DE69117942T2 - Verfahren und vorrichtung zur optischen messung der konzentration eines analyten - Google Patents
Verfahren und vorrichtung zur optischen messung der konzentration eines analytenInfo
- Publication number
- DE69117942T2 DE69117942T2 DE69117942T DE69117942T DE69117942T2 DE 69117942 T2 DE69117942 T2 DE 69117942T2 DE 69117942 T DE69117942 T DE 69117942T DE 69117942 T DE69117942 T DE 69117942T DE 69117942 T2 DE69117942 T2 DE 69117942T2
- Authority
- DE
- Germany
- Prior art keywords
- analyt
- concentration
- optically measuring
- optically
- measuring
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000012491 analyte Substances 0.000 title 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
- G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
- G01N21/64—Fluorescence; Phosphorescence
- G01N21/645—Specially adapted constructive features of fluorimeters
- G01N21/648—Specially adapted constructive features of fluorimeters using evanescent coupling or surface plasmon coupling for the excitation of fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/1717—Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/1717—Systems in which incident light is modified in accordance with the properties of the material investigated with a modulation of one or more physical properties of the sample during the optical investigation, e.g. electro-reflectance
- G01N2021/1725—Modulation of properties by light, e.g. photoreflectance
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N2021/7706—Reagent provision
- G01N2021/772—Tip coated light guide
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N21/7703—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator using reagent-clad optical fibres or optical waveguides
- G01N2021/7706—Reagent provision
- G01N2021/773—Porous polymer jacket; Polymer matrix with indicator
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
- G01N21/77—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated by observing the effect on a chemical indicator
- G01N2021/7769—Measurement method of reaction-produced change in sensor
- G01N2021/7786—Fluorescence
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2201/00—Features of devices classified in G01N21/00
- G01N2201/12—Circuits of general importance; Signal processing
- G01N2201/122—Kinetic analysis; determining reaction rate
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Physics & Mathematics (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Plasma & Fusion (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Investigating Or Analysing Materials By The Use Of Chemical Reactions (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US07/643,403 US5212099A (en) | 1991-01-18 | 1991-01-18 | Method and apparatus for optically measuring concentration of an analyte |
PCT/US1991/009510 WO1992013266A1 (en) | 1991-01-18 | 1991-12-18 | Method and apparatus for optically measuring concentration of an analyte |
Publications (2)
Publication Number | Publication Date |
---|---|
DE69117942D1 DE69117942D1 (de) | 1996-04-18 |
DE69117942T2 true DE69117942T2 (de) | 1996-08-08 |
Family
ID=24580669
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69117942T Expired - Fee Related DE69117942T2 (de) | 1991-01-18 | 1991-12-18 | Verfahren und vorrichtung zur optischen messung der konzentration eines analyten |
Country Status (5)
Country | Link |
---|---|
US (1) | US5212099A (de) |
EP (1) | EP0521128B1 (de) |
JP (1) | JPH05505679A (de) |
DE (1) | DE69117942T2 (de) |
WO (1) | WO1992013266A1 (de) |
Families Citing this family (47)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5456252A (en) * | 1993-09-30 | 1995-10-10 | Cedars-Sinai Medical Center | Induced fluorescence spectroscopy blood perfusion and pH monitor and method |
US5577137A (en) * | 1995-02-22 | 1996-11-19 | American Research Corporation Of Virginia | Optical chemical sensor and method using same employing a multiplicity of fluorophores contained in the free volume of a polymeric optical waveguide or in pores of a ceramic waveguide |
US5814565A (en) * | 1995-02-23 | 1998-09-29 | University Of Utah Research Foundation | Integrated optic waveguide immunosensor |
US5591407A (en) * | 1995-04-21 | 1997-01-07 | American Research Corporation Of Virginia | Laser diode sensor |
US5567622A (en) * | 1995-07-05 | 1996-10-22 | The Aerospace Corporation | Sensor for detection of nitrogen dioxide and nitrogen tetroxide |
US6232609B1 (en) | 1995-12-01 | 2001-05-15 | Cedars-Sinai Medical Center | Glucose monitoring apparatus and method using laser-induced emission spectroscopy |
AT404514B (de) * | 1996-11-06 | 1998-12-28 | Robert Dr Kellner | Vorrichtung und verfahren zur messung der konzentration von stoffen in flüssigkeiten |
JP3308173B2 (ja) * | 1996-11-07 | 2002-07-29 | 松下電器産業株式会社 | 尿検査方法およびそれに用いる尿検査装置 |
US6328932B1 (en) * | 1997-05-08 | 2001-12-11 | Eltron Research, Inc. | Devices and methods for the detection of basic gases |
US6222619B1 (en) | 1997-09-18 | 2001-04-24 | University Of Utah Research Foundation | Diagnostic device and method |
US6055451A (en) * | 1997-12-12 | 2000-04-25 | Spectrx, Inc. | Apparatus and method for determining tissue characteristics |
US20030135122A1 (en) * | 1997-12-12 | 2003-07-17 | Spectrx, Inc. | Multi-modal optical tissue diagnostic system |
WO2000015101A1 (en) * | 1998-09-11 | 2000-03-23 | Spectrx, Inc. | Multi-modal optical tissue diagnostic system |
JP2002502028A (ja) | 1998-02-02 | 2002-01-22 | シグネチャー バイオサイエンス,インコーポレイティド | 分子結合現象を検出するための方法及び装置 |
US6395480B1 (en) | 1999-02-01 | 2002-05-28 | Signature Bioscience, Inc. | Computer program and database structure for detecting molecular binding events |
US6338968B1 (en) | 1998-02-02 | 2002-01-15 | Signature Bioscience, Inc. | Method and apparatus for detecting molecular binding events |
US6277651B1 (en) | 1998-07-09 | 2001-08-21 | Calspan Srl Corporation | Diode laser electrochemical sensor for detecting chemical and biological analytes |
US20040147843A1 (en) * | 1999-11-05 | 2004-07-29 | Shabbir Bambot | System and method for determining tissue characteristics |
AT408376B (de) * | 1999-04-07 | 2001-11-26 | Lendl Bernhard Dr | Verfahren zur infrarot-optischen bestimmung der konzentration zumindest eines analyten in einer flüssigen probe |
WO2001009605A1 (en) * | 1999-07-30 | 2001-02-08 | Lakowicz Joseph R | Background suppression in fluorometry |
DE60032853T2 (de) | 1999-10-28 | 2007-11-15 | Matsushita Electric Industrial Co., Ltd., Kadoma | Verfahren zur Messung der Konzentration einer Lösung |
JP2001174457A (ja) | 1999-12-21 | 2001-06-29 | Matsushita Electric Ind Co Ltd | 溶液濃度計測方法、溶液濃度計測装置及び尿検査方法。 |
US7690840B2 (en) * | 1999-12-22 | 2010-04-06 | Siemens Energy, Inc. | Method and apparatus for measuring on-line failure of turbine thermal barrier coatings |
JP2001249134A (ja) * | 1999-12-28 | 2001-09-14 | Matsushita Electric Ind Co Ltd | タンパク質濃度計測用試薬、これを用いたタンパク質濃度計測方法および尿検査方法 |
US6387672B1 (en) | 2000-12-04 | 2002-05-14 | Beckman Coulter, Inc. | Photo-induced electron transfer fluorescent sensor molecules |
EP1251346B1 (de) * | 2001-04-17 | 2008-10-15 | Dynasol Elastomeros, S.A. | Sensor zur Bestimmung von metallorganischen Verbindungen |
DE10139914A1 (de) * | 2001-08-14 | 2003-03-13 | Michael Schroeder | Verfahren und Vorrichtung zur simultanen Bestimmung der Konzentration mehrerer Komponenten in einem flüssigen oder gasförmigen Mehrkomponentensystem |
US20030068827A1 (en) * | 2001-10-05 | 2003-04-10 | Ocean Optics, Inc. | Enhanced scattering membranes for improved sensitivity and signal-to-noise of optical chemical sensors, fiber optic oxygen sensor for real time respiration monitoring utilizing same, and method of using sensor |
US7042570B2 (en) * | 2002-01-25 | 2006-05-09 | The Regents Of The University Of California | Porous thin film time-varying reflectivity analysis of samples |
US20040222893A1 (en) * | 2002-03-28 | 2004-11-11 | Nahar Singh | Method for temperature measurement using intensity modulated fiber optic temperature switching immersion probe |
US7416899B2 (en) * | 2002-07-29 | 2008-08-26 | Tohoku Techno Arch Co., Ltd. | Method and apparatus for measuring trace ingredients in water |
US7027924B2 (en) * | 2002-10-31 | 2006-04-11 | Itt Manufacturing Enterprises, Inc | Detecting natural gas pipeline failures |
US7057398B2 (en) * | 2003-02-11 | 2006-06-06 | Zhangwu Zhu | Microwave spectrometer |
US7358094B2 (en) * | 2003-05-01 | 2008-04-15 | Bell Michael L | Sensor system for saccharides |
US20040263852A1 (en) * | 2003-06-03 | 2004-12-30 | Lasen, Inc. | Aerial leak detector |
US20040252748A1 (en) * | 2003-06-13 | 2004-12-16 | Gleitman Daniel D. | Fiber optic sensing systems and methods |
JP2005239042A (ja) * | 2004-02-27 | 2005-09-08 | Nippon Seiki Co Ltd | 車両用情報表示装置及び車両用情報表示方法 |
DE102004017956B4 (de) * | 2004-04-14 | 2022-07-07 | Leica Microsystems Cms Gmbh | Verfahren zur Untersuchung der Lebensdauer angeregter Zustände in einer Probe |
US7695970B2 (en) * | 2005-03-04 | 2010-04-13 | University Of Connecticut | Optical fiber based fluorescence sensor for in-situ measurement and control of fuel cells |
JP4846467B2 (ja) * | 2006-06-30 | 2011-12-28 | 株式会社東芝 | 発色反応検出機器及びその製造方法 |
US9052289B2 (en) * | 2010-12-13 | 2015-06-09 | Schlumberger Technology Corporation | Hydrogen sulfide (H2S) detection using functionalized nanoparticles |
EP2828654B1 (de) * | 2012-03-23 | 2017-12-06 | Ecole Polytechnique Fédérale de Lausanne (EPFL) | Verfahren und Vorrichtung zum Nachweis von Feuchtigkeit mit reversibler molekularer Dimerisierung und Verfahren zur Herstellung der Vorrichtung. |
US10101278B2 (en) * | 2013-05-09 | 2018-10-16 | University Of Central Florida Research Foundation, Inc. | Portable spectrometer for the presumptive identification of illicit drugs and substances of abuse |
US11199498B2 (en) | 2013-05-09 | 2021-12-14 | University Of Central Florida Research Foundation, Inc. | Portable spectrometer for the presumptive identification of substances |
US9625385B2 (en) * | 2015-02-24 | 2017-04-18 | Tokitae Llc | Photothermal spectroscopy systems for offset synchronous testing of flow assays and methods of using same |
US20210404951A1 (en) * | 2019-08-01 | 2021-12-30 | Viavi Solutions Inc. | Sensor device |
CN114755202B (zh) * | 2022-06-15 | 2022-09-02 | 中国空气动力研究与发展中心设备设计与测试技术研究所 | 一种基于聚酰亚胺的光纤分布式湿度传感器及定位检测的方法 |
Family Cites Families (35)
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US2460071A (en) * | 1945-02-07 | 1949-01-25 | Davison Chemical Corp | Cobalt chloride relative humidity indicators |
US2526938A (en) * | 1946-09-11 | 1950-10-24 | Davison Chemical Corp | Moisture indicator |
US2505079A (en) * | 1948-09-03 | 1950-04-25 | Int Minerals & Chem Corp | Manufacture of gel compositions |
US2580737A (en) * | 1949-01-19 | 1952-01-01 | Davison Chemical Corp | Cobalt chloride humidity indicator |
US3528278A (en) * | 1967-09-05 | 1970-09-15 | Technology Inc | Method and apparatus for determining the presence of vapor in a gas |
US4166891A (en) * | 1972-04-19 | 1979-09-04 | Elliott Stanley B | Visual-type hygrometer |
US3881992A (en) * | 1973-07-02 | 1975-05-06 | Wilson Ralston | Optical rate measurement method |
US3926052A (en) * | 1974-05-06 | 1975-12-16 | Johnson Service Co | Relative humidity computer |
DE2632710C3 (de) * | 1976-07-21 | 1979-11-08 | Max-Planck-Gesellschaft Zur Foerderung Der Wissenschaften E.V., 3400 Goettingen | Anordnung zur optischen Messung von Stoffkonzentrationen |
US4200110A (en) * | 1977-11-28 | 1980-04-29 | United States Of America | Fiber optic pH probe |
DE2814843C2 (de) * | 1978-04-06 | 1980-05-29 | Draegerwerk Ag, 2400 Luebeck | Gasmeß- und Warnvorrichtung |
US4179397A (en) * | 1978-05-22 | 1979-12-18 | American Can Company | Indicator ink |
SE424022B (sv) * | 1980-10-21 | 1982-06-21 | Asea Ab | Fiberoptiskt metdon for spektralanalys |
JPS5782753A (en) * | 1980-11-10 | 1982-05-24 | Hitachi Ltd | Method and device for analysis with automatic setting of reaction limit |
DE3170955D1 (en) * | 1980-12-17 | 1985-07-18 | Ici Plc | Apparatus for gathering data from a plurality of condition responsive optical sensors |
GB2103786A (en) * | 1981-08-14 | 1983-02-23 | Ici Plc | Fibre optic sensor |
US4608344A (en) * | 1981-09-18 | 1986-08-26 | Battelle Memorial Institute | Method for the determination of species in solution with an optical wave-guide |
ATE29073T1 (de) * | 1981-09-18 | 1987-09-15 | Battelle Memorial Institute | Verfahren und vorrichtung zur bestimmung von geloesten stoffen mit hilfe eines optischen wellenleiters. |
US4523092A (en) * | 1982-07-29 | 1985-06-11 | Aetna Telecommunications Laboratories | Fiber optic sensors for simultaneously detecting different parameters in a single sensing tip |
US4513087A (en) * | 1983-01-31 | 1985-04-23 | The United States Of America As Represented By The Secretary Of The Navy | Reversible optical waveguide vapor sensor |
US4749856A (en) * | 1983-12-07 | 1988-06-07 | Monsanto Company | Wavelength-independent polymer/optical sensing apparatus and method |
US4637729A (en) * | 1983-12-14 | 1987-01-20 | Carrier Corporation | Fiber optic moisture analysis probe |
EP0184600B1 (de) * | 1984-12-10 | 1990-03-14 | Prutec Limited | Verfahren zum optischen Nachweis von Parametern von Substanzen in einem flüssigen Analyt |
AU589619B2 (en) * | 1985-03-20 | 1989-10-19 | Monash University | Fibre optic chemical sensor |
US4681855A (en) * | 1985-08-05 | 1987-07-21 | The United States Of America As Represented By The Secretary Of Commerce | Humidity sensing and measurement employing halogenated organic polymer membranes |
US4682895A (en) * | 1985-08-06 | 1987-07-28 | Texas A&M University | Fiber optic probe for quantification of colorimetric reactions |
US4641524A (en) * | 1985-08-15 | 1987-02-10 | Kms Fusion, Inc. | Optical humidity sensor |
US4703175A (en) * | 1985-08-19 | 1987-10-27 | Tacan Corporation | Fiber-optic sensor with two different wavelengths of light traveling together through the sensor head |
US4764671A (en) * | 1986-10-03 | 1988-08-16 | Kollmorgen Corporation | Fiber optic fluid sensor using coated sensor tip |
IT1196798B (it) * | 1986-11-24 | 1988-11-25 | Cselt Centro Studi Lab Telecom | Sensore distribuito di temperatura utilizzante una fibra ottica come elemento sensibile |
US4834497A (en) * | 1987-02-27 | 1989-05-30 | The United States Of American As Represented By The United States Department Of Energy | Fiber optic fluid detector |
US4846548A (en) * | 1987-05-06 | 1989-07-11 | St&E, Inc. | Fiber optic which is an inherent chemical sensor |
US4834496A (en) * | 1987-05-22 | 1989-05-30 | American Telephone And Telegraph Company, At&T Bell Laboratories | Optical fiber sensors for chemical detection |
US4841778A (en) * | 1988-01-21 | 1989-06-27 | The United States Of America As Represented By The Department Of Energy | Optical fiber sensor technique for strain measurement |
US4894532A (en) * | 1988-03-28 | 1990-01-16 | Westinghouse Electric Corp. | Optical fiber sensor with light absorbing moisture-sensitive coating |
-
1991
- 1991-01-18 US US07/643,403 patent/US5212099A/en not_active Expired - Lifetime
- 1991-12-18 EP EP92903877A patent/EP0521128B1/de not_active Expired - Lifetime
- 1991-12-18 DE DE69117942T patent/DE69117942T2/de not_active Expired - Fee Related
- 1991-12-18 JP JP92504342A patent/JPH05505679A/ja active Pending
- 1991-12-18 WO PCT/US1991/009510 patent/WO1992013266A1/en active IP Right Grant
Also Published As
Publication number | Publication date |
---|---|
US5212099A (en) | 1993-05-18 |
EP0521128A1 (de) | 1993-01-07 |
JPH05505679A (ja) | 1993-08-19 |
DE69117942D1 (de) | 1996-04-18 |
EP0521128B1 (de) | 1996-03-13 |
WO1992013266A1 (en) | 1992-08-06 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8364 | No opposition during term of opposition | ||
8339 | Ceased/non-payment of the annual fee |