DE60315796D1 - Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen - Google Patents

Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen

Info

Publication number
DE60315796D1
DE60315796D1 DE60315796T DE60315796T DE60315796D1 DE 60315796 D1 DE60315796 D1 DE 60315796D1 DE 60315796 T DE60315796 T DE 60315796T DE 60315796 T DE60315796 T DE 60315796T DE 60315796 D1 DE60315796 D1 DE 60315796D1
Authority
DE
Germany
Prior art keywords
sup
inhibitors
hiv
compounds
hydroxynaphthyridinoncarboxyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60315796T
Other languages
English (en)
Other versions
DE60315796T2 (de
Inventor
Melissa Egbertson
Jeffrey Y Melamed
H Marie Langford
Steven D Young
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck Sharp and Dohme LLC
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE60315796D1 publication Critical patent/DE60315796D1/de
Application granted granted Critical
Publication of DE60315796T2 publication Critical patent/DE60315796T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Virology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Molecular Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DE60315796T 2002-01-17 2003-01-13 Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen Expired - Lifetime DE60315796T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US34977502P 2002-01-17 2002-01-17
US349775P 2002-01-17
PCT/US2003/000813 WO2003062204A1 (en) 2002-01-17 2003-01-13 Hydroxynaphthyridinone carboxamides useful as hiv integrase inhibitors

Publications (2)

Publication Number Publication Date
DE60315796D1 true DE60315796D1 (de) 2007-10-04
DE60315796T2 DE60315796T2 (de) 2008-06-05

Family

ID=27613314

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60315796T Expired - Lifetime DE60315796T2 (de) 2002-01-17 2003-01-13 Hydroxynaphthyridinoncarbonsäureamide, die sich als inhibitoren der hiv-integrase eignen

Country Status (9)

Country Link
US (1) US7279487B2 (de)
EP (1) EP1467970B1 (de)
JP (1) JP4523281B2 (de)
AT (1) ATE370948T1 (de)
AU (1) AU2003216049B2 (de)
CA (1) CA2472372C (de)
DE (1) DE60315796T2 (de)
ES (1) ES2291642T3 (de)
WO (1) WO2003062204A1 (de)

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US7169932B2 (en) 2001-06-11 2007-01-30 Pfizer Inc. HIV protease inhibitors, compositions containing the same, their pharmaceutical uses, material for their synthesis
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EP2045242A1 (de) 2002-08-13 2009-04-08 Shionogi&Co., Ltd. Heterozyklische Verbindungen mit hemmender HIV-Integrase-Aktivität
PA8586801A1 (es) 2002-10-31 2005-02-04 Pfizer Inhibidores de hiv-integrasa, composiciones farmaceuticas y metodos para su uso
EP1578748B1 (de) * 2002-12-27 2010-09-15 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. Tetrahydro-4h-pyrido[1,2-a]pyrimidine und verwandte verbindungen verwendbar als hiv integrase hemmer
BRPI0407052A (pt) 2003-01-27 2006-01-17 Pfizer Inibidores da hiv-integrase, composições farmacêuticas, e métodos para sua utilização
TW200510425A (en) * 2003-08-13 2005-03-16 Japan Tobacco Inc Nitrogen-containing fused ring compound and use thereof as HIV integrase inhibitor
CA2542047A1 (en) 2003-10-20 2005-05-12 Merck & Co., Inc. Hydroxy pyridopyrrolopyrazine dione compounds useful as hiv integrase inhibitors
BRPI0507628A (pt) * 2004-02-11 2007-07-03 Smithkline Beecham Corp composto ou sal farmaceuticamente aceitável do mesmo, método de tratamento de uma infecção viral em um ser humano, uso de um composto composição farmacêutica, e, processo para a preparação de um composto
AU2005227258A1 (en) 2004-03-09 2005-10-06 Merck & Co., Inc. HIV integrase inhibitors
CN101014574A (zh) * 2004-03-09 2007-08-08 默克公司 Hiv整合酶抑制剂
WO2005087766A1 (en) 2004-03-09 2005-09-22 Istituto Di Ricerche Di Biologia Molecolare P Angeletti Spa Hiv integrase inhibitors
EP1725556A1 (de) * 2004-03-09 2006-11-29 Merck & Co., Inc. Hiv-integrasehemmer
CA2563761C (en) 2004-04-26 2009-12-29 Pfizer Inc. Inhibitors of the hiv integrase enzyme
WO2005103003A2 (en) 2004-04-26 2005-11-03 Pfizer Inc. Pyrrolopyridine derivatives and their use as hiv-integrase inhibitors
WO2005110414A2 (en) * 2004-05-07 2005-11-24 Merck & Co., Inc. Hiv integrase inhibitors
US7476666B2 (en) 2004-06-09 2009-01-13 Merck & Co., Inc. HIV integrase inhibitors
US7981879B2 (en) * 2005-03-31 2011-07-19 Instituto di Ricerchi di Biologia Molecolare P. Angeletti S.p.A. HIV integrase inhibitors
WO2006116764A1 (en) 2005-04-28 2006-11-02 Smithkline Beecham Corporation Polycyclic carbamoylpyridone derivative having hiv integrase inhibitory activity
EP1881825B1 (de) * 2005-05-10 2013-07-24 Merck Sharp & Dohme Corp. Hiv-integrasehemmer
EP1910355A4 (de) * 2005-08-04 2010-11-24 Glaxosmithkline Llc Hiv-integrasehemmer
EP1910356A4 (de) * 2005-08-04 2009-10-21 Smithkline Beecham Corp Hiv-integrasehemmer
US20080234231A1 (en) * 2005-08-04 2008-09-25 Johns Brian A Hiv Integrase Inhibitors
US7939537B2 (en) 2005-10-04 2011-05-10 Istituto Di Ricerche Di Biologia Molecolare P. Angeletti S.P.A. HIV integrase inhibitors
EP1942736A2 (de) * 2005-10-27 2008-07-16 Merck & Co., Inc. Hiv-integrasehemmer
WO2008004100A2 (en) 2006-07-05 2008-01-10 Pfizer Products Inc. Therapeutic compounds
EP3696171A1 (de) 2006-07-07 2020-08-19 Gilead Sciences, Inc. Modulatoren der pharmakokinetischen eigenschaften von therapeutika
CA2657287A1 (en) * 2006-07-17 2008-01-24 Merck & Co., Inc. 1-hydroxy naphthyridine compounds as anti-hiv agents
EP2084160A1 (de) * 2006-10-18 2009-08-05 Merck & Co., Inc. Hiv-integrasehemmer
ES2603617T3 (es) * 2007-02-23 2017-02-28 Gilead Sciences, Inc. Moduladores de propiedades farmacocinéticas de la terapéutica
EP2318406B1 (de) 2008-07-17 2016-01-27 Critical Outcome Technologies, Inc. Thiosemicarbazonhemmerverbindungen und krebsbehandlungsverfahren
WO2010011818A1 (en) * 2008-07-25 2010-01-28 Smithkline Beecham Corporation Chemical compounds
JP4880097B1 (ja) * 2008-10-06 2012-02-22 メルク・シャープ・エンド・ドーム・コーポレイション Ｈｉｖインテグラーゼ阻害剤
AU2010334958B2 (en) 2009-12-23 2015-02-05 Katholieke Universiteit Leuven Novel antiviral compounds
US8283366B2 (en) 2010-01-22 2012-10-09 Ambrilia Biopharma, Inc. Derivatives of pyridoxine for inhibiting HIV integrase
WO2011120153A1 (en) 2010-04-01 2011-10-06 Critical Outcome Technologies Inc. Compounds and method for treatment of hiv
BR112013007850A2 (pt) 2010-10-14 2016-06-07 Immunahr Ab 1,2-diidro-4-hidróxi-2-oxo-quinolina-3-carboxanilidas como ativadores de ahr
AU2011331301A1 (en) 2010-11-15 2013-05-23 Katholieke Universiteit Leuven Antiviral condensed heterocyclic compounds
WO2012066442A1 (en) 2010-11-15 2012-05-24 Pfizer Limited Inhibitors of hiv replication
WO2014099586A1 (en) 2012-12-17 2014-06-26 Merck Sharp & Dohme Corp. 4-pyridinonetriazine derivatives as hiv integrase inhibitors
US9493479B2 (en) 2013-04-16 2016-11-15 Merck Sharp & Dohme Corp. Substituted pyrido[1,2-a]pyrazines as HIV integrase inhibitors
ME02977B (de) 2013-05-17 2018-10-20 Merck Sharp & Dohme Kondensierte tricyclische heterocyclische verbindungen als hiv-integrase-hemmer
EP3008044B1 (de) 2013-06-13 2018-11-21 Merck Sharp & Dohme Corp. Kondensierte tricyclische heterocyclische verbindungen als hiv-integrase-hemmer
EA030695B1 (ru) 2013-09-27 2018-09-28 Мерк Шарп И Доум Корп. Замещенные производные хинолизина, которые можно использовать как ингибиторы интегразы вич
WO2016187788A1 (en) 2015-05-25 2016-12-01 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds useful for treating hiv infection
WO2017087257A1 (en) 2015-11-17 2017-05-26 Merck Sharp & Dohme Corp. Amido-substituted pyridotriazine derivatives useful as hiv integrase inhibitors
WO2017106071A1 (en) 2015-12-15 2017-06-22 Merck Sharp & Dohme Corp. Spirocyclic quinolizine derivatives useful as hiv integrase inhibitors
WO2017113288A1 (en) 2015-12-31 2017-07-06 Merck Sharp & Dohme Corp. Fused tricyclic heterocyclic compounds as hiv integrase inhibitors
CN106008283B (zh) * 2016-06-29 2018-03-16 常州市阳光药业有限公司 牛磺酰胺盐酸盐的制备方法
JOP20190130A1 (ar) 2016-12-02 2019-06-02 Merck Sharp & Dohme مركبات حلقية غير متجانسة رباعية الحلقات مفيدة كمثبطات إنزيم مدمج لفيروس نقص المناعة البشرية (hiv)
JP2020500866A (ja) 2016-12-02 2020-01-16 メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． Ｈｉｖインテグラーゼ阻害剤として有用な三環式複素環化合物
EP3573984A4 (de) 2017-01-26 2020-07-29 Merck Sharp & Dohme Corp. Als hiv-integrase-inhibitoren nützliche, substituierte chinolizinderivate

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Also Published As

Publication number Publication date
US7279487B2 (en) 2007-10-09
US20050119482A1 (en) 2005-06-02
CA2472372A1 (en) 2003-07-31
ES2291642T3 (es) 2008-03-01
EP1467970A1 (de) 2004-10-20
ATE370948T1 (de) 2007-09-15
JP4523281B2 (ja) 2010-08-11
EP1467970B1 (de) 2007-08-22
AU2003216049B2 (en) 2008-07-17
EP1467970A4 (de) 2005-12-21
JP2005519907A (ja) 2005-07-07
WO2003062204A1 (en) 2003-07-31
CA2472372C (en) 2010-08-17
DE60315796T2 (de) 2008-06-05

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Legal Events

Date Code Title Description
8364 No opposition during term of opposition
8327 Change in the person/name/address of the patent owner

Owner name: MERCK SHARP & DOHME CORP., RAHWAY, N.J., US

8328 Change in the person/name/address of the agent

Representative=s name: MARKS & CLERK (LUXEMBOURG) LLP, LUXEMBOURG, LU