DE60332445D1 - Neue curcuminanaloga und deren anwendungen - Google Patents

Neue curcuminanaloga und deren anwendungen

Info

Publication number
DE60332445D1
DE60332445D1 DE60332445T DE60332445T DE60332445D1 DE 60332445 D1 DE60332445 D1 DE 60332445D1 DE 60332445 T DE60332445 T DE 60332445T DE 60332445 T DE60332445 T DE 60332445T DE 60332445 D1 DE60332445 D1 DE 60332445D1
Authority
DE
Germany
Prior art keywords
androgen
spermatogenesis
limited
curcuminaloga
applications
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60332445T
Other languages
English (en)
Inventor
Kuo-Hsiung Lee
Junko Ishida
Hironori Ohtsu
Hui-Kang Wang
Hideji Itokawa
Chawnshang Chang
Charles C Shih
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of North Carolina at Chapel Hill
AndroScience Corp
University of North Carolina System
University of Rochester Medical Center
Original Assignee
University of North Carolina at Chapel Hill
AndroScience Corp
University of North Carolina System
University of Rochester Medical Center
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of North Carolina at Chapel Hill, AndroScience Corp, University of North Carolina System, University of Rochester Medical Center filed Critical University of North Carolina at Chapel Hill
Application granted granted Critical
Publication of DE60332445D1 publication Critical patent/DE60332445D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/753—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups
    • C07C49/755—Unsaturated compounds containing a keto groups being part of a ring containing ether groups, groups, groups, or groups a keto group being part of a condensed ring system with two or three rings, at least one ring being a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/04—Saturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/17—Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/172—Saturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4741—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having oxygen as a ring hetero atom, e.g. tubocuraran derivatives, noscapine, bicuculline
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/16—Masculine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/10—Anti-acne agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/14—Drugs for dermatological disorders for baldness or alopecia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/28—Antiandrogens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/45—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by at least one doubly—bound oxygen atom, not being part of a —CHO group
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/24—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups
    • C07C49/245—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings
    • C07C49/248—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing hydroxy groups containing six-membered aromatic rings having unsaturation outside the aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/20—Unsaturated compounds containing keto groups bound to acyclic carbon atoms
    • C07C49/255—Unsaturated compounds containing keto groups bound to acyclic carbon atoms containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/84—Ketones containing a keto group bound to a six-membered aromatic ring containing ether groups, groups, groups, or groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C59/00—Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O—metal, —CHO, keto, ether, groups, groups, or groups
    • C07C59/40—Unsaturated compounds
    • C07C59/76—Unsaturated compounds containing keto groups
    • C07C59/84—Unsaturated compounds containing keto groups containing six membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/738—Esters of keto-carboxylic acids or aldehydo-carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/76—Esters of carboxylic acids having a carboxyl group bound to a carbon atom of a six-membered aromatic ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Biomedical Technology (AREA)
  • Diabetes (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Communicable Diseases (AREA)
  • Pregnancy & Childbirth (AREA)
  • Hematology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Epidemiology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Compounds That Contain Two Or More Ring Oxygen Atoms (AREA)
  • Heterocyclic Compounds Containing Sulfur Atoms (AREA)
  • Pyrane Compounds (AREA)
DE60332445T 2002-04-17 2003-03-27 Neue curcuminanaloga und deren anwendungen Expired - Lifetime DE60332445D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US10/124,642 US6790979B2 (en) 2002-04-17 2002-04-17 Curcumin analogues and uses thereof
PCT/US2003/009350 WO2003088927A2 (en) 2002-04-17 2003-03-27 Novel curcumin analogues and uses thereof

Publications (1)

Publication Number Publication Date
DE60332445D1 true DE60332445D1 (de) 2010-06-17

Family

ID=29248380

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60332445T Expired - Lifetime DE60332445D1 (de) 2002-04-17 2003-03-27 Neue curcuminanaloga und deren anwendungen

Country Status (15)

Country Link
US (1) US6790979B2 (de)
EP (1) EP1494993B1 (de)
JP (2) JP5108198B2 (de)
KR (2) KR101025226B1 (de)
CN (1) CN1646473B (de)
AT (1) ATE466832T1 (de)
AU (1) AU2003222087B8 (de)
CA (1) CA2482002C (de)
DE (1) DE60332445D1 (de)
DK (1) DK1494993T3 (de)
ES (1) ES2345930T3 (de)
HK (1) HK1078846A1 (de)
MX (1) MXPA04010180A (de)
NZ (1) NZ535773A (de)
WO (1) WO2003088927A2 (de)

Families Citing this family (62)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6790979B2 (en) * 2002-04-17 2004-09-14 University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
US7355081B2 (en) * 2002-04-17 2008-04-08 The University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
WO2003105751A2 (en) * 2002-06-17 2003-12-24 Ho-Jeong Kwon Novel curcumin derivatives
WO2004037269A1 (en) * 2002-10-23 2004-05-06 Pantarhei Bioscience B.V. Pharmaceutical compositions comprising estetrol derivatives for use in cancer therapy
ATE340580T1 (de) * 2003-05-22 2006-10-15 Pantarhei Bioscience Bv Verwendung von zusammensetzungen enthaltend ein oestrogen zur behandlung und verhinderung von muskelskelettschmerzen
WO2005020908A2 (en) * 2003-08-26 2005-03-10 Research Development Foundation Selective inhibitors of stat-3 activation and uses thereof
EP1692317A4 (de) * 2003-12-12 2007-12-19 Univ Rochester Nicht androgenabhängige rollen für den androgenrezeptor sowie nicht androgenverwandte inhibitoren des androgenrezeptors
CA2554025A1 (en) * 2004-01-28 2005-08-11 Androscience Corporation Enhancement of anti-androgenic activity by a combination of inhibitors targeting different steps of a steroid-dependent gene activation pathway and uses thereof
US20060084704A1 (en) * 2004-01-28 2006-04-20 Charles Shih Methods and compositions for enhancing degradation of nuclear receptor transcription factors and uses thereof
EP1734963A4 (de) 2004-04-02 2008-06-18 Merck & Co Inc Verfahren zur behandlung von menschen mit metabolischen und anthropometrischen störungen
CA2578159A1 (en) * 2004-09-02 2006-03-16 Androscience Corporation Methods and compositions for enhancing degradation of nuclear receptor transcription factors and uses thereof
JP5063351B2 (ja) * 2004-09-17 2012-10-31 エグゼリクシス， インコーポレイテッド ピラゾールキナーゼモジュレーターおよび使用方法
FR2880276A1 (fr) * 2005-01-05 2006-07-07 Lefebvre Dominique Caparros Utilisation des anti-androgenes dans le traitement des comportements agressifs ou impulsifs induits par des maladies du systeme nerveux central
AU2007254134A1 (en) * 2006-05-19 2007-11-29 University Of Rochester Prostate epithelial androgen receptor suppresses prostate growth and tumor invasion
US7507864B2 (en) * 2006-08-01 2009-03-24 Salisbury University Method for the synthesis of curcumin analogues
JP2010506836A (ja) * 2006-10-12 2010-03-04 リサーチ ファウンデイション オブ ザ シティー ユニヴァーシティ オブ ニューヨーク 新規なクルクミンおよびテトラヒドロクルクミン誘導体
KR101563370B1 (ko) * 2007-01-08 2015-10-26 앤드로사이언스 코포레이션 (치환된 페닐)-프로페날 잔기를 갖는 화합물, 이의 유도체, 생물학적 활성, 및 이의 용도
US9000222B2 (en) 2007-01-08 2015-04-07 Androscience Corporation Compounds with (1E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
US8710272B2 (en) 2007-01-08 2014-04-29 Androscience Corporation Compounds with (1 E, 6E)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituted-hepta-1,6-diene-3,5-dione structural scaffold, their biological activity, and uses thereof
CN101003470B (zh) * 2007-01-22 2011-11-02 温州医学院生物与天然药物开发中心有限公司 姜黄素单羰基结构类似物及其用途
CN102432447B (zh) * 2007-01-22 2014-01-08 温州医学院生物与天然药物开发中心有限公司 含环戊酮的姜黄素单羰基结构类似物及其用途
CN102381951B (zh) * 2007-01-22 2013-09-04 温州医学院生物与天然药物开发中心有限公司 含环己酮的姜黄素单羰基结构类似物及其用途
EP2749552B1 (de) * 2007-04-17 2015-11-18 Codman & Shurtleff, Inc. Curcumin-Resveratrol-Hybride
US8383865B2 (en) * 2007-04-17 2013-02-26 Codman & Shurtleff, Inc. Curcumin derivatives
MX2010001125A (es) * 2007-07-31 2010-09-30 Androscience Corp Composiciones incluyendo receptor androgeno de degradacion (ard) ponteciadores y metodos de tratamiento profilactico o terapeutico de trastornos de la piel y la caida de cabello.
CN101255119B (zh) * 2008-01-07 2014-05-21 沈阳药科大学 四氢姜黄素衍生物及盐类
US20090282496A1 (en) * 2008-04-04 2009-11-12 University Of Rochester Medical Center Androgen Receptor Related Methods for Treating Bladder Cancer
CN102046575B (zh) * 2008-05-30 2014-10-29 国立大学法人东京工业大学 阿尔茨海默病治疗药
CN101434525B (zh) * 2008-06-05 2012-07-04 福建医科大学 4-(4-羟基-3-甲氧基苯甲基)姜黄素及其用于制备抗肿瘤药物的应用
US7985776B2 (en) * 2008-06-27 2011-07-26 Codman & Shurtleff, Inc. Iontophoretic delivery of curcumin and curcumin analogs for the treatment of Alzheimer's Disease
US9221877B2 (en) * 2008-09-19 2015-12-29 Board Of Supervisors Of Louisiana State University And Agricultural And Mechanical College Curcumin conjugates for treating and preventing cancers
US20100286585A1 (en) * 2009-01-26 2010-11-11 Codman & Shurtleff, Inc. Shunt Delivery of Curcumin
US7723515B1 (en) * 2009-01-26 2010-05-25 Codman & Shurtleff, Inc. Methylene blue—curcumin analog for the treatment of alzheimer's disease
CN101805285B (zh) * 2009-02-13 2012-02-22 南华大学 含烟酸姜黄素酯衍生物及其制造方法和用途
WO2010132815A1 (en) 2009-05-15 2010-11-18 The Research Foundation Of State University Of New York Curcumin analogues as zinc chelators and their uses
CN101570515B (zh) * 2009-06-12 2011-10-19 乐山师范学院 姜黄素取代嘧啶类衍生物及其制备方法与用途
CN102091060A (zh) * 2009-12-10 2011-06-15 温州医学院 治疗或预防糖皮质激素介导的性腺功能减退性功能障碍和/或不育的药物及其应用
US8575221B2 (en) 2010-03-17 2013-11-05 Concert Pharmaceuticals, Inc. Derivatives of dimethylcurcumin
CN102126938B (zh) * 2010-12-15 2013-03-27 厦门大学 一种姜黄素类似物及其制备方法和应用
CA2832650C (en) * 2011-04-11 2019-05-07 Pharma Eight Co. Ltd. Pyrazole derivative
WO2013076275A1 (en) * 2011-11-23 2013-05-30 The Provost, Fellows, Foundation Scholars, & The Other Members Of Board, Of The College Of The Holy & Undiv.Trinity Of Queen Elizabeth Near Dublin Androgen receptor ligands
CN102649750B (zh) * 2012-04-11 2014-01-22 福建医科大学 姜黄素水杨酰单酯及其合成方法以及其在抗肿瘤、抗炎方面的应用
EP2861222A4 (de) * 2012-06-18 2015-08-05 Androscience Corp Verbindungen mit (1e,6e)-1,7-bis-(3,4-dimethoxyphenyl)-4,4-disubstituiertem-hepa-1,6-dien-3,5-dion-strukturgerüst, deren biologische aktivität und verwendungen davon
US9220695B2 (en) 2012-06-29 2015-12-29 The Research Foundation For The State University Of New York Polyenolic zinc-binding agents (pezbins) actively promote inactivation of cancer stem cells and potentiate cytotoxic anti-tumor drug substances
EP2887929A2 (de) * 2012-08-23 2015-07-01 Symrise AG Verbindungen zur prävention, verringerung und/oder linderung von juckreiz(en) der haut
KR102212146B1 (ko) 2012-10-10 2021-02-03 그린 테크 가부시키가이샤 신규 피라졸 유도체
CN103159644B (zh) * 2013-04-08 2015-04-15 唐山师范学院 类姜黄素缩芳香胺希夫碱衍生物及其在制备抗菌药物的应用
CN103222970B (zh) * 2013-04-10 2019-03-26 温州医科大学 不对称单羰基姜黄素类似物在制备抗肿瘤药物中的应用
CN103254051B (zh) * 2013-05-28 2015-08-12 常州大学 一种二烷基姜黄素的制备方法
JP6369751B2 (ja) * 2014-09-05 2018-08-08 二村　芳弘 ケラチン産生作用を呈するクルクミン誘導体及びその製造方法
US10092550B2 (en) 2014-10-21 2018-10-09 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing curcumin, harmine, and isovanillin components, and methods of use thereof
US9402834B2 (en) 2014-10-21 2016-08-02 Ions Pharmaceutical S.À R.L. Human therapeutic agents
US9907786B2 (en) 2014-10-21 2018-03-06 Ions Pharmaceutical S.À R.L. Therapeutic compositions containing harmine and isovanillin components, and methods of use thereof
CN104557496B (zh) * 2015-01-21 2018-03-16 温州医科大学 单羰基类化合物、组合物及在制备药物中的应用
WO2018005732A1 (en) 2016-06-29 2018-01-04 The General Hospital Corporation Half-curcuminoids as amyloid-beta pet imaging agents
US10300000B2 (en) 2016-09-12 2019-05-28 The Research Foundation For The State University Of New York Inhibition of melanogenesis by chemically modified curcumins
CN106800547B (zh) * 2017-01-03 2019-07-23 中国人民解放军第二军医大学 一种双取代芳基类化合物及其应用
EP3582747B1 (de) * 2017-02-15 2021-10-13 Unilever Global IP Limited Körperpflegezusammensetzung
KR20200014295A (ko) 2017-05-01 2020-02-10 에스피지 테라퓨틱스, 인코포레이티드 트리파타이트(tripartite) 안드로겐 수용체 제거제, 그 방법 및 용도
US11602514B2 (en) 2018-07-28 2023-03-14 Suzhou Pharmavan Co., Ltd Medicament having anti-inflammatory bowel disease function, and preparation method therefor and application thereof
US11707438B2 (en) * 2019-10-15 2023-07-25 Sami-Sabinsa Group Limited Curcuminoid composition for therapeutic management of metabolic syndrome
US12129265B2 (en) 2020-07-21 2024-10-29 Ankh Life Sciences Limited Therapeutic agents and uses thereof

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH07165724A (ja) * 1993-12-13 1995-06-27 Nkk Corp ピラゾール誘導体及び血液凝固阻害剤
IL112205A0 (en) * 1994-01-06 1995-03-15 Res Dev Foundation Curcumin, analogues of curcumin and novel uses thereof
US5565491A (en) * 1994-01-31 1996-10-15 Bristol-Myers Squibb Company Use of phosphotyrosine phospatase inhibitors for controlling cellular proliferation
US5679864A (en) * 1995-11-03 1997-10-21 Gene Print Inc. Process for the synthesis of curcumin-related compounds
KR20010031501A (ko) * 1997-10-31 2001-04-16 추후제출 5-알파 환원효소 활성을 조절하는 방법 및 조성물
JP2000258904A (ja) * 1999-03-04 2000-09-22 Fujifilm Olin Co Ltd ネガ型化学増幅系感光性組成物
US6673843B2 (en) * 1999-06-30 2004-01-06 Emory University Curcumin and curcuminoid inhibition of angiogenesis
WO2001030335A2 (en) 1999-10-22 2001-05-03 The Board Of Trustees Of The University Of Illinois Pharmaceutical compositions useful in the prevention and treatment of beta-amyloid protein-induced disease
CA2393440A1 (en) 1999-12-03 2001-06-07 Emory University Curcumin analogs with anti-tumor and anti-angiogenic properties
US6790979B2 (en) * 2002-04-17 2004-09-14 University Of North Carolina At Chapel Hill Curcumin analogues and uses thereof
ES2329238T3 (es) * 2002-12-06 2009-11-24 Dsm Ip Assets B.V. Nuevo uso de licopeno para el tratamiento de enfermedades asociadas con la señalizacion de androgenos.
WO2004080396A2 (en) * 2003-03-07 2004-09-23 The University Of Texas Md Anderson Cancer Center Liposomal curcumin for treatment of cancer

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JP2005534626A (ja) 2005-11-17
ATE466832T1 (de) 2010-05-15
MXPA04010180A (es) 2005-02-03
CA2482002C (en) 2012-07-17
NZ535773A (en) 2007-01-26
AU2003222087B2 (en) 2008-08-21
AU2003222087A1 (en) 2003-11-03
CA2482002A1 (en) 2003-10-30
KR20090132590A (ko) 2009-12-30
KR100984512B1 (ko) 2010-09-30
CN1646473A (zh) 2005-07-27
WO2003088927A2 (en) 2003-10-30
US6790979B2 (en) 2004-09-14
KR20050009989A (ko) 2005-01-26
EP1494993B1 (de) 2010-05-05
ES2345930T3 (es) 2010-10-06
EP1494993A2 (de) 2005-01-12
US20030203933A1 (en) 2003-10-30
EP1494993A4 (de) 2005-09-14
HK1078846A1 (en) 2006-03-24
AU2003222087B8 (en) 2008-09-04
DK1494993T3 (da) 2010-08-23
WO2003088927A3 (en) 2004-04-01
KR101025226B1 (ko) 2011-04-01
JP5108198B2 (ja) 2012-12-26
CN1646473B (zh) 2010-10-13

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