DE68929248D1 - Oberflächenaktives lungenprotein und verwandte polypeptide - Google Patents

Oberflächenaktives lungenprotein und verwandte polypeptide

Info

Publication number
DE68929248D1
DE68929248D1 DE68929248T DE68929248T DE68929248D1 DE 68929248 D1 DE68929248 D1 DE 68929248D1 DE 68929248 T DE68929248 T DE 68929248T DE 68929248 T DE68929248 T DE 68929248T DE 68929248 D1 DE68929248 D1 DE 68929248D1
Authority
DE
Germany
Prior art keywords
amino acid
surface active
acid residue
related polypeptides
lung protein
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE68929248T
Other languages
English (en)
Other versions
DE68929248T2 (de
Inventor
G Cochrane
D Revak
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Scripps Research Institute
Original Assignee
Scripps Research Institute
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Scripps Research Institute filed Critical Scripps Research Institute
Application granted granted Critical
Publication of DE68929248D1 publication Critical patent/DE68929248D1/de
Publication of DE68929248T2 publication Critical patent/DE68929248T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/04—Drugs for disorders of the respiratory system for throat disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pulmonology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Otolaryngology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Materials For Medical Uses (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE68929248T 1988-01-06 1989-01-05 Oberflächenaktives lungenprotein und verwandte polypeptide Expired - Lifetime DE68929248T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US14120088A 1988-01-06 1988-01-06
US07/293,201 US5164369A (en) 1988-01-06 1989-01-04 Pulmonary surfactant protein and related polypeptide
PCT/US1989/000046 WO1989006657A1 (en) 1988-01-06 1989-01-05 Pulmonary surfactant protein and related polypeptide

Publications (2)

Publication Number Publication Date
DE68929248D1 true DE68929248D1 (de) 2000-10-19
DE68929248T2 DE68929248T2 (de) 2001-01-25

Family

ID=26838883

Family Applications (2)

Application Number Title Priority Date Filing Date
DE68929287T Expired - Lifetime DE68929287T2 (de) 1988-01-06 1989-01-05 Oberflächenaktives Lungenprotein und verwandte Polypeptide
DE68929248T Expired - Lifetime DE68929248T2 (de) 1988-01-06 1989-01-05 Oberflächenaktives lungenprotein und verwandte polypeptide

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DE68929287T Expired - Lifetime DE68929287T2 (de) 1988-01-06 1989-01-05 Oberflächenaktives Lungenprotein und verwandte Polypeptide

Country Status (8)

Country Link
US (1) US5164369A (de)
EP (2) EP0593094B1 (de)
JP (2) JP3009690B2 (de)
AT (2) ATE199730T1 (de)
DE (2) DE68929287T2 (de)
DK (1) DK174818B1 (de)
FI (1) FI102180B1 (de)
WO (1) WO1989006657A1 (de)

Families Citing this family (49)

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US5330682A (en) * 1987-11-07 1994-07-19 Agricultural & Food Research Council Methods of emulsification with peptide emulsifiers
US6613734B2 (en) * 1988-01-06 2003-09-02 The Scripps Research Institute Peptides-containing liposomal surfactants
US6013619A (en) * 1988-01-06 2000-01-11 The Scripps Research Institute Pulmonary surfactants and therapeutic uses, including pulmonary lavage
US5260273A (en) * 1988-01-06 1993-11-09 The Scripps Research Institute Pulmonary surfactant protein and related polypeptide
US5238920A (en) * 1989-08-22 1993-08-24 Abbott Laboratories Pulmonary surfactant protein fragments
US5272252A (en) * 1991-11-04 1993-12-21 Merrell Dow Pharmaceuticals Inc. Synthetic lung surfactant having antioxidant properties
AU3662593A (en) * 1992-04-10 1993-11-18 Abbott Laboratories Pulmonary surfactant protein fragments
US6129934A (en) * 1995-06-07 2000-10-10 Ony, Inc. Modification of animal lung surfactant for treating respiratory disease due to lung surfactant deficiency or dysfunction
DE69620801T2 (de) * 1995-11-20 2002-10-10 Ortho Mcneil Pharm Inc Verfahren zur solubisierung des pulmonnären oberflächeraktiven peptides
ATE212220T1 (de) 1996-01-24 2002-02-15 Byk Gulden Lomberg Chem Fab Verfahren zur herstellung von pulverförmigen lungensurfactant-zubereitungen
US6031075A (en) * 1996-02-05 2000-02-29 Children's Hospital Medical Center Mature alveolar SP-B and a process for producing the same
AU2322097A (en) * 1996-03-27 1997-10-17 Ortho Pharmaceutical Corporation Lyophilized pulmonary surfactant peptide compositions
US6013764A (en) * 1996-07-17 2000-01-11 Ortho Pharmaceutical Corp. Liquid phase peptide synthesis of KL-4 pulmonary surfactant
ES2346048T3 (es) 2001-10-11 2010-10-08 Nycomed Gmbh Nueva utilizacion de un agente tensioactivo pulmonar.
NZ536796A (en) * 2002-04-25 2007-03-30 Scripps Research Inst Treatment and prevention of pulmonary conditions comprising at least one lung surfactant polypeptide and at least one protease inhibitor, lipase inhibitor or an anti-oxidant
WO2005055994A1 (en) * 2003-12-04 2005-06-23 The Scripps Research Institute Treatment and preventions of asthma
AU2005247410A1 (en) * 2004-05-20 2005-12-08 Discovery Laboratories, Inc. Methods , systems and devices for noninvasive pulmonary delivery
US8236750B2 (en) 2004-08-06 2012-08-07 Nycomed Gmbh Composition comprising a pulmonary surfactant and a TNF-derived peptide
US7582312B2 (en) * 2004-11-15 2009-09-01 Discovery Laboratories, Inc. Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof
US7464012B2 (en) * 2004-12-10 2008-12-09 L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude Simplified process simulator
US8337815B2 (en) * 2004-12-23 2012-12-25 Discovery Laboratories, Inc. Pulmonary surfactant formulations
EP1841458B9 (de) 2005-01-06 2012-12-12 Discovery Laboratories, Inc. Dosierungsschema unter verwendung eines tensids zur behandlung oder verhinderung von lungendysplasien
US8028697B2 (en) 2005-04-28 2011-10-04 Trudell Medical International Ventilator circuit and method for the use thereof
HUE032584T2 (en) 2006-02-08 2017-09-28 Morphotek Inc Antigen GM-CSF peptides and GM-CSF antibodies
CA2663795A1 (en) * 2006-09-19 2008-03-27 Discovery Laboratories, Inc. Pulmonary surfactant formulations and methods for promoting mucus clearance
US7951781B2 (en) 2006-11-02 2011-05-31 University Of Iowa Research Foundation Methods and compositions related to PLUNC surfactant polypeptides
WO2008151235A2 (en) * 2007-06-05 2008-12-11 Forma Therapeutics, Inc. Compositions for delivering medicaments into the lungs, uses thereof
US8048043B2 (en) 2007-06-08 2011-11-01 Chiesi Farmaceutici S. P. A. Method of administration of a pulmonary surfactant
HUE028653T2 (en) 2008-03-17 2016-12-28 Discovery Lab Inc Respiratory circuit adapter and direct aerosol delivery system
CA2683353C (en) 2008-10-22 2015-12-15 Trudell Medical International Modular aerosol delivery system
WO2010068754A2 (en) 2008-12-10 2010-06-17 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of medicaments to the lungs
BR112012004651B1 (pt) 2009-09-08 2022-02-08 Chiesi Farmaceutici S.P.A. Surfactante pulmonar exógeno, uso de uma combinação terapêutica, medicamento e kit
WO2011035140A1 (en) 2009-09-18 2011-03-24 Paka Pulmonary Pharmaceuticals, Inc. Methods and compositions for delivery of contrast moieties to the lungs
WO2013188016A2 (en) 2012-05-04 2013-12-19 Discovery Laboratories, Inc. Surfactant therapy for exposure to ionizing radiation
EP3106090A1 (de) 2015-06-15 2016-12-21 CHIESI FARMACEUTICI S.p.A. System zur effektiven und atemsynchronisierten abgabe eines medikaments in die lungen
US20180110948A1 (en) 2015-04-22 2018-04-26 Chiesi Farmaceutici S.P.A Method and system for effective breath-synchronized delivery of medicament to the lungs
US11311691B2 (en) 2015-04-28 2022-04-26 Chiesi Farmaceutici S.P.A Device for facilitating the administration of a medicament to the lung by a catheter
US20180147262A1 (en) 2015-04-30 2018-05-31 University Of Bremen Novel skin medical and cosmetic care product
MA45772A (fr) 2016-07-28 2021-04-28 Chiesi Farm Spa Procédé et système d'administration d'un médicament sous forme d'aérosol
CN109890446B (zh) 2016-10-26 2022-03-22 奇斯药制品公司 用于帮助通过导管向肺给送药剂的装置
JP2020502242A (ja) 2016-12-22 2020-01-23 キエージ・フアルマチエウテイチ・エツセ・ピ・ア 進行性のｂｐｄの処置のための肺サーファクタント及びステロイドを含む処置的組み合わせ物
WO2019115771A1 (en) 2017-12-15 2019-06-20 Pari Pharma Gmbh Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method
TW201927286A (zh) 2017-12-15 2019-07-16 義大利商凱西製藥公司 用於噴霧投藥之包含肺表面張力素的藥學調配物
KR20210005614A (ko) 2018-04-23 2021-01-14 키에시 파르마슈티시 엣스. 피. 에이. Bpd의 예방을 위한 폐 계면활성제 및 스테로이드를 포함하는 치료학적 조합물
EP3666316A1 (de) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosolabgabevorrichtung und verfahren zum betrieb der aerosolabgabevorrichtung
EP3666315A1 (de) 2018-12-14 2020-06-17 PARI Pharma GmbH Aerosolabgabevorrichtung und verfahren zum betrieb der aerosolabgabevorrichtung
EP3843105A1 (de) 2019-12-23 2021-06-30 PARI Pharma GmbH Steuerungsvorrichtung für aerosolzerstäubersystem
US20230257446A1 (en) 2020-01-28 2023-08-17 Chiesi Farmaceutici S.P.A. Polypeptides having improved properties
EP4411745A1 (de) 2023-02-01 2024-08-07 Pari Medical Holding GmbH Medizinisches beurteilungsverfahren, aerosolzerstäuber und medizinisches beurteilungssystem

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4562003A (en) * 1984-10-26 1985-12-31 California Biotechnology, Inc. Monoclonal antibodies against alveolar surfactant protein
US4659805A (en) * 1984-12-11 1987-04-21 California Biotechnology, Inc. Recombinant alveolar surfactant protein
US4933280A (en) * 1984-12-11 1990-06-12 California Biotechnology Inc. Recombinant DNA sequence encoding Alveolar Surfactant Protein
WO1987006943A1 (en) * 1986-05-06 1987-11-19 Children's Hospital Medical Center Pulmonary hydrophobic surfactant-associated protein of 6,000 daltons molecular weight and multimers thereof
WO1988003170A1 (en) * 1986-10-24 1988-05-05 Whitsett Jeffrey A Pulmonary hydrophobic surfactant-associated proteins
ATE163013T1 (de) * 1987-11-04 1998-02-15 Byk Gulden Lomberg Chem Fab Alveolare oberflächenaktive proteine
US4861756A (en) * 1988-03-08 1989-08-29 Merrell Dow Pharmaceuticals Inc. Synthetic pulmonary surfactant

Also Published As

Publication number Publication date
EP0593094A2 (de) 1994-04-20
ATE199730T1 (de) 2001-03-15
US5164369A (en) 1992-11-17
DE68929287T2 (de) 2001-07-05
AU3960089A (en) 1989-08-11
EP0593094B1 (de) 2001-03-14
EP0350506B1 (de) 2000-09-13
DE68929248T2 (de) 2001-01-25
AU629233B2 (en) 1992-10-01
JPH02502917A (ja) 1990-09-13
EP0350506A4 (en) 1992-01-22
DK174818B1 (da) 2003-12-01
EP0593094A3 (de) 1994-11-02
FI894187A0 (fi) 1989-09-05
FI102180B (fi) 1998-10-30
JP3009690B2 (ja) 2000-02-14
ATE196298T1 (de) 2000-09-15
DE68929287D1 (de) 2001-04-19
FI102180B1 (fi) 1998-10-30
EP0350506A1 (de) 1990-01-17
WO1989006657A1 (en) 1989-07-27
JPH11262389A (ja) 1999-09-28
DK439089A (da) 1989-09-05
DK439089D0 (da) 1989-09-05

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Legal Events

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8364 No opposition during term of opposition