DE60329687D1 - Topische wasser-und ethanolfreie Pimecrolimus enthaltende Zusammensetzungen - Google Patents

Topische wasser-und ethanolfreie Pimecrolimus enthaltende Zusammensetzungen

Info

Publication number
DE60329687D1
DE60329687D1 DE60329687T DE60329687T DE60329687D1 DE 60329687 D1 DE60329687 D1 DE 60329687D1 DE 60329687 T DE60329687 T DE 60329687T DE 60329687 T DE60329687 T DE 60329687T DE 60329687 D1 DE60329687 D1 DE 60329687D1
Authority
DE
Germany
Prior art keywords
pimecrolimus
compositions containing
containing water
topical compositions
ethanol free
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60329687T
Other languages
English (en)
Inventor
Dorothea Ledergerber
Jean-Claude Sonntag
Katrin Kriwet
Nabila Sekkat
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Novartis AG
Original Assignee
Novartis AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis AG filed Critical Novartis AG
Application granted granted Critical
Publication of DE60329687D1 publication Critical patent/DE60329687D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Molecular Biology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Dermatology (AREA)
  • Biochemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
DE60329687T 2002-08-14 2003-08-13 Topische wasser-und ethanolfreie Pimecrolimus enthaltende Zusammensetzungen Expired - Lifetime DE60329687D1 (de)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0218996.7A GB0218996D0 (en) 2002-08-14 2002-08-14 Organic compounds
PCT/EP2003/008999 WO2004016289A1 (en) 2002-08-14 2003-08-13 Topical anhydrous and ethanol-free ascomycin compositions

Publications (1)

Publication Number Publication Date
DE60329687D1 true DE60329687D1 (de) 2009-11-26

Family

ID=9942370

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60329687T Expired - Lifetime DE60329687D1 (de) 2002-08-14 2003-08-13 Topische wasser-und ethanolfreie Pimecrolimus enthaltende Zusammensetzungen

Country Status (23)

Country Link
US (1) US20050220850A1 (de)
EP (1) EP1534339B1 (de)
JP (1) JP2005537302A (de)
KR (1) KR100624583B1 (de)
CN (1) CN1674940A (de)
AR (1) AR040859A1 (de)
AT (1) ATE445416T1 (de)
AU (1) AU2003258607B2 (de)
BR (1) BR0313462A (de)
CA (1) CA2495345A1 (de)
DE (1) DE60329687D1 (de)
EC (1) ECSP055597A (de)
GB (1) GB0218996D0 (de)
IL (1) IL166601A0 (de)
MX (1) MXPA05001767A (de)
NO (1) NO20051232L (de)
NZ (1) NZ538138A (de)
PE (1) PE20040330A1 (de)
PL (1) PL373230A1 (de)
RU (1) RU2343919C2 (de)
TW (1) TW200410713A (de)
WO (1) WO2004016289A1 (de)
ZA (1) ZA200500815B (de)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0307866D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Pharmaceutical composition
RU2375044C2 (ru) * 2004-04-08 2009-12-10 Новартис Аг Пимекролимусная пенная композиция, включающая гексиленгликоль, необязательно олеиловый спирт, диметилизосорбид и/или триглицериды со средними цепями
CA2580286A1 (en) * 2004-09-16 2006-03-23 Bayer Healthcare Ag Dermally applicable formulations for treating skin diseases in animals
GB0425255D0 (en) * 2004-11-16 2004-12-15 Novartis Ag Pharmaceutical composition
DE102005037844A1 (de) * 2005-08-04 2007-04-05 Intendis Gmbh Wasserfreies Mehr-Phasen-Gel-System
GB0518769D0 (en) * 2005-09-14 2005-10-19 Medpharm Ltd Topical formulations
WO2008063563A2 (en) 2006-11-16 2008-05-29 Transderm, Inc. Methods of treating keratin hyperproliferation disorders using mtor inhibitors
WO2011013009A2 (en) 2009-07-29 2011-02-03 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
EP2948134B1 (de) 2013-01-24 2020-03-04 Palvella Therapeutics, Inc. Zusammensetzungen zur transdermalen verabreichung von mtor-inhibitoren
US10398641B2 (en) 2016-09-08 2019-09-03 Foamix Pharmaceuticals Ltd. Compositions and methods for treating rosacea and acne
FR3061009B1 (fr) * 2016-12-22 2020-09-25 Oreal Composition cosmetique comprenant une ou plusieurs huile(s) polaire(s), un monoalcool aliphatique en c2-c6 et un polyol, au moins un actif hydrophile, et comprenant moins de 7% en poids d’eau
FR3061008B1 (fr) * 2016-12-22 2020-05-01 L'oreal Composition cosmetique comprenant une ou plusieurs huile(s) polaire(s), un monoalcool aliphatique en c2-c6 et un polyol, et comprenant moins de 5% en poids d’eau
IL267869B2 (en) * 2017-01-06 2023-10-01 Palvella Therapeutics Inc Non-aqueous preparations of mTOR inhibitors and methods of use
WO2020010073A1 (en) * 2018-07-02 2020-01-09 Palvella Therapeutics, Inc. ANHYDROUS COMPOSITIONS OF mTOR INHIBITORS AND METHODS OF USE
FR3104962B1 (fr) * 2019-12-20 2021-12-31 Oreal Composition cosmétique comprenant au moins une huile polaire, un monoalcool aliphatique, un mélange de polyols et au moins un actif hydrophile
CN116602914B (zh) * 2023-07-05 2024-02-13 江苏知原药业股份有限公司 一种皮炎用乳膏及其生产工艺及其生产设备

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537776A (en) * 1983-06-21 1985-08-27 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
ATE150304T1 (de) * 1990-09-04 1997-04-15 Fujisawa Pharmaceutical Co Tricyclische verbindungen enthaltende salben
CH686761A5 (de) * 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
JPH06345646A (ja) * 1993-06-08 1994-12-20 Fujisawa Pharmaceut Co Ltd ローション剤
ATE246909T1 (de) * 1994-03-07 2003-08-15 Theratech Inc Medikament enthaltende, adhesive, zusammenbaubare,transdermale abgabevorrichtung
PL184750B1 (pl) * 1994-10-26 2002-12-31 Novartis Ag Kompozycja w postaci emulsji do stosowania miejscowego
GB2327610B (en) * 1994-11-04 1999-06-02 Novartis Ag Macrolide compositions
CA2326222C (en) * 1998-04-27 2008-09-23 Fujisawa Pharmaceutical Co., Ltd. Medicinal compositions
GB9826656D0 (en) * 1998-12-03 1999-01-27 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
MXPA05001767A (es) 2005-04-25
JP2005537302A (ja) 2005-12-08
NZ538138A (en) 2008-05-30
AR040859A1 (es) 2005-04-20
IL166601A0 (en) 2006-01-15
ATE445416T1 (de) 2009-10-15
EP1534339B1 (de) 2009-10-14
US20050220850A1 (en) 2005-10-06
ECSP055597A (es) 2005-04-18
RU2343919C2 (ru) 2009-01-20
ZA200500815B (en) 2006-07-26
CA2495345A1 (en) 2004-02-26
KR100624583B1 (ko) 2006-09-15
TW200410713A (en) 2004-07-01
WO2004016289A1 (en) 2004-02-26
NO20051232L (no) 2005-05-12
PE20040330A1 (es) 2004-07-15
EP1534339A1 (de) 2005-06-01
AU2003258607B2 (en) 2007-01-04
GB0218996D0 (en) 2002-09-25
RU2005107317A (ru) 2005-10-10
PL373230A1 (en) 2005-08-22
CN1674940A (zh) 2005-09-28
AU2003258607A1 (en) 2004-03-03
BR0313462A (pt) 2005-07-05
KR20050042475A (ko) 2005-05-09

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Legal Events

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