DE69011516T2 - Verfahren zur herstellung von l-alpha-glycerylphosphorylcholin und von l-alpha-glycerylphosphorylethanolamin. - Google Patents
Verfahren zur herstellung von l-alpha-glycerylphosphorylcholin und von l-alpha-glycerylphosphorylethanolamin.Info
- Publication number
- DE69011516T2 DE69011516T2 DE69011516T DE69011516T DE69011516T2 DE 69011516 T2 DE69011516 T2 DE 69011516T2 DE 69011516 T DE69011516 T DE 69011516T DE 69011516 T DE69011516 T DE 69011516T DE 69011516 T2 DE69011516 T2 DE 69011516T2
- Authority
- DE
- Germany
- Prior art keywords
- pct
- alpha
- glycerylphosphorylethanolamine
- glycerylphosphorylcholine
- date nov
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000008777 Glycerylphosphorylcholine Substances 0.000 title abstract 4
- SUHOQUVVVLNYQR-MRVPVSSYSA-N choline alfoscerate Chemical compound C[N+](C)(C)CCOP([O-])(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-N 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- SUHOQUVVVLNYQR-MRVPVSSYSA-O glycerylphosphorylcholine Chemical compound C[N+](C)(C)CCO[P@](O)(=O)OC[C@H](O)CO SUHOQUVVVLNYQR-MRVPVSSYSA-O 0.000 abstract 3
- 229960004956 glycerylphosphorylcholine Drugs 0.000 abstract 3
- FRMZOWIQVCBEAC-UHFFFAOYSA-N glycerylphosphorylethanolamine Chemical compound OCCN(P(O)(O)=O)CC(O)CO FRMZOWIQVCBEAC-UHFFFAOYSA-N 0.000 abstract 3
- 239000011347 resin Substances 0.000 abstract 3
- 229920005989 resin Polymers 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 238000005406 washing Methods 0.000 abstract 2
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 abstract 1
- 239000002253 acid Substances 0.000 abstract 1
- 125000002091 cationic group Chemical group 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 238000000746 purification Methods 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P—C bonds
- C07F9/08—Esters of oxyacids of phosphorus
- C07F9/09—Esters of phosphoric acids
- C07F9/091—Esters of phosphoric acids with hydroxyalkyl compounds with further substituents on alkyl
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT8920413A IT1229238B (it) | 1989-05-08 | 1989-05-08 | Procedimento per la preparazione di l-alfa-glicerilfosforilcolina e l alfa glicerilfosforiletanolammina. |
| PCT/EP1990/000717 WO1990013552A1 (en) | 1989-05-08 | 1990-05-04 | PROCESS FOR THE PREPARATION OF L-α-GLYCERYLPHOSPHORYLCHOLINE AND OF L-α-GLYCERYLPHOSPHORYLETHANOLAMINE |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE69011516D1 DE69011516D1 (de) | 1994-09-15 |
| DE69011516T2 true DE69011516T2 (de) | 1994-12-08 |
Family
ID=11166558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE69011516T Expired - Fee Related DE69011516T2 (de) | 1989-05-08 | 1990-05-04 | Verfahren zur herstellung von l-alpha-glycerylphosphorylcholin und von l-alpha-glycerylphosphorylethanolamin. |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US5250719A (de) |
| EP (1) | EP0471706B1 (de) |
| JP (1) | JP2883202B2 (de) |
| AT (1) | ATE109785T1 (de) |
| AU (1) | AU5550490A (de) |
| CA (1) | CA2055503C (de) |
| DE (1) | DE69011516T2 (de) |
| DK (1) | DK0471706T3 (de) |
| ES (1) | ES2057561T3 (de) |
| IT (1) | IT1229238B (de) |
| WO (1) | WO1990013552A1 (de) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2108715T3 (es) * | 1991-07-04 | 1998-01-01 | Asta Medica Ag | Procedimiento para la preparacion de alquilfosfocolinas y purificacion de las mismas. |
| GB9201371D0 (en) * | 1992-01-22 | 1992-03-11 | Enzymatix Ltd | Crystallisation process |
| IT1254991B (it) * | 1992-06-24 | 1995-10-11 | Chemi Spa | Procedimento per la preparazione di glicerofosfolipidi |
| US5917068A (en) * | 1995-12-29 | 1999-06-29 | Eastman Chemical Company | Polyunsaturated fatty acid and fatty acid ester mixtures free of sterols and phosphorus compounds |
| US6200624B1 (en) | 1996-01-26 | 2001-03-13 | Abbott Laboratories | Enteral formula or nutritional supplement containing arachidonic and docosahexaenoic acids |
| US6063946A (en) * | 1996-01-26 | 2000-05-16 | Eastman Chemical Company | Process for the isolation of polyunsaturated fatty acids and esters thereof from complex mixtures which contain sterols and phosphorus compounds |
| US5883273A (en) * | 1996-01-26 | 1999-03-16 | Abbott Laboratories | Polyunsaturated fatty acids and fatty acid esters free of sterols and phosphorus compounds |
| CA2726329A1 (en) * | 2008-06-02 | 2009-12-10 | University Of Saskatchewan | Recovery of multiple compounds and recyclable water from thin stillage |
| US8658401B2 (en) * | 2011-03-24 | 2014-02-25 | Jiannan University | Method for preparing high purity L-α glycerylphosphorylcholine |
| ITVI20120063A1 (it) * | 2012-03-22 | 2013-09-23 | Fortom Chimica S R L | Procedimento per l'estrazione e raffinazione di fosfatidilcolina e altri fosfolipidi da lecitine vegetali |
| CN102875592A (zh) * | 2012-09-29 | 2013-01-16 | 常熟富士莱医药化工有限公司 | 天然的L-α-甘油磷脂酰胆碱的制备方法 |
| CN103172659A (zh) * | 2013-03-29 | 2013-06-26 | 山东罗欣药业股份有限公司 | L-α-甘油磷酰胆碱晶型化合物 |
| WO2015108355A1 (ko) * | 2014-01-15 | 2015-07-23 | 지준홍 | 글리세릴 포스포릴 콜린 결정 및 이의 제조 방법 |
| KR101616945B1 (ko) | 2014-02-10 | 2016-04-29 | 엔자이텍 주식회사 | 라세믹 또는 광학적으로 활성이 있는 α―글리세로포스포릴 콜린의 제조방법 |
| PE20170386A1 (es) | 2014-06-10 | 2017-04-21 | Chemi Spa | Proceso para la purificacion de l-alfa-glicerofosforilcolina |
| RU2685238C1 (ru) * | 2016-07-01 | 2019-04-17 | Общество с ограниченной ответственностью "ФАРМАЦЕЛЬ" | Способ получения кристаллического глицерофосфатидилхолина |
| RU2635665C1 (ru) * | 2017-02-16 | 2017-11-15 | Общество с ограниченной ответственностью "БИОН" | Способ получения l-a-глицерофосфорилхолина фармакопейного качества |
| WO2023026449A1 (ja) * | 2021-08-26 | 2023-03-02 | 協和発酵バイオ株式会社 | シチジン－５'－ジリン酸化合物の製造方法 |
| CN114106036A (zh) * | 2021-11-08 | 2022-03-01 | 云南开放大学(云南国防工业职业技术学院) | 一种L-α-甘油磷脂酰胆碱的分离提取方法 |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE1543722A1 (de) * | 1966-08-25 | 1969-09-11 | Knoll Ag | Verfahren zur Gewinnung von reinen natuerlichen Cholinphosphorsaeurediglyceridestern |
| FR2587574B1 (fr) * | 1985-09-18 | 1987-10-30 | Commissariat Energie Atomique | Resistor pour le traitement de materiaux |
| IT1201477B (it) * | 1985-10-04 | 1989-02-02 | Istituto Chemioterapico | Procedimento per la preparazione di l-alfa-glicerilfosforilcolina,l-alfa-glicerilfosforiletanolommina e l-alfa-glicerilfosforilinositolo da lecitine grezze e/o deoleate |
-
1989
- 1989-05-08 IT IT8920413A patent/IT1229238B/it active
-
1990
- 1990-05-04 CA CA002055503A patent/CA2055503C/en not_active Expired - Fee Related
- 1990-05-04 DK DK90906950.2T patent/DK0471706T3/da active
- 1990-05-04 JP JP2506592A patent/JP2883202B2/ja not_active Expired - Fee Related
- 1990-05-04 AT AT90906950T patent/ATE109785T1/de not_active IP Right Cessation
- 1990-05-04 EP EP90906950A patent/EP0471706B1/de not_active Expired - Lifetime
- 1990-05-04 US US07/773,923 patent/US5250719A/en not_active Expired - Lifetime
- 1990-05-04 DE DE69011516T patent/DE69011516T2/de not_active Expired - Fee Related
- 1990-05-04 ES ES90906950T patent/ES2057561T3/es not_active Expired - Lifetime
- 1990-05-04 WO PCT/EP1990/000717 patent/WO1990013552A1/en active IP Right Grant
- 1990-05-04 AU AU55504/90A patent/AU5550490A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US5250719A (en) | 1993-10-05 |
| CA2055503C (en) | 2000-01-18 |
| JP2883202B2 (ja) | 1999-04-19 |
| DK0471706T3 (da) | 1994-11-21 |
| EP0471706A1 (de) | 1992-02-26 |
| ES2057561T3 (es) | 1994-10-16 |
| IT1229238B (it) | 1991-07-26 |
| AU5550490A (en) | 1990-11-29 |
| IT8920413A0 (it) | 1989-05-08 |
| DE69011516D1 (de) | 1994-09-15 |
| JPH04505013A (ja) | 1992-09-03 |
| WO1990013552A1 (en) | 1990-11-15 |
| CA2055503A1 (en) | 1990-11-09 |
| ATE109785T1 (de) | 1994-08-15 |
| EP0471706B1 (de) | 1994-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |