DE69219602D1 - Pyrazolopyrimidin- und pyrimidinylbisphosphonsäureester als entzündungshemmende mittel - Google Patents

Pyrazolopyrimidin- und pyrimidinylbisphosphonsäureester als entzündungshemmende mittel

Info

Publication number
DE69219602D1
DE69219602D1 DE69219602T DE69219602T DE69219602D1 DE 69219602 D1 DE69219602 D1 DE 69219602D1 DE 69219602 T DE69219602 T DE 69219602T DE 69219602 T DE69219602 T DE 69219602T DE 69219602 D1 DE69219602 D1 DE 69219602D1
Authority
DE
Germany
Prior art keywords
agents
pyrimidinylbisphosphonic
flamming
pyrazolopyrimidine
acid esters
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69219602T
Other languages
German (de)
English (en)
Inventor
Richard Nugent
Stephen Schlachter
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Pharmacia and Upjohn Co
Original Assignee
Pharmacia and Upjohn Co
Upjohn Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pharmacia and Upjohn Co, Upjohn Co filed Critical Pharmacia and Upjohn Co
Application granted granted Critical
Publication of DE69219602D1 publication Critical patent/DE69219602D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6561—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing systems of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring or ring system, with or without other non-condensed hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/645—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having two nitrogen atoms as the only ring hetero atoms
    • C07F9/6509—Six-membered rings
    • C07F9/6512—Six-membered rings having the nitrogen atoms in positions 1 and 3

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Rheumatology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
DE69219602T 1991-07-03 1992-07-01 Pyrazolopyrimidin- und pyrimidinylbisphosphonsäureester als entzündungshemmende mittel Expired - Lifetime DE69219602D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US72504791A 1991-07-03 1991-07-03
US72504691A 1991-07-03 1991-07-03
PCT/US1992/005398 WO1993001198A1 (en) 1991-07-03 1992-07-01 Pyrazolopyrimidine and pyrimidinyl bisphosphonic esters as anti-inflammatories

Publications (1)

Publication Number Publication Date
DE69219602D1 true DE69219602D1 (de) 1997-06-12

Family

ID=27111084

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69219602T Expired - Lifetime DE69219602D1 (de) 1991-07-03 1992-07-01 Pyrazolopyrimidin- und pyrimidinylbisphosphonsäureester als entzündungshemmende mittel

Country Status (19)

Country Link
US (1) US5397774A (cg-RX-API-DMAC10.html)
EP (2) EP0521622B1 (cg-RX-API-DMAC10.html)
JP (1) JPH06509100A (cg-RX-API-DMAC10.html)
CN (1) CN1031826C (cg-RX-API-DMAC10.html)
AT (1) ATE152728T1 (cg-RX-API-DMAC10.html)
AU (1) AU653428B2 (cg-RX-API-DMAC10.html)
CA (1) CA2110167A1 (cg-RX-API-DMAC10.html)
CZ (1) CZ19595A3 (cg-RX-API-DMAC10.html)
DE (1) DE69219602D1 (cg-RX-API-DMAC10.html)
FI (1) FI935944A7 (cg-RX-API-DMAC10.html)
HU (2) HUT70758A (cg-RX-API-DMAC10.html)
IE (1) IE922162A1 (cg-RX-API-DMAC10.html)
IL (1) IL102171A (cg-RX-API-DMAC10.html)
MX (1) MX9203945A (cg-RX-API-DMAC10.html)
NO (1) NO940009L (cg-RX-API-DMAC10.html)
RU (1) RU2079506C1 (cg-RX-API-DMAC10.html)
SK (1) SK277986B6 (cg-RX-API-DMAC10.html)
TW (1) TW222638B (cg-RX-API-DMAC10.html)
WO (1) WO1993001198A1 (cg-RX-API-DMAC10.html)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE157097T1 (de) * 1992-08-07 1997-09-15 Upjohn Co Phosphonoessigsäure und ester als antientzündungsmittel
JPH08502287A (ja) * 1992-10-09 1996-03-12 ジ・アップジョン・カンパニー 抗炎症剤としてのピリミジンビスホスホン酸エステルおよび（アルコキシメチルホスフィニル）アルキルホスホン酸
WO1995011235A1 (en) * 1993-10-20 1995-04-27 The Upjohn Company Pyrimidinones as antiarthritic and anti-inflammatories
US5880111A (en) * 1995-06-07 1999-03-09 Farcasiu; Dan Therapeutic derivations of diphosphonates
US7094782B1 (en) 1996-07-24 2006-08-22 Bristol-Myers Squibb Company Azolo triazines and pyrimidines
US6060478A (en) * 1996-07-24 2000-05-09 Dupont Pharmaceuticals Azolo triazines and pyrimidines
US6191131B1 (en) 1997-07-23 2001-02-20 Dupont Pharmaceuticals Company Azolo triazines and pyrimidines
US6124289A (en) * 1996-07-24 2000-09-26 Dupont Pharmaceuticals Co. Azolo triazines and pyrimidines
US6313124B1 (en) 1997-07-23 2001-11-06 Dupont Pharmaceuticals Company Tetrazine bicyclic compounds
IT1303672B1 (it) * 1998-07-28 2001-02-23 Nicox Sa Sali nitrati di farmaci attivi nei disordini ossei
US6579860B1 (en) * 1998-12-25 2003-06-17 Toray Industries, Inc. Interleukin-6 production inhibitors
WO2000059908A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolopyrimidines as crf antagonists
WO2000059907A2 (en) 1999-04-06 2000-10-12 Du Pont Pharmaceuticals Company Pyrazolotriazines as crf antagonists
US6630476B2 (en) 2000-07-07 2003-10-07 Bristol-Myers Squibb Pharma Company Pyrrolo [3,4-d] pyrimidines as corticotropin releasing factor (CRF) antagonists
RU2183610C1 (ru) * 2000-11-15 2002-06-20 Институт молекулярной генетики РАН Высокомеченный тритием n-[3-(3-цианопиразоло[1,5-а]пиримидин-7-ил)фенил]-n-этилацетамид
AU783516B2 (en) 2001-04-30 2005-11-03 Warner-Lambert Company Methods, kits and compositions for using pyrrole derivatives
CA2619365A1 (en) 2005-08-22 2007-03-01 Amgen Inc. Pyrazolopyridine and pyrazolopyrimidine compounds useful as kinase enzymes modulators
EP2270021A1 (en) 2009-06-18 2011-01-05 Centre National de la Recherche Scientifique Phosphonates synthons for the synthesis of phosphonates derivatives showing better bioavailability
CN104114570B (zh) * 2011-10-14 2016-08-31 齐多夫定生产和商业协会封闭式股份公司 作为人免疫缺陷病毒hiv-1产生的选择性抑制剂的氨基甲酰基膦酸酯盐
JP6632532B2 (ja) * 2014-08-29 2020-01-22 国立大学法人 東京大学 オートタキシン阻害活性を有するピリミジノン誘導体
US10183949B2 (en) 2014-08-29 2019-01-22 The University Of Tokyo Pyrimidinone derivative having autotaxin-inhibitory activity

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3683080A (en) * 1970-08-28 1972-08-08 Procter & Gamble Compositions for inhibiting anomalous deposition and mobilization of calcium phosphate in animal tissue
DE2703712A1 (de) * 1977-01-29 1978-08-03 Bayer Ag Substituierte pyrimidinon eckige klammer auf (di)-thio eckige klammer zu -phosphor-(phosphon)-saeureester bzw. -esteramide, verfahren zu ihrer herstellung und ihre verwendung als insektizide, akarizide und nematizide
FR2531088B1 (fr) * 1982-07-29 1987-08-28 Sanofi Sa Produits anti-inflammatoires derives de l'acide methylenediphosphonique et leur procede de preparation
PH27078A (en) * 1984-12-21 1993-02-01 Procter & Gamble Pharmaceutical compositions containing geminal diphosphonates
DE3626058A1 (de) * 1986-08-01 1988-02-11 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4871720A (en) * 1986-11-21 1989-10-03 Ciba-Geigy Corporation Aromatically substituted azacycloalkyl-alkanediphosphonic acids useful for the treatment of illnesses that can be attributed to calcium metabolism disorders
IL84731A0 (en) * 1986-12-19 1988-05-31 Norwich Eaton Pharma Heterocycle-substituted diphosphonic acids and salts and esters and pharmaceutical compositions containing them
US5071840A (en) * 1986-12-19 1991-12-10 Norwich Eaton Pharmaceuticals, Inc. Certain heterocyclic substituted diphosphonate compounds pharmaceutical compositions, and methods of treating abnormal calcium and phosphate metabolism
DE3719513A1 (de) * 1987-06-11 1988-12-22 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4990503A (en) * 1988-08-12 1991-02-05 Yamanouchi Pharmaceutical Co., Ltd. Heterocyclic bisphosphonic acid derivatives
JPH07509241A (ja) * 1992-07-16 1995-10-12 ジ・アップジョン・カンパニー 抗炎症および抗関節炎薬としてのホスホノ誘導体
JPH08502287A (ja) * 1992-10-09 1996-03-12 ジ・アップジョン・カンパニー 抗炎症剤としてのピリミジンビスホスホン酸エステルおよび（アルコキシメチルホスフィニル）アルキルホスホン酸

Also Published As

Publication number Publication date
EP0593575A1 (en) 1994-04-27
EP0593575B1 (en) 1997-05-07
ATE152728T1 (de) 1997-05-15
JPH06509100A (ja) 1994-10-13
MX9203945A (es) 1993-04-01
HU211488A9 (en) 1995-11-28
FI935944A0 (fi) 1993-12-30
AU2240892A (en) 1993-02-11
WO1993001198A1 (en) 1993-01-21
CZ19595A3 (en) 1995-10-18
IE922162A1 (en) 1993-01-13
EP0521622B1 (en) 1997-08-13
IL102171A (en) 1996-11-14
RU2079506C1 (ru) 1997-05-20
CA2110167A1 (en) 1993-01-21
FI935944L (fi) 1993-12-30
SK277986B6 (en) 1995-09-13
IL102171A0 (en) 1993-01-14
TW222638B (cg-RX-API-DMAC10.html) 1994-04-21
NO940009L (no) 1994-01-09
US5397774A (en) 1995-03-14
AU653428B2 (en) 1994-09-29
HUT70758A (en) 1995-10-30
NO940009D0 (no) 1994-01-03
SK150493A3 (en) 1994-11-09
FI935944A7 (fi) 1993-12-30
CN1068332A (zh) 1993-01-27
EP0521622A1 (en) 1993-01-07
HU9400003D0 (en) 1994-05-30
CN1031826C (zh) 1996-05-22

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Legal Events

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8332 No legal effect for de