GR3019885T3 - Dideoxy-L-arabinitol derivatives as antiviral compounds - Google Patents

Dideoxy-L-arabinitol derivatives as antiviral compounds

Info

Publication number
GR3019885T3
GR3019885T3 GR960401265T GR960401265T GR3019885T3 GR 3019885 T3 GR3019885 T3 GR 3019885T3 GR 960401265 T GR960401265 T GR 960401265T GR 960401265 T GR960401265 T GR 960401265T GR 3019885 T3 GR3019885 T3 GR 3019885T3
Authority
GR
Greece
Prior art keywords
antiviral compounds
dideoxy
arabinitol
derivatives
alkanoyl
Prior art date
Application number
GR960401265T
Other languages
English (en)
Inventor
Francis Jan Koszyk
Richard Allen Partis
Richard August Mueller
Original Assignee
Searle & Co
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US07/266,718 external-priority patent/US4876268A/en
Priority claimed from US07/410,640 external-priority patent/US4973602A/en
Priority claimed from US07/410,638 external-priority patent/US4937357A/en
Application filed by Searle & Co filed Critical Searle & Co
Publication of GR3019885T3 publication Critical patent/GR3019885T3/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/12—Oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C43/00—Ethers; Compounds having groups, groups or groups
    • C07C43/02—Ethers
    • C07C43/03—Ethers having all ether-oxygen atoms bound to acyclic carbon atoms
    • C07C43/14—Unsaturated ethers
    • C07C43/164—Unsaturated ethers containing six-membered aromatic rings
    • C07C43/166—Unsaturated ethers containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/40—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by oxidation with ozone; by ozonolysis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C47/00—Compounds having —CHO groups
    • C07C47/20—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms
    • C07C47/277—Unsaturated compounds having —CHO groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Virology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Immunology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Engineering & Computer Science (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyrrole Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
GR960401265T 1988-11-03 1996-05-10 Dideoxy-L-arabinitol derivatives as antiviral compounds GR3019885T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US07/266,718 US4876268A (en) 1988-11-03 1988-11-03 Antiviral compounds and use thereof
US07/410,640 US4973602A (en) 1988-11-03 1989-09-26 Antiviral compounds and a method of use thereas
US07/410,638 US4937357A (en) 1988-11-03 1989-09-26 Intermediates for antiviral compounds

Publications (1)

Publication Number Publication Date
GR3019885T3 true GR3019885T3 (en) 1996-08-31

Family

ID=27401904

Family Applications (1)

Application Number Title Priority Date Filing Date
GR960401265T GR3019885T3 (en) 1988-11-03 1996-05-10 Dideoxy-L-arabinitol derivatives as antiviral compounds

Country Status (7)

Country Link
EP (1) EP0367747B1 (el)
JP (1) JP2840334B2 (el)
AT (1) ATE135346T1 (el)
CA (1) CA2002105C (el)
DE (1) DE68925940T2 (el)
ES (1) ES2086323T3 (el)
GR (1) GR3019885T3 (el)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0884050A1 (en) 1995-09-08 1998-12-16 Novo Nordisk A/S Use of 3,4-dihydroxy-2-hydroxymethylpyrrolidine for the treatment of diabetes
EP1037636A4 (en) 1997-12-11 2004-08-18 Univ Oxford INHIBITATION OF MEMBRANE-TIED VIRAL REPLICATION
DE60037664T2 (de) * 1999-08-10 2008-12-24 The Chancellor, Masters And Scholars Of The University Of Oxford Langkettige n-alkyl verbindungen und deren oxa-derivate zur verwendung als anitvirale mittel
EP2023927B1 (en) * 2006-05-24 2015-02-25 United Therapeutics Corporation Deoxynojirimycin and d-arabinitol analogs and methods of using

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4999360A (en) * 1987-12-21 1991-03-12 Monsanto Company Method of inhibiting virus

Also Published As

Publication number Publication date
DE68925940D1 (de) 1996-04-18
CA2002105A1 (en) 1990-05-03
DE68925940T2 (de) 1996-10-24
EP0367747A2 (en) 1990-05-09
EP0367747B1 (en) 1996-03-13
JPH02172972A (ja) 1990-07-04
ATE135346T1 (de) 1996-03-15
EP0367747A3 (en) 1991-05-08
JP2840334B2 (ja) 1998-12-24
ES2086323T3 (es) 1996-07-01
CA2002105C (en) 1999-01-19

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