DE68923883D1 - Verfahren zur herstellung optisch aktiver glycidat-ester. - Google Patents
Verfahren zur herstellung optisch aktiver glycidat-ester.Info
- Publication number
- DE68923883D1 DE68923883D1 DE68923883T DE68923883T DE68923883D1 DE 68923883 D1 DE68923883 D1 DE 68923883D1 DE 68923883 T DE68923883 T DE 68923883T DE 68923883 T DE68923883 T DE 68923883T DE 68923883 D1 DE68923883 D1 DE 68923883D1
- Authority
- DE
- Germany
- Prior art keywords
- ester
- product
- methoxyphenyl
- disclosed
- production
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- -1 GLYCIDATE ESTER Chemical class 0.000 title abstract 3
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 238000000034 method Methods 0.000 abstract 4
- 238000006243 chemical reaction Methods 0.000 abstract 3
- 150000002148 esters Chemical class 0.000 abstract 3
- 230000002255 enzymatic effect Effects 0.000 abstract 2
- 239000000047 product Substances 0.000 abstract 2
- 229940127291 Calcium channel antagonist Drugs 0.000 abstract 1
- 239000006227 byproduct Substances 0.000 abstract 1
- 239000000480 calcium channel blocker Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- HSUGRBWQSSZJOP-RTWAWAEBSA-N diltiazem Chemical compound C1=CC(OC)=CC=C1[C@H]1[C@@H](OC(C)=O)C(=O)N(CCN(C)C)C2=CC=CC=C2S1 HSUGRBWQSSZJOP-RTWAWAEBSA-N 0.000 abstract 1
- 229960004166 diltiazem Drugs 0.000 abstract 1
- 238000010931 ester hydrolysis Methods 0.000 abstract 1
- 125000002485 formyl group Chemical class [H]C(*)=O 0.000 abstract 1
- 230000002401 inhibitory effect Effects 0.000 abstract 1
- 239000012528 membrane Substances 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 230000000707 stereoselective effect Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
- 238000000844 transformation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D303/00—Compounds containing three-membered rings having one oxygen atom as the only ring hetero atom
- C07D303/02—Compounds containing oxirane rings
- C07D303/48—Compounds containing oxirane rings with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms, e.g. ester or nitrile radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
- C07D281/02—Seven-membered rings
- C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
- C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
- C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
- C12P17/02—Oxygen as only ring hetero atoms
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Wood Science & Technology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26517188A | 1988-10-26 | 1988-10-26 | |
| US07/309,769 US5274300A (en) | 1988-10-26 | 1989-02-10 | Enzymatic hydrolysis of glycidate esters in the presence of bisulfite anion |
| US07/335,636 US6521445B1 (en) | 1988-10-26 | 1989-04-10 | Process for preparing optically active glycidate esters |
| PCT/US1989/004784 WO1990004643A1 (en) | 1988-10-26 | 1989-10-26 | Process for preparing optically active glycidate esters |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68923883D1 true DE68923883D1 (de) | 1995-09-21 |
| DE68923883T2 DE68923883T2 (de) | 1995-12-14 |
Family
ID=27401773
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68923883T Expired - Lifetime DE68923883T2 (de) | 1988-10-26 | 1989-10-26 | Verfahren zur herstellung optisch aktiver glycidat-ester. |
| DE68928516T Expired - Lifetime DE68928516D1 (de) | 1988-10-26 | 1989-10-26 | Verfahren zur Herstellung von optisch aktiven Glycidat-Estern |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE68928516T Expired - Lifetime DE68928516D1 (de) | 1988-10-26 | 1989-10-26 | Verfahren zur Herstellung von optisch aktiven Glycidat-Estern |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US6521445B1 (de) |
| EP (2) | EP0657544B1 (de) |
| JP (1) | JP2693248B2 (de) |
| AT (2) | ATE161583T1 (de) |
| AU (1) | AU4497289A (de) |
| CA (1) | CA2001515C (de) |
| DE (2) | DE68923883T2 (de) |
| IL (1) | IL92122A (de) |
| WO (1) | WO1990004643A1 (de) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| NL8801311A (nl) * | 1988-05-20 | 1989-12-18 | Stamicarbon | Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem. |
| JP2687789B2 (ja) * | 1991-08-13 | 1997-12-08 | 田辺製薬株式会社 | 光学活性３−フェニルグリシッド酸エステル類化合物の製法 |
| FI93833C (fi) * | 1992-05-14 | 1995-06-12 | Orion Yhtymae Oy | Menetelmä propionihappojohdosten valmistamiseksi |
| US5273895A (en) * | 1992-10-26 | 1993-12-28 | Sepracor, Inc. | Enantioselective production of chiral carboxylic acids |
| NL9202208A (nl) * | 1992-12-18 | 1994-07-18 | Dsm Nv | Werkwijze voor de enzymatische bereiding van optisch aktieve glycidezure esters. |
| US5770438A (en) * | 1994-11-01 | 1998-06-23 | Takeda Chemical Industries, Ltd. | Process for enantioselective hydrolysis of α-(2-amino)-phenyl-benzenemethanol ester type compounds using bacillus, pseudomonas or streptomyces |
| TW438787B (en) * | 1997-02-27 | 2001-06-07 | Tanabe Seiyaku Co | Process for preparing optically active trans-3-substituted glycidic acid ester |
| EP1051480A2 (de) * | 1998-01-26 | 2000-11-15 | Pharm-Eco Laboratoires, Incorporated | Enzym-aktivierte träger für enantiomer-trennung |
| WO2014030106A2 (en) * | 2012-08-18 | 2014-02-27 | Unimark Remedies Ltd. | Process for preparation of optically active (2r,3s)-3-(4- methoxyphenyl)glycidic acid methyl ester and cis lactam and uses thereof |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3635795A (en) * | 1968-12-27 | 1972-01-18 | Merck & Co Inc | Enzymatic resolution of racemic (cis-1,2-epoxypropyl) phosphonic acid compounds |
| US4585768A (en) * | 1984-04-10 | 1986-04-29 | Tanabe Seiyaku Co., Ltd. | 1,5-benzothiazepine derivatives and processes for preparing the same |
| US4732853A (en) * | 1984-11-21 | 1988-03-22 | President And Fellows Of Harvard College | Method of making chiral epoxy alcohols |
| IT1189069B (it) * | 1986-03-14 | 1988-01-28 | Donegani Guido Ist | Processo per la preparazione biotecnologica della l(-)-carnitina cloruro |
| WO1987006269A1 (en) * | 1986-04-16 | 1987-10-22 | Sumitomo Chemical Company, Limited | Process for preparing optically active cyclopropanecarboxylic acids |
| JPS6315398A (ja) * | 1986-07-07 | 1988-01-22 | 株式会社東芝 | 状態監視用端末装置 |
| US4800162A (en) * | 1987-04-01 | 1989-01-24 | Sepracor, Inc. | Method for resolution of steroisomers in multiphase and extractive membrane reactors |
| JP2627627B2 (ja) * | 1987-11-09 | 1997-07-09 | 昭和飛行機工業株式会社 | 保冷コンテナ |
| NL8801311A (nl) * | 1988-05-20 | 1989-12-18 | Stamicarbon | Fenylglycidaatstereoisomeren, omzettingsprodukten daarvan met 2-nitrothiofenol en de bereiding van diltiazem. |
| FI95931C (fi) * | 1988-09-02 | 1996-04-10 | Tanabe Seiyaku Co | Menetelmä (2R,3S)-3-(4-metoksifenyyli)glysidiinihapon alemman alkyyliesterin valmistamiseksi |
| JPH0678A (ja) * | 1992-06-22 | 1994-01-11 | Fujiwara Techno Art:Kk | 固体培養装置の空気調和装置における加湿方法 |
-
1989
- 1989-04-10 US US07/335,636 patent/US6521445B1/en not_active Expired - Lifetime
- 1989-10-25 CA CA002001515A patent/CA2001515C/en not_active Expired - Lifetime
- 1989-10-26 AT AT95200168T patent/ATE161583T1/de not_active IP Right Cessation
- 1989-10-26 AU AU44972/89A patent/AU4497289A/en not_active Abandoned
- 1989-10-26 DE DE68923883T patent/DE68923883T2/de not_active Expired - Lifetime
- 1989-10-26 WO PCT/US1989/004784 patent/WO1990004643A1/en active IP Right Grant
- 1989-10-26 JP JP1511470A patent/JP2693248B2/ja not_active Expired - Lifetime
- 1989-10-26 DE DE68928516T patent/DE68928516D1/de not_active Expired - Lifetime
- 1989-10-26 EP EP95200168A patent/EP0657544B1/de not_active Expired - Lifetime
- 1989-10-26 EP EP89912309A patent/EP0440723B1/de not_active Expired - Lifetime
- 1989-10-26 AT AT89912309T patent/ATE126541T1/de not_active IP Right Cessation
- 1989-10-26 IL IL9212289A patent/IL92122A/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0440723A1 (de) | 1991-08-14 |
| IL92122A0 (en) | 1990-07-12 |
| US6521445B1 (en) | 2003-02-18 |
| JP2693248B2 (ja) | 1997-12-24 |
| DE68928516D1 (de) | 1998-02-05 |
| CA2001515C (en) | 2005-05-10 |
| ATE161583T1 (de) | 1998-01-15 |
| CA2001515A1 (en) | 1990-04-26 |
| ATE126541T1 (de) | 1995-09-15 |
| AU4497289A (en) | 1990-05-14 |
| EP0657544A1 (de) | 1995-06-14 |
| JPH04501360A (ja) | 1992-03-12 |
| EP0440723B1 (de) | 1995-08-16 |
| WO1990004643A1 (en) | 1990-05-03 |
| IL92122A (en) | 1996-06-18 |
| EP0440723A4 (en) | 1992-05-20 |
| DE68923883T2 (de) | 1995-12-14 |
| EP0657544B1 (de) | 1997-12-29 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition |