ECSP055597A - Composiciones tópicas de ascomicina anhidras y desprovistas de etanol - Google Patents

Composiciones tópicas de ascomicina anhidras y desprovistas de etanol

Info

Publication number
ECSP055597A
ECSP055597A EC2005005597A ECSP055597A ECSP055597A EC SP055597 A ECSP055597 A EC SP055597A EC 2005005597 A EC2005005597 A EC 2005005597A EC SP055597 A ECSP055597 A EC SP055597A EC SP055597 A ECSP055597 A EC SP055597A
Authority
EC
Ecuador
Prior art keywords
weight
desprovistas
ashychicine
anhydrais
etanol
Prior art date
Application number
EC2005005597A
Other languages
English (en)
Inventor
Dorothea Ledergerber
Jean-Claude Sonntag
Katrin Kriwet
Nabila Sekkat
Original Assignee
Novartis Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Novartis Ag filed Critical Novartis Ag
Publication of ECSP055597A publication Critical patent/ECSP055597A/es

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/14—Esters of carboxylic acids, e.g. fatty acid monoglycerides, medium-chain triglycerides, parabens or PEG fatty acid esters
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0014—Skin, i.e. galenical aspects of topical compositions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/44—Oils, fats or waxes according to two or more groups of A61K47/02-A61K47/42; Natural or modified natural oils, fats or waxes, e.g. castor oil, polyethoxylated castor oil, montan wax, lignite, shellac, rosin, beeswax or lanolin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/46—Ingredients of undetermined constitution or reaction products thereof, e.g. skin, bone, milk, cotton fibre, eggshell, oxgall or plant extracts

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Dermatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

Composiciones farmacéuticas líquidas o semi-sólidas tópicas de una sola fase sustancialmente exentas de etanol y agua, y que comprenden una ascomicina, tal como pimecrolimus, en un vehículo portador que comprende una mezcla de solventes de tres componentes que suman cuando menos el 40 por ciento en peso/peso del peso total de la composición, y que consiste en: i) un alcanol de 3 a 8 átomos de carbono y/o alcanodiol de 1 a 8 átomos de carbono; ii) un alcohol graso; y iii) un solvente adicional seleccionado a partir de: a) un alquiléster de ácido alcancarboxílico y/o alquiléster de ácido alcandicarboxílico, y/o b) un co-componente hidrofílico, y/o c) un triglicérido; y opcionalmente, excipientes convencionales adicionales.
EC2005005597A 2002-08-14 2005-02-14 Composiciones tópicas de ascomicina anhidras y desprovistas de etanol ECSP055597A (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0218996.7A GB0218996D0 (en) 2002-08-14 2002-08-14 Organic compounds

Publications (1)

Publication Number Publication Date
ECSP055597A true ECSP055597A (es) 2005-04-18

Family

ID=9942370

Family Applications (1)

Application Number Title Priority Date Filing Date
EC2005005597A ECSP055597A (es) 2002-08-14 2005-02-14 Composiciones tópicas de ascomicina anhidras y desprovistas de etanol

Country Status (23)

Country Link
US (1) US20050220850A1 (es)
EP (1) EP1534339B1 (es)
JP (1) JP2005537302A (es)
KR (1) KR100624583B1 (es)
CN (1) CN1674940A (es)
AR (1) AR040859A1 (es)
AT (1) ATE445416T1 (es)
AU (1) AU2003258607B2 (es)
BR (1) BR0313462A (es)
CA (1) CA2495345A1 (es)
DE (1) DE60329687D1 (es)
EC (1) ECSP055597A (es)
GB (1) GB0218996D0 (es)
IL (1) IL166601A0 (es)
MX (1) MXPA05001767A (es)
NO (1) NO20051232L (es)
NZ (1) NZ538138A (es)
PE (1) PE20040330A1 (es)
PL (1) PL373230A1 (es)
RU (1) RU2343919C2 (es)
TW (1) TW200410713A (es)
WO (1) WO2004016289A1 (es)
ZA (1) ZA200500815B (es)

Families Citing this family (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0307866D0 (en) * 2003-04-04 2003-05-14 Novartis Ag Pharmaceutical composition
EP1734927B8 (en) 2004-04-08 2013-10-23 MEDA Pharma S.à.r.l. Pimecrolimus foam composition containing hexylene glycol, optionally oleyl alcohol, dimethylisosorbide and/or medium chain triglycerides
AU2005284422A1 (en) * 2004-09-16 2006-03-23 Bayer Healthcare Ag Dermally applicable formulations for treating skin diseases in animals
GB0425255D0 (en) * 2004-11-16 2004-12-15 Novartis Ag Pharmaceutical composition
DE102005037844A1 (de) * 2005-08-04 2007-04-05 Intendis Gmbh Wasserfreies Mehr-Phasen-Gel-System
GB0518769D0 (en) * 2005-09-14 2005-10-19 Medpharm Ltd Topical formulations
US9205080B2 (en) 2006-11-16 2015-12-08 Transderm, Inc. Methods of treating keratin hyperproliferation disorders using mTOR inhibitors
CA2769625C (en) 2009-07-29 2017-04-11 Foamix Ltd. Non surfactant hydro-alcoholic foamable compositions, breakable foams and their uses
EP2948134B1 (en) 2013-01-24 2020-03-04 Palvella Therapeutics, Inc. Compositions for transdermal delivery of mtor inhibitors
MX2020012139A (es) 2016-09-08 2021-01-29 Vyne Pharmaceuticals Inc Composiciones y metodos para tratar rosacea y acne.
FR3061009B1 (fr) 2016-12-22 2020-09-25 Oreal Composition cosmetique comprenant une ou plusieurs huile(s) polaire(s), un monoalcool aliphatique en c2-c6 et un polyol, au moins un actif hydrophile, et comprenant moins de 7% en poids d’eau
FR3061008B1 (fr) * 2016-12-22 2020-05-01 L'oreal Composition cosmetique comprenant une ou plusieurs huile(s) polaire(s), un monoalcool aliphatique en c2-c6 et un polyol, et comprenant moins de 5% en poids d’eau
EP3565520A4 (en) * 2017-01-06 2020-08-19 Palvella Therapeutics, Inc. Anhydrous compositions of MTOR inhibitors and method of use
JP2021530463A (ja) * 2018-07-02 2021-11-11 パルヴェラ セラピューティクス、インク． ｍＴＯＲ阻害剤の無水組成物および使用方法
FR3104962B1 (fr) * 2019-12-20 2021-12-31 Oreal Composition cosmétique comprenant au moins une huile polaire, un monoalcool aliphatique, un mélange de polyols et au moins un actif hydrophile
CN116602914B (zh) * 2023-07-05 2024-02-13 江苏知原药业股份有限公司 一种皮炎用乳膏及其生产工艺及其生产设备

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4537776A (en) * 1983-06-21 1985-08-27 The Procter & Gamble Company Penetrating topical pharmaceutical compositions containing N-(2-hydroxyethyl) pyrrolidone
DE69125230T2 (de) * 1990-09-04 1997-07-10 Fujisawa Pharmaceutical Co Tricyclische Verbindungen enthaltende Salben
CH686761A5 (de) * 1993-05-27 1996-06-28 Sandoz Ag Galenische Formulierungen.
JPH06345646A (ja) * 1993-06-08 1994-12-20 Fujisawa Pharmaceut Co Ltd ローション剤
AU676430B2 (en) * 1994-03-07 1997-03-06 Theratech, Inc. Drug-containing adhesive composite transdermal delivery device
CZ289773B6 (cs) * 1994-10-26 2002-04-17 Novartis Ag Farmaceutický prostředek pro místní aplikaci
GB2327610B (en) * 1994-11-04 1999-06-02 Novartis Ag Macrolide compositions
KR100406823B1 (ko) * 1998-04-27 2003-11-21 후지사와 야꾸힝 고교 가부시키가이샤 의약 조성물
GB9826656D0 (en) * 1998-12-03 1999-01-27 Novartis Ag Organic compounds

Also Published As

Publication number Publication date
PL373230A1 (en) 2005-08-22
KR100624583B1 (ko) 2006-09-15
EP1534339B1 (en) 2009-10-14
NO20051232L (no) 2005-05-12
PE20040330A1 (es) 2004-07-15
MXPA05001767A (es) 2005-04-25
JP2005537302A (ja) 2005-12-08
EP1534339A1 (en) 2005-06-01
DE60329687D1 (de) 2009-11-26
IL166601A0 (en) 2006-01-15
BR0313462A (pt) 2005-07-05
ZA200500815B (en) 2006-07-26
GB0218996D0 (en) 2002-09-25
RU2343919C2 (ru) 2009-01-20
CN1674940A (zh) 2005-09-28
KR20050042475A (ko) 2005-05-09
TW200410713A (en) 2004-07-01
AR040859A1 (es) 2005-04-20
CA2495345A1 (en) 2004-02-26
ATE445416T1 (de) 2009-10-15
AU2003258607B2 (en) 2007-01-04
US20050220850A1 (en) 2005-10-06
WO2004016289A1 (en) 2004-02-26
RU2005107317A (ru) 2005-10-10
AU2003258607A1 (en) 2004-03-03
NZ538138A (en) 2008-05-30

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