DE69033676T2 - Zusammensetzungen, die von pflanzen produzierte glykopolypeptidmultimere enthalten, sowie verfahren zu deren herstellung - Google Patents
Zusammensetzungen, die von pflanzen produzierte glykopolypeptidmultimere enthalten, sowie verfahren zu deren herstellungInfo
- Publication number
- DE69033676T2 DE69033676T2 DE69033676T DE69033676T DE69033676T2 DE 69033676 T2 DE69033676 T2 DE 69033676T2 DE 69033676 T DE69033676 T DE 69033676T DE 69033676 T DE69033676 T DE 69033676T DE 69033676 T2 DE69033676 T2 DE 69033676T2
- Authority
- DE
- Germany
- Prior art keywords
- plants
- production
- compositions containing
- glycopolypeptide multimers
- multimers produced
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
- C07K16/1203—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria
- C07K16/1228—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-negative bacteria from Enterobacteriaceae (F), e.g. Citrobacter, Serratia, Proteus, Providencia, Morganella, Yersinia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/82—Vectors or expression systems specially adapted for eukaryotic hosts for plant cells, e.g. plant artificial chromosomes (PACs)
- C12N15/8241—Phenotypically and genetically modified plants via recombinant DNA technology
- C12N15/8242—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits
- C12N15/8257—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon
- C12N15/8258—Phenotypically and genetically modified plants via recombinant DNA technology with non-agronomic quality (output) traits, e.g. for industrial processing; Value added, non-agronomic traits for the production of primary gene products, e.g. pharmaceutical products, interferon for the production of oral vaccines (antigens) or immunoglobulins
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0002—Antibodies with enzymatic activity, e.g. abzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
- C12N9/18—Carboxylic ester hydrolases (3.1.1)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/10—Immunoglobulins specific features characterized by their source of isolation or production
- C07K2317/13—Immunoglobulins specific features characterized by their source of isolation or production isolated from plants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
- C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S424/00—Drug, bio-affecting and body treating compositions
- Y10S424/804—Drug, bio-affecting and body treating compositions involving IgG3, IgG4, IgA, or IgY
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
- Y10S530/861—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof involving IgG3, IgG4, IgA, or IgY
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Biophysics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Cell Biology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Breeding Of Plants And Reproduction By Means Of Culturing (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Plant Substances (AREA)
- Polysaccharides And Polysaccharide Derivatives (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US42776589A | 1989-10-27 | 1989-10-27 | |
US591823 | 1990-10-02 | ||
US07/591,823 US5202422A (en) | 1989-10-27 | 1990-10-02 | Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins and method of their use |
PCT/US1990/006179 WO1991006320A1 (en) | 1989-10-27 | 1990-10-25 | Compositions containing plant-produced glycopolypeptide multimers, multimeric proteins, and their use |
US427765 | 1999-10-28 |
Publications (3)
Publication Number | Publication Date |
---|---|
DE69033676D1 DE69033676D1 (de) | 2001-02-01 |
DE69033676T2 true DE69033676T2 (de) | 2001-08-09 |
DE69033676T3 DE69033676T3 (de) | 2009-08-13 |
Family
ID=27027505
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69033676T Expired - Fee Related DE69033676T3 (de) | 1989-10-27 | 1990-10-25 | Verfahren und transgene Pflanzen für die Herstellung von in Pflanzen produzierten Glykopolypeptid-Multimeren |
DE69034259T Expired - Fee Related DE69034259D1 (de) | 1989-10-27 | 1990-10-25 | Verfahren um Pflanzen herzustellen, die Glykopolypeptidmultimere, z.B. Immunoglobuline, enthalten |
Family Applications After (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE69034259T Expired - Fee Related DE69034259D1 (de) | 1989-10-27 | 1990-10-25 | Verfahren um Pflanzen herzustellen, die Glykopolypeptidmultimere, z.B. Immunoglobuline, enthalten |
Country Status (7)
Country | Link |
---|---|
US (2) | US5202422A (de) |
EP (2) | EP0497904B2 (de) |
JP (3) | JP3238700B2 (de) |
AU (1) | AU6753290A (de) |
CA (1) | CA2071502A1 (de) |
DE (2) | DE69033676T3 (de) |
WO (1) | WO1991006320A1 (de) |
Families Citing this family (88)
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---|---|---|---|---|
US5959177A (en) * | 1989-10-27 | 1999-09-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
US7005560B1 (en) * | 1989-10-27 | 2006-02-28 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
US6995014B1 (en) * | 1989-10-27 | 2006-02-07 | The Scripps Research Institute | Transgenic plants expressing assembled secretory antibodies |
US5665595A (en) * | 1991-06-07 | 1997-09-09 | Dowelanco | Immunoglobulins against insect tissue |
IT1248361B (it) * | 1991-06-28 | 1995-01-05 | Enea | Vettori plasmidici per l'espressione di geni in piante |
GB9319429D0 (en) | 1993-09-21 | 1993-11-03 | London Health Ass | Methods and products for controlling immune responses in mammals |
US5693506A (en) * | 1993-11-16 | 1997-12-02 | The Regents Of The University Of California | Process for protein production in plants |
IT1264083B1 (it) * | 1993-12-10 | 1996-09-10 | Enea Ente Nuove Tec | Procedimento per la produzione in piante di anticorpi ingegnerizzati, anticorpi prodotti e loro uso in diagnosi e terapia. |
US6140466A (en) | 1994-01-18 | 2000-10-31 | The Scripps Research Institute | Zinc finger protein derivatives and methods therefor |
TW414713B (en) * | 1994-05-12 | 2000-12-11 | Dentsply Gmbh | Fluoride releasing liquid dental primer product and method |
US5686600A (en) * | 1994-06-28 | 1997-11-11 | Novartis Finance Corporation | Antibodies which bind to insect gut proteins and their use |
US6080560A (en) * | 1994-07-25 | 2000-06-27 | Monsanto Company | Method for producing antibodies in plant cells |
US6140075A (en) * | 1994-07-25 | 2000-10-31 | Monsanto Company | Method for producing antibodies and protein toxins in plant cells |
ATE369423T1 (de) * | 1994-12-30 | 2007-08-15 | Planet Biotechnology Inc | Verfahren zur herstellung von schutzproteine enthaltende immunoglobuline und ihre verwendung |
US6046037A (en) * | 1994-12-30 | 2000-04-04 | Hiatt; Andrew C. | Method for producing immunoglobulins containing protection proteins in plants and their use |
US6808709B1 (en) * | 1994-12-30 | 2004-10-26 | The Regents Of The University Of California | Immunoglobulins containing protection proteins and their use |
FR2736930B1 (fr) | 1995-07-17 | 1997-09-19 | Biocem | Procede de production, par des cellules vegetales, de proteines heminiques, proteines ainsi obtenues et produits contenant ces proteines |
US6403371B1 (en) * | 1996-02-08 | 2002-06-11 | Institut für Pflanzengenetik und Kulturpflanzenforschung | Cassettes for the expression of storable proteins in plants |
US5855881A (en) * | 1996-02-22 | 1999-01-05 | Loike; John D. | Mammalian alcohol dehydrogenase and aldehyde dehydrogenase production in plants |
JP4503706B2 (ja) | 1996-06-07 | 2010-07-14 | ポニアード ファーマシューティカルズ,インコーポレイティド | グリコシル化が改質されたヒト化抗体 |
AU740918B2 (en) | 1997-01-10 | 2001-11-15 | Plantibodies Corporation | Novel epithelial tissue targeting agent |
US6045774A (en) * | 1997-01-10 | 2000-04-04 | Epicyte Pharmaceutical Inc. | J chain polypeptide targeting molecule linked to an imaging agent |
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US6395962B1 (en) | 1999-06-22 | 2002-05-28 | University Of South Carolina | Enhancing expression of a silenced target sequence in plants using plant viral enhancers and amplicons |
DE60044858D1 (de) * | 1999-10-26 | 2010-09-30 | Stichting Dienst Landbouwkundi | Säugetierartige Glykosylierung in Pflanzen |
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WO2013136274A1 (en) | 2012-03-13 | 2013-09-19 | University Of Guelph | Myb55 promoter and use thereof |
US9616114B1 (en) | 2014-09-18 | 2017-04-11 | David Gordon Bermudes | Modified bacteria having improved pharmacokinetics and tumor colonization enhancing antitumor activity |
CN107810271B (zh) * | 2014-11-20 | 2021-09-28 | 耶路撒冷希伯来大学伊萨姆研发公司 | 用于在植物细胞中生产具有改变的糖基化模式的多肽的组合物和方法 |
US11129906B1 (en) | 2016-12-07 | 2021-09-28 | David Gordon Bermudes | Chimeric protein toxins for expression by therapeutic bacteria |
US11180535B1 (en) | 2016-12-07 | 2021-11-23 | David Gordon Bermudes | Saccharide binding, tumor penetration, and cytotoxic antitumor chimeric peptides from therapeutic bacteria |
WO2019124527A1 (ja) * | 2017-12-20 | 2019-06-27 | ユニ・チャーム株式会社 | リサイクル資材の清浄度の評価方法、リサイクル資材の製造方法、リサイクルパルプ繊維、及びリサイクルパルプ繊維の製造方法 |
JP6907147B2 (ja) * | 2018-03-30 | 2021-07-21 | ユニ・チャーム株式会社 | リサイクル資材の清浄度を評価する方法、及び使用済の衛生用品からリサイクル資材を製造する方法 |
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Publication number | Priority date | Publication date | Assignee | Title |
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US3518576A (en) * | 1967-06-27 | 1970-06-30 | North American Rockwell | Crossed guide directional coupler |
US4762785A (en) * | 1982-08-12 | 1988-08-09 | Calgene, Inc. | Novel method and compositions for introducting alien DNA in vivo |
GB8308235D0 (en) * | 1983-03-25 | 1983-05-05 | Celltech Ltd | Polypeptides |
US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
US4771002A (en) * | 1984-02-24 | 1988-09-13 | Lubrizol Genetics, Inc. | Transcription in plants and bacteria |
US4956282A (en) * | 1985-07-29 | 1990-09-11 | Calgene, Inc. | Mammalian peptide expression in plant cells |
SE8605621D0 (sv) * | 1986-12-30 | 1986-12-30 | Biokonsult Ab | Heteromultimeric proteins and their manufacture |
IL85035A0 (en) * | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
GB8901677D0 (en) * | 1989-01-26 | 1989-03-15 | Ici Plc | Hybrid seed production |
GB8901674D0 (en) * | 1989-01-26 | 1989-03-15 | Ici Plc | Regulation of plant gene expression |
-
1990
- 1990-10-02 US US07/591,823 patent/US5202422A/en not_active Expired - Lifetime
- 1990-10-25 EP EP90917366A patent/EP0497904B2/de not_active Expired - Lifetime
- 1990-10-25 DE DE69033676T patent/DE69033676T3/de not_active Expired - Fee Related
- 1990-10-25 WO PCT/US1990/006179 patent/WO1991006320A1/en active IP Right Grant
- 1990-10-25 AU AU67532/90A patent/AU6753290A/en not_active Abandoned
- 1990-10-25 JP JP50043691A patent/JP3238700B2/ja not_active Ceased
- 1990-10-25 CA CA002071502A patent/CA2071502A1/en not_active Abandoned
- 1990-10-25 DE DE69034259T patent/DE69034259D1/de not_active Expired - Fee Related
- 1990-10-25 EP EP00200970A patent/EP1048734B1/de not_active Expired - Lifetime
-
1992
- 1992-11-05 US US07/971,951 patent/US5639947A/en not_active Expired - Lifetime
-
2000
- 2000-08-22 JP JP2000251610A patent/JP3920545B2/ja not_active Expired - Lifetime
-
2004
- 2004-10-05 JP JP2004293032A patent/JP4045268B2/ja not_active Expired - Lifetime
Also Published As
Publication number | Publication date |
---|---|
JPH05504333A (ja) | 1993-07-08 |
EP0497904A4 (en) | 1992-12-09 |
EP1048734A2 (de) | 2000-11-02 |
AU6753290A (en) | 1991-05-31 |
US5639947A (en) | 1997-06-17 |
CA2071502A1 (en) | 1991-04-28 |
DE69033676T3 (de) | 2009-08-13 |
JP3920545B2 (ja) | 2007-05-30 |
US5202422A (en) | 1993-04-13 |
DE69033676D1 (de) | 2001-02-01 |
EP0497904B2 (de) | 2009-03-04 |
WO1991006320A1 (en) | 1991-05-16 |
EP1048734B1 (de) | 2008-08-13 |
JP3238700B2 (ja) | 2001-12-17 |
EP1048734A3 (de) | 2001-11-28 |
JP2005112857A (ja) | 2005-04-28 |
EP0497904B1 (de) | 2000-12-27 |
EP0497904A1 (de) | 1992-08-12 |
JP4045268B2 (ja) | 2008-02-13 |
DE69034259D1 (de) | 2008-09-25 |
JP2001086891A (ja) | 2001-04-03 |
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