DE68902071T2 - Human-wachstumshormon-derivat. - Google Patents
Human-wachstumshormon-derivat.Info
- Publication number
- DE68902071T2 DE68902071T2 DE8989302509T DE68902071T DE68902071T2 DE 68902071 T2 DE68902071 T2 DE 68902071T2 DE 8989302509 T DE8989302509 T DE 8989302509T DE 68902071 T DE68902071 T DE 68902071T DE 68902071 T2 DE68902071 T2 DE 68902071T2
- Authority
- DE
- Germany
- Prior art keywords
- growth hormone
- hgh
- human growth
- derivative
- column
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Fee Related
Links
- 239000000854 Human Growth Hormone Substances 0.000 title claims abstract description 21
- 102000002265 Human Growth Hormone Human genes 0.000 title abstract description 18
- 108010000521 Human Growth Hormone Proteins 0.000 title abstract description 18
- 229940121366 growth hormone derivative Drugs 0.000 title 1
- 102000018997 Growth Hormone Human genes 0.000 claims description 2
- 108010051696 Growth Hormone Proteins 0.000 claims description 2
- 230000001195 anabolic effect Effects 0.000 claims description 2
- 239000000122 growth hormone Substances 0.000 claims description 2
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
- 230000004071 biological effect Effects 0.000 abstract description 4
- BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 15
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 12
- 235000018102 proteins Nutrition 0.000 description 9
- 102000004169 proteins and genes Human genes 0.000 description 9
- 108090000623 proteins and genes Proteins 0.000 description 9
- 150000001875 compounds Chemical class 0.000 description 6
- 239000007983 Tris buffer Substances 0.000 description 5
- 102000004196 processed proteins & peptides Human genes 0.000 description 5
- 108090000765 processed proteins & peptides Proteins 0.000 description 5
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 5
- QKNYBSVHEMOAJP-UHFFFAOYSA-N 2-amino-2-(hydroxymethyl)propane-1,3-diol;hydron;chloride Chemical compound Cl.OCC(N)(CO)CO QKNYBSVHEMOAJP-UHFFFAOYSA-N 0.000 description 4
- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 238000000034 method Methods 0.000 description 3
- 238000000746 purification Methods 0.000 description 3
- 239000002904 solvent Substances 0.000 description 3
- 239000012588 trypsin Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- ATRRKUHOCOJYRX-UHFFFAOYSA-N Ammonium bicarbonate Chemical compound [NH4+].OC([O-])=O ATRRKUHOCOJYRX-UHFFFAOYSA-N 0.000 description 2
- 229910000013 Ammonium bicarbonate Inorganic materials 0.000 description 2
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 102000004142 Trypsin Human genes 0.000 description 2
- 108090000631 Trypsin Proteins 0.000 description 2
- 235000001014 amino acid Nutrition 0.000 description 2
- 229940024606 amino acid Drugs 0.000 description 2
- 235000012538 ammonium bicarbonate Nutrition 0.000 description 2
- 239000001099 ammonium carbonate Substances 0.000 description 2
- 125000000613 asparagine group Chemical group N[C@@H](CC(N)=O)C(=O)* 0.000 description 2
- CKLJMWTZIZZHCS-REOHCLBHSA-N aspartic acid group Chemical group N[C@@H](CC(=O)O)C(=O)O CKLJMWTZIZZHCS-REOHCLBHSA-N 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 125000000404 glutamine group Chemical group N[C@@H](CCC(N)=O)C(=O)* 0.000 description 2
- 239000005556 hormone Substances 0.000 description 2
- 229940088597 hormone Drugs 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 238000004007 reversed phase HPLC Methods 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- 206010000599 Acromegaly Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 229920005654 Sephadex Polymers 0.000 description 1
- 239000012507 Sephadex™ Substances 0.000 description 1
- 125000003275 alpha amino acid group Chemical group 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000005349 anion exchange Methods 0.000 description 1
- 230000001851 biosynthetic effect Effects 0.000 description 1
- 239000000337 buffer salt Substances 0.000 description 1
- 230000021523 carboxylation Effects 0.000 description 1
- 238000006473 carboxylation reaction Methods 0.000 description 1
- 239000007857 degradation product Substances 0.000 description 1
- 239000001064 degrader Substances 0.000 description 1
- 238000004090 dissolution Methods 0.000 description 1
- 238000010828 elution Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 125000000291 glutamic acid group Chemical group N[C@@H](CCC(O)=O)C(=O)* 0.000 description 1
- 230000013595 glycosylation Effects 0.000 description 1
- 238000006206 glycosylation reaction Methods 0.000 description 1
- 239000000463 material Substances 0.000 description 1
- 108091005601 modified peptides Proteins 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 239000003960 organic solvent Substances 0.000 description 1
- 238000012510 peptide mapping method Methods 0.000 description 1
- 230000001817 pituitary effect Effects 0.000 description 1
- 239000011148 porous material Substances 0.000 description 1
- 239000000377 silicon dioxide Substances 0.000 description 1
- 239000011780 sodium chloride Substances 0.000 description 1
- 238000012453 sprague-dawley rat model Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 239000000758 substrate Substances 0.000 description 1
- 210000002303 tibia Anatomy 0.000 description 1
- PIEPQKCYPFFYMG-UHFFFAOYSA-N tris acetate Chemical compound CC(O)=O.OCC(N)(CO)CO PIEPQKCYPFFYMG-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/61—Growth hormone [GH], i.e. somatotropin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Toxicology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US16828188A | 1988-03-15 | 1988-03-15 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE68902071D1 DE68902071D1 (de) | 1992-08-20 |
| DE68902071T2 true DE68902071T2 (de) | 1993-07-01 |
Family
ID=22610844
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE8989302509T Expired - Fee Related DE68902071T2 (de) | 1988-03-15 | 1989-03-14 | Human-wachstumshormon-derivat. |
Country Status (12)
| Country | Link |
|---|---|
| EP (1) | EP0333438B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2738948B2 (cg-RX-API-DMAC7.html) |
| AT (1) | ATE78173T1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU608699B2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA1338720C (cg-RX-API-DMAC7.html) |
| DE (1) | DE68902071T2 (cg-RX-API-DMAC7.html) |
| DK (1) | DK119589A (cg-RX-API-DMAC7.html) |
| ES (1) | ES2043001T3 (cg-RX-API-DMAC7.html) |
| GR (1) | GR3005206T3 (cg-RX-API-DMAC7.html) |
| IE (1) | IE62541B1 (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ228313A (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA891863B (cg-RX-API-DMAC7.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6429186B1 (en) | 1991-05-10 | 2002-08-06 | Genentech, Inc. | Ligand antagonists for treatment of breast cancer |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS63500941A (ja) * | 1985-09-18 | 1988-04-07 | ジ・アップジョン・カンパニ− | 選択的脱アミノ化による哺乳動物ソマトトロピンの生物学的活性の増強 |
-
1989
- 1989-03-10 CA CA000593307A patent/CA1338720C/en not_active Expired - Fee Related
- 1989-03-10 ZA ZA891863A patent/ZA891863B/xx unknown
- 1989-03-13 AU AU31254/89A patent/AU608699B2/en not_active Ceased
- 1989-03-13 NZ NZ228313A patent/NZ228313A/en unknown
- 1989-03-13 DK DK119589A patent/DK119589A/da not_active Application Discontinuation
- 1989-03-14 EP EP89302509A patent/EP0333438B1/en not_active Expired - Lifetime
- 1989-03-14 DE DE8989302509T patent/DE68902071T2/de not_active Expired - Fee Related
- 1989-03-14 IE IE81289A patent/IE62541B1/en not_active IP Right Cessation
- 1989-03-14 ES ES89302509T patent/ES2043001T3/es not_active Expired - Lifetime
- 1989-03-14 JP JP1063414A patent/JP2738948B2/ja not_active Expired - Lifetime
- 1989-03-14 AT AT89302509T patent/ATE78173T1/de active
-
1992
- 1992-07-16 GR GR920401468T patent/GR3005206T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| DE68902071D1 (de) | 1992-08-20 |
| AU3125489A (en) | 1989-09-21 |
| ES2043001T3 (es) | 1993-12-16 |
| JP2738948B2 (ja) | 1998-04-08 |
| ZA891863B (en) | 1990-11-28 |
| NZ228313A (en) | 1990-11-27 |
| AU608699B2 (en) | 1991-04-11 |
| ATE78173T1 (de) | 1992-08-15 |
| IE890812L (en) | 1989-09-15 |
| IE62541B1 (en) | 1995-02-08 |
| CA1338720C (en) | 1996-11-12 |
| DK119589A (da) | 1989-09-18 |
| EP0333438A3 (en) | 1989-11-29 |
| GR3005206T3 (cg-RX-API-DMAC7.html) | 1993-05-24 |
| EP0333438B1 (en) | 1992-07-15 |
| DK119589D0 (da) | 1989-03-13 |
| JPH01275599A (ja) | 1989-11-06 |
| EP0333438A2 (en) | 1989-09-20 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |