DE68909724T2 - Gereinigte hämoglobin-lösungen und verfahren zur herstellung. - Google Patents

Gereinigte hämoglobin-lösungen und verfahren zur herstellung.

Info

Publication number
DE68909724T2
DE68909724T2 DE89902335T DE68909724T DE68909724T2 DE 68909724 T2 DE68909724 T2 DE 68909724T2 DE 89902335 T DE89902335 T DE 89902335T DE 68909724 T DE68909724 T DE 68909724T DE 68909724 T2 DE68909724 T2 DE 68909724T2
Authority
DE
Germany
Prior art keywords
cleaned
production method
hemoglobin solutions
hemoglobin
solutions
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Revoked
Application number
DE89902335T
Other languages
English (en)
Other versions
DE68909724D1 (de
Inventor
Timothy Estep
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Baxter International Inc
Original Assignee
Baxter International Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=22540455&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE68909724(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Baxter International Inc filed Critical Baxter International Inc
Application granted granted Critical
Publication of DE68909724D1 publication Critical patent/DE68909724D1/de
Publication of DE68909724T2 publication Critical patent/DE68909724T2/de
Anticipated expiration legal-status Critical
Revoked legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
    • A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
    • A61L2/0011—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using physical methods
    • A61L2/0023—Heat
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/795—Porphyrin- or corrin-ring-containing peptides
    • C07K14/805—Haemoglobins; Myoglobins

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE89902335T 1988-02-03 1989-01-30 Gereinigte hämoglobin-lösungen und verfahren zur herstellung. Revoked DE68909724T2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/151,842 US4831012A (en) 1984-03-23 1988-02-03 Purified hemoglobin solutions and method for making same

Publications (2)

Publication Number Publication Date
DE68909724D1 DE68909724D1 (de) 1993-11-11
DE68909724T2 true DE68909724T2 (de) 1994-02-03

Family

ID=22540455

Family Applications (1)

Application Number Title Priority Date Filing Date
DE89902335T Revoked DE68909724T2 (de) 1988-02-03 1989-01-30 Gereinigte hämoglobin-lösungen und verfahren zur herstellung.

Country Status (6)

Country Link
US (1) US4831012A (de)
EP (1) EP0356481B1 (de)
JP (1) JP2668446B2 (de)
CA (1) CA1319611C (de)
DE (1) DE68909724T2 (de)
WO (1) WO1989006969A1 (de)

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JP2954347B2 (ja) * 1989-12-29 1999-09-27 テキサス・テック・ユニバーシティー・ヘルス・サイエンシズ・センター プリン誘導体及びグルタチオンで安定化されたポリヘモグロビン
US5439882A (en) * 1989-12-29 1995-08-08 Texas Tech University Health Sciences Center Blood substitute
SE9001378D0 (sv) * 1990-04-18 1990-04-18 Kabivitrum Ab A method for the preparation of pyridoxylated hemoglobin
AU9067791A (en) * 1990-11-20 1992-06-11 Enzon, Inc. Method of enhancing long-term storage stability of hemoglobin products
DE69130483T2 (de) * 1991-02-12 1999-06-10 Univ Texas Tech Verbesserter blutersatz
US5739037A (en) * 1992-09-29 1998-04-14 Drew Scientific Limited Process for eliminating labile glycohaemoglobin from a sample
EP0600247A3 (de) * 1992-11-05 1995-05-10 Hoechst Ag Verfahren zur selektiven Desaktivierung von unerwünschten Proteinen in einem Proteingemisch mittels Mikrowelleneinstrahlung.
DE4237977A1 (de) * 1992-11-11 1994-05-19 Braun Melsungen Ag Pasteurisierung von Hemoglobin
US5578564A (en) * 1993-07-23 1996-11-26 Somatogen, Inc. Nickel-free hemoglobin and methods for producing such hemoglobin
US5840851A (en) * 1993-07-23 1998-11-24 Plomer; J. Jeffrey Purification of hemoglobin
US5840701A (en) * 1993-08-16 1998-11-24 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
TW381022B (en) * 1993-08-16 2000-02-01 Hsia Jen Chang Compositions and methods utilizing nitroxides to avoid oxygen toxicity, particularly in stabilized, polymerized, conjugated, or encapsulated hemoglobin used as a red cell substitute
US5817632A (en) * 1993-08-16 1998-10-06 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5807831A (en) * 1993-08-16 1998-09-15 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5725839A (en) * 1993-08-16 1998-03-10 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules for ERI or MRI
US5741893A (en) * 1993-08-16 1998-04-21 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5767089A (en) * 1993-08-16 1998-06-16 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5824781A (en) * 1993-08-16 1998-10-20 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5804561A (en) * 1993-08-16 1998-09-08 Hsia; Jen-Chang Compositions and methods utilizing nitroxides in combination with biocompatible macromolecules
US5665869A (en) * 1993-11-15 1997-09-09 Somatogen, Inc. Method for the rapid removal of protoporphyrin from protoporphyrin IX-containing solutions of hemoglobin
US6140071A (en) * 1994-01-27 2000-10-31 Somatogen, Inc. Proteins with mutations to decrease N-terminal methylation
WO1995024470A1 (en) 1994-03-09 1995-09-14 Pacific Biotech International, Inc. Activating virus
US6627738B2 (en) * 1995-09-15 2003-09-30 Duke University No-modified hemoglobins and uses therefor
US5741894A (en) * 1995-09-22 1998-04-21 Baxter International, Inc. Preparation of pharmaceutical grade hemoglobins by heat treatment in partially oxygenated form
US5786458A (en) * 1996-06-28 1998-07-28 Bayer Corporation Selective stabilization of protein during viral inactivation
US5837519A (en) * 1996-11-21 1998-11-17 Bayer Corporation Dry-heat viral inactivation under controlled moisture conditions
AU735799C (en) * 1997-02-28 2005-04-28 Regents Of The University Of California, The Methods and compositions for optimisation of oxygen transport by cell-free systems
US5814601A (en) * 1997-02-28 1998-09-29 The Regents Of The University Of California Methods and compositions for optimization of oxygen transport by cell-free systems
DK2193809T3 (en) 1999-02-22 2015-05-26 Univ Connecticut The albumin-free Factor VIII formulation
CA2266174A1 (en) * 1999-03-18 2000-09-18 Hemosol Inc. Hemoglobin-antioxidant conjugates
JP3466516B2 (ja) * 1999-09-07 2003-11-10 科学技術振興事業団 安定保存可能な酸素輸液剤
US7038016B2 (en) 2001-08-21 2006-05-02 Apex Bioscience, Inc. Methods for purification of an activated PEG solution and for the synthesis of a modified hemoglobin solution
US20050164915A1 (en) 2002-04-01 2005-07-28 Sangart, Inc. Compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20030153491A1 (en) * 2002-01-11 2003-08-14 Winslow Robert M. Methods and compositions for oxygen transport comprising a high oxygen affinity modified hemoglobin
US20030224994A1 (en) * 2002-04-05 2003-12-04 Newton Colin John Storage stable liquid sealer protein complex
JP3912206B2 (ja) * 2002-07-05 2007-05-09 株式会社日立製作所 筒内直接燃料噴射装置用燃料ポンプ
US20040072729A1 (en) * 2002-10-10 2004-04-15 Sunbio Inc. High oxygen affinity PEG-hemoglobin as treatment for brain stroke
US7759306B2 (en) * 2006-05-16 2010-07-20 Simoni Jan S Methods of treating acute blood loss
MX339060B (es) 2008-11-07 2016-05-09 Baxter Int Formulaciones del factor viii.
US10172949B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
DK2440239T3 (en) 2009-06-09 2017-10-16 Prolong Pharmaceuticals Llc HEMOGLOBIN FORMATIONS
US10172950B2 (en) 2009-06-09 2019-01-08 Prolong Pharmaceuticals, LLC Hemoglobin compositions
US8273857B2 (en) * 2009-09-22 2012-09-25 Jen-Chang Hsia Compositions and methods of use of neurovascular protective multifunctional polynitroxylated pegylated carboxy hemoglobins for transfusion and critical care medicine
US9199016B2 (en) 2009-10-12 2015-12-01 New Health Sciences, Inc. System for extended storage of red blood cells and methods of use
US11284616B2 (en) 2010-05-05 2022-03-29 Hemanext Inc. Irradiation of red blood cells and anaerobic storage
US20110250670A1 (en) * 2010-04-08 2011-10-13 University Of Calcutta Light energy-induced stability of biomaterials
US7989593B1 (en) 2010-05-27 2011-08-02 Bing Lou Wong Method for the preparation of a high-temperature stable oxygen-carrier-containing pharmaceutical composition and the use thereof
US8048856B1 (en) 2010-06-23 2011-11-01 Billion King, Ltd. Treatment methods using a heat stable oxygen carrier-containing pharmaceutical composition
US7932356B1 (en) 2010-06-23 2011-04-26 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing pharmaceutical composition
WO2012027582A1 (en) 2010-08-25 2012-03-01 New Health Sciences Method for enhancing red blood cell quality and survival during storage
PT3539381T (pt) 2010-11-05 2023-09-26 Hemanext Inc Irradiação de glóbulos vermelhos e armazenamento anaeróbico
US20120157905A1 (en) * 2010-12-15 2012-06-21 Biovec Transfusion, Llc Methods for treating carbon monoxide poisoning by tangential flow filtration of blood
US9067004B2 (en) 2011-03-28 2015-06-30 New Health Sciences, Inc. Method and system for removing oxygen and carbon dioxide during red cell blood processing using an inert carrier gas and manifold assembly
EP2691160A4 (de) * 2011-03-28 2015-04-08 New Health Sciences Inc Verfahren und system zur entfernung von sauerstoff und kohlendioxid während einer erythrozytenbehandlung mithilfe eines trägen trägergases und verteileranordnung
US8084581B1 (en) 2011-04-29 2011-12-27 Bing Lou Wong Method for removing unmodified hemoglobin from cross-linked hemoglobin solutions including polymeric hemoglobin with a high temperature short time heat treatment apparatus
ES2742949T3 (es) 2011-08-10 2020-02-17 New Health Sciences Inc Dispositivo integrado de filtrado para el agotamiento de leucocitos, oxígeno y/o co2 y separación de plasma
US20130052232A1 (en) 2011-08-31 2013-02-28 Bing Lou Wong Method for the preparation of a heat stable oxygen carrier-containing composition facilating beta-beta cross-linking
PT2961269T (pt) 2013-02-28 2021-12-16 Hemanext Inc Dispositivo de depleção de gás para produtos sanguíneos
CN113694272A (zh) 2015-03-10 2021-11-26 希玛奈克斯特股份有限公司 氧减少一次性套件、装置及其使用方法
KR102661405B1 (ko) 2015-04-23 2024-04-25 헤마넥스트 인코포레이티드 혐기성 혈액 저장 용기
CN107735095B (zh) 2015-05-18 2022-06-14 希玛奈克斯特股份有限公司 储存全血的方法及其组合物
ES2910948T3 (es) 2016-05-27 2022-05-17 Hemanext Inc Almacenamiento anaeróbico de sangre y procedimiento de inactivación de patógenos

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3130770C2 (de) * 1981-08-04 1986-06-19 Biotest-Serum-Institut Gmbh, 6000 Frankfurt Verfahren zur Gewinnung von hepatitissicheren, sterilen, pyrogenfreien und stromafreien Hämoglobinlösungen
US4456590B2 (en) * 1981-11-02 1989-05-30 Heat treatment of lyphilized blood clotting factor viii concentrate
US4540573A (en) * 1983-07-14 1985-09-10 New York Blood Center, Inc. Undenatured virus-free biologically active protein derivatives
GB8328917D0 (en) * 1983-10-28 1983-11-30 Fisons Plc Blood substitute
JPS61501510A (ja) * 1984-03-23 1986-07-24 バクスタ−、トラベノ−ル、ラボラトリ−ズ、インコ−ポレイテッド ビ−ルスリスクを減らしたヘモグロビンおよびその製造方法

Also Published As

Publication number Publication date
CA1319611C (en) 1993-06-29
WO1989006969A1 (en) 1989-08-10
JP2668446B2 (ja) 1997-10-27
US4831012A (en) 1989-05-16
EP0356481A4 (de) 1990-06-05
EP0356481B1 (de) 1993-10-06
DE68909724D1 (de) 1993-11-11
EP0356481A1 (de) 1990-03-07
JPH02503676A (ja) 1990-11-01

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Legal Events

Date Code Title Description
8363 Opposition against the patent
8331 Complete revocation