ATE72435T1 - Derivate von phenyl-, pyrrolidin-2-ylsubstituierten 5-ring heterocyclen mit antipsychotischer wirkung. - Google Patents

Derivate von phenyl-, pyrrolidin-2-ylsubstituierten 5-ring heterocyclen mit antipsychotischer wirkung.

Info

Publication number
ATE72435T1
ATE72435T1 AT87201706T AT87201706T ATE72435T1 AT E72435 T1 ATE72435 T1 AT E72435T1 AT 87201706 T AT87201706 T AT 87201706T AT 87201706 T AT87201706 T AT 87201706T AT E72435 T1 ATE72435 T1 AT E72435T1
Authority
AT
Austria
Prior art keywords
phenyl
pyrrolidin
substituted
sychotic
heterocyclene
Prior art date
Application number
AT87201706T
Other languages
English (en)
Inventor
Wijngaarden Ineke Van
Cornelis G Kruse
Hes Roelof Van
Der Heyden Johannes A M Van
Original Assignee
Duphar Int Res
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Duphar Int Res filed Critical Duphar Int Res
Application granted granted Critical
Publication of ATE72435T1 publication Critical patent/ATE72435T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/333—Radicals substituted by oxygen or sulfur atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/32—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/33—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms with substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • C07D207/335—Radicals substituted by nitrogen atoms not forming part of a nitro radical
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
AT87201706T 1986-09-12 1987-09-09 Derivate von phenyl-, pyrrolidin-2-ylsubstituierten 5-ring heterocyclen mit antipsychotischer wirkung. ATE72435T1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
NL8602305 1986-09-12
EP87201706A EP0259930B1 (de) 1986-09-12 1987-09-09 Derivate von Phenyl-, Pyrrolidin-2-yl-substituierten 5-Ring Heterocyclen mit antipsychotischer Wirkung

Publications (1)

Publication Number Publication Date
ATE72435T1 true ATE72435T1 (de) 1992-02-15

Family

ID=19848538

Family Applications (1)

Application Number Title Priority Date Filing Date
AT87201706T ATE72435T1 (de) 1986-09-12 1987-09-09 Derivate von phenyl-, pyrrolidin-2-ylsubstituierten 5-ring heterocyclen mit antipsychotischer wirkung.

Country Status (14)

Country Link
US (1) US4791132A (de)
EP (1) EP0259930B1 (de)
JP (1) JPH0794432B2 (de)
AT (1) ATE72435T1 (de)
AU (1) AU609415B2 (de)
DE (1) DE3776611D1 (de)
DK (1) DK166275C (de)
ES (1) ES2033297T3 (de)
GR (1) GR3004436T3 (de)
IE (1) IE60294B1 (de)
IL (1) IL83841A (de)
NZ (1) NZ221731A (de)
PH (1) PH23898A (de)
ZA (1) ZA876749B (de)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4992441A (en) * 1987-10-14 1991-02-12 Mcneilab, Inc. 1-[[5-[[4-substituted-1-piperazinyl]methyl]-pyrrol-2-yl or furan-2-yl]methyl-2-piperidinones useful in treating schizophrenia
CA2141791A1 (en) * 1992-08-06 1994-02-17 Geoffrey Stemp 5-(2-oxyphenyl)-pyrrole derivatives as dopamine d3 receptor antagonists
GB9307400D0 (en) * 1993-04-08 1993-06-02 Smithkline Beecham Plc Compounds
GB9309573D0 (en) * 1993-05-10 1993-06-23 Merck Sharp & Dohme Therapeutic agents
JPH08511789A (ja) * 1993-06-25 1996-12-10 スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー フェニルピロール誘導体およびドーパミンｄ３拮抗薬としてのそれらの使用
GB9315801D0 (en) * 1993-07-30 1993-09-15 Smithkline Beecham Plc Compounds
GB9315800D0 (en) * 1993-07-30 1993-09-15 Smithkline Beecham Plc Compounds
GB9320855D0 (en) * 1993-10-09 1993-12-01 Smithkline Beecham Plc Compounds
GB9402197D0 (en) * 1994-02-04 1994-03-30 Smithkline Beecham Plc Compounds
GB9403199D0 (en) * 1994-02-19 1994-04-13 Smithkline Beecham Plc Compounds
GB9512129D0 (en) * 1995-06-15 1995-08-16 Smithkline Beecham Plc Compounds

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4219560A (en) * 1978-04-17 1980-08-26 Sandoz, Inc. Piperidine and pyrrolidine alcohols
DE2835439A1 (de) * 1978-08-12 1980-02-28 Basf Ag 2-(o-hydroxyphenyl)-pyrrol
US4321385A (en) * 1980-02-04 1982-03-23 Hoechst Roussel Pharmaceuticals Inc. [(Aryl-1-pyrryl) methyl]-piperidinols and pyrrolidinols
US4539332A (en) * 1983-11-14 1985-09-03 Merck & Co., Inc. 2,5-Diaryl tetrahydrofurans and analogs thereof as PAF-antagonists

Also Published As

Publication number Publication date
AU609415B2 (en) 1991-05-02
EP0259930B1 (de) 1992-02-05
ES2033297T3 (es) 1993-03-16
JPS6377856A (ja) 1988-04-08
DK166275B (da) 1993-03-29
NZ221731A (en) 1990-07-26
GR3004436T3 (de) 1993-03-31
EP0259930A1 (de) 1988-03-16
DE3776611D1 (de) 1992-03-19
DK470687A (da) 1988-03-13
IL83841A0 (en) 1988-02-29
DK470687D0 (da) 1987-09-09
IE872409L (en) 1988-03-12
DK166275C (da) 1993-08-23
PH23898A (en) 1989-12-18
US4791132A (en) 1988-12-13
ZA876749B (en) 1988-03-14
JPH0794432B2 (ja) 1995-10-11
IE60294B1 (en) 1994-06-29
AU7819187A (en) 1988-03-17
IL83841A (en) 1991-11-21

Similar Documents

Publication Publication Date Title
ATE116306T1 (de) Hypoglykämische oxazolidindion-derivate.
ATE126517T1 (de) Verwendung von bis(3,4- dialkylbenzyliden)sorbitolacetale und diese enthaltende zusammensetzungen.
ATE107636T1 (de) Substituierte phenyl-2-propensäure derivate und ihre verwendung als fungizide.
DK506587D0 (da) Imidderivater
ATE72435T1 (de) Derivate von phenyl-, pyrrolidin-2-ylsubstituierten 5-ring heterocyclen mit antipsychotischer wirkung.
ES2031892T3 (es) Agentes antialergicos y antiinflamatorios.
ATE89003T1 (de) Dioxaphosphorin-verbindungen und damit stabilisierte polyolefin-zusammensetzungen.
ATE141272T1 (de) Beta-lactam-verbindungen und ihre herstellung
ATE145200T1 (de) Pyridyl-cyclopropan-derivate mit fungizider wirkung
ITMI931012A1 (it) Composti spiro-piranici dotati di caratteristiche fotocromatiche
ES2056194T3 (es) Compuestos tetraciclicos antidepresivos.
DK568483D0 (da) Tropyl- og pseudotropylalkylbenzoater
DK348389D0 (da) Phenylpropenderivater
ES2077697T3 (es) Derivados de 1-fenoxicarbonil-2-pirrolidinona y agentes nootropicos.
ES2015297B3 (es) Herbicidas de fenilurea.

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification
REN Ceased due to non-payment of the annual fee