DE673852C - Process for obtaining therapeutically usable conversion products of ergosterol and similar substances - Google Patents
Process for obtaining therapeutically usable conversion products of ergosterol and similar substancesInfo
- Publication number
- DE673852C DE673852C DEW101258D DEW0101258D DE673852C DE 673852 C DE673852 C DE 673852C DE W101258 D DEW101258 D DE W101258D DE W0101258 D DEW0101258 D DE W0101258D DE 673852 C DE673852 C DE 673852C
- Authority
- DE
- Germany
- Prior art keywords
- ergosterol
- conversion products
- similar substances
- therapeutically usable
- usable conversion
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired
Links
- OILXMJHPFNGGTO-UHFFFAOYSA-N (22E)-(24xi)-24-methylcholesta-5,22-dien-3beta-ol Natural products C1C=C2CC(O)CCC2(C)C2C1C1CCC(C(C)C=CC(C)C(C)C)C1(C)CC2 OILXMJHPFNGGTO-UHFFFAOYSA-N 0.000 title claims description 9
- RQOCXCFLRBRBCS-UHFFFAOYSA-N (22E)-cholesta-5,7,22-trien-3beta-ol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CCC(C)C)CCC33)C)C3=CC=C21 RQOCXCFLRBRBCS-UHFFFAOYSA-N 0.000 title claims description 9
- OQMZNAMGEHIHNN-UHFFFAOYSA-N 7-Dehydrostigmasterol Natural products C1C(O)CCC2(C)C(CCC3(C(C(C)C=CC(CC)C(C)C)CCC33)C)C3=CC=C21 OQMZNAMGEHIHNN-UHFFFAOYSA-N 0.000 title claims description 9
- DNVPQKQSNYMLRS-NXVQYWJNSA-N Ergosterol Natural products CC(C)[C@@H](C)C=C[C@H](C)[C@H]1CC[C@H]2C3=CC=C4C[C@@H](O)CC[C@]4(C)[C@@H]3CC[C@]12C DNVPQKQSNYMLRS-NXVQYWJNSA-N 0.000 title claims description 9
- DNVPQKQSNYMLRS-SOWFXMKYSA-N ergosterol Chemical compound C1[C@@H](O)CC[C@]2(C)[C@H](CC[C@]3([C@H]([C@H](C)/C=C/[C@@H](C)C(C)C)CC[C@H]33)C)C3=CC=C21 DNVPQKQSNYMLRS-SOWFXMKYSA-N 0.000 title claims description 9
- 239000000126 substance Substances 0.000 title claims description 9
- 238000000034 method Methods 0.000 title claims description 7
- 239000012084 conversion product Substances 0.000 title claims description 5
- 229930003316 Vitamin D Natural products 0.000 description 4
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 description 4
- 235000019166 vitamin D Nutrition 0.000 description 4
- 239000011710 vitamin D Substances 0.000 description 4
- 150000003710 vitamin D derivatives Chemical class 0.000 description 4
- 229940046008 vitamin d Drugs 0.000 description 4
- PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
- 239000007858 starting material Substances 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229930182558 Sterol Natural products 0.000 description 1
- 210000000988 bone and bone Anatomy 0.000 description 1
- 159000000007 calcium salts Chemical group 0.000 description 1
- 238000001311 chemical methods and process Methods 0.000 description 1
- 238000006243 chemical reaction Methods 0.000 description 1
- 239000011248 coating agent Substances 0.000 description 1
- 238000000576 coating method Methods 0.000 description 1
- 230000008021 deposition Effects 0.000 description 1
- 230000000694 effects Effects 0.000 description 1
- 238000002474 experimental method Methods 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 229910052759 nickel Inorganic materials 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003287 optical effect Effects 0.000 description 1
- 229910052697 platinum Inorganic materials 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 208000007442 rickets Diseases 0.000 description 1
- 150000003432 sterols Chemical class 0.000 description 1
- 235000003702 sterols Nutrition 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/593—9,10-Secocholestane derivatives, e.g. cholecalciferol, i.e. vitamin D3
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
- A61K31/592—9,10-Secoergostane derivatives, e.g. ergocalciferol, i.e. vitamin D2
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Radiation-Therapy Devices (AREA)
Description
Verfahren zur Gewinnung therapeutisch verwendbarer Umwandlungsprodukte des Ergosterins und ähnlicher Stoffe Die Bedeutung der Vitamine für den Aufbau und die Lebensfunktionen des tierischen und menschlichen Organismus ist heute allgemein anerkannt, und die Herstellung vitaminreicher Nährstoffe spielt heute eine große Rolle. Das Vitamin D, das bekanntlich die Wirkung hat, die normale Ablagerung von Calciumsalzen in den Knochen sicherzustellen und so das Auftreten von Rachitis zu verhüten, spielt hier eine besondere Rolle.Process for obtaining therapeutically usable conversion products of ergosterol and similar substances The importance of vitamins for the structure and the vital functions of the animal and human organism are general today recognized, and the production of vitamin-rich nutrients plays a big role today Role. The vitamin D that is known to have the effect of normal deposition of Calcium salts in the bones ensure and thus the occurrence of rickets prevention plays a special role here.
Es sind bereits Verfahren zur Anreicherung von Vitamin D durch Behandlung von Sterinen mit ultravioletten Strahlen oder mit Kathodenstrahlen bekanntgeworden. Die bisheri-c Art der Behandlung von Ergosterin mit Kathodenstrahlen hat den Nachteil, daß in großem L; infange eine Zer trüninierung des Ausgangsmaterials stattfindet, da man nur schnelle, durch ein Fenster geschossene Elektronen auf das Ergosterin einwirken läßt. Man war bisher der Ansicht, daß den Molekülen des Ausgangsstoffes eine große Energicmengc zage. führt werden muß, um eine Umwandlung zu erzielen.Processes for enriching vitamin D by treating sterols with ultraviolet rays or with cathode rays have already become known. The previous type of treatment of ergosterol with cathode rays has the disadvantage that in large L; Infange trunination of the starting material takes place, since only fast electrons shot through a window are allowed to act on the ergosterol. It was previously of the opinion that the molecules of the starting material contained a large amount of energy. must be performed in order to achieve a conversion.
Das vorliegende Verfahren zur. Gel\lnnung therapeutisch verwendbarer Umwandlungsprodukte des Ergosterins und ähnlicher Stoffe durch Bestrahlen finit von einer Glühkathode ausgesandten Elektronen basiert auf der Erkenntnis, daß das elektrische Energiequant, welches zur Umwandlung eines Ergosterinmoleküls in Vitamin D erforderlich ist, etwa dein optischen Lichtenergiequant entsprechen muß, daß man also den (las Ergosterin bombardierenden lacktronen einen gailz 1>cstimmten, relativ niedrigen Esnergieinhalt gel'ell 11.u1.', um ein Optimum :in Vitamin D zti erhalten.The present procedure for. Gel \ lnment therapeutically usable Conversion products of ergosterol and similar substances through irradiation finite Electrons emitted by a hot cathode are based on the knowledge that the electrical energy quantum, which converts an ergosterol molecule into a vitamin D is required, about your optical light energy quantum must correspond to that one so the (read ergosterine bombing Lacktronen a gailz 1> correct, relatively low esnergy content gel'ell 11.u1. 'To achieve an optimum: in Vitamin D received zti.
Das Verfahren nach der Erfindung ermöglicht die Erfüllung dieser ßc<lingun@ und bc. steht darin, daß plan den zu bestrahlenden Stoff- direkt in (las Feld zwischen einer Glühkathode -und einer Anode bringt, sa daß die mit einem bestimmten einstellbaren Energieinhalt zur Kathode fliegenden Elektronen den zu bestrahlenden Stoff- treffen müssen. auf diese Weise kann man den Energieinhalt der Elektronen gcitatt dosieren und die crrecliiiet:n oder durch das Experiment geftiildeilrli Wzrtc einstellen.The method according to the invention enables the fulfillment of this ßc <lingun @ and bc. stands in the fact that the substance to be irradiated is planar directly in (read field between a hot cathode and an anode brings, sa that the with a certain adjustable Energy content Electrons flying towards the cathode hit the substance to be irradiated have to. in this way the energy content of the electrons can be dosed properly and the crrecliiiet: n or set by the experiment geftiildeilrli Wzrtc.
Die Herstellung der Umwandlungsprodukte erfolgt ztveckm;ißig in der Weise, da(:') man eine ätherische Lösung des -Ergosterins oder eines ähnlichen Stoffes auf das zweckmäßig aus Platin oder Nickel bestehende Anodenblech eines Hoclivakuumgefäßes aufträgt, so daß nach dein Verdunstet. das Anodenblech mit einem Lberzug von Ergosterin versehen ist. Nach dem Evakuieren des Gefäßes bringt man die Kathode zum Emittieren und legt eine geeignete Anodenspannung an, so daß die Beschießung der Anode mit Elektronen einsetzt. Die geeignete Stärke dieses Elektronenbombardements, d. h. sowohl die klärt( als auch die Zahl der auftreffenden Elektronen, läßt sich bei gegebenem Abstand zwi. scher Kathode und Anode in bekannter Weise durch die Höhe der Anodenspannung sowie durch die Art (Oxydkathode) und den Heizgrad der Kathode leicht regulieren.The conversion products are usually produced in the Way, because (: ') one has an ethereal solution of -ergosterol or a similar substance onto the anode plate of a hoclive vacuum vessel, which is expediently made of platinum or nickel applies, so that after your evaporates. the anode plate with a coating of ergosterine is provided. After evacuating the vessel, the cathode is made to emit and applies a suitable anode voltage, so that the bombardment of the anode with Uses electrons. The appropriate strength of this electron bombardment, i.e. H. both the clarifies (and the number of the impinging electrons can be found in given distance between shear cathode and anode in a known manner through the height the anode voltage as well as the type (oxide cathode) and the degree of heating of the cathode regulate easily.
Ist so die Ergosterinschicht eine bestimmte Zeit dem Elektronenbombardement ausgesetzt worden, so wird das Gefäß abgeschaltet und das so bearbeitete Ergosterin von dem Anodenblech abgelöst und nach an sich bekannten chemischen Verfahren aufgearbeitet.So is the ergosterol layer exposed to electron bombardment for a certain time has been exposed, the vessel is switched off and the ergosterol thus processed detached from the anode plate and worked up according to known chemical processes.
Naturgemäß ist es möglich, dieses Verfahren auch bei vielen anderen Substanzen mit gutem Erfolg anzuwenden.Naturally, it is possible to use this procedure for many others as well Use substances with good success.
Claims (1)
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEW101258D DE673852C (en) | 1937-06-04 | 1937-06-04 | Process for obtaining therapeutically usable conversion products of ergosterol and similar substances |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DEW101258D DE673852C (en) | 1937-06-04 | 1937-06-04 | Process for obtaining therapeutically usable conversion products of ergosterol and similar substances |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE673852C true DE673852C (en) | 1939-03-30 |
Family
ID=7615524
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DEW101258D Expired DE673852C (en) | 1937-06-04 | 1937-06-04 | Process for obtaining therapeutically usable conversion products of ergosterol and similar substances |
Country Status (1)
| Country | Link |
|---|---|
| DE (1) | DE673852C (en) |
-
1937
- 1937-06-04 DE DEW101258D patent/DE673852C/en not_active Expired
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