DE69133511D1 - Zuckermodifizierte oligonukleotide zum erkennen und steuern der genexpression - Google Patents

Zuckermodifizierte oligonukleotide zum erkennen und steuern der genexpression

Info

Publication number
DE69133511D1
DE69133511D1 DE69133511T DE69133511T DE69133511D1 DE 69133511 D1 DE69133511 D1 DE 69133511D1 DE 69133511 T DE69133511 T DE 69133511T DE 69133511 T DE69133511 T DE 69133511T DE 69133511 D1 DE69133511 D1 DE 69133511D1
Authority
DE
Germany
Prior art keywords
detecting
gene expression
modified oligonucleotides
sugar modified
controlling gene
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE69133511T
Other languages
English (en)
Other versions
DE69133511T2 (de
Inventor
Dan Cook
Mamoto Kawasaki
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Ionis Pharmaceuticals Inc
Original Assignee
Isis Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=24265247&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE69133511(D1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Isis Pharmaceuticals Inc filed Critical Isis Pharmaceuticals Inc
Application granted granted Critical
Publication of DE69133511D1 publication Critical patent/DE69133511D1/de
Publication of DE69133511T2 publication Critical patent/DE69133511T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

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    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • A61P31/12—Antivirals
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    • C12Y113/11012—Linoleate 13S-lipoxygenase (1.13.11.12)
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    • C12N2310/3533—Halogen

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  • Saccharide Compounds (AREA)
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  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE69133511T 1990-08-13 1991-08-12 Zuckermodifizierte oligonukleotide zum erkennen und steuern der genexpression Revoked DE69133511T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US56697790A 1990-08-13 1990-08-13
US566977 1990-08-13
PCT/US1991/005720 WO1992003568A1 (en) 1990-08-13 1991-08-12 Sugar modified oligonucleotides that detect and modulate gene expression

Publications (2)

Publication Number Publication Date
DE69133511D1 true DE69133511D1 (de) 2006-04-27
DE69133511T2 DE69133511T2 (de) 2006-09-28

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ID=24265247

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69133511T Revoked DE69133511T2 (de) 1990-08-13 1991-08-12 Zuckermodifizierte oligonukleotide zum erkennen und steuern der genexpression

Country Status (10)

Country Link
EP (2) EP1443051A3 (de)
JP (2) JPH0813274B2 (de)
AT (1) ATE318273T1 (de)
AU (1) AU661662B2 (de)
BR (1) BR9106826A (de)
CA (1) CA2089376C (de)
DE (1) DE69133511T2 (de)
DK (1) DK0549615T3 (de)
ES (1) ES2259177T3 (de)
WO (1) WO1992003568A1 (de)

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US5872232A (en) * 1990-01-11 1999-02-16 Isis Pharmaceuticals Inc. 2'-O-modified oligonucleotides
US5859221A (en) * 1990-01-11 1999-01-12 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US6399754B1 (en) 1991-12-24 2002-06-04 Isis Pharmaceuticals, Inc. Sugar modified oligonucleotides
US6005087A (en) * 1995-06-06 1999-12-21 Isis Pharmaceuticals, Inc. 2'-modified oligonucleotides
US6759392B1 (en) 1990-06-11 2004-07-06 Gilead Sciences, Inc. High affinity RNA ligands of basic fibroblast growth factor
US6177557B1 (en) 1990-06-11 2001-01-23 Nexstar Pharmaceuticals, Inc. High affinity ligands of basic fibroblast growth factor and thrombin
US5686592A (en) * 1990-06-11 1997-11-11 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to immunoglobulin E (IgE)
US5580737A (en) * 1990-06-11 1996-12-03 Nexstar Pharmaceuticals, Inc. High-affinity nucleic acid ligands that discriminate between theophylline and caffeine
US5587468A (en) * 1990-06-11 1996-12-24 University Research Corporation High affinity nucleic acid ligands to HIV integrase
US5476766A (en) * 1990-06-11 1995-12-19 Nexstar Pharmaceuticals, Inc. Ligands of thrombin
US5459015A (en) * 1990-06-11 1995-10-17 Nexstar Pharmaceuticals, Inc. High-affinity RNA ligands of basic fibroblast growth factor
US5637682A (en) * 1990-06-11 1997-06-10 Nexstar Pharmaceuticals, Inc. High-affinity oligonucleotide ligands to the tachykinin substance P
US5648214A (en) * 1990-06-11 1997-07-15 University Research Corporation High-affinity oligonucleotide ligands to the tachykinin substance P
US5783682A (en) 1990-07-27 1998-07-21 Isis Pharmaceuticals, Inc. Oligonucleotide mimics having nitrogen-containing linkages
US5677437A (en) * 1990-07-27 1997-10-14 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
US5792844A (en) * 1990-07-27 1998-08-11 Isis Pharmaceuticals, Inc. Oligonucleoside linkages containing adjacent nitrogen atoms
US6087482A (en) * 1990-07-27 2000-07-11 Isis Pharmaceuticals, Inc. Heteroatomic oligonucleoside linkages
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CA2089376A1 (en) 1992-02-14
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AU8440391A (en) 1992-03-17
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