DE69010000D1 - Expression von menschlichen apolipoproteinen ai-milano in hefe. - Google Patents

Expression von menschlichen apolipoproteinen ai-milano in hefe.

Info

Publication number
DE69010000D1
DE69010000D1 DE69010000T DE69010000T DE69010000D1 DE 69010000 D1 DE69010000 D1 DE 69010000D1 DE 69010000 T DE69010000 T DE 69010000T DE 69010000 T DE69010000 T DE 69010000T DE 69010000 D1 DE69010000 D1 DE 69010000D1
Authority
DE
Germany
Prior art keywords
yeast
milano
expression
human apolipoproteins
apolipoprotein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE69010000T
Other languages
English (en)
Other versions
DE69010000T2 (de
Inventor
Alessandro Sidoli
Francisco Baralle
Cesare Sirtori
Guido Franceschini
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esperion Therapeutics Inc
Original Assignee
FRANCESCHINI GUIDO MAILAND/MILANO
SIRTORI CESARE MILANO
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by FRANCESCHINI GUIDO MAILAND/MILANO, SIRTORI CESARE MILANO filed Critical FRANCESCHINI GUIDO MAILAND/MILANO
Application granted granted Critical
Publication of DE69010000D1 publication Critical patent/DE69010000D1/de
Publication of DE69010000T2 publication Critical patent/DE69010000T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/775—Apolipopeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/06—Antihyperlipidemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/37—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi
    • C07K14/39—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts
    • C07K14/395—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from fungi from yeasts from Saccharomyces
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Zoology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Wood Science & Technology (AREA)
  • Cardiology (AREA)
  • Diabetes (AREA)
  • Obesity (AREA)
  • Physics & Mathematics (AREA)
  • Plant Pathology (AREA)
  • Urology & Nephrology (AREA)
  • Vascular Medicine (AREA)
  • Toxicology (AREA)
  • Hematology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
DE69010000T 1989-04-20 1990-04-17 Expression von menschlichen apolipoproteinen ai-milano in hefe. Expired - Fee Related DE69010000T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
IT8920226A IT1229996B (it) 1989-04-20 1989-04-20 Espressione di apolipoproteina ai e apolipoproteina ai-milano in lievito e composizioni farmaceutiche che contengono dette apolipoproteine.
PCT/EP1990/000617 WO1990012879A2 (en) 1989-04-20 1990-04-17 Expression of human apolipoproteins ai-milano in yeast

Publications (2)

Publication Number Publication Date
DE69010000D1 true DE69010000D1 (de) 1994-07-21
DE69010000T2 DE69010000T2 (de) 1994-09-22

Family

ID=11164927

Family Applications (1)

Application Number Title Priority Date Filing Date
DE69010000T Expired - Fee Related DE69010000T2 (de) 1989-04-20 1990-04-17 Expression von menschlichen apolipoproteinen ai-milano in hefe.

Country Status (10)

Country Link
EP (1) EP0469017B1 (de)
JP (3) JP3082941B2 (de)
AT (1) ATE107360T1 (de)
AU (1) AU641389B2 (de)
CA (1) CA2053288C (de)
DE (1) DE69010000T2 (de)
DK (1) DK0469017T3 (de)
ES (1) ES2054353T3 (de)
IT (1) IT1229996B (de)
WO (1) WO1990012879A2 (de)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE9103701D0 (sv) * 1991-12-13 1991-12-13 Kabi Pharmacia Ab Apolipoprotein
FR2686605B1 (fr) * 1992-01-27 1994-03-11 Rhone Poulenc Rorer Sa Nouveaux polypeptides, leur preparation et leur utilisation.
SE9203753D0 (sv) * 1992-12-11 1992-12-11 Kabi Pharmacia Ab Expression system for producing apolipoprotein ai-m
SE9500778D0 (sv) 1995-03-03 1995-03-03 Pharmacia Ab Process for producing a protein
SE9603068D0 (sv) * 1996-08-23 1996-08-23 Pharmacia & Upjohn Ab Process for purifying a protein
SE9603304D0 (sv) 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a compound
JP2000513945A (ja) * 1996-09-11 2000-10-24 エスペリオン セラピューティクス インコーポレイテッド プロセスにおける使用のためにアポリポタンパク質および組成物を精製するためのプロセス
DK0954524T3 (da) * 1996-09-11 2003-08-04 Pharmacia Ab Fremgangsmåde til rensning af apolipoproteiner
SE9603303D0 (sv) 1996-09-11 1996-09-11 Pharmacia & Upjohn Ab Process for purifying a protein
EP1335938B1 (de) 2000-11-10 2010-09-22 F. Hoffmann-La Roche Ltd. Apolipoprotein-Konstrukte
KR20040081418A (ko) * 2001-09-28 2004-09-21 에스페리온 테라피유틱스 인코포레이티드 약물의 국소투여를 통한 재협착의 예방 및 치료
CN1870894B (zh) * 2003-10-20 2011-08-10 埃斯普里昂治疗公司 用于治疗和预防急性冠状动脉综合征的药物制剂、方法和给药方案
WO2005051413A2 (en) * 2003-11-26 2005-06-09 Novartis Ag Disease associated genes
WO2005097206A2 (en) 2004-04-06 2005-10-20 Cedars-Sinai Medical Center Prevention and treatment of vascular disease with recombinant adeno-associated virus vectors encoding apolipoprotein a-i and apolipoprotein a-i milano
KR100560102B1 (ko) 2004-06-25 2006-03-13 한국생명공학연구원 프로아포리포단백질 ａ－ⅰ 변이체와, 이를 포함하는고지혈증 또는 동맥경화증 예방 및 치료제
CN1320119C (zh) * 2004-12-09 2007-06-06 复旦大学 人载脂蛋白ApoAⅠ在毕赤氏酵母胞内表达的方法
US7759315B2 (en) 2005-03-09 2010-07-20 Csl Behring Ag Treatment of inflammatory conditions of the intestine
DK2465519T3 (da) 2007-03-01 2014-02-03 Csl Ltd Behandling af endotel funktionsforstyrrelse hos diabetespatienter
US10894098B2 (en) 2012-04-09 2021-01-19 Signablok, Inc. Methods and compositions for targeted imaging
US20130137628A1 (en) 2010-05-11 2013-05-30 Esperion Therapeutics, Inc. Dimeric Oxidation-Resistant Apolipoprotein A1 Variants
WO2011159810A2 (en) * 2010-06-15 2011-12-22 Lawyer Matthew C Compositions and methods for the treatment of atherosclerosis
FR2961814B1 (fr) * 2010-06-29 2014-09-26 Isp Investments Inc Nouveaux peptides activateurs de la sirtuine 6 et composition cosmetique ou pharmaceutiques les comprenant.
DK2767546T3 (en) 2011-02-07 2019-02-04 Cerenis Therapeutics Holding Sa Lipoprotein complexes and their preparation and uses

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4546082A (en) * 1982-06-17 1985-10-08 Regents Of The Univ. Of California E. coli/Saccharomyces cerevisiae plasmid cloning vector containing the alpha-factor gene for secretion and processing of hybrid proteins
AU6522486A (en) * 1985-10-04 1987-04-24 Biotechnology Research Partners Limited Recombinant apolipoproteins and methods
GB8625435D0 (en) * 1986-10-23 1986-11-26 Erba Farmitalia Human apolipoprotein ai
GB8712540D0 (en) * 1987-05-28 1987-07-01 Ucb Sa Expression of human proapolipoprotein a-i
DK463887D0 (da) * 1987-09-07 1987-09-07 Novo Industri As Gaerleader

Also Published As

Publication number Publication date
DE69010000T2 (de) 1994-09-22
EP0469017B1 (de) 1994-06-15
CA2053288C (en) 2006-06-06
AU641389B2 (en) 1993-09-23
WO1990012879A2 (en) 1990-11-01
JP3845101B2 (ja) 2006-11-15
ATE107360T1 (de) 1994-07-15
DK0469017T3 (da) 1994-10-03
JPH05504673A (ja) 1993-07-22
JP2004339229A (ja) 2004-12-02
EP0469017A1 (de) 1992-02-05
JP3082941B2 (ja) 2000-09-04
ES2054353T3 (es) 1994-08-01
IT1229996B (it) 1991-09-20
AU5424590A (en) 1990-11-16
JP2000212098A (ja) 2000-08-02
CA2053288A1 (en) 1990-10-21
IT8920226A0 (it) 1989-04-20
WO1990012879A3 (en) 1991-05-16

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: ESPERION THERAPEUTICS INC., ANN ARBOR, MICH., US

8339 Ceased/non-payment of the annual fee