DE68928946T2 - Verfahren zum aufspüren von diagnostischen oder therapeutischen mitteln durch antikörper - Google Patents
Verfahren zum aufspüren von diagnostischen oder therapeutischen mitteln durch antikörperInfo
- Publication number
- DE68928946T2 DE68928946T2 DE68928946T DE68928946T DE68928946T2 DE 68928946 T2 DE68928946 T2 DE 68928946T2 DE 68928946 T DE68928946 T DE 68928946T DE 68928946 T DE68928946 T DE 68928946T DE 68928946 T2 DE68928946 T2 DE 68928946T2
- Authority
- DE
- Germany
- Prior art keywords
- enzyme
- agent
- antibody
- substrate
- conjugate
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
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- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
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- A61K47/6899—Antibody-Directed Enzyme Prodrug Therapy [ADEPT]
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- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/085—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier conjugated systems
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
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- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
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- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
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Landscapes
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- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Mycology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Fastening Of Light Sources Or Lamp Holders (AREA)
- Arrangement Of Elements, Cooling, Sealing, Or The Like Of Lighting Devices (AREA)
- Non-Portable Lighting Devices Or Systems Thereof (AREA)
- Led Device Packages (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| PCT/US1989/005441 WO1991008770A1 (en) | 1989-12-11 | 1989-12-11 | Method for antibody targeting of diagnostic or therapeutic agents |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68928946D1 DE68928946D1 (de) | 1999-04-15 |
| DE68928946T2 true DE68928946T2 (de) | 1999-10-21 |
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| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68928946T Expired - Fee Related DE68928946T2 (de) | 1989-12-11 | 1989-12-11 | Verfahren zum aufspüren von diagnostischen oder therapeutischen mitteln durch antikörper |
Country Status (7)
| Country | Link |
|---|---|
| EP (1) | EP0505357B1 (enExample) |
| JP (1) | JP3032287B2 (enExample) |
| KR (1) | KR100236375B1 (enExample) |
| AT (1) | ATE177321T1 (enExample) |
| AU (1) | AU649952B2 (enExample) |
| DE (1) | DE68928946T2 (enExample) |
| WO (1) | WO1991008770A1 (enExample) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5773435A (en) * | 1987-08-04 | 1998-06-30 | Bristol-Myers Squibb Company | Prodrugs for β-lactamase and uses thereof |
| US6610299B1 (en) | 1989-10-19 | 2003-08-26 | Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
| DE4106389A1 (de) * | 1991-02-28 | 1992-09-03 | Behringwerke Ag | Fusionsproteine zur prodrug-aktivierung, ihre herstellung und verwendung |
| US7241595B2 (en) | 1989-10-20 | 2007-07-10 | Sanofi-Aventis Pharma Deutschland Gmbh | Glycosyl-etoposide prodrugs, a process for preparation thereof and the use thereof in combination with functionalized tumor-specific enzyme conjugates |
| US5965106A (en) * | 1992-03-04 | 1999-10-12 | Perimmune Holdings, Inc. | In vivo binding pair pretargeting |
| EP0590109A4 (en) * | 1992-03-04 | 1995-04-19 | Akzo Nv | -I (IN VIVO) BINDING TO A PAIR OF TARGETED MOLECULES. |
| DE4233152A1 (de) * | 1992-10-02 | 1994-04-07 | Behringwerke Ag | Antikörper-Enzym-Konjugate zur Prodrug-Aktivierung |
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| FR2523445A1 (fr) * | 1982-03-17 | 1983-09-23 | Sanofi Sa | Nouveaux conjugues associant, par liaison covalente, une enzyme et un anticorps, et associations medicamenteuses utilisant lesdits conjugues |
| US4472509A (en) * | 1982-06-07 | 1984-09-18 | Gansow Otto A | Metal chelate conjugated monoclonal antibodies |
| CA1282069C (en) * | 1985-09-12 | 1991-03-26 | Damon L. Meyer | Antibody complexes of hapten-modified diagnostic or therapeutic agents |
| US4699784A (en) * | 1986-02-25 | 1987-10-13 | Center For Molecular Medicine & Immunology | Tumoricidal methotrexate-antibody conjugate |
| GB8705477D0 (en) * | 1987-03-09 | 1987-04-15 | Carlton Med Prod | Drug delivery systems |
| NZ225599A (en) * | 1987-08-04 | 1991-09-25 | Bristol Myers Co | Antibody-enzyme conjugates and combinations with prodrugs for the treatment of tumour cells |
| GB8809616D0 (en) | 1988-04-22 | 1988-05-25 | Cancer Res Campaign Tech | Further improvements relating to drug delivery systems |
| ES2075893T3 (es) * | 1989-01-23 | 1995-10-16 | Akzo Nobel Nv | Activacion in vivo especifica de sede de farmacos terapeuticos. |
| AU633867B2 (en) * | 1989-02-02 | 1993-02-11 | Eli Lilly And Company | Delivery of cytotoxic agents |
| DE3935016A1 (de) * | 1989-10-20 | 1991-04-25 | Behringwerke Ag | Glycosyl-etoposid-prodrugs, verfahren zu ihrer herstellung und ihre anwendung in kombination mit funktionalisiertem tumorspezifischen enzym-konjugaten |
-
1989
- 1989-12-11 JP JP02508109A patent/JP3032287B2/ja not_active Expired - Fee Related
- 1989-12-11 WO PCT/US1989/005441 patent/WO1991008770A1/en not_active Ceased
- 1989-12-11 KR KR1019910700828A patent/KR100236375B1/ko not_active Expired - Fee Related
- 1989-12-11 DE DE68928946T patent/DE68928946T2/de not_active Expired - Fee Related
- 1989-12-11 AU AU56736/90A patent/AU649952B2/en not_active Ceased
- 1989-12-11 AT AT90908737T patent/ATE177321T1/de not_active IP Right Cessation
- 1989-12-11 EP EP90908737A patent/EP0505357B1/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JPH05501543A (ja) | 1993-03-25 |
| AU649952B2 (en) | 1994-06-09 |
| KR100236375B1 (ko) | 1999-12-15 |
| EP0505357B1 (en) | 1999-03-10 |
| EP0505357A4 (enExample) | 1994-03-16 |
| ATE177321T1 (de) | 1999-03-15 |
| AU5673690A (en) | 1991-07-18 |
| EP0505357A1 (en) | 1992-09-30 |
| WO1991008770A1 (en) | 1991-06-27 |
| JP3032287B2 (ja) | 2000-04-10 |
| DE68928946D1 (de) | 1999-04-15 |
| KR920702819A (ko) | 1992-10-28 |
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