DE69208604T2 - Imidazol-Verbindungen, ihre Herstellung und Verwendung als Calcium-Kanal Blocker - Google Patents

Imidazol-Verbindungen, ihre Herstellung und Verwendung als Calcium-Kanal Blocker

Info

Publication number
DE69208604T2
DE69208604T2 DE69208604T DE69208604T DE69208604T2 DE 69208604 T2 DE69208604 T2 DE 69208604T2 DE 69208604 T DE69208604 T DE 69208604T DE 69208604 T DE69208604 T DE 69208604T DE 69208604 T2 DE69208604 T2 DE 69208604T2
Authority
DE
Germany
Prior art keywords
production
calcium channel
channel blockers
imidazole compounds
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE69208604T
Other languages
English (en)
Other versions
DE69208604D1 (de
Inventor
Oskar Axelsson
Mikkel Thaning
Peter Moldt
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
NTG Nordic Transport Group AS
Original Assignee
Neurosearch AS
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Neurosearch AS filed Critical Neurosearch AS
Publication of DE69208604D1 publication Critical patent/DE69208604D1/de
Application granted granted Critical
Publication of DE69208604T2 publication Critical patent/DE69208604T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/24—Benzimidazoles; Hydrogenated benzimidazoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached in position 2
    • C07D235/30—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/12—Drugs for disorders of the metabolism for electrolyte homeostasis
    • A61P3/14—Drugs for disorders of the metabolism for electrolyte homeostasis for calcium homeostasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Pain & Pain Management (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Rheumatology (AREA)
  • Cardiology (AREA)
  • Psychiatry (AREA)
  • Endocrinology (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Urology & Nephrology (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Epoxy Resins (AREA)
  • Developing Agents For Electrophotography (AREA)
  • Dental Preparations (AREA)
  • Optical Fibers, Optical Fiber Cores, And Optical Fiber Bundles (AREA)
  • Lubricants (AREA)
  • Polyesters Or Polycarbonates (AREA)
DE69208604T 1991-12-03 1992-11-20 Imidazol-Verbindungen, ihre Herstellung und Verwendung als Calcium-Kanal Blocker Expired - Lifetime DE69208604T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US80175491A 1991-12-03 1991-12-03

Publications (2)

Publication Number Publication Date
DE69208604D1 DE69208604D1 (de) 1996-04-04
DE69208604T2 true DE69208604T2 (de) 1996-09-05

Family

ID=25181970

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69208604T Expired - Lifetime DE69208604T2 (de) 1991-12-03 1992-11-20 Imidazol-Verbindungen, ihre Herstellung und Verwendung als Calcium-Kanal Blocker

Country Status (15)

Country Link
US (1) US5314903A (de)
EP (1) EP0545845B1 (de)
JP (1) JPH072796A (de)
KR (1) KR100220303B1 (de)
AT (1) ATE134622T1 (de)
AU (1) AU649899B2 (de)
CA (1) CA2084233A1 (de)
DE (1) DE69208604T2 (de)
DK (1) DK0545845T3 (de)
ES (1) ES2084972T3 (de)
FI (1) FI925501A (de)
GR (1) GR3019439T3 (de)
NO (1) NO300832B1 (de)
NZ (1) NZ245287A (de)
ZA (1) ZA929268B (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK154092D0 (da) * 1992-12-23 1992-12-23 Neurosearch As Imidazolforbindelser, deres fremstilling og anvendelse
ATE292120T1 (de) * 1998-07-02 2005-04-15 Neurosearch As Kaliumkanal-blockierende mittel
US6194447B1 (en) 1998-07-02 2001-02-27 Neurosearch A/S Bis (benzimidazole) derivatives serving as potassium blocking agents
AU760250B2 (en) 1998-12-04 2003-05-08 Neurosearch A/S New benzimidazolone-, benzoxazolone-, or benzothiazolone derivatives as ion channel modulating agents
WO2004064835A1 (en) * 2003-01-17 2004-08-05 Neurosearch A/S Use of ion channel modulating agents for treating pain
WO2004093816A2 (en) * 2003-04-22 2004-11-04 Pharmacia Corporation Compositions comprising a selective cox-2 inhibitor and a calcium modulating agent
WO2004093813A2 (en) * 2003-04-22 2004-11-04 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a calcium modulating agent for the treatment of pain, inflammation or inflammation mediated disorders
US7166603B2 (en) 2003-07-23 2007-01-23 Bristol-Myers Squibb Co. Dihydropyrimidone inhibitors of calcium channel function
WO2005007124A2 (en) 2003-07-23 2005-01-27 Bristol-Myers Squibb Company Substituted dihydropyrimidine inhibitors of calcium channel function
DE10342503A1 (de) * 2003-09-12 2005-04-14 Merck Patent Gmbh Benzyl-Benzimidazolylderivate
US7504431B2 (en) 2004-04-16 2009-03-17 Bristol-Myers Squibb Company Sulfonyl amide inhibitors of calcium channel function
EP2308852A1 (de) 2005-08-21 2011-04-13 Abbott GmbH & Co. KG 5-Ring-Heteroaromaten-Verbindungen und ihre Verwendung als Bindungspartner für 5-HT5-Rezeptoren
GB0715103D0 (en) * 2007-08-03 2007-09-12 Lectus Therapeutics Ltd Calcium ion channel modulators and uses thereof
US10501421B1 (en) * 2017-01-27 2019-12-10 Vanderbilt University Substituted benzimidazoles as modulators of Ras signaling

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4004016A (en) * 1975-08-11 1977-01-18 E. R. Squibb & Sons, Inc. Amino-benzimidazole derivatives
NZ232396A (en) * 1989-02-10 1991-07-26 Merrell Dow Pharma 2-(diphenylalkylamino) -1,3 nn heterocyclic compounds and pharmaceutical compositions
DE3928177A1 (de) * 1989-04-08 1991-02-28 Thomae Gmbh Dr K Benzimidazole, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung
US5210091A (en) * 1991-06-24 1993-05-11 Neurosearch A/S Imidazole compounds and their use

Also Published As

Publication number Publication date
DE69208604D1 (de) 1996-04-04
ZA929268B (en) 1993-06-29
NO300832B1 (no) 1997-08-04
AU2965192A (en) 1993-06-10
KR100220303B1 (ko) 1999-09-15
JPH072796A (ja) 1995-01-06
DK0545845T3 (da) 1996-08-05
FI925501A (fi) 1993-06-04
NO924646D0 (no) 1992-12-02
AU649899B2 (en) 1994-06-02
ES2084972T3 (es) 1996-05-16
CA2084233A1 (en) 1993-06-04
NO924646L (no) 1993-06-04
NZ245287A (en) 1995-04-27
ATE134622T1 (de) 1996-03-15
GR3019439T3 (en) 1996-06-30
FI925501A0 (fi) 1992-12-03
EP0545845A1 (de) 1993-06-09
US5314903A (en) 1994-05-24
EP0545845B1 (de) 1996-02-28

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition