DE68927019T2 - Kassette mit einem kapillaren Detektor für Elektroforese - Google Patents
Kassette mit einem kapillaren Detektor für ElektroforeseInfo
- Publication number
- DE68927019T2 DE68927019T2 DE68927019T DE68927019T DE68927019T2 DE 68927019 T2 DE68927019 T2 DE 68927019T2 DE 68927019 T DE68927019 T DE 68927019T DE 68927019 T DE68927019 T DE 68927019T DE 68927019 T2 DE68927019 T2 DE 68927019T2
- Authority
- DE
- Germany
- Prior art keywords
- cassette
- capillary tube
- capillary
- channel
- replaceable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 238000001962 electrophoresis Methods 0.000 title description 27
- 238000001514 detection method Methods 0.000 claims description 19
- 239000002826 coolant Substances 0.000 claims description 18
- 239000012530 fluid Substances 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 230000003287 optical effect Effects 0.000 claims description 5
- 238000000926 separation method Methods 0.000 claims description 5
- 230000000717 retained effect Effects 0.000 claims 1
- PZNSFCLAULLKQX-UHFFFAOYSA-N Boron nitride Chemical compound N#B PZNSFCLAULLKQX-UHFFFAOYSA-N 0.000 description 14
- 238000001816 cooling Methods 0.000 description 14
- 239000003792 electrolyte Substances 0.000 description 14
- 230000008901 benefit Effects 0.000 description 12
- 238000002347 injection Methods 0.000 description 12
- 239000007924 injection Substances 0.000 description 12
- 229910052582 BN Inorganic materials 0.000 description 10
- 238000010438 heat treatment Methods 0.000 description 10
- 238000005251 capillar electrophoresis Methods 0.000 description 9
- 238000000034 method Methods 0.000 description 9
- 238000007789 sealing Methods 0.000 description 9
- 239000011248 coating agent Substances 0.000 description 7
- 238000000576 coating method Methods 0.000 description 7
- 230000000694 effects Effects 0.000 description 7
- 239000000463 material Substances 0.000 description 5
- 238000005259 measurement Methods 0.000 description 5
- 239000007787 solid Substances 0.000 description 5
- 239000004033 plastic Substances 0.000 description 4
- 239000011253 protective coating Substances 0.000 description 4
- 238000010521 absorption reaction Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 239000011810 insulating material Substances 0.000 description 3
- 238000004949 mass spectrometry Methods 0.000 description 3
- 239000002245 particle Substances 0.000 description 3
- 239000000565 sealant Substances 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- 239000004642 Polyimide Substances 0.000 description 2
- 229910052782 aluminium Inorganic materials 0.000 description 2
- XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 2
- 239000004020 conductor Substances 0.000 description 2
- 238000010276 construction Methods 0.000 description 2
- 239000000110 cooling liquid Substances 0.000 description 2
- 238000009792 diffusion process Methods 0.000 description 2
- 239000012153 distilled water Substances 0.000 description 2
- 230000005684 electric field Effects 0.000 description 2
- 239000000835 fiber Substances 0.000 description 2
- 150000008282 halocarbons Chemical class 0.000 description 2
- 229910052751 metal Inorganic materials 0.000 description 2
- 239000002184 metal Substances 0.000 description 2
- 238000000465 moulding Methods 0.000 description 2
- 229920001721 polyimide Polymers 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000004804 winding Methods 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 1
- WYTGDNHDOZPMIW-RCBQFDQVSA-N alstonine Natural products C1=CC2=C3C=CC=CC3=NC2=C2N1C[C@H]1[C@H](C)OC=C(C(=O)OC)[C@H]1C2 WYTGDNHDOZPMIW-RCBQFDQVSA-N 0.000 description 1
- 238000005266 casting Methods 0.000 description 1
- 238000003486 chemical etching Methods 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000006735 deficit Effects 0.000 description 1
- 238000010292 electrical insulation Methods 0.000 description 1
- 238000004049 embossing Methods 0.000 description 1
- 238000004401 flow injection analysis Methods 0.000 description 1
- 238000001917 fluorescence detection Methods 0.000 description 1
- 229930195733 hydrocarbon Natural products 0.000 description 1
- 150000002430 hydrocarbons Chemical class 0.000 description 1
- 230000001771 impaired effect Effects 0.000 description 1
- 238000007689 inspection Methods 0.000 description 1
- 230000031700 light absorption Effects 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 238000003801 milling Methods 0.000 description 1
- 238000003825 pressing Methods 0.000 description 1
- 229920002379 silicone rubber Polymers 0.000 description 1
- 239000004945 silicone rubber Substances 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000011144 upstream manufacturing Methods 0.000 description 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
- G01N27/26—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating electrochemical variables; by using electrolysis or electrophoresis
- G01N27/416—Systems
- G01N27/447—Systems using electrophoresis
- G01N27/44704—Details; Accessories
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Electrochemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
- Investigating Or Analyzing Materials By The Use Of Electric Means (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18825288A | 1988-04-29 | 1988-04-29 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68927019D1 DE68927019D1 (de) | 1996-10-02 |
| DE68927019T2 true DE68927019T2 (de) | 1997-01-23 |
Family
ID=22692384
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68927019T Expired - Lifetime DE68927019T2 (de) | 1988-04-29 | 1989-03-14 | Kassette mit einem kapillaren Detektor für Elektroforese |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US5198091A (https=) |
| EP (1) | EP0339780B1 (https=) |
| JP (1) | JP2510956Y2 (https=) |
| DE (1) | DE68927019T2 (https=) |
Families Citing this family (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5085757A (en) * | 1987-11-25 | 1992-02-04 | Northeastern University | Integrated temperature control/alignment system for high performance capillary electrophoretic apparatus |
| US4985129A (en) * | 1988-12-02 | 1991-01-15 | Bio-Rad Laboratories, Inc. | Apparatus for capillary electrophoresis |
| US5037523A (en) * | 1990-01-25 | 1991-08-06 | Spectra-Physics, Inc. | Air cooled cartridge for capillary electrophoresis |
| US5066382A (en) * | 1990-01-25 | 1991-11-19 | Spectra-Physics, Inc. | Thermal control for capillary electrophoresis apparatus |
| US5019236A (en) * | 1990-03-19 | 1991-05-28 | Hewlett-Packard Company | Retractable member for fluid, optical and electrical communication in capillary zone electrophoresis |
| US5131997A (en) * | 1990-05-11 | 1992-07-21 | Hewlett-Packard Company | Capillary zone electrophoresis cassette |
| US5122253A (en) * | 1990-05-11 | 1992-06-16 | Hewlett-Packard Company | Transverse forced gas cooling for capillary zone electrophoresis |
| US5269901A (en) * | 1992-11-13 | 1993-12-14 | Bio-Rad Laboratories, Inc. | HPCE capillary cartridge for uncoiled capillaries with liquid coolant |
| US5643717A (en) * | 1992-12-16 | 1997-07-01 | Hybridon, Inc. | Substrate useful for separating modified oligonucleotides |
| US5420265A (en) * | 1992-12-16 | 1995-05-30 | Hybridon, Inc. | Separation of phosphorothioate oligonucleotides by capillary gel electrophoresis |
| US5430541A (en) * | 1993-01-12 | 1995-07-04 | Applied Biosystems Inc. | High efficiency fluorescence flow cell for capillary liquid chromatography or capillary electrophoresis |
| US5605666A (en) * | 1993-04-16 | 1997-02-25 | Beckman Instruments, Inc. | Capillary retaining system |
| US5641400A (en) * | 1994-10-19 | 1997-06-24 | Hewlett-Packard Company | Use of temperature control devices in miniaturized planar column devices and miniaturized total analysis systems |
| US5571410A (en) * | 1994-10-19 | 1996-11-05 | Hewlett Packard Company | Fully integrated miniaturized planar liquid sample handling and analysis device |
| US5885430A (en) * | 1996-10-04 | 1999-03-23 | Spectrumedix Corporation | Capillary tube holder for an electrophoretic apparatus |
| US6063251A (en) * | 1997-05-30 | 2000-05-16 | Spectrumedix Corporation | Electrically insulated capillary arrays for electrophoretic applications |
| US6103081A (en) * | 1996-12-11 | 2000-08-15 | The Regents Of The University Of Michigan | Heat sink for capillary electrophoresis |
| JP3736007B2 (ja) * | 1997-03-03 | 2006-01-18 | 株式会社島津製作所 | マイクロチップ電気泳動装置 |
| US6365024B1 (en) | 1997-06-30 | 2002-04-02 | Spectrumedix Corporation | Motorized positioning apparatus having coaxial carrousels |
| US6027627A (en) * | 1997-06-30 | 2000-02-22 | Spectrumedix Corporation | Automated parallel capillary electrophoretic system |
| JP2001523001A (ja) * | 1997-11-12 | 2001-11-20 | ピーイー コーポレイション （エヌワイ） | 自己修正ベンドをもつ蛇行電気泳動チャネル |
| US6352633B1 (en) * | 1999-08-31 | 2002-03-05 | Spectrumedix Corporation | Automated parallel capillary electrophoresis system with hydrodynamic sample injection |
| US6406604B1 (en) * | 1999-11-08 | 2002-06-18 | Norberto A. Guzman | Multi-dimensional electrophoresis apparatus |
| US7329388B2 (en) * | 1999-11-08 | 2008-02-12 | Princeton Biochemicals, Inc. | Electrophoresis apparatus having staggered passage configuration |
| FR2808089B1 (fr) * | 2000-04-25 | 2002-07-05 | Sebia Sa | Dispositif perfectionne d'analyse d'echantillons par electrophorese multicapillaire a thermo-regulation solide/solide |
| US6544396B1 (en) * | 2000-07-20 | 2003-04-08 | Symyx Technologies, Inc. | Multiplexed capillary electrophoresis system |
| CA2430086A1 (en) * | 2000-12-01 | 2002-06-06 | Cetek Corporation | High throughput capillary electrophoresis system |
| CN1257405C (zh) | 2001-01-26 | 2006-05-24 | 比奥卡尔技术公司 | 多通道生物分离系统中的光学检测 |
| US7309409B2 (en) * | 2001-01-26 | 2007-12-18 | Biocal Technology, Inc. | Multi-channel bio-separation cartridge |
| CN1198020C (zh) * | 2001-06-20 | 2005-04-20 | 谢庆道 | 联体筒桩地下连续墙施工方法及其专用联体筒桩成孔器 |
| US6932940B2 (en) * | 2001-06-22 | 2005-08-23 | Biocal Technology, Inc. | Optical detection in bio-separation device using axial radiation input |
| US6929779B2 (en) | 2001-06-22 | 2005-08-16 | Biocal Technology, Inc. | Optical detection in bio-separation device using axial radiation output |
| DE10142789C1 (de) * | 2001-08-31 | 2003-05-28 | Advalytix Ag | Bewegungselement für kleine Flüssigkeitsmengen |
| US6870165B2 (en) | 2001-10-19 | 2005-03-22 | Biocal Technology, Inc. | Multi-color multiplexed analysis in a bio-separation system |
| WO2003062815A1 (en) * | 2002-01-18 | 2003-07-31 | Biocal Technology, Inc. | Multi-segment cartridge for bio-separation with multiplexed fluorescence detection |
| JP4038386B2 (ja) * | 2002-04-26 | 2008-01-23 | 株式会社日立ハイテクノロジーズ | キャピラリアレイ及び電気泳動装置 |
| US8007724B2 (en) * | 2003-11-07 | 2011-08-30 | Princeton Biochemicals, Inc. | Electrophoresis apparatus having at least one auxiliary buffer passage |
| JP2007510935A (ja) * | 2003-11-07 | 2007-04-26 | プリンストン・バイオケミカルズ・インコーポレーテッド | 多次元電気泳動装置 |
| US8641882B2 (en) * | 2010-06-29 | 2014-02-04 | Waters Technologies Corporation | Capillary column cartridge |
| JP6049621B2 (ja) * | 2010-09-26 | 2016-12-21 | ダ・ユー・エンタープライジズ、エルエルシー | 分析物の分離 |
| EP2872742B1 (en) * | 2012-07-16 | 2022-04-20 | Services Pétroliers Schlumberger | Capillary electrophoresis for reservoir fluid analysis at wellsite and laboratory |
| US10018590B2 (en) | 2013-08-15 | 2018-07-10 | Schlumberger Technology Corporation | Capillary electrophoresis for subterranean applications |
| EP3404407A1 (en) | 2017-05-16 | 2018-11-21 | Universität Basel | Device and method for capillary electrophoresis |
| EP4301494A4 (en) * | 2021-03-04 | 2025-01-22 | ProteinSimple | SHELL CHANNEL FORMATION BETWEEN CAPILLARIES FOR HIGH-THROUGHPUT CAPILLARY ELECTROPHORESIS |
| USD1078086S1 (en) * | 2022-06-03 | 2025-06-03 | Princeton Biochemicals, Inc. | Interchangeable support for a capillary electrophoresis cartridge cassette |
| US20260108878A1 (en) * | 2022-09-22 | 2026-04-23 | Virginia Tech Intellectual Properties, Inc. | Microfluidic modules and interface components |
| USD1054583S1 (en) * | 2023-07-01 | 2024-12-17 | Life Technologies Corporation | Laboratory instrument |
| USD1116152S1 (en) * | 2024-03-29 | 2026-03-03 | Idexx Laboratories, Inc. | Cartridge |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3932264A (en) * | 1973-11-12 | 1976-01-13 | Shimadzu Seisakusho Ltd. | Electrophoretic measurement system including means for determining zone boundries |
| SE386742B (sv) * | 1973-11-14 | 1976-08-16 | Lkb Produkter Ab | Apparat for preparativ, isotachoforetisk separation i mikroskala |
| US4294799A (en) * | 1980-04-24 | 1981-10-13 | Beckman Instruments, Inc. | Temperature regulating apparatus |
| US5144139A (en) * | 1985-08-05 | 1992-09-01 | Biotrack, Inc. | Capillary flow device |
| US4816123A (en) * | 1986-04-16 | 1989-03-28 | The Perkin-Elmer Corporation | Method of fabricating capillary electrophoresis separation channels |
| EP0241940B1 (en) * | 1986-04-16 | 1993-01-27 | The Perkin-Elmer Corporation | Method of forming a capillary element for use in an electrophoresis instrument |
| US4705616A (en) * | 1986-09-15 | 1987-11-10 | Sepragen Corporation | Electrophoresis-mass spectrometry probe |
| EP0304295A1 (en) * | 1987-08-19 | 1989-02-22 | The Board Of Trustees Of The Leland Stanford Junior University | Electrokinetic analysis method and apparatus employing heat removal |
| US5085757A (en) * | 1987-11-25 | 1992-02-04 | Northeastern University | Integrated temperature control/alignment system for high performance capillary electrophoretic apparatus |
| US5045172A (en) * | 1987-11-25 | 1991-09-03 | Princeton Biochemicals, Inc. | Capillary electrophoresis apparatus |
-
1989
- 1989-03-14 DE DE68927019T patent/DE68927019T2/de not_active Expired - Lifetime
- 1989-03-14 EP EP89302490A patent/EP0339780B1/en not_active Expired - Lifetime
- 1989-04-28 JP JP1989049724U patent/JP2510956Y2/ja not_active Expired - Lifetime
-
1990
- 1990-11-13 US US07/614,059 patent/US5198091A/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| JP2510956Y2 (ja) | 1996-09-18 |
| DE68927019D1 (de) | 1996-10-02 |
| EP0339780A3 (en) | 1991-09-04 |
| US5198091A (en) | 1993-03-30 |
| JPH02140355U (https=) | 1990-11-22 |
| EP0339780B1 (en) | 1996-08-28 |
| EP0339780A2 (en) | 1989-11-02 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |