DE60313499D1 - Mutante nichtmenschliche säuger mit sigmarezeptormangel und anwendungen dafür - Google Patents

Mutante nichtmenschliche säuger mit sigmarezeptormangel und anwendungen dafür

Info

Publication number
DE60313499D1
DE60313499D1 DE60313499T DE60313499T DE60313499D1 DE 60313499 D1 DE60313499 D1 DE 60313499D1 DE 60313499 T DE60313499 T DE 60313499T DE 60313499 T DE60313499 T DE 60313499T DE 60313499 D1 DE60313499 D1 DE 60313499D1
Authority
DE
Germany
Prior art keywords
sigmare
deceptor
mental
mammals
deficiency
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60313499T
Other languages
English (en)
Other versions
DE60313499T2 (de
Inventor
Castanedo Daniel Zamanillo
Jose Lluis Montoliu
Vives Francina Langa
Judez Alfonso Javier Lavado
Herrador Victoria Eugeni Tovar
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Esteve Pharmaceuticals SA
Original Assignee
Laboratorios del Dr Esteve SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Laboratorios del Dr Esteve SA filed Critical Laboratorios del Dr Esteve SA
Application granted granted Critical
Publication of DE60313499D1 publication Critical patent/DE60313499D1/de
Publication of DE60313499T2 publication Critical patent/DE60313499T2/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
    • A01K67/027—New or modified breeds of vertebrates
    • A01K67/0275—Genetically modified vertebrates, e.g. transgenic
    • A01K67/0276—Knock-out vertebrates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
    • C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2217/00—Genetically modified animals
    • A01K2217/07—Animals genetically altered by homologous recombination
    • A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2227/00—Animals characterised by species
    • A01K2227/10—Mammal
    • A01K2227/105—Murine
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A—HUMAN NECESSITIES
    • A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
    • A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
    • A01K2267/00—Animals characterised by purpose
    • A01K2267/03—Animal model, e.g. for test or diseases
    • A01K2267/035—Animal model for multifactorial diseases
    • A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Engineering & Computer Science (AREA)
  • Environmental Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Plant Pathology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Animal Husbandry (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DE60313499T 2002-12-09 2003-12-09 Mutante nichtmenschliche säuger mit sigmarezeptormangel und anwendungen dafür Expired - Lifetime DE60313499T2 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ES200202815A ES2209650B2 (es) 2002-12-09 2002-12-09 Mamiferos no humanos mutantes deficientes en receptores sigma y sus aplicaciones.
ES200202815 2002-12-09
PCT/ES2003/000624 WO2004052092A1 (es) 2002-12-09 2003-12-09 Mamíferos no humanos mutantes deficientes en receptores sigma y sus aplicaciones

Publications (2)

Publication Number Publication Date
DE60313499D1 true DE60313499D1 (de) 2007-06-06
DE60313499T2 DE60313499T2 (de) 2008-01-03

Family

ID=32480022

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60313499T Expired - Lifetime DE60313499T2 (de) 2002-12-09 2003-12-09 Mutante nichtmenschliche säuger mit sigmarezeptormangel und anwendungen dafür

Country Status (15)

Country Link
US (1) US8003847B2 (de)
EP (2) EP1752540A3 (de)
JP (1) JP4515915B2 (de)
AR (1) AR042300A1 (de)
AT (1) ATE360362T1 (de)
AU (1) AU2003285369C1 (de)
CA (1) CA2508697A1 (de)
CY (1) CY1106675T1 (de)
DE (1) DE60313499T2 (de)
DK (1) DK1584232T3 (de)
ES (2) ES2209650B2 (de)
HK (1) HK1083987A1 (de)
NO (1) NO20053367L (de)
PT (1) PT1584232E (de)
WO (1) WO2004052092A1 (de)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2625153A1 (en) 2005-10-21 2007-04-26 Braincells, Inc. Modulation of neurogenesis by pde inhibition
AU2006308889A1 (en) 2005-10-31 2007-05-10 Braincells, Inc. GABA receptor mediated modulation of neurogenesis
US20100216734A1 (en) 2006-03-08 2010-08-26 Braincells, Inc. Modulation of neurogenesis by nootropic agents
WO2007134077A2 (en) 2006-05-09 2007-11-22 Braincells, Inc. 5 ht receptor mediated neurogenesis
EP2382975A3 (de) 2006-05-09 2012-02-29 Braincells, Inc. Neurogenese mittels Angiotensin-Modulation
MX2009002496A (es) 2006-09-08 2009-07-10 Braincells Inc Combinaciones que contienen un derivado de 4-acilaminopiridina.
US20100184806A1 (en) 2006-09-19 2010-07-22 Braincells, Inc. Modulation of neurogenesis by ppar agents
US20100216805A1 (en) 2009-02-25 2010-08-26 Braincells, Inc. Modulation of neurogenesis using d-cycloserine combinations

Family Cites Families (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5464764A (en) 1989-08-22 1995-11-07 University Of Utah Research Foundation Positive-negative selection methods and vectors
WO1998020112A1 (en) 1996-11-07 1998-05-14 The Wistar Institute Of Anatomy And Biology Sparc-deficient transgenic mice
US6194633B1 (en) 1998-01-26 2001-02-27 University Of Iowa Research Foundation Non-human animal having a functionally disrupted SLP-76 gene
US6207876B1 (en) 1998-04-28 2001-03-27 Board Of Regents, The University Of Texas System Adenosine deaminase deficient transgenic mice and methods for the use thereof
US6252132B1 (en) 1998-11-02 2001-06-26 Institut Pasteur Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor
US6245965B1 (en) 1999-01-29 2001-06-12 St. Jude Children's Research Hospital Knockout mice and cells that lack p19INK4d and p27KIP1 activity and methods of use thereof
US6245963B1 (en) 1999-05-28 2001-06-12 Academia Sinica Knockout-transgenic mouse model of spinal muscular atrophy
JP4470077B2 (ja) * 1999-11-16 2010-06-02 和男 鈴木 好中球走化性因子ｌｅｃｔ２遺伝子の機能が欠損したマウス

Also Published As

Publication number Publication date
JP4515915B2 (ja) 2010-08-04
US20050132429A1 (en) 2005-06-16
AU2003285369C1 (en) 2010-02-18
EP1752540A2 (de) 2007-02-14
CA2508697A1 (en) 2004-06-24
AU2003285369A1 (en) 2004-06-30
EP1584232B1 (de) 2007-04-25
DE60313499T2 (de) 2008-01-03
AR042300A1 (es) 2005-06-15
JP2006508673A (ja) 2006-03-16
AU2003285369B2 (en) 2009-09-10
ES2286484T3 (es) 2007-12-01
CY1106675T1 (el) 2012-05-23
ES2209650B2 (es) 2006-11-01
EP1752540A3 (de) 2007-11-21
NO20053367D0 (no) 2005-07-11
US8003847B2 (en) 2011-08-23
EP1584232A1 (de) 2005-10-12
NO20053367L (no) 2005-07-11
HK1083987A1 (en) 2006-07-21
ATE360362T1 (de) 2007-05-15
DK1584232T3 (da) 2007-07-30
ES2209650A1 (es) 2004-06-16
PT1584232E (pt) 2007-07-24
WO2004052092A1 (es) 2004-06-24

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