein (MCP) |
CA1341094C (en) * | 1989-09-25 | 2000-09-05 | Ronald G. Worton | Diagnosis for malignant hyperthermia |
WO1992010518A1 (en) * | 1990-12-07 | 1992-06-25 | Yale University | Purified slit protein and sequence elements thereof |
GB9108652D0 (en) * | 1991-04-23 | 1991-06-12 | Antisoma Ltd | Immunoreactive compounds |
-
1991
- 1991-04-23 GB GB919108652A patent/GB9108652D0/en active Pending
-
1992
- 1992-04-23 WO PCT/GB1992/000746 patent/WO1992018534A1/en active IP Right Grant
- 1992-04-23 AT AT92908820T patent/ATE159727T1/de not_active IP Right Cessation
- 1992-04-23 US US08/122,546 patent/US5591593A/en not_active Expired - Fee Related
- 1992-04-23 ES ES92908820T patent/ES2111066T3/es not_active Expired - Lifetime
- 1992-04-23 GB GB9319300A patent/GB2270078B/en not_active Expired - Fee Related
- 1992-04-23 EP EP92908820A patent/EP0672063B1/de not_active Expired - Lifetime
- 1992-04-23 JP JP50806192A patent/JP3280966B2/ja not_active Expired - Fee Related
- 1992-04-23 DE DE69222956T patent/DE69222956T2/de not_active Expired - Fee Related
- 1992-04-23 DK DK92908820.1T patent/DK0672063T3/da active
-
1996
- 1996-12-13 US US08/764,938 patent/US5833943A/en not_active Expired - Fee Related
-
1998
- 1998-01-21 GR GR980400152T patent/GR3025982T3/el unknown
- 1998-08-07 US US09/131,053 patent/US6174691B1/en not_active Expired - Fee Related
- 1998-08-07 US US09/131,052 patent/US6107469A/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
JPH06506927A (ja) | 1994-08-04 |
US6174691B1 (en) | 2001-01-16 |
GB2270078A (en) | 1994-03-02 |
GB9319300D0 (en) | 1993-12-22 |
WO1992018534A1 (en) | 1992-10-29 |
DK0672063T3 (da) | 1998-05-18 |
GB2270078B (en) | 1995-07-12 |
GR3025982T3 (en) | 1998-04-30 |
GB9108652D0 (en) | 1991-06-12 |
US5833943A (en) | 1998-11-10 |
US6107469A (en) | 2000-08-22 |
JP3280966B2 (ja) | 2002-05-13 |
EP0672063A1 (de) | 1995-09-20 |
DE69222956D1 (de) | 1997-12-04 |
ES2111066T3 (es) | 1998-03-01 |
EP0672063B1 (de) | 1997-10-29 |
ATE159727T1 (de) | 1997-11-15 |
US5591593A (en) | 1997-01-07 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |