DE69024163D1 - Koinzidenzarbitrierung für durchflusszytometrie - Google Patents

Koinzidenzarbitrierung für durchflusszytometrie

Info

Publication number
DE69024163D1
DE69024163D1 DE69024163T DE69024163T DE69024163D1 DE 69024163 D1 DE69024163 D1 DE 69024163D1 DE 69024163 T DE69024163 T DE 69024163T DE 69024163 T DE69024163 T DE 69024163T DE 69024163 D1 DE69024163 D1 DE 69024163D1
Authority
DE
Germany
Prior art keywords
concidence
arbitration
flow cytometry
cytometry
flow
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69024163T
Other languages
English (en)
Other versions
DE69024163T2 (de
Inventor
Robert Auer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beckman Coulter Inc
Original Assignee
Coulter Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Coulter Corp filed Critical Coulter Corp
Publication of DE69024163D1 publication Critical patent/DE69024163D1/de
Application granted granted Critical
Publication of DE69024163T2 publication Critical patent/DE69024163T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
    • B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
    • B07C5/36—Sorting apparatus characterised by the means used for distribution
    • B07C5/361—Processing or control devices therefor, e.g. escort memory
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B07—SEPARATING SOLIDS FROM SOLIDS; SORTING
    • B07C—POSTAL SORTING; SORTING INDIVIDUAL ARTICLES, OR BULK MATERIAL FIT TO BE SORTED PIECE-MEAL, e.g. BY PICKING
    • B07C5/00—Sorting according to a characteristic or feature of the articles or material being sorted, e.g. by control effected by devices which detect or measure such characteristic or feature; Sorting by manually actuated devices, e.g. switches
    • B07C5/34—Sorting according to other particular properties
    • B07C5/342—Sorting according to other particular properties according to optical properties, e.g. colour
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G01N15/1492—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties within droplets
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N15/149—Optical investigation techniques, e.g. flow cytometry specially adapted for sorting particles, e.g. by their size or optical properties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N15/00—Investigating characteristics of particles; Investigating permeability, pore-volume or surface-area of porous materials
    • G01N15/10—Investigating individual particles
    • G01N15/14—Optical investigation techniques, e.g. flow cytometry
    • G01N2015/1481—Optical analysis of particles within droplets
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S209/00—Classifying, separating, and assorting solids
    • Y10S209/906—Pneumatic or liquid stream feeding item

Landscapes

  • Chemical & Material Sciences (AREA)
  • Dispersion Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
DE69024163T 1989-05-01 1990-05-01 Koinzidenzarbitrierung für durchflusszytometrie Expired - Fee Related DE69024163T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/345,975 US4981580A (en) 1989-05-01 1989-05-01 Coincidence arbitration in a flow cytomery sorting system
PCT/US1990/002418 WO1990013368A1 (en) 1989-05-01 1990-05-01 Coincidence arbitration in a flow cytometry sorting system

Publications (2)

Publication Number Publication Date
DE69024163D1 true DE69024163D1 (de) 1996-01-25
DE69024163T2 DE69024163T2 (de) 1996-08-08

Family

ID=23357386

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69024163T Expired - Fee Related DE69024163T2 (de) 1989-05-01 1990-05-01 Koinzidenzarbitrierung für durchflusszytometrie

Country Status (7)

Country Link
US (1) US4981580A (de)
EP (1) EP0423328B1 (de)
JP (1) JPH0786456B2 (de)
AU (1) AU5720090A (de)
CA (1) CA1331793C (de)
DE (1) DE69024163T2 (de)
WO (1) WO1990013368A1 (de)

Families Citing this family (87)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5204884A (en) * 1991-03-18 1993-04-20 University Of Rochester System for high-speed measurement and sorting of particles
US5199576A (en) * 1991-04-05 1993-04-06 University Of Rochester System for flexibly sorting particles
US5763170A (en) * 1991-04-16 1998-06-09 Amersham International Plc Method for forming an array of biological particles
US5437200A (en) * 1993-01-15 1995-08-01 Coulter Corporation Liquid metering and transfer valve assembly particularly for flow cytometer
US5353937A (en) * 1993-05-17 1994-10-11 Esm International, Inc. Automatic variable ejector delay time and dwell type mechanism in a sorting apparatus
US5483469A (en) * 1993-08-02 1996-01-09 The Regents Of The University Of California Multiple sort flow cytometer
US5700692A (en) * 1994-09-27 1997-12-23 Becton Dickinson And Company Flow sorter with video-regulated droplet spacing
US5602039A (en) * 1994-10-14 1997-02-11 The University Of Washington Flow cytometer jet monitor system
US5643796A (en) * 1994-10-14 1997-07-01 University Of Washington System for sensing droplet formation time delay in a flow cytometer
US5602349A (en) * 1994-10-14 1997-02-11 The University Of Washington Sample introduction system for a flow cytometer
EP0786078B1 (de) * 1994-10-14 2004-01-07 University of Washington Methode und vorrichtung zur tröpfchenerzeugung mit hoher rate bei der durchfluss-cytometrie
US6861265B1 (en) 1994-10-14 2005-03-01 University Of Washington Flow cytometer droplet formation system
US6819411B1 (en) 1997-01-31 2004-11-16 Xy, Inc. Optical apparatus
US6149867A (en) * 1997-12-31 2000-11-21 Xy, Inc. Sheath fluids and collection systems for sex-specific cytometer sorting of sperm
US6071689A (en) * 1997-12-31 2000-06-06 Xy, Inc. System for improving yield of sexed embryos in mammals
US6746873B1 (en) * 1998-02-20 2004-06-08 Xy, Inc. Vibratory system for a sorting flow cytometer
US6281018B1 (en) 1998-02-26 2001-08-28 Coulter International Corp. Selective purification and enrichment sorting of flow cytometer droplets based upon analysis of droplet precursor regions
US6248590B1 (en) 1998-02-27 2001-06-19 Cytomation, Inc. Method and apparatus for flow cytometry
EP1100534B1 (de) 1998-07-30 2008-01-16 XY, Inc. System zur künstlichen nicht-chirurgischen besamung von pferden
US6372506B1 (en) * 1999-07-02 2002-04-16 Becton, Dickinson And Company Apparatus and method for verifying drop delay in a flow cytometer
US7024316B1 (en) 1999-10-21 2006-04-04 Dakocytomation Colorado, Inc. Transiently dynamic flow cytometer analysis system
US7208265B1 (en) * 1999-11-24 2007-04-24 Xy, Inc. Method of cryopreserving selected sperm cells
EP2258174A3 (de) 2000-05-09 2012-06-13 Xy, Llc Hochreines X-Chromosom-Lager und Y-Chromosom-Lagerpopulationen von Spermatozoiden
NZ523569A (en) * 2000-06-12 2005-11-25 Colorado State University Thro Integrated herd management system utilizing isolated populations of X-chromosome bearing and Y-chromosome bearing spermatozoa
US20040031071A1 (en) * 2000-10-05 2004-02-12 Xy, Inc. System of hysteroscopic insemination of mares
WO2002043574A2 (en) 2000-11-29 2002-06-06 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
US7713687B2 (en) 2000-11-29 2010-05-11 Xy, Inc. System to separate frozen-thawed spermatozoa into x-chromosome bearing and y-chromosome bearing populations
EP1395374B1 (de) 2001-05-17 2013-04-17 Beckman Coulter, Inc. Durchflusszytometer mit aktivem automatisiertem optischem ausrichtungssystem
US20030211009A1 (en) * 2001-05-18 2003-11-13 Buchanan Kris S. Rapid multi-material sample input system
US6744245B2 (en) 2001-07-27 2004-06-01 Coulter International Corp. Particle count correction method and apparatus
AUPR846501A0 (en) * 2001-10-26 2001-11-15 Btf Pty Ltd A cytometer
DE10157032A1 (de) * 2001-11-21 2003-06-12 Evotec Ag Verfahren und Vorrichtung zum Sortieren von Partikeln
US8486618B2 (en) 2002-08-01 2013-07-16 Xy, Llc Heterogeneous inseminate system
CA2532376C (en) 2002-08-01 2015-05-12 Colorado State University Research Foundation Low pressure sperm cell separation system
US7855078B2 (en) * 2002-08-15 2010-12-21 Xy, Llc High resolution flow cytometer
US7169548B2 (en) 2002-09-13 2007-01-30 Xy, Inc. Sperm cell processing and preservation systems
US6941005B2 (en) * 2002-11-01 2005-09-06 Coulter International Corp. Monitoring and control of droplet sorting
JP3891925B2 (ja) * 2002-12-03 2007-03-14 ベイバイオサイエンス株式会社 生物学的粒子の情報を得る装置
NZ564309A (en) 2003-03-28 2009-07-31 Inguran Llc Apparatus and methods for providing sex-sorted animal sperm
GB0307403D0 (en) 2003-03-31 2003-05-07 Medical Res Council Selection by compartmentalised screening
US20060078893A1 (en) 2004-10-12 2006-04-13 Medical Research Council Compartmentalised combinatorial chemistry by microfluidic control
GB0307428D0 (en) * 2003-03-31 2003-05-07 Medical Res Council Compartmentalised combinatorial chemistry
EP1625203B1 (de) 2003-05-15 2015-04-08 Xy, Llc Effiziente sortierung haploider zellen für durchflusszytometer-systeme
US7892725B2 (en) 2004-03-29 2011-02-22 Inguran, Llc Process for storing a sperm dispersion
US20050221339A1 (en) * 2004-03-31 2005-10-06 Medical Research Council Harvard University Compartmentalised screening by microfluidic control
JP4304120B2 (ja) * 2004-04-30 2009-07-29 ベイバイオサイエンス株式会社 生物学的粒子をソーティングする装置及び方法
DE102005052752A1 (de) 2005-11-04 2007-05-10 Clondiag Chip Technologies Gmbh Vorrichtung und Verfahren zum Nachweis von molekularen Wechselwirkungen
JP2008507287A (ja) 2004-07-22 2008-03-13 モンサント テクノロジー エルエルシー 精子細胞の集団を富化する方法
PL2884258T3 (pl) 2004-07-27 2017-04-28 Beckman Coulter, Inc. Poprawa zdolności dyskryminacji w cytometrii przepływowej przy użyciu transformacji geometrycznej realizowanej za pomocą komputera
US7968287B2 (en) 2004-10-08 2011-06-28 Medical Research Council Harvard University In vitro evolution in microfluidic systems
JP2006234559A (ja) * 2005-02-24 2006-09-07 Mitsui Eng & Shipbuild Co Ltd フローサイトメータ
US7618770B2 (en) * 2005-07-29 2009-11-17 Xy, Inc. Methods and apparatus for reducing protein content in sperm cell extenders
US20100137163A1 (en) 2006-01-11 2010-06-03 Link Darren R Microfluidic Devices and Methods of Use in The Formation and Control of Nanoreactors
DE102006021487B3 (de) * 2006-05-05 2007-09-06 Parsum Gmbh Verfahren und Vorrichtung zur Bestimmung der in einem Partikelstrom enthaltenen Partikel
US9562837B2 (en) 2006-05-11 2017-02-07 Raindance Technologies, Inc. Systems for handling microfludic droplets
US9074242B2 (en) 2010-02-12 2015-07-07 Raindance Technologies, Inc. Digital analyte analysis
EP4190448A3 (de) 2006-05-11 2023-09-20 Bio-Rad Laboratories, Inc. Mikrofluidische vorrichtungen
US9012390B2 (en) 2006-08-07 2015-04-21 Raindance Technologies, Inc. Fluorocarbon emulsion stabilizing surfactants
US8772046B2 (en) 2007-02-06 2014-07-08 Brandeis University Manipulation of fluids and reactions in microfluidic systems
US8592221B2 (en) 2007-04-19 2013-11-26 Brandeis University Manipulation of fluids, fluid components and reactions in microfluidic systems
EP2315629B1 (de) 2008-07-18 2021-12-15 Bio-Rad Laboratories, Inc. Tröpfchenbibliotheken
EP2157599A1 (de) * 2008-08-21 2010-02-24 Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO Verfahren und Vorrichtung zur Identifikation biologischer Materialien
US8154273B2 (en) * 2008-10-10 2012-04-10 Beckman Coulter, Inc. Detecting and handling coincidence in particle analysis
WO2010111231A1 (en) 2009-03-23 2010-09-30 Raindance Technologies, Inc. Manipulation of microfluidic droplets
WO2011042564A1 (en) 2009-10-09 2011-04-14 Universite De Strasbourg Labelled silica-based nanomaterial with enhanced properties and uses thereof
US8589851B2 (en) * 2009-12-15 2013-11-19 Memoir Systems, Inc. Intelligent memory system compiler
WO2011079176A2 (en) 2009-12-23 2011-06-30 Raindance Technologies, Inc. Microfluidic systems and methods for reducing the exchange of molecules between droplets
US9399797B2 (en) 2010-02-12 2016-07-26 Raindance Technologies, Inc. Digital analyte analysis
US9366632B2 (en) 2010-02-12 2016-06-14 Raindance Technologies, Inc. Digital analyte analysis
US10351905B2 (en) 2010-02-12 2019-07-16 Bio-Rad Laboratories, Inc. Digital analyte analysis
US9562897B2 (en) 2010-09-30 2017-02-07 Raindance Technologies, Inc. Sandwich assays in droplets
EP3412778A1 (de) 2011-02-11 2018-12-12 Raindance Technologies, Inc. Verfahren zur bildung gemischter tröpfchen
WO2012112804A1 (en) 2011-02-18 2012-08-23 Raindance Technoligies, Inc. Compositions and methods for molecular labeling
US8841071B2 (en) 2011-06-02 2014-09-23 Raindance Technologies, Inc. Sample multiplexing
DE202012013668U1 (de) 2011-06-02 2019-04-18 Raindance Technologies, Inc. Enzymquantifizierung
US8658430B2 (en) 2011-07-20 2014-02-25 Raindance Technologies, Inc. Manipulating droplet size
ES2865108T3 (es) * 2011-12-20 2021-10-15 Becton Dickinson Co Método, sistema, medio de almacenamiento legible por ordenador y clasificador de células para mejorar el rendimiento de partículas clasificadas
JP6192665B2 (ja) * 2012-02-09 2017-09-06 ベックマン コールター， インコーポレイテッド 選別フローサイトメータ
BR112015022073B1 (pt) 2013-04-12 2020-10-06 Becton, Dickinson And Company Organização automatizada para classificação de célula
US9645080B2 (en) 2013-04-16 2017-05-09 University Of Washington Systems, devices, and methods for separating, concentrating, and/or differentiating between cells from a cell sample
US11901041B2 (en) 2013-10-04 2024-02-13 Bio-Rad Laboratories, Inc. Digital analysis of nucleic acid modification
US9944977B2 (en) 2013-12-12 2018-04-17 Raindance Technologies, Inc. Distinguishing rare variations in a nucleic acid sequence from a sample
EP3090063B1 (de) 2013-12-31 2019-11-06 Bio-Rad Laboratories, Inc. Verfahren zur detektion von latentem retrovirus
US10456767B2 (en) * 2014-10-22 2019-10-29 Hitachi High-Technologies Corporation Cytometric mechanism, cell culture device comprising same, and cytometric method
US10647981B1 (en) 2015-09-08 2020-05-12 Bio-Rad Laboratories, Inc. Nucleic acid library generation methods and compositions
US11698364B2 (en) 2018-06-27 2023-07-11 University Of Washington Real-time cell-surface marker detection
WO2022204600A1 (en) * 2021-03-26 2022-09-29 Cytonome/St, Llc Systems and methods for particle sorting with automated adjustment of operational parameters

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3380584A (en) * 1965-06-04 1968-04-30 Atomic Energy Commission Usa Particle separator
US3675768A (en) * 1969-03-17 1972-07-11 Gildardo Legorreta Sanchez Method and apparatus for classifying and segregating particles with electrical and optical means
US3826364A (en) * 1972-05-22 1974-07-30 Univ Leland Stanford Junior Particle sorting method and apparatus
US3963606A (en) * 1974-06-03 1976-06-15 Coulter Electronics, Inc. Semi-automatic adjusting delay for an electronic particle separator
GB1563856A (en) * 1976-06-10 1980-04-02 Coulter Electronics Methods and apparatus for delectively separating small particles suspended in a liquid
US4230558A (en) * 1978-10-02 1980-10-28 Coulter Electronics, Inc. Single drop separator
US4318483A (en) * 1979-08-20 1982-03-09 Ortho Diagnostics, Inc. Automatic relative droplet charging time delay system for an electrostatic particle sorting system using a relatively moveable stream surface sensing system
US4487320A (en) * 1980-11-03 1984-12-11 Coulter Corporation Method of and apparatus for detecting change in the breakoff point in a droplet generation system
US4447883A (en) * 1981-05-26 1984-05-08 Technicon Instruments Corporation Coincidence-error correcting apparatus and method
US4667830A (en) * 1981-06-15 1987-05-26 The Board Of Trustees Of The Leland Stanford Junior University Method and means for sorting individual particles into containers for culturing, cloning, analysis, or the like
US4510438A (en) * 1982-02-16 1985-04-09 Coulter Electronics, Inc. Coincidence correction in particle analysis system
JPS59174742A (ja) * 1983-03-25 1984-10-03 Agency Of Ind Science & Technol 微小粒子を区分又は選別する方法及びその装置

Also Published As

Publication number Publication date
CA1331793C (en) 1994-08-30
EP0423328A1 (de) 1991-04-24
JPH0786456B2 (ja) 1995-09-20
EP0423328A4 (en) 1992-06-03
WO1990013368A1 (en) 1990-11-15
EP0423328B1 (de) 1995-12-13
JPH03503808A (ja) 1991-08-22
US4981580A (en) 1991-01-01
DE69024163T2 (de) 1996-08-08
AU5720090A (en) 1990-11-29

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: COULTER INTERNATIONAL CORP., MIAMI, FLA., US

8339 Ceased/non-payment of the annual fee