DE68924773T2 - Monoklonale antikörper gegen den bereich der leichten kette von menschlichem faktor xii sowie methoden zu deren herstellung und verwendung. - Google Patents

Monoklonale antikörper gegen den bereich der leichten kette von menschlichem faktor xii sowie methoden zu deren herstellung und verwendung.

Info

Publication number
DE68924773T2
DE68924773T2 DE68924773T DE68924773T DE68924773T2 DE 68924773 T2 DE68924773 T2 DE 68924773T2 DE 68924773 T DE68924773 T DE 68924773T DE 68924773 T DE68924773 T DE 68924773T DE 68924773 T2 DE68924773 T2 DE 68924773T2
Authority
DE
Germany
Prior art keywords
human factor
light chain
monoclonal antibodies
production
methods
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68924773T
Other languages
English (en)
Other versions
DE68924773D1 (de
Inventor
Robin Pixley
Robert Colman
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Temple University of Commonwealth System of Higher Education
Original Assignee
Temple University of Commonwealth System of Higher Education
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Temple University of Commonwealth System of Higher Education filed Critical Temple University of Commonwealth System of Higher Education
Application granted granted Critical
Publication of DE68924773D1 publication Critical patent/DE68924773D1/de
Publication of DE68924773T2 publication Critical patent/DE68924773T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6451—Coagulation factor XIIa (3.4.21.38)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Y—ENZYMES
    • C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
    • C12Y304/21—Serine endopeptidases (3.4.21)
    • C12Y304/21038—Coagulation factor XIIa (3.4.21.38)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Immunology (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
DE68924773T 1988-06-09 1989-05-26 Monoklonale antikörper gegen den bereich der leichten kette von menschlichem faktor xii sowie methoden zu deren herstellung und verwendung. Expired - Fee Related DE68924773T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/204,657 US4963657A (en) 1988-06-09 1988-06-09 Monoclonal antibodies to the light chain region of human factor XII and methods of preparing and using the same
PCT/US1989/002211 WO1989011865A1 (en) 1988-06-09 1989-05-26 Monoclonal antibodies to the light chain region of human factor xii and methods of preparing and using the same

Publications (2)

Publication Number Publication Date
DE68924773D1 DE68924773D1 (de) 1995-12-14
DE68924773T2 true DE68924773T2 (de) 1996-05-15

Family

ID=22758870

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68924773T Expired - Fee Related DE68924773T2 (de) 1988-06-09 1989-05-26 Monoklonale antikörper gegen den bereich der leichten kette von menschlichem faktor xii sowie methoden zu deren herstellung und verwendung.

Country Status (7)

Country Link
US (1) US4963657A (de)
EP (1) EP0419574B1 (de)
JP (1) JPH03505665A (de)
AT (1) ATE129902T1 (de)
CA (1) CA1315716C (de)
DE (1) DE68924773T2 (de)
WO (1) WO1989011865A1 (de)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8901859D0 (en) * 1989-01-27 1989-03-15 Shield Diagnostics Limited Diagnostic test
US5500349A (en) * 1989-01-27 1996-03-19 Coagen Limited Blood-coagulation factor XIIA β monoclonal antibody and immunoassay
AU7793291A (en) * 1990-05-10 1991-11-27 Cetus Corporation Inhibitors of factor xii activation and applications thereof
JPH06505496A (ja) * 1991-03-11 1994-06-23 ザ・ジェネラル・ホスピタル・コーポレーション 活性因子ｘ１１１の活性化を阻害するための組成物と方法
FR2696095B1 (fr) * 1992-09-30 1994-11-25 Inoteb Colle biologique à base de protéines coagulables par la thrombine, enrichie en facteurs plaquettaires, sa préparation et son application.
US5846933A (en) 1996-06-28 1998-12-08 Korngold; Robert CD-4 derived peptides that inhibit immune responses
US7345020B2 (en) * 1995-06-29 2008-03-18 Thomas Jefferson University Mimetics of CD4 that inhibit immune response
BR0317404A (pt) * 2002-12-20 2005-11-16 Axis Shield Diagnostics Ltd Variantes do fator xiia
EP1830924B1 (de) * 2004-12-23 2013-02-27 CSL Behring GmbH Verhinderung der thrombusbildung und/oder stabilisierung
GB0607515D0 (en) * 2006-04-13 2006-05-24 Axis Shield Diagnostics Ltd Anti-factor xlla therapy
ES2702365T3 (es) 2008-06-19 2019-02-28 Prothix Bv Uso de anticuerpos antifactor XI para la prevención o el tratamiento de la formación de trombos
SE1050124A1 (sv) 2010-02-08 2011-08-09 Linkoping Biocontrols Ab Stabil lösning
EP2371857A1 (de) * 2010-04-01 2011-10-05 CSL Behring GmbH Faktor-XII-Inhibitoren zur Behandlung von interstitieller Pneumonie
CA2841185C (en) 2011-07-22 2021-05-25 Csl Behring Gmbh Inhibitory anti -factor xii/xiia monoclonal antibodies and their uses
EP2548892A1 (de) 2011-07-22 2013-01-23 CSL Behring GmbH Inhibitorische Antikörper gegen Factor XII/XIIa und ihre Verwendungen
EP2623110A1 (de) 2012-01-31 2013-08-07 CSL Behring GmbH Faktor-XII-Hemmer zur Behandlung neurologischer Entzündungserkrankungen
EP2964255B1 (de) 2013-03-08 2020-11-04 CSL Behring GmbH Behandlung und vorbeugung eines entfernten ischämiebedingten reperfusionsschadens
EP3013366B1 (de) 2013-06-28 2021-08-25 CSL Behring GmbH Kombinationstherapie mit einem faktor xii-hemmer und einem c1-hemmer
AU2015276089B2 (en) 2014-06-18 2021-03-18 Csl Behring Gmbh Therapy using a Factor XII inhibitor in a neurotraumatic disorder
CN107405399B (zh) 2015-01-02 2022-02-08 武田药品工业株式会社 针对血浆激肽释放酶和因子xii的双特异性抗体
JOP20200312A1 (ar) 2015-06-26 2017-06-16 Novartis Ag الأجسام المضادة للعامل xi وطرق الاستخدام
NZ739088A (en) 2015-07-21 2024-01-26 Takeda Pharmaceuticals Co A monoclonal antibody inhibitor of factor xiia
CN109071629A (zh) * 2016-04-06 2018-12-21 杰特有限公司 治疗动脉粥样硬化的方法
TW201802121A (zh) 2016-05-25 2018-01-16 諾華公司 抗因子XI/XIa抗體之逆轉結合劑及其用途
CN110325550B (zh) 2016-12-23 2024-03-08 诺华股份有限公司 因子xi抗体和使用方法
CA3104470A1 (en) 2018-06-19 2019-12-26 Regeneron Pharmaceuticals, Inc. Anti-factor xii/xiia antibodies and uses thereof

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8901859D0 (en) * 1989-01-27 1989-03-15 Shield Diagnostics Limited Diagnostic test

Also Published As

Publication number Publication date
EP0419574A4 (en) 1991-05-02
US4963657A (en) 1990-10-16
DE68924773D1 (de) 1995-12-14
WO1989011865A1 (en) 1989-12-14
CA1315716C (en) 1993-04-06
JPH03505665A (ja) 1991-12-12
EP0419574B1 (de) 1995-11-08
EP0419574A1 (de) 1991-04-03
ATE129902T1 (de) 1995-11-15

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee