DE68925940T2 - Dideoxy-L-arabinitol Derivate als Antivirus-Verbindungen - Google Patents

Dideoxy-L-arabinitol Derivate als Antivirus-Verbindungen

Info

Publication number
DE68925940T2
DE68925940T2 DE68925940T DE68925940T DE68925940T2 DE 68925940 T2 DE68925940 T2 DE 68925940T2 DE 68925940 T DE68925940 T DE 68925940T DE 68925940 T DE68925940 T DE 68925940T DE 68925940 T2 DE68925940 T2 DE 68925940T2
Authority
DE
Germany
Prior art keywords
compounds
antivirus
dideoxy
arabinitol
derivatives
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68925940T
Other languages
English (en)
Other versions
DE68925940D1 (de
Inventor
Francis Jan Koszyk
Richard Allen Partis
Richard August Mueller
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
GD Searle LLC
Original Assignee
GD Searle LLC
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/266,718 external-priority patent/US4876268A/en
Priority claimed from US07/410,640 external-priority patent/US4973602A/en
Priority claimed from US07/410,638 external-priority patent/US4937357A/en
Application filed by GD Searle LLC filed Critical GD Searle LLC
Application granted granted Critical
Publication of DE68925940D1 publication Critical patent/DE68925940D1/de
Publication of DE68925940T2 publication Critical patent/DE68925940T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • C07C43/166—Unsaturated ethers containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/40—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with ozone; by ozonolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Virology (AREA)
  • Immunology (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
DE68925940T 1988-11-03 1989-10-31 Dideoxy-L-arabinitol Derivate als Antivirus-Verbindungen Expired - Fee Related DE68925940T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/266,718 US4876268A (en) 1988-11-03 1988-11-03 Antiviral compounds and use thereof
US07/410,640 US4973602A (en) 1988-11-03 1989-09-26 Antiviral compounds and a method of use thereas
US07/410,638 US4937357A (en) 1988-11-03 1989-09-26 Intermediates for antiviral compounds

Publications (2)

Publication Number Publication Date
DE68925940D1 DE68925940D1 (de) 1996-04-18
DE68925940T2 true DE68925940T2 (de) 1996-10-24

Family

ID=27401904

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68925940T Expired - Fee Related DE68925940T2 (de) 1988-11-03 1989-10-31 Dideoxy-L-arabinitol Derivate als Antivirus-Verbindungen

Country Status (7)

Country Link
EP (1) EP0367747B1 (de)
JP (1) JP2840334B2 (de)
AT (1) ATE135346T1 (de)
CA (1) CA2002105C (de)
DE (1) DE68925940T2 (de)
ES (1) ES2086323T3 (de)
GR (1) GR3019885T3 (de)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1997009040A1 (en) 1995-09-08 1997-03-13 Novo Nordisk A/S 2-alkylpyrrolidines
EP1037636A4 (de) 1997-12-11 2004-08-18 Univ Oxford Hemmung der membrangebundenen viralen replikation
ES2302697T3 (es) 1999-08-10 2008-08-01 The Chancellor, Masters And Scholars Of The University Of Oxford Compuestos n-alquilicos de cadena larga y derivados oxa de los mismos y uso como composiciones antivirales.
WO2007140184A2 (en) * 2006-05-24 2007-12-06 United Therapeutics Corporation Deoxynojirimycin and d-arabinitol analogs and methods of using

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999360A (en) * 1987-12-21 1991-03-12 Monsanto Company Method of inhibiting virus

Also Published As

Publication number Publication date
ES2086323T3 (es) 1996-07-01
EP0367747A2 (de) 1990-05-09
ATE135346T1 (de) 1996-03-15
EP0367747B1 (de) 1996-03-13
EP0367747A3 (de) 1991-05-08
GR3019885T3 (en) 1996-08-31
CA2002105A1 (en) 1990-05-03
JP2840334B2 (ja) 1998-12-24
CA2002105C (en) 1999-01-19
JPH02172972A (ja) 1990-07-04
DE68925940D1 (de) 1996-04-18

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee