DE60317712D1 - Prozess zum Entfernen von Verunreinigung S von Olanzapin polymorpher Form I - Google Patents
Prozess zum Entfernen von Verunreinigung S von Olanzapin polymorpher Form IInfo
- Publication number
- DE60317712D1 DE60317712D1 DE60317712T DE60317712T DE60317712D1 DE 60317712 D1 DE60317712 D1 DE 60317712D1 DE 60317712 T DE60317712 T DE 60317712T DE 60317712 T DE60317712 T DE 60317712T DE 60317712 D1 DE60317712 D1 DE 60317712D1
- Authority
- DE
- Germany
- Prior art keywords
- polymorphic form
- removing impurity
- olanzapine polymorphic
- olanzapine
- impurity
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
- 239000012535 impurity Substances 0.000 title 1
- KVWDHTXUZHCGIO-UHFFFAOYSA-N olanzapine Chemical compound C1CN(C)CCN1C1=NC2=CC=CC=C2NC2=C1C=C(C)S2 KVWDHTXUZHCGIO-UHFFFAOYSA-N 0.000 title 1
- 229960005017 olanzapine Drugs 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/13—Crystalline forms, e.g. polymorphs
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
PL357928A PL202856B1 (pl) | 2002-12-20 | 2002-12-20 | Sposób otrzymywania farmaceutycznie czystej polimorficznej postaci I olanzapiny |
PCT/IB2003/005931 WO2004056833A1 (en) | 2002-12-20 | 2003-12-15 | A process for the preparation of a pharmaceutically pure polymorphic form i of olanzapine |
Publications (1)
Publication Number | Publication Date |
---|---|
DE60317712D1 true DE60317712D1 (de) | 2008-01-03 |
Family
ID=32678125
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DE60317712T Expired - Lifetime DE60317712D1 (de) | 2002-12-20 | 2003-12-15 | Prozess zum Entfernen von Verunreinigung S von Olanzapin polymorpher Form I |
Country Status (13)
Country | Link |
---|---|
EP (1) | EP1581537B1 (de) |
CN (1) | CN100354280C (de) |
AU (1) | AU2003292452A1 (de) |
BR (1) | BR0317594A (de) |
CA (1) | CA2506663A1 (de) |
DE (1) | DE60317712D1 (de) |
ES (1) | ES2294333T3 (de) |
HR (1) | HRP20050549A2 (de) |
MX (1) | MXPA05006711A (de) |
NO (1) | NO20053368D0 (de) |
PL (1) | PL202856B1 (de) |
UA (1) | UA82213C2 (de) |
WO (1) | WO2004056833A1 (de) |
Families Citing this family (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7323459B2 (en) | 2002-12-24 | 2008-01-29 | Teva Pharmaceutical Industries Ltd. | Crystal forms, methods for their preparation and method for preparation of olanzapine |
WO2006025065A1 (en) * | 2004-08-31 | 2006-03-09 | Lee Pharma Private Limited | A process for the preparation of anhydrous olanzopine hydrochloride of form-1 |
US7829700B2 (en) | 2004-09-06 | 2010-11-09 | Shasun Chemicals And Drugs Limited | Process for preparation of a pharmaceutically pure polymorphic form I of Olanzapine |
GB0522473D0 (en) | 2005-11-03 | 2005-12-14 | Actavis Group | A pharmaceutical formulation |
WO2007144901A1 (en) * | 2006-06-12 | 2007-12-21 | Jubilant Organosys Limited | Process for stabilization of olanzapine polymorphic form i |
PL381564A1 (pl) | 2007-01-22 | 2008-08-04 | Koźluk Tomasz Nobilus Ent | Sposób wytwarzania zasadniczo czystej odmiany polimorficznej I olanzapiny |
EP2292624A1 (de) | 2009-07-20 | 2011-03-09 | LEK Pharmaceuticals d.d. | Olanzapinreinigungsverfahren |
CN103910747B (zh) * | 2014-04-24 | 2016-03-23 | 东南大学 | 一种奥氮平药物晶型f及其制备方法 |
CN109456336A (zh) * | 2017-09-06 | 2019-03-12 | 万全万特制药江苏有限公司 | 奥氮平的精制方法 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9009229D0 (en) * | 1990-04-25 | 1990-06-20 | Lilly Industries Ltd | Pharmaceutical compounds |
US5229382A (en) * | 1990-04-25 | 1993-07-20 | Lilly Industries Limited | 2-methyl-thieno-benzodiazepine |
CR5278A (es) * | 1995-03-24 | 1996-07-04 | Lilly Co Eli | Formulacion oral de 2-metil-tieno-benzodiacepina |
US5631250A (en) * | 1995-03-24 | 1997-05-20 | Eli Lilly And Company | Process and solvate of 2-methyl-thieno-benzodiazepine |
EG23659A (en) * | 1995-03-24 | 2007-03-26 | Lilly Co Eli | Process and crystal forms of methyl-thieno-benzodiazepine |
US6348458B1 (en) * | 1999-12-28 | 2002-02-19 | U & I Pharmaceuticals Ltd. | Polymorphic forms of olanzapine |
BR0114031A (pt) * | 2000-08-31 | 2003-09-09 | Reddy S Lab Ltd | Processo para a preparação de hidratos de olanzapina e sua conversão em formas cristalinas de olanzapina |
PL196814B1 (pl) * | 2002-05-17 | 2008-02-29 | Inst Farmaceutyczny | Sposób wytwarzania odmiany polimorficznej I olanzapiny i jej solwaty |
AU2003237305A1 (en) * | 2002-05-31 | 2003-12-19 | Geneva Pharmaceuticals, Inc. | Process of preparation of olanzapine form i |
SI21270A (sl) * | 2002-07-15 | 2004-02-29 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Kristalne oblike olanzapina in postopki za njihovo pripravo |
-
2002
- 2002-12-20 PL PL357928A patent/PL202856B1/pl unknown
-
2003
- 2003-12-15 DE DE60317712T patent/DE60317712D1/de not_active Expired - Lifetime
- 2003-12-15 CN CNB200380106963XA patent/CN100354280C/zh not_active Expired - Fee Related
- 2003-12-15 EP EP03768031A patent/EP1581537B1/de not_active Expired - Lifetime
- 2003-12-15 UA UAA200507207A patent/UA82213C2/uk unknown
- 2003-12-15 WO PCT/IB2003/005931 patent/WO2004056833A1/en active IP Right Grant
- 2003-12-15 BR BR0317594-4A patent/BR0317594A/pt not_active IP Right Cessation
- 2003-12-15 AU AU2003292452A patent/AU2003292452A1/en not_active Abandoned
- 2003-12-15 MX MXPA05006711A patent/MXPA05006711A/es unknown
- 2003-12-15 ES ES03768031T patent/ES2294333T3/es not_active Expired - Lifetime
- 2003-12-15 CA CA002506663A patent/CA2506663A1/en not_active Abandoned
-
2005
- 2005-06-15 HR HR20050549A patent/HRP20050549A2/hr not_active Application Discontinuation
- 2005-07-11 NO NO20053368A patent/NO20053368D0/no not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
WO2004056833A1 (en) | 2004-07-08 |
CN100354280C (zh) | 2007-12-12 |
AU2003292452A1 (en) | 2004-07-14 |
EP1581537A1 (de) | 2005-10-05 |
NO20053368L (no) | 2005-07-11 |
MXPA05006711A (es) | 2005-11-23 |
EP1581537B1 (de) | 2007-11-21 |
PL202856B1 (pl) | 2009-07-31 |
PL357928A1 (en) | 2004-06-28 |
HRP20050549A2 (en) | 2005-12-31 |
UA82213C2 (uk) | 2008-03-25 |
ES2294333T3 (es) | 2008-04-01 |
CN1729195A (zh) | 2006-02-01 |
BR0317594A (pt) | 2005-11-22 |
CA2506663A1 (en) | 2004-07-08 |
NO20053368D0 (no) | 2005-07-11 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
8332 | No legal effect for de |