DE69126469D1 - Pyrimidin-Nukleosid-Derivate und antivirale Mittel, die diese Derivate als aktiven Bestandteil enthalten - Google Patents

Pyrimidin-Nukleosid-Derivate und antivirale Mittel, die diese Derivate als aktiven Bestandteil enthalten

Info

Publication number
DE69126469D1
DE69126469D1 DE69126469T DE69126469T DE69126469D1 DE 69126469 D1 DE69126469 D1 DE 69126469D1 DE 69126469 T DE69126469 T DE 69126469T DE 69126469 T DE69126469 T DE 69126469T DE 69126469 D1 DE69126469 D1 DE 69126469D1
Authority
DE
Germany
Prior art keywords
derivatives
active ingredient
antiviral agents
agents containing
pyrimidine nucleoside
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69126469T
Other languages
English (en)
Other versions
DE69126469T2 (de
Inventor
Tadashi Miyasaka
Hiromichi Tanaka
Clercq Erik Desire Alice De
Masanori Baba
Richard Thomas Walker
Masaru Ubasawa
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Mitsubishi Chemical Corp
Original Assignee
Mitsubishi Chemical Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from JP2200897A external-priority patent/JPH075465B2/ja
Application filed by Mitsubishi Chemical Corp filed Critical Mitsubishi Chemical Corp
Publication of DE69126469D1 publication Critical patent/DE69126469D1/de
Application granted granted Critical
Publication of DE69126469T2 publication Critical patent/DE69126469T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/52—Two oxygen atoms
    • C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/56—One oxygen atom and one sulfur atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/58—Two sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DE69126469T 1990-03-29 1991-03-26 Pyrimidin-Nukleosid-Derivate und antivirale Mittel, die diese Derivate als aktiven Bestandteil enthalten Expired - Fee Related DE69126469T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP8184390 1990-03-29
JP2200897A JPH075465B2 (ja) 1990-03-29 1990-07-27 抗ウイルス剤
JP2200896A JPH075570B2 (ja) 1990-03-29 1990-07-27 ピリミジンヌクレオシド誘導体及び該誘導体を有効成分とする抗ウイルス剤

Publications (2)

Publication Number Publication Date
DE69126469D1 true DE69126469D1 (de) 1997-07-17
DE69126469T2 DE69126469T2 (de) 1998-01-29

Family

ID=27303717

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69126469T Expired - Fee Related DE69126469T2 (de) 1990-03-29 1991-03-26 Pyrimidin-Nukleosid-Derivate und antivirale Mittel, die diese Derivate als aktiven Bestandteil enthalten

Country Status (4)

Country Link
US (1) US5318972A (de)
EP (1) EP0449726B1 (de)
CA (1) CA2039039C (de)
DE (1) DE69126469T2 (de)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9214720D0 (en) * 1992-07-10 1992-08-19 Wellcome Found Enzyme inhibitors
EP0631783A1 (de) * 1993-06-03 1995-01-04 Mitsubishi Chemical Corporation Antivirale Kombinationen von 2',3-Di-deoxyribonukleosiden mit 6-benzyl-1-ethoxy-methyl-5-substituierten Uracil-Derivaten
US5476855A (en) * 1993-11-02 1995-12-19 Mahmoud H. el Kouni Enzyme inhibitors, their synthesis and methods for use
KR0151811B1 (ko) * 1993-12-21 1998-10-15 강박광 신규한 항바이러스성 2,4-피리미딘디온 유도체 및 그의 제조방법
BR9408370A (pt) * 1994-02-28 1997-08-26 Sunkyong Ind Ltd Derivados aciclonucleosídeo de pirimidina
US5744475A (en) * 1995-03-29 1998-04-28 Taiho Pharmaceutical Co., Ltd. Uracil derivatives, and antitumor effect potentiator and antitumor agent containing the same
AU710490B2 (en) * 1996-02-22 1999-09-23 Samjin Pharmaceutical Co., Ltd. New antiviral substituted pyrimidinedione homocarbocyclic nucleoside derivatives and methods for the preparation thereof and compositions containing the same as active ingredients
US20040181078A1 (en) * 1997-10-10 2004-09-16 Pharmasset, Ltd. Tetraphosphonate bicyclic trisanhydrides
US5998411A (en) * 1998-03-17 1999-12-07 Hughes Institute Heterocyclic nonnucleoside inhibitors of reverse transcriptase
FR2779721A1 (fr) * 1998-06-15 1999-12-17 Expansia Sa Substitution d'une 1,5-dialkyl uracile en position 6
JP2002538144A (ja) * 1999-03-04 2002-11-12 コリア・リサーチ・インスティテュート・オブ・ケミカル・テクノロジー 抗ウイルス性２，４−ピリミジンジオン誘導体およびその製造方法
WO2009005693A1 (en) * 2007-06-29 2009-01-08 Gilead Sciences, Inc. Novel hiv reverse transcriptase inhibitors
ES2533863T3 (es) * 2007-06-29 2015-04-15 Korea Research Institute Of Chemical Technology Inhibidores novedosos de la transcriptasa inversa de VIH
WO2009085797A1 (en) * 2007-12-21 2009-07-09 Gilead Sciences, Inc. Processes for preparing hiv reverse transcriptase inhibitors

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4868187A (en) * 1980-09-16 1989-09-19 Syntex (U.S.A.) Inc. Anti-viral N-substituted pyrimidines
JPS5839672A (ja) * 1981-09-03 1983-03-08 Chugai Pharmaceut Co Ltd ウラシル誘導体
DD232492A1 (de) * 1984-12-08 1986-01-29 Akad Wissenschaften Ddr Verfahren zur herstellung von nucleosidanalogen 6-amino-substituierten thymin-derivaten
US4613604A (en) * 1985-07-31 1986-09-23 Brown University Research Foundation Hydroxymethyl derivatives of 5-benzylacyclouridine and 5-benzoyloxybenzylacyclouridine and their use as potentiators for 5-fluoro-2'-deoxyuridine
WO1989009213A1 (en) * 1988-03-31 1989-10-05 Mitsubishi Kasei Corporation 6-substituted acyclicpyrimidine nucleoside derivatives and antiviral agents containing same as active ingredients
JPH02104586A (ja) * 1988-06-21 1990-04-17 Moses Nam Fong Lee ピリミジン誘導体及びその使用
ATE123285T1 (de) * 1988-12-19 1995-06-15 Wellcome Found Antivirale pyrimidin- und purinverbindungen, verfahren zu ihrer herstellung und sie enthaltende pharmazeutische präparate.

Also Published As

Publication number Publication date
EP0449726B1 (de) 1997-06-11
DE69126469T2 (de) 1998-01-29
CA2039039C (en) 2001-05-15
US5318972A (en) 1994-06-07
CA2039039A1 (en) 1991-09-30
EP0449726A1 (de) 1991-10-02

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee