DE60315471T2 - 2,5-disubstituierte 3-mercaptopentansaure - Google Patents
2,5-disubstituierte 3-mercaptopentansaure Download PDFInfo
- Publication number
- DE60315471T2 DE60315471T2 DE60315471T DE60315471T DE60315471T2 DE 60315471 T2 DE60315471 T2 DE 60315471T2 DE 60315471 T DE60315471 T DE 60315471T DE 60315471 T DE60315471 T DE 60315471T DE 60315471 T2 DE60315471 T2 DE 60315471T2
- Authority
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- Germany
- Prior art keywords
- phenyl
- optionally substituted
- hydroxy
- alkyl
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 150000001875 compounds Chemical class 0.000 claims description 62
- -1 cyano, hydroxy Chemical group 0.000 claims description 56
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 29
- 125000000217 alkyl group Chemical group 0.000 claims description 26
- 150000003839 salts Chemical class 0.000 claims description 26
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 24
- 239000012453 solvate Substances 0.000 claims description 24
- 108090000201 Carboxypeptidase B2 Proteins 0.000 claims description 23
- 229910052736 halogen Inorganic materials 0.000 claims description 23
- 102000003847 Carboxypeptidase B2 Human genes 0.000 claims description 21
- 238000011282 treatment Methods 0.000 claims description 15
- 125000004093 cyano group Chemical group *C#N 0.000 claims description 14
- 125000005843 halogen group Chemical group 0.000 claims description 14
- 125000004076 pyridyl group Chemical group 0.000 claims description 13
- 125000006239 protecting group Chemical group 0.000 claims description 12
- 125000003545 alkoxy group Chemical group 0.000 claims description 11
- 238000011321 prophylaxis Methods 0.000 claims description 11
- 125000005958 tetrahydrothienyl group Chemical group 0.000 claims description 11
- 238000002360 preparation method Methods 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 125000002373 5 membered heterocyclic group Chemical group 0.000 claims description 5
- 125000004070 6 membered heterocyclic group Chemical group 0.000 claims description 5
- 239000003814 drug Substances 0.000 claims description 5
- 229910052739 hydrogen Inorganic materials 0.000 claims description 5
- 230000005764 inhibitory process Effects 0.000 claims description 5
- 125000001624 naphthyl group Chemical group 0.000 claims description 5
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- RYZXQKCIALZPFZ-UHFFFAOYSA-N 3-[3-[(4-methoxyphenyl)methylsulfanyl]-5-[(2-methylpropan-2-yl)oxy]-4-[[6-[(2-methylpropan-2-yl)oxycarbonylamino]pyridin-3-yl]methyl]-5-oxopentyl]benzoic acid Chemical compound C1=CC(OC)=CC=C1CSC(C(CC=1C=NC(NC(=O)OC(C)(C)C)=CC=1)C(=O)OC(C)(C)C)CCC1=CC=CC(C(O)=O)=C1 RYZXQKCIALZPFZ-UHFFFAOYSA-N 0.000 description 3
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- 239000007821 HATU Substances 0.000 description 3
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- 235000018977 lysine Nutrition 0.000 description 3
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 3
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 3
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- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 3
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- LBHQIXKNIZIWGQ-UHFFFAOYSA-N tert-butyl 2-[[6-[(2-methylpropan-2-yl)oxycarbonylamino]pyridin-3-yl]methyl]-5-(3-phenylphenyl)pent-2-enoate Chemical compound C1=NC(NC(=O)OC(C)(C)C)=CC=C1CC(C(=O)OC(C)(C)C)=CCCC1=CC=CC(C=2C=CC=CC=2)=C1 LBHQIXKNIZIWGQ-UHFFFAOYSA-N 0.000 description 3
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Classifications
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- C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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- C07D—HETEROCYCLIC COMPOUNDS
- C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
- C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
- C07D409/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Dermatology (AREA)
- Vascular Medicine (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Cardiology (AREA)
- Rheumatology (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Gastroenterology & Hepatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pyridine Compounds (AREA)
- Thiazole And Isothizaole Compounds (AREA)
- Other In-Based Heterocyclic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| SE0201837 | 2002-06-14 | ||
| SE0201837A SE0201837D0 (sv) | 2002-06-14 | 2002-06-14 | Chemical compounds |
| PCT/SE2003/000970 WO2003106420A1 (en) | 2002-06-14 | 2003-06-10 | 2,5-disubstituted 3-mercaptopentanoic acid |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DE60315471D1 DE60315471D1 (de) | 2007-09-20 |
| DE60315471T2 true DE60315471T2 (de) | 2008-04-24 |
Family
ID=20288202
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE60315471T Expired - Fee Related DE60315471T2 (de) | 2002-06-14 | 2003-06-10 | 2,5-disubstituierte 3-mercaptopentansaure |
Country Status (28)
| Country | Link |
|---|---|
| US (1) | US7572817B2 (enExample) |
| EP (1) | EP1532111B1 (enExample) |
| JP (1) | JP2005533064A (enExample) |
| KR (1) | KR20050010051A (enExample) |
| CN (1) | CN100415719C (enExample) |
| AR (1) | AR040240A1 (enExample) |
| AT (1) | ATE369342T1 (enExample) |
| AU (1) | AU2003241260B2 (enExample) |
| BR (1) | BR0311384A (enExample) |
| CA (1) | CA2488606A1 (enExample) |
| CY (1) | CY1107753T1 (enExample) |
| DE (1) | DE60315471T2 (enExample) |
| DK (1) | DK1532111T3 (enExample) |
| ES (1) | ES2289297T3 (enExample) |
| IS (1) | IS7609A (enExample) |
| MX (1) | MXPA04012604A (enExample) |
| MY (1) | MY160429A (enExample) |
| NO (1) | NO20045051L (enExample) |
| NZ (1) | NZ536814A (enExample) |
| PL (1) | PL373883A1 (enExample) |
| PT (1) | PT1532111E (enExample) |
| RU (1) | RU2365583C2 (enExample) |
| SA (1) | SA03240142B1 (enExample) |
| SE (1) | SE0201837D0 (enExample) |
| TW (1) | TW200401766A (enExample) |
| UA (1) | UA78042C2 (enExample) |
| WO (1) | WO2003106420A1 (enExample) |
| ZA (1) | ZA200409955B (enExample) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7276497B2 (en) * | 2003-05-20 | 2007-10-02 | Immunogen Inc. | Cytotoxic agents comprising new maytansinoids |
| GB0403864D0 (en) | 2004-02-20 | 2004-03-24 | Ucl Ventures | Modulator |
| JP2008538107A (ja) | 2005-03-18 | 2008-10-09 | ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア | 変異型ｃｆｔｒプロセシングの修正において活性を有する化合物及びその用途 |
| JPWO2010050525A1 (ja) | 2008-10-29 | 2012-03-29 | 大正製薬株式会社 | ＴＡＦＩａ阻害活性を有する化合物 |
| TR201901110T4 (tr) | 2013-04-05 | 2019-02-21 | Boehringer Ingelheim Int | Empagliflozinin terapötik kullanımları. |
| CA2812519A1 (en) | 2013-04-05 | 2014-10-05 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US20140303097A1 (en) | 2013-04-05 | 2014-10-09 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| US11813275B2 (en) | 2013-04-05 | 2023-11-14 | Boehringer Ingelheim International Gmbh | Pharmaceutical composition, methods for treating and uses thereof |
| CN113181161A (zh) | 2013-04-18 | 2021-07-30 | 勃林格殷格翰国际有限公司 | 药物组合物、治疗方法及其用途 |
| BR112015029667A2 (pt) | 2013-06-10 | 2017-07-25 | Sanofi Sa | derivados de ureia macrocíclica como inibidores de tafia, sua preparação e seus usos como produtos farmacêuticos |
| MA46742A (fr) | 2016-11-10 | 2019-09-18 | Boehringer Ingelheim Int | Composition pharmaceutique, méthodes de traitement et leurs utilisations |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU4687500A (en) * | 1999-04-29 | 2000-11-17 | Allergan Sales, Inc. | Thromboxane ligands without blood clotting side effects |
| SE9901573D0 (sv) * | 1999-05-03 | 1999-05-03 | Astra Ab | New compounds |
-
2002
- 2002-06-14 SE SE0201837A patent/SE0201837D0/xx unknown
-
2003
- 2003-06-02 AR ARP030101959A patent/AR040240A1/es unknown
- 2003-06-08 SA SA03240142A patent/SA03240142B1/ar unknown
- 2003-06-10 NZ NZ536814A patent/NZ536814A/en unknown
- 2003-06-10 WO PCT/SE2003/000970 patent/WO2003106420A1/en not_active Ceased
- 2003-06-10 KR KR10-2004-7020285A patent/KR20050010051A/ko not_active Ceased
- 2003-06-10 CA CA002488606A patent/CA2488606A1/en not_active Abandoned
- 2003-06-10 DK DK03730987T patent/DK1532111T3/da active
- 2003-06-10 AT AT03730987T patent/ATE369342T1/de not_active IP Right Cessation
- 2003-06-10 PL PL03373883A patent/PL373883A1/xx not_active Application Discontinuation
- 2003-06-10 EP EP03730987A patent/EP1532111B1/en not_active Expired - Lifetime
- 2003-06-10 BR BR0311384-1A patent/BR0311384A/pt not_active IP Right Cessation
- 2003-06-10 RU RU2004134563/04A patent/RU2365583C2/ru not_active IP Right Cessation
- 2003-06-10 MX MXPA04012604A patent/MXPA04012604A/es active IP Right Grant
- 2003-06-10 US US10/517,713 patent/US7572817B2/en not_active Expired - Fee Related
- 2003-06-10 AU AU2003241260A patent/AU2003241260B2/en not_active Ceased
- 2003-06-10 PT PT03730987T patent/PT1532111E/pt unknown
- 2003-06-10 ES ES03730987T patent/ES2289297T3/es not_active Expired - Lifetime
- 2003-06-10 CN CNB038138409A patent/CN100415719C/zh not_active Expired - Fee Related
- 2003-06-10 JP JP2004513253A patent/JP2005533064A/ja not_active Withdrawn
- 2003-06-10 DE DE60315471T patent/DE60315471T2/de not_active Expired - Fee Related
- 2003-06-12 MY MYPI20032192A patent/MY160429A/en unknown
- 2003-06-12 TW TW092115988A patent/TW200401766A/zh unknown
- 2003-10-06 UA UA20041109447A patent/UA78042C2/uk unknown
-
2004
- 2004-11-19 NO NO20045051A patent/NO20045051L/no not_active Application Discontinuation
- 2004-12-08 ZA ZA200409955A patent/ZA200409955B/en unknown
- 2004-12-22 IS IS7609A patent/IS7609A/is unknown
-
2007
- 2007-10-08 CY CY20071101274T patent/CY1107753T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2005533064A (ja) | 2005-11-04 |
| BR0311384A (pt) | 2005-03-15 |
| EP1532111B1 (en) | 2007-08-08 |
| CN1662504A (zh) | 2005-08-31 |
| CN100415719C (zh) | 2008-09-03 |
| ES2289297T3 (es) | 2008-02-01 |
| MY160429A (en) | 2017-03-15 |
| AR040240A1 (es) | 2005-03-23 |
| CA2488606A1 (en) | 2003-12-24 |
| ZA200409955B (en) | 2006-08-30 |
| KR20050010051A (ko) | 2005-01-26 |
| PL373883A1 (en) | 2005-09-19 |
| US20050176780A1 (en) | 2005-08-11 |
| TW200401766A (en) | 2004-02-01 |
| SE0201837D0 (sv) | 2002-06-14 |
| WO2003106420A1 (en) | 2003-12-24 |
| US7572817B2 (en) | 2009-08-11 |
| RU2004134563A (ru) | 2005-07-20 |
| MXPA04012604A (es) | 2005-03-23 |
| NO20045051L (no) | 2005-01-13 |
| AU2003241260A1 (en) | 2003-12-31 |
| IS7609A (is) | 2004-12-22 |
| HK1077296A1 (en) | 2006-02-10 |
| ATE369342T1 (de) | 2007-08-15 |
| AU2003241260B2 (en) | 2007-04-26 |
| RU2365583C2 (ru) | 2009-08-27 |
| EP1532111A1 (en) | 2005-05-25 |
| SA03240142B1 (ar) | 2007-07-31 |
| UA78042C2 (en) | 2007-02-15 |
| DE60315471D1 (de) | 2007-09-20 |
| DK1532111T3 (da) | 2007-10-22 |
| PT1532111E (pt) | 2007-09-25 |
| CY1107753T1 (el) | 2013-04-18 |
| NZ536814A (en) | 2006-11-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8364 | No opposition during term of opposition | ||
| 8339 | Ceased/non-payment of the annual fee |