DE604703C - Process for the preparation of an oxyketone of the formula C H O - Google Patents

Process for the preparation of an oxyketone of the formula C H O

Info

Publication number
DE604703C
DE604703C DESCH99335D DESC099335D DE604703C DE 604703 C DE604703 C DE 604703C DE SCH99335 D DESCH99335 D DE SCH99335D DE SC099335 D DESC099335 D DE SC099335D DE 604703 C DE604703 C DE 604703C
Authority
DE
Germany
Prior art keywords
formula
oxyketone
preparation
hydrogen
alcohol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
DESCH99335D
Other languages
German (de)
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Schering Kahlbaum AG
Original Assignee
Schering Kahlbaum AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Schering Kahlbaum AG filed Critical Schering Kahlbaum AG
Priority to DESCH99335D priority Critical patent/DE604703C/en
Application granted granted Critical
Publication of DE604703C publication Critical patent/DE604703C/en
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J1/00—Normal steroids containing carbon, hydrogen, halogen or oxygen, not substituted in position 17 beta by a carbon atom, e.g. estrane, androstane

Description

Verfahren zur Darstellung eines Oxyketons der Formel C1sH2s02 Es wurde gefunden, daß man zu Oxyketonen der Formel C18H2802 gelangt, wenn man das z. B. durch Einwirkung von katalytisch erregtem Wasserstoff auf das Follikelhormon Cl$H2202 bzw. sein Hydrat C1gHM03 erhältliche, der Formel C18 H30 02 @entsprechende Hydrierun,gsprodukt des Follikelhormons C18 H22 02 durch Behandlung mit entsprechenden Mengen von Oxydationsmitteln in das Diketon der Formel C18H2602 überführt und dieses durch Behandlung mit der berechneten Menge Wasserstoff partiell zu dem Oxyketon der Formel C18 H28 O. reduziert.Process for the preparation of an oxyketone of the formula C1sH2s02 Es was found that one arrives at oxyketones of the formula C18H2802 if one uses the z. B. by the action of catalytically excited hydrogen on the follicle hormone Cl $ H2202 or its hydrate C1gHM03 available hydrogenation product corresponding to the formula C18 H30 02 @ of the follicle hormone C18 H22 02 by treatment with appropriate amounts of oxidizing agents converted into the diketone of the formula C18H2602 and this by treatment with the calculated amount of hydrogen partially reduced to the oxyketone of the formula C18 H28 O.

Beispiel i g des Reduktionsproduktes des Follikelhormons der Formel C1gH3002 wird mit überschüssiger Chromsäure und Schwefelsäure bei 6o° oxydiert. Das so erhaltene rohe Keton C1sH_>6O. wird in Alkohol oder Eisessig gelöst, mit Platinoxydkatalysator versetzt und nun mit Wasserstoff so lange behandelt, bis zwei Atome Wasserstoff aufgenommen sind. Nunmehr wird vom Katalysator abfiltriert und mit Wasser verdünnt. Dann scheidet sich das Reaktionsprodukt als Kristallmasse aus, welche durch Umkristallisieren aus verdünntem Alkohol gereinigt wird. Man erhält den Ketonalkohol der Formel C18H.802 in weißen Kristallen.Example i g of the reduction product of the follicular hormone of the formula C1gH3002 is oxidized with excess chromic acid and sulfuric acid at 60 °. The crude ketone obtained in this way C1sH_> 6O. is dissolved in alcohol or glacial acetic acid, with Platinum oxide catalyst added and now treated with hydrogen until two Atoms of hydrogen are added. The catalyst is now filtered off and diluted with water. Then the reaction product separates out as a crystal mass, which is purified by recrystallization from dilute alcohol. You get the ketone alcohol of the formula C18H.802 in white crystals.

Claims (1)

PATENTANSPRUCH: Verfahren zur Darstellung eines Oxyketons der Formel C18H2802, dadurch gekennzeichnet, daB, man das Follikelhormonhydrierungsprodukt der Formel C18H3002 mit Oxydationsmitteln zum Diketon oxydiert und dieses durch Reduktion mit der berechneten Menge Wasserstoff in das -Oxyketon überführt. -PATENT CLAIM: Process for the preparation of an oxyketone of the formula C18H2802, characterized in that one is the follicular hormone hydrogenation product of the formula C18H3002 oxidized with oxidizing agents to the diketone and this through Reduction with the calculated amount of hydrogen converted into the -oxyketone. -
DESCH99335D 1932-10-28 1932-10-28 Process for the preparation of an oxyketone of the formula C H O Expired DE604703C (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
DESCH99335D DE604703C (en) 1932-10-28 1932-10-28 Process for the preparation of an oxyketone of the formula C H O

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DESCH99335D DE604703C (en) 1932-10-28 1932-10-28 Process for the preparation of an oxyketone of the formula C H O

Publications (1)

Publication Number Publication Date
DE604703C true DE604703C (en) 1934-10-26

Family

ID=7446578

Family Applications (1)

Application Number Title Priority Date Filing Date
DESCH99335D Expired DE604703C (en) 1932-10-28 1932-10-28 Process for the preparation of an oxyketone of the formula C H O

Country Status (1)

Country Link
DE (1) DE604703C (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150063062A (en) * 2012-10-03 2015-06-08 프랙스에어 테크놀로지, 인코포레이티드 Compressed gas production and control

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20150063062A (en) * 2012-10-03 2015-06-08 프랙스에어 테크놀로지, 인코포레이티드 Compressed gas production and control

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