DE69215537D1 - t-PA SUBSTITUTIONSVARIANTEN MIT VERBESSERTER FIBRINSPEZIFITÄT - Google Patents
t-PA SUBSTITUTIONSVARIANTEN MIT VERBESSERTER FIBRINSPEZIFITÄTInfo
- Publication number
- DE69215537D1 DE69215537D1 DE69215537T DE69215537T DE69215537D1 DE 69215537 D1 DE69215537 D1 DE 69215537D1 DE 69215537 T DE69215537 T DE 69215537T DE 69215537 T DE69215537 T DE 69215537T DE 69215537 D1 DE69215537 D1 DE 69215537D1
- Authority
- DE
- Germany
- Prior art keywords
- variants
- specificity
- fibrine
- improved
- prepared
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US80812191A | 1991-12-16 | 1991-12-16 | |
PCT/US1992/010902 WO1993012238A1 (en) | 1991-12-16 | 1992-12-14 | t-PA SUBSTITUTION VARIANTS WITH IMPROVED FIBRIN-SPECIFICITY |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69215537D1 true DE69215537D1 (de) | 1997-01-09 |
DE69215537T2 DE69215537T2 (de) | 1997-04-30 |
Family
ID=25197925
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69215537T Expired - Lifetime DE69215537T2 (de) | 1991-12-16 | 1992-12-14 | t-PA SUBSTITUTIONSVARIANTEN MIT VERBESSERTER FIBRINSPEZIFITÄT |
Country Status (8)
Country | Link |
---|---|
EP (1) | EP0618973B1 (de) |
JP (1) | JP3696617B2 (de) |
AT (1) | ATE145669T1 (de) |
AU (1) | AU665979B2 (de) |
CA (1) | CA2124937C (de) |
DE (1) | DE69215537T2 (de) |
NZ (1) | NZ246467A (de) |
WO (1) | WO1993012238A1 (de) |
Families Citing this family (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP3112480B2 (ja) * | 1991-12-16 | 2000-11-27 | ジェネンテク,インコーポレイテッド | 新規な組織プラスミノーゲン活性化因子変異体 |
DE10153601A1 (de) | 2001-11-02 | 2003-05-22 | Paion Gmbh | DSPA zur Behandlung von Schlaganfall |
DE10342518A1 (de) * | 2003-09-12 | 2005-05-12 | Paion Gmbh | Plasminogen-Aktivatoren mit verringerter Lysin-Bindungskapazität |
Family Cites Families (2)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR2581652B1 (fr) * | 1985-04-22 | 1989-12-22 | Genentech Inc | Nouveaux mutants de l'activateur tissulaire du plasminogene humain |
NO882226L (no) * | 1987-05-22 | 1988-11-23 | Zymogenetics Inc | Fibrinolytiske proteiner. |
-
1992
- 1992-12-14 EP EP93901234A patent/EP0618973B1/de not_active Expired - Lifetime
- 1992-12-14 DE DE69215537T patent/DE69215537T2/de not_active Expired - Lifetime
- 1992-12-14 CA CA002124937A patent/CA2124937C/en not_active Expired - Lifetime
- 1992-12-14 NZ NZ246467A patent/NZ246467A/en unknown
- 1992-12-14 JP JP51116893A patent/JP3696617B2/ja not_active Expired - Lifetime
- 1992-12-14 AU AU33242/93A patent/AU665979B2/en not_active Expired
- 1992-12-14 AT AT93901234T patent/ATE145669T1/de active
- 1992-12-14 WO PCT/US1992/010902 patent/WO1993012238A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
NZ246467A (en) | 1995-10-26 |
AU3324293A (en) | 1993-07-19 |
CA2124937A1 (en) | 1993-06-24 |
EP0618973B1 (de) | 1996-11-27 |
CA2124937C (en) | 2001-06-05 |
EP0618973A1 (de) | 1994-10-12 |
WO1993012238A1 (en) | 1993-06-24 |
JPH07501946A (ja) | 1995-03-02 |
AU665979B2 (en) | 1996-01-25 |
JP3696617B2 (ja) | 2005-09-21 |
DE69215537T2 (de) | 1997-04-30 |
ATE145669T1 (de) | 1996-12-15 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
FI120348B (fi) | Menetelmä terapeuttisesti käyttökelpoisen trombiini-inhibiittorin valmistamiseksi | |
Shimokawa et al. | Sequence and Biological Activity of Catrocollastatin-C: A Disintegrin-Like/Cysteine-Rich Two-Domain Protein fromCrotalus atroxVenom | |
NO910811L (no) | Vevsplasminogen-aktivator med zymogeniske- eller fibrinspesifikke egenskaper. | |
US5491129A (en) | Synthetic peptides derived from vitronectin and pharmaceutical compositions comprising them | |
WO2002048180A3 (de) | Peptide und/oder proteine sowie verwendung desselben zur herstellung eines therapeutischen und/oder präventiven arzneimittels | |
AU3744889A (en) | Variants of plasminogen activators and processes for their production | |
DE69215537D1 (de) | t-PA SUBSTITUTIONSVARIANTEN MIT VERBESSERTER FIBRINSPEZIFITÄT | |
Davis III et al. | Human factor. hivin. D of the alternative complement pathway. Physicochemical characteristics and N-terminal amino acid sequence | |
DE69113049D1 (de) | Varianten des gewebeplasminogenaktivators mit vermindertem abbau. | |
DE69105121D1 (de) | Gewebeplasminogenaktivator mit fibrin-spezifischen eigenschaften. | |
Cierniewski et al. | Localization of the cross‐linking site of GPRVVERHK in the γ‐chain of human fibrinogen | |
JP3277227B2 (ja) | 血液凝固阻害ペプチドの製造法 | |
DE69105213T2 (de) | Substitutionsvariante des gewebeplasminogenaktivators. | |
JPH0618782B2 (ja) | 組織プラスミノーゲン活性化因子製剤 | |
JPH05500906A (ja) | 血栓性疾患の治療 | |
RU2049819C1 (ru) | Фибрин-изопептидаза |
Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
R071 | Expiry of right |
Ref document number: 618973 Country of ref document: EP |