DE68918860D1 - Photoempfindliche mittel. - Google Patents

Photoempfindliche mittel.

Info

Publication number
DE68918860D1
DE68918860D1 DE68918860T DE68918860T DE68918860D1 DE 68918860 D1 DE68918860 D1 DE 68918860D1 DE 68918860 T DE68918860 T DE 68918860T DE 68918860 T DE68918860 T DE 68918860T DE 68918860 D1 DE68918860 D1 DE 68918860D1
Authority
DE
Germany
Prior art keywords
compounds
tissue
pyropheophorbide
photodynamic therapy
tumor
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
DE68918860T
Other languages
English (en)
Other versions
DE68918860T2 (de
Inventor
Ravindra Pandey
Thomas Dougherty
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Health Research Inc
Original Assignee
Health Research Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Health Research Inc filed Critical Health Research Inc
Publication of DE68918860D1 publication Critical patent/DE68918860D1/de
Application granted granted Critical
Publication of DE68918860T2 publication Critical patent/DE68918860T2/de
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A61K41/0057—Photodynamic therapy with a photosensitizer, i.e. agent able to produce reactive oxygen species upon exposure to light or radiation, e.g. UV or visible light; photocleavage of nucleic acids with an agent
    • A61K41/0071—PDT with porphyrins having exactly 20 ring atoms, i.e. based on the non-expanded tetrapyrrolic ring system, e.g. bacteriochlorin, chlorin-e6, or phthalocyanines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
    • A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
DE68918860T 1988-07-20 1989-07-19 Photoempfindliche mittel. Expired - Fee Related DE68918860T2 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/221,804 US5002962A (en) 1988-07-20 1988-07-20 Photosensitizing agents
PCT/US1989/003115 WO1990000895A1 (en) 1988-07-20 1989-07-19 New photosensitizing agents

Publications (2)

Publication Number Publication Date
DE68918860D1 true DE68918860D1 (de) 1994-11-17
DE68918860T2 DE68918860T2 (de) 1995-02-16

Family

ID=22829459

Family Applications (1)

Application Number Title Priority Date Filing Date
DE68918860T Expired - Fee Related DE68918860T2 (de) 1988-07-20 1989-07-19 Photoempfindliche mittel.

Country Status (7)

Country Link
US (3) US5002962A (de)
EP (1) EP0425566B1 (de)
JP (1) JPH04500955A (de)
AT (1) ATE112680T1 (de)
AU (1) AU641362B2 (de)
DE (1) DE68918860T2 (de)
WO (1) WO1990000895A1 (de)

Families Citing this family (111)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4968715A (en) * 1988-07-06 1990-11-06 Health Research, Inc. Use of purified hematoporphyrin trimers in photodynamic therapy
USRE38994E1 (en) 1988-07-20 2006-02-28 Health Research, Inc. Pyropheophorbides conjugates and their use in photodynamic therapy
US5002962A (en) * 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
USRE39094E1 (en) * 1988-07-20 2006-05-09 Health Research, Inc. Pyropheophorbides and their use in photodynamic therapy
US5198460A (en) * 1988-07-20 1993-03-30 Health Research Inc. Pyropheophorbides and their use in photodynamic therapy
CN1039283C (zh) * 1988-12-12 1998-07-29 Fmc公司 卟啉的应用
US5219878A (en) * 1990-10-05 1993-06-15 Queen's University Tetrapyrrole hydroxyalkylamide photochemotherapeutic agents
IL102645A (en) * 1992-07-26 1998-02-22 Yeda Res & Dev Chlorophyll and bacteriochlorophyll derivatives, their preparation and pharmaceutical compositions comprising them
US6100392A (en) * 1992-08-14 2000-08-08 The Trustees Of The University Of Pennsylavania Electron-deficient porphyrins and processes and intermediates for preparing same
US5422362A (en) * 1993-07-29 1995-06-06 Quadra Logic Technologies, Inc. Method to inhibit restenosis
US5492924A (en) * 1993-09-24 1996-02-20 Fox Chase Cancer Center Phorbine derivatives and their use in the diagnosis and therapy of cancer
US5591847A (en) * 1994-05-23 1997-01-07 Health Research, Inc. Long wavelength absorbing photosensitizers related to purpurin-18, bacteriopurpurin-18 and related compounds with imide linkages
US5882328A (en) * 1995-01-13 1999-03-16 Qlt Phototherapeutics, Inc. Method to prevent transplant rejection
US6316007B1 (en) 1995-04-04 2001-11-13 Wound Healing Of Oklahoma Combined physical and immunotherapy for cancer
CA2215978A1 (en) * 1995-04-04 1996-10-10 Wound Healing Of Oklahoma Cancer treatment by photodynamic therapy, in combination with an immunoadjuvant
CA2231114A1 (en) 1995-09-06 1997-03-13 The Research Foundation Of State University Of New York Two-photon upconverting dyes and applications
US5877165A (en) * 1995-11-02 1999-03-02 Brookhaven Science Associates Boronated porhyrins and methods for their use
US5770730A (en) * 1996-03-08 1998-06-23 Health Research, Inc. Synthesis of carbodimide analogs of chlorins and bacteriochlorins and their use for diagnosis and treatment of cancer
US5952366A (en) * 1996-03-08 1999-09-14 Health Research, Inc. Alkyl ether analogs of chlorins having an N-substituted imide ring
US6756396B1 (en) * 1997-05-07 2004-06-29 Qlt Inc. Ethylene glycol esters as photoactive agents
US6331537B1 (en) 1998-06-03 2001-12-18 Gpi Nil Holdings, Inc. Carboxylic acids and carboxylic acid isosteres of N-heterocyclic compounds
US6103751A (en) * 1998-06-22 2000-08-15 Health Research, Inc. Carotene analogs of porphyrins, chlorins and bacteriochlorins as therapeutic and diagnostic agents
IL143591A0 (en) * 1998-12-09 2002-04-21 Yeda Res & Dev Palladium-substituted bacteriochlorophyll derivatives and use thereof
DE60001629T2 (de) * 1999-01-15 2003-12-18 Light Sciences Corp Therapeutische zusammensetzungen fur knochenstoffwechselstörungen oder knochenmetastasen enthaltend einen photosensitizer und ein bisphosphonat
US6602274B1 (en) 1999-01-15 2003-08-05 Light Sciences Corporation Targeted transcutaneous cancer therapy
US6454789B1 (en) * 1999-01-15 2002-09-24 Light Science Corporation Patient portable device for photodynamic therapy
EP1131099A2 (de) * 1999-01-15 2001-09-12 Light Sciences Corporation Nichtinvasiven vaskulären therapie
US20040229295A1 (en) * 1999-05-17 2004-11-18 Marchitto Kevin S. Activated delivery of biomolecules using electromagnetic energy
US6376483B1 (en) 1999-05-27 2002-04-23 Miravant Pharmaceuticals, Inc. Bacteriochlorins and bacteriopurpurins useful as photoselective compounds for photodynamic therapy and a process for their production
US6417189B1 (en) 1999-11-12 2002-07-09 Gpi Nil Holdings, Inc. AZA compounds, pharmaceutical compositions and methods of use
US7045117B2 (en) * 1999-12-01 2006-05-16 Yeda Research And Development Co. Ltd. Method for tumor diagnosis comprising administering of palladium-substituted bacteriochlorophyll derivatives
DE60026568D1 (de) 1999-12-21 2006-05-04 Mgi Gp Inc Hydantoin derivate, pharmazeutische zusammensetzungen und verfahren zu ihrer verwendung
US7078014B2 (en) * 1999-12-23 2006-07-18 Health Research, Inc. Method for using chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US7897140B2 (en) * 1999-12-23 2011-03-01 Health Research, Inc. Multi DTPA conjugated tetrapyrollic compounds for phototherapeutic contrast agents
US7097826B2 (en) * 1999-12-23 2006-08-29 Health Research, Inc. Chlorin and bacteriochlorin-based difunctional aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
US6534040B2 (en) 1999-12-23 2003-03-18 Health Research, Inc. Chlorin and bacteriochlorin-based aminophenyl DTPA and N2S2 conjugates for MR contrast media and radiopharmaceuticals
CA2395567A1 (en) 2000-01-12 2001-07-19 Light Sciences Corporation Novel treatment for eye disease
US6794505B1 (en) * 2000-03-30 2004-09-21 Miravant Pharmaceuticals, Inc. Chlorins possessing fused ring systems useful as photoselective compounds for photodynamic therapy
US6624187B1 (en) * 2000-06-12 2003-09-23 Health Research, Inc. Long wave length absorbing bacteriochlorin alkyl ether analogs
US6462192B2 (en) 2001-01-23 2002-10-08 Miravant Pharmaceuticals, Inc. Processes for large scale production of tetrapyrroles
US20030031655A1 (en) * 2001-02-08 2003-02-13 Sequitur, Inc. Methods of light activated release of ligands from endosomes
US6495585B2 (en) * 2001-03-07 2002-12-17 Health Research, Inc. Method for treating hyperproliferative tissue in a mammal
US6894161B2 (en) * 2001-03-27 2005-05-17 The University Of British Columbia Methods and compositions for photo-cross linking photoactive compounds to target tissue
RU2183956C1 (ru) 2001-03-30 2002-06-27 Общество с ограниченной ответственностью "РАДА-ФАРМА" Фотосенсибилизатор и способ его получения
US20030203888A1 (en) * 2001-06-06 2003-10-30 Boyle Ross William Chromophores
GB0130778D0 (en) * 2001-12-21 2002-02-06 Catalyst Biomedica Ltd Novel compounds
US20030167033A1 (en) * 2002-01-23 2003-09-04 James Chen Systems and methods for photodynamic therapy
US6846311B2 (en) * 2002-04-02 2005-01-25 Acueity, Inc. Method and apparatus for in VIVO treatment of mammary ducts by light induced fluorescence
AU2003248747A1 (en) 2002-06-27 2004-01-19 Health Research, Inc. Fluorinated chlorin and bacteriochlorin photosensitizers for photodynamic therapy
EP2036908A3 (de) * 2002-07-02 2009-05-13 Health Research, INC. Effiziente Synthese von Pyropheophorbid-A-Derivaten
US20060231107A1 (en) * 2003-03-07 2006-10-19 Glickman Randolph D Antibody-targeted photodynamic therapy
US7057100B2 (en) * 2003-06-26 2006-06-06 The J.C. Robinson Seed Co. Inbred corn line W23129
US20060141049A1 (en) * 2003-11-12 2006-06-29 Allergan, Inc. Triamcinolone compositions for intravitreal administration to treat ocular conditions
US20050101582A1 (en) 2003-11-12 2005-05-12 Allergan, Inc. Compositions and methods for treating a posterior segment of an eye
US20070224278A1 (en) * 2003-11-12 2007-09-27 Lyons Robert T Low immunogenicity corticosteroid compositions
US20050250737A1 (en) * 2003-11-12 2005-11-10 Allergan, Inc. Therapeutic ophthalmic compositions containing retinal friendly excipients and related methods
EP1541091A1 (de) * 2003-12-10 2005-06-15 EL.EN. S.p.A. Vorrichtung zur Tumorbehandlung mittels Laser-Thermotherapie
CA2553381C (en) 2004-01-20 2011-03-22 Allergan, Inc. Compositions for localized therapy of the eye, comprising preferably triamcinolone acetonide and hyaluronic acid
US20050244463A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular vasculopathies
US8722097B2 (en) 2004-04-30 2014-05-13 Allergan, Inc. Oil-in-water method for making polymeric implants containing a hypotensive lipid
US8455656B2 (en) 2004-04-30 2013-06-04 Allergan, Inc. Kinase inhibitors
US20050244478A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Anti-excititoxic sustained release intraocular implants and related methods
US7993634B2 (en) 2004-04-30 2011-08-09 Allergan, Inc. Oil-in-oil emulsified polymeric implants containing a hypotensive lipid and related methods
US8147865B2 (en) * 2004-04-30 2012-04-03 Allergan, Inc. Steroid-containing sustained release intraocular implants and related methods
US8591885B2 (en) * 2004-04-30 2013-11-26 Allergan, Inc. Carbonic anhydrase inhibitor sustained release intraocular drug delivery systems
US20070059336A1 (en) * 2004-04-30 2007-03-15 Allergan, Inc. Anti-angiogenic sustained release intraocular implants and related methods
BRPI0510485A (pt) 2004-04-30 2007-11-13 Allergan Inc implantes inibidores de tirosina cinase intravìtreos biodegradáveis
US20050244471A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Estradiol derivative and estratopone containing sustained release intraocular implants and related methods
US20050244465A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Drug delivery systems and methods for treatment of an eye
US20050244466A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Photodynamic therapy in conjunction with intraocular implants
US9498457B2 (en) 2004-04-30 2016-11-22 Allergan, Inc. Hypotensive prostamide-containing biodegradable intraocular implants and related implants
US20050244500A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Intravitreal implants in conjuction with photodynamic therapy to improve vision
US8425929B2 (en) * 2004-04-30 2013-04-23 Allergan, Inc. Sustained release intraocular implants and methods for preventing retinal dysfunction
US8119154B2 (en) * 2004-04-30 2012-02-21 Allergan, Inc. Sustained release intraocular implants and related methods
US20050244461A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Controlled release drug delivery systems and methods for treatment of an eye
US20050244458A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Sustained release intraocular implants and methods for treating ocular neuropathies
US7799336B2 (en) 2004-04-30 2010-09-21 Allergan, Inc. Hypotensive lipid-containing biodegradable intraocular implants and related methods
US7771742B2 (en) 2004-04-30 2010-08-10 Allergan, Inc. Sustained release intraocular implants containing tyrosine kinase inhibitors and related methods
US20050244462A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Devices and methods for treating a mammalian eye
US20050244472A1 (en) * 2004-04-30 2005-11-03 Allergan, Inc. Intraocular drug delivery systems containing excipients with reduced toxicity and related methods
US8673341B2 (en) * 2004-04-30 2014-03-18 Allergan, Inc. Intraocular pressure reduction with intracameral bimatoprost implants
AU2005271700B2 (en) * 2004-07-12 2010-11-11 Allergan, Inc. Opthalmic compositions and methods for treating ophthalmic conditions
JP4733126B2 (ja) * 2004-07-16 2011-07-27 ヘルス リサーチ インコーポレイテッド 蛍光色素と腫瘍親和性テトラピロールの付加物
WO2006020979A2 (en) * 2004-08-13 2006-02-23 Yale University Factor vii conjugates for selectively treating neovascularization disorders
US20060223750A1 (en) * 2005-04-01 2006-10-05 Allergan, Inc. Agents and methods for enhancing photodynamic therapy
US8969415B2 (en) 2006-12-01 2015-03-03 Allergan, Inc. Intraocular drug delivery systems
KR20090108071A (ko) * 2007-01-09 2009-10-14 헬스 리서치 인코포레이티드 광역학 치료를 이용한 식도의 고 등급 형성이상증의 치료
US20100144820A1 (en) * 2007-01-09 2010-06-10 Health Research, Inc. Therapeutic hpph dosage for pdt
US7911053B2 (en) * 2007-04-19 2011-03-22 Marvell World Trade Ltd. Semiconductor packaging with internal wiring bus
KR100912446B1 (ko) 2007-09-12 2009-08-14 인제대학교 산학협력단 항암활성을 가지는 클로린 유도체
WO2009038660A1 (en) * 2007-09-14 2009-03-26 Health Research, Inc. Multimodality agents for tumor imaging and therapy
US20100056983A1 (en) * 2007-09-27 2010-03-04 Health Research, Inc. Treatment of cancer using photodynamic therapy
RU2367434C1 (ru) * 2008-04-22 2009-09-20 Виктор Александрович Борисов Фотосенсибилизатор и способ его получения
WO2011009020A2 (en) 2009-07-16 2011-01-20 Mallinckrodt Inc. Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
BR122017013201B1 (pt) 2009-11-09 2018-05-15 Allergan, Inc. Composição para a estimulação de crescimento capilar
US8609837B2 (en) 2010-07-06 2013-12-17 Health Research, Inc. Metallation enhancements in tumor-imaging and PDT therapy
KR20140117487A (ko) 2012-01-20 2014-10-07 임무노포토닉스 인코퍼레이티드 키토산 유래 조성물
US11773188B2 (en) 2012-01-20 2023-10-03 Immunophotonics, Inc Chitosan-derived compositions
CN103705532B (zh) 2012-10-08 2016-09-14 浙江海正药业股份有限公司 靶向胸苷激酶光敏剂及其药物组合物与治疗癌症的用途
US9642916B2 (en) * 2012-12-12 2017-05-09 The Regents Of The University Of California Porphyrin modified telodendrimers
WO2014091241A1 (en) * 2012-12-14 2014-06-19 Rmw Cho Group Limited Chlorin derivative useful in photodynamic therapy and diagnosis
CA2901280A1 (en) 2013-02-15 2014-08-21 Allergan, Inc. Sustained drug delivery implant
CA2877585C (en) 2013-03-15 2016-04-12 Suncor Energy Inc. Herbicidal compositions
CN104086554B (zh) * 2014-05-30 2016-02-17 桂林晖昂生化药业有限责任公司 一种新型的完全水溶的光敏剂单体及其制备方法及应用
US20190002594A1 (en) 2014-07-16 2019-01-03 Immunophotonics, Inc. Chitosan-Derived Compositions
US10035806B2 (en) 2015-10-06 2018-07-31 California Institute Of Technology Derivatized corroles and metallocorroles and their use as imaging and therapeutic agents
EP3512569A4 (de) 2016-09-15 2020-09-23 The Regents of The University of California Verbesserte hybride telodendrimere
WO2018112111A1 (en) * 2016-12-13 2018-06-21 Health Research, Inc. Epidermal growth factor receptor (egfr) targeted photosensitizers
US11872194B2 (en) 2017-03-14 2024-01-16 Ohio State Innovation Foundation Methods and compositions related to a tissue factor-targeting IGG3 immunoconjugates
CN112028898B (zh) * 2019-06-04 2023-06-23 康宏耀源（天津）科技有限公司 不同连接链偶联的叶酸靶向卟吩类光敏剂及其合成和应用
CN113461697B (zh) 2021-06-29 2023-03-10 西南交通大学 一种二氢卟吩类化合物及其制备方法和用途

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4649151A (en) * 1982-09-27 1987-03-10 Health Research, Inc. Drugs comprising porphyrins
US4649191A (en) * 1984-05-10 1987-03-10 Gibson-Stephens Neuropharmaceuticals, Inc. Conformationally constrained alpha-melanotropin analogs with specific central nervous system activity
EP0220686B1 (de) * 1985-10-23 1992-12-30 Nihon Medi-Physics Co., Ltd. Porphyrinderivate, ihre Herstellung und Verwendung
JPS63101384A (ja) * 1986-10-17 1988-05-06 Hamari Yakuhin Kogyo Kk フエオフオルバイド誘導体
US4883790A (en) * 1987-01-20 1989-11-28 University Of British Columbia Wavelength-specific cytotoxic agents
US4920143A (en) * 1987-04-23 1990-04-24 University Of British Columbia Hydro-monobenzoporphyrin wavelength-specific cytotoxic agents
US5198460A (en) * 1988-07-20 1993-03-30 Health Research Inc. Pyropheophorbides and their use in photodynamic therapy
US5002962A (en) * 1988-07-20 1991-03-26 Health Research, Inc. Photosensitizing agents
US5093349A (en) * 1988-07-20 1992-03-03 Health Research Inc. Photosensitizing agents

Also Published As

Publication number Publication date
AU3971489A (en) 1990-02-19
AU641362B2 (en) 1993-09-23
WO1990000895A1 (en) 1990-02-08
EP0425566A1 (de) 1991-05-08
US5314905A (en) 1994-05-24
ATE112680T1 (de) 1994-10-15
US5002962A (en) 1991-03-26
EP0425566A4 (en) 1992-03-11
DE68918860T2 (de) 1995-02-16
US5459159A (en) 1995-10-17
EP0425566B1 (de) 1994-10-12
JPH04500955A (ja) 1992-02-20

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Legal Events

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8364 No opposition during term of opposition
8339 Ceased/non-payment of the annual fee