DE69215925D1 - Verfahren zur Messung von immunoreaktiven Substanzen mit Elektro-Chemilumineszenz - Google Patents
Verfahren zur Messung von immunoreaktiven Substanzen mit Elektro-ChemilumineszenzInfo
- Publication number
- DE69215925D1 DE69215925D1 DE69215925T DE69215925T DE69215925D1 DE 69215925 D1 DE69215925 D1 DE 69215925D1 DE 69215925 T DE69215925 T DE 69215925T DE 69215925 T DE69215925 T DE 69215925T DE 69215925 D1 DE69215925 D1 DE 69215925D1
- Authority
- DE
- Germany
- Prior art keywords
- chemiluminescence
- electro
- measurement
- immunoreactive substances
- immunoreactive
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
- G01N33/54313—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being characterised by its particulate form
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/66—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light electrically excited, e.g. electroluminescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/76—Chemiluminescence; Bioluminescence
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Urology & Nephrology (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP4605491 | 1991-02-19 | ||
JP3206336A JPH0534345A (ja) | 1991-02-19 | 1991-07-23 | 化学発光を利用する抗原・抗体の測定方法 |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69215925D1 true DE69215925D1 (de) | 1997-01-30 |
DE69215925T2 DE69215925T2 (de) | 1997-05-22 |
Family
ID=26386168
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69215925T Expired - Fee Related DE69215925T2 (de) | 1991-02-19 | 1992-02-18 | Verfahren zur Messung von immunoreaktiven Substanzen mit Elektro-Chemilumineszenz |
Country Status (4)
Country | Link |
---|---|
US (1) | US5240863A (de) |
EP (1) | EP0500305B1 (de) |
JP (1) | JPH0534345A (de) |
DE (1) | DE69215925T2 (de) |
Families Citing this family (50)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5779976A (en) * | 1988-11-03 | 1998-07-14 | Igen International, Inc. | Apparatus for improved luminescence assays |
ZA92803B (en) | 1991-02-06 | 1992-11-25 | Igen Inc | Method and apparatus for magnetic microparticulate based luminescene asay including plurality of magnets |
GB9225354D0 (en) * | 1992-12-04 | 1993-01-27 | Univ Manchester | Immunoassay |
US5993740A (en) * | 1995-01-20 | 1999-11-30 | Hitachi, Ltd. | Immunoassay method and analyzer using magnetic particles |
US6207369B1 (en) * | 1995-03-10 | 2001-03-27 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
US6140045A (en) * | 1995-03-10 | 2000-10-31 | Meso Scale Technologies | Multi-array, multi-specific electrochemiluminescence testing |
US6673533B1 (en) | 1995-03-10 | 2004-01-06 | Meso Scale Technologies, Llc. | Multi-array multi-specific electrochemiluminescence testing |
WO1996028538A1 (en) * | 1995-03-10 | 1996-09-19 | Meso Scale Technologies, Llc | Multi-array, multi-specific electrochemiluminescence testing |
AU2003200956B2 (en) * | 1998-05-11 | 2006-01-19 | Bioveris Corporation | Improved Apparatus and Methods for Carrying Out Electrochemiluminescence Test Measurements |
AU2006201608B2 (en) * | 1998-05-11 | 2007-06-07 | Bioveris Corporation | Improved Apparatus and Methods for Carrying Out Electrochemiluminescence Test Measurements |
US6200531B1 (en) * | 1998-05-11 | 2001-03-13 | Igen International, Inc. | Apparatus for carrying out electrochemiluminescence test measurements |
GB0103765D0 (en) * | 2001-02-15 | 2001-04-04 | Affitech As | Assay |
WO2003001889A2 (en) | 2001-06-29 | 2003-01-09 | Meso Scale Technologies, Llc. | Assay plates reader systems and methods for luminescence test measurements |
ATE471369T1 (de) * | 2001-07-30 | 2010-07-15 | Meso Scale Technologies Llc | Assay-elektroden mit schichten aus immobilisiertem lipid/protein sowie verfahren zu deren herstellung und verwendung |
JP4768224B2 (ja) | 2001-09-10 | 2011-09-07 | メソ スケイル テクノロジーズ,エルエルシー | 1つの試料について複数の測定を実施する方法及び装置 |
AU2003249350A1 (en) | 2002-06-20 | 2004-01-06 | Igen International, Inc | Electrochemiluminescence flow cell and flow cell components |
KR100434690B1 (ko) * | 2002-07-19 | 2004-06-04 | 소광섭 | 생명체에 대한 자기장의 영향을 측정하는 장치 및 방법 |
US7000870B2 (en) * | 2002-11-07 | 2006-02-21 | Aerion Corporation | Laminar flow wing for transonic cruise |
US8211279B2 (en) * | 2005-06-03 | 2012-07-03 | Board Of Regents Of The University Of Texas System | Electrochemistry and electrogenerated chemiluminescence with a single faradaic electrode |
US20100261292A1 (en) | 2009-04-10 | 2010-10-14 | Meso Scale Technologies, Llc | Methods for Conducting Assays |
JP5816173B2 (ja) * | 2009-07-27 | 2015-11-18 | メソ スケール テクノロジーズ エルエルシー | 分析装置、消耗品及び方法 |
WO2012051386A2 (en) | 2010-10-14 | 2012-04-19 | Meso Scale Technologies, Llc | Reagent storage in an assay device |
MX336940B (es) | 2010-10-25 | 2016-02-08 | Hoffmann La Roche | Uso de compuestos mejoradores de señal en deteccion de electroquimioluminiscencia. |
ES2884100T3 (es) | 2011-11-11 | 2021-12-10 | Eli N Glezer | Procedimientos de ensayo asistidos por coagente de unión |
EP4345460A3 (de) | 2013-01-04 | 2024-06-26 | Meso Scale Technologies, LLC. | Testvorrichtungen, verfahren und reagenzien |
KR20220147717A (ko) | 2013-03-11 | 2022-11-03 | 메소 스케일 테크놀러지즈, 엘엘시 | 다중화 어세이를 수행하기 위한 개선된 방법 |
US10114015B2 (en) | 2013-03-13 | 2018-10-30 | Meso Scale Technologies, Llc. | Assay methods |
AU2014248759B2 (en) | 2013-03-13 | 2020-02-27 | Meso Scale Technologies, Llc. | Improved assay methods |
WO2014143623A1 (en) | 2013-03-15 | 2014-09-18 | The Lubrizol Corporation | Heavy metal free cpvc compositions |
US10955412B2 (en) | 2014-05-09 | 2021-03-23 | Meso Scale Technologies, Llc. | Graphene-modified electrodes |
WO2015175856A1 (en) | 2014-05-15 | 2015-11-19 | Meso Scale Technologies, Llc. | Improved assay methods |
CN107003305B (zh) | 2014-12-08 | 2021-04-02 | 豪夫迈·罗氏有限公司 | 用于测量维生素d的方法 |
ES2974284T3 (es) | 2016-03-11 | 2024-06-26 | Roche Diagnostics Gmbh | Aminas de cadena ramificada en la detección de electroquimioluminiscencia |
CN106124753B (zh) * | 2016-07-08 | 2018-03-06 | 广州东林生物科技有限公司 | 电化学发光缓冲液及清洗液 |
US11686013B2 (en) | 2018-02-23 | 2023-06-27 | Meso Scale Technologies, Llc. | Methods of screening antigen-binding molecules by normalizing for the concentration of antigen-binding molecule |
US20210389304A1 (en) | 2018-05-17 | 2021-12-16 | Meso Scale Technologies, Llc. | Methods for isolating surface marker displaying agents |
EP3870348A1 (de) | 2018-10-23 | 2021-09-01 | Meso Scale Technologies, LLC | Verfahren zur isolierung von oberflächenmarkerindikatoren |
SG11202106924VA (en) | 2019-01-03 | 2021-07-29 | Meso Scale Technologies Llc | Compositions and methods for carrying out assay measurements |
KR20220010471A (ko) | 2019-03-01 | 2022-01-25 | 메소 스케일 테크놀러지즈, 엘엘시 | 면역검정 방법에서 사용을 위한 전기화학발광성 표지화된 프로브, 이의 사용 방법 및 이를 포함하는 키트 |
BR112021024624A2 (pt) | 2019-06-07 | 2022-01-18 | Hoffmann La Roche | Métodos para selecionar e fornecer um par de ligação de oligonucleotídeos de fita simples, para formar um duplex antiparalelo e para realizar um ensaio, par de ss-oligonucleotídeos complementares separados, duplex antiparalelo, uso de um par de ss-oligonucleotídeos separados, kit para realizar um ensaio e composição líquida |
US20240018571A1 (en) | 2020-05-19 | 2024-01-18 | Meso Scale Technologies, Llc. | Methods, compositions, and kits for nucleic acid detection |
EP4176263A1 (de) | 2020-07-01 | 2023-05-10 | Meso Scale Technologies, LLC | Zusammensetzungen und verfahren für assay-messungen |
CN116507738A (zh) | 2020-09-02 | 2023-07-28 | 中尺度技术有限责任公司 | 用于检测样品中的一种或多种靶分析物的试剂盒及其制造和使用方法 |
EP4208720A2 (de) | 2020-09-04 | 2023-07-12 | Meso Scale Technologies, LLC | Verfahren zur isolierung von markern für die oberfläche des zentralen nervensystems |
JP2023554517A (ja) | 2020-12-22 | 2023-12-27 | エフ. ホフマン-ラ ロシュ アーゲー | 試料中の目的の分析物を検出するための方法 |
US20240159746A1 (en) | 2021-03-01 | 2024-05-16 | Meso Scale Technologies, Llc. | System and method for conducting a multiplexed assay |
US20240210399A1 (en) | 2021-04-26 | 2024-06-27 | Meso Scale Technologies, Llc. | Methods for isolating and analyzing a target analyte encapsulated by a surface marker displaying agent |
US20230279290A1 (en) | 2021-12-30 | 2023-09-07 | Meso Scale Technologies, Llc. | Compositions and methods for assay measurements |
WO2023156510A1 (en) | 2022-02-18 | 2023-08-24 | F. Hoffmann-La Roche Ag | Method for detecting an analyte of interest in a sample |
WO2023212315A2 (en) | 2022-04-29 | 2023-11-02 | Meso Scale Technologies, Llc. | Methods for detecting and isolating extracellular vesicles |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4041146A (en) * | 1975-05-01 | 1977-08-09 | General Electric Company | Method for detection of biological particles |
US4181650A (en) * | 1975-08-25 | 1980-01-01 | Maier Charles L Jr | Procedure for the assay of pharmacologically immunologically and biochemically active compounds in biological fluids |
AU531777B2 (en) * | 1978-04-05 | 1983-09-08 | Syva Co. | Label/solid conjugate immunoassay system |
US4280815A (en) * | 1979-06-18 | 1981-07-28 | Technicon Instruments Corporation | Electrochemiluminescent immunoassay and apparatus therefor |
AU9094982A (en) * | 1982-02-01 | 1983-08-11 | Miles Laboratories Inc. | Photogenic labels to alleviate quenching in immuno assays |
JPH0678985B2 (ja) * | 1987-03-06 | 1994-10-05 | ティーディーケイ株式会社 | 電気化学的光学特性検出用電極および電気化学的光学特性検出方法 |
KR0143993B1 (ko) * | 1988-11-03 | 1998-07-15 | 리차아드 제이 매씨이 | 전기화학 발광성 분석 |
JPH03107746A (ja) * | 1989-09-21 | 1991-05-08 | Tdk Corp | 電気化学発光検出用容器 |
-
1991
- 1991-07-23 JP JP3206336A patent/JPH0534345A/ja active Pending
-
1992
- 1992-02-18 DE DE69215925T patent/DE69215925T2/de not_active Expired - Fee Related
- 1992-02-18 EP EP92301295A patent/EP0500305B1/de not_active Expired - Lifetime
- 1992-02-19 US US07/836,740 patent/US5240863A/en not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
US5240863A (en) | 1993-08-31 |
DE69215925T2 (de) | 1997-05-22 |
EP0500305A3 (en) | 1992-12-02 |
EP0500305A2 (de) | 1992-08-26 |
EP0500305B1 (de) | 1996-12-18 |
JPH0534345A (ja) | 1993-02-09 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8320 | Willingness to grant licences declared (paragraph 23) | ||
8339 | Ceased/non-payment of the annual fee |