CY1106675T1 - Μεταλλαγμενα, μη ανθρωπινα θηλαστικα με ελλειψη σιγμα υποδοχεα και εφαρμογες αυτων - Google Patents
Μεταλλαγμενα, μη ανθρωπινα θηλαστικα με ελλειψη σιγμα υποδοχεα και εφαρμογες αυτωνInfo
- Publication number
- CY1106675T1 CY1106675T1 CY20071100839T CY071100839T CY1106675T1 CY 1106675 T1 CY1106675 T1 CY 1106675T1 CY 20071100839 T CY20071100839 T CY 20071100839T CY 071100839 T CY071100839 T CY 071100839T CY 1106675 T1 CY1106675 T1 CY 1106675T1
- Authority
- CY
- Cyprus
- Prior art keywords
- receptor
- sigma
- mutant
- sigma receptor
- endogenous
- Prior art date
Links
- 241000124008 Mammalia Species 0.000 title abstract 2
- 108010085082 sigma receptors Proteins 0.000 abstract 3
- 238000001727 in vivo Methods 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 208000026139 Memory disease Diseases 0.000 abstract 1
- 241001465754 Metazoa Species 0.000 abstract 1
- 206010028980 Neoplasm Diseases 0.000 abstract 1
- 102100028662 Sigma intracellular receptor 2 Human genes 0.000 abstract 1
- 101710109012 Sigma intracellular receptor 2 Proteins 0.000 abstract 1
- 102100028656 Sigma non-opioid intracellular receptor 1 Human genes 0.000 abstract 1
- 101710104750 Sigma non-opioid intracellular receptor 1 Proteins 0.000 abstract 1
- 230000036592 analgesia Effects 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 abstract 1
- 208000015114 central nervous system disease Diseases 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 230000003412 degenerative effect Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000003176 neuroleptic agent Substances 0.000 abstract 1
- 230000004112 neuroprotection Effects 0.000 abstract 1
- 230000007170 pathology Effects 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 208000011117 substance-related disease Diseases 0.000 abstract 1
- 230000001225 therapeutic effect Effects 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0356—Animal model for processes and diseases of the central nervous system, e.g. stress, learning, schizophrenia, pain, epilepsy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Environmental Sciences (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Biodiversity & Conservation Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Animal Husbandry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Plant Pathology (AREA)
- Neurosurgery (AREA)
- Neurology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
Το γονιδίωμα των μη ανθρώπινων, μεταλλαγμένων θηλαστικών, τα οποία δεν διαθέτουν έναν ενδογενή Σίγμα υποδοχέα, περιέχει μια μετάλλαξη, η οποία περιλαμβάνει μια ρήξη σε ένα ενδογενές γονίδιο Σίγμα υποδοχέα, όπου η αναφερθείσα ρήξη γονίδιου προκαλεί ένα μετάλλαγμα, το οποίο δεν διαθέτει ανιχνεύσιμα επίπεδα ενδογενούς Σίγμα υποδοχέα. Το μετάλλαγμα μπορεί να χρησιμοποιηθεί ως ζώο ελέγχου για in vivo δοκιμές, καθώς και ως πηγή κυττάρων, τα οποία μπορούν να χρησιμοποιηθούν σε in vitro δοκιμές. Τα μεταλλάγματα τα οποία δεν διαθέτουν Σίγμα-1 υποδοχέα μπορούν να χρησιμοποιηθούν ως μοντέλα για την in vivo μελέτη των διαταραχών του κεντρικού νευρικού συστήματος, των διαταραχών της μνήμης, των καταστάσεων στρες και εθισμών σε ουσίες, των διαδικασιών αναλγησίας και νευροπροστασίας. Τα μεταλλάγματα που δεν διαθέτουν Σίγμα-2 υποδοχέα μπορούν να χρησιμοποιηθούν για τη μελέτη διαγνωστικών ή θεραπευτικών εργαλείων για την καταπολέμηση του καρκίνου και/ ή εκφυλιστικών διαδικασιών και/ ή τον σχεδιασμό ενώσεων που μπορούν να προλάβουν, να μειώσουν ή να μετριάσουν τη δευτερογενή παθολογία που σχετίζεται με τη χορήγηση νευροληπτικών αντιδραστηρίων.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200202815A ES2209650B2 (es) | 2002-12-09 | 2002-12-09 | Mamiferos no humanos mutantes deficientes en receptores sigma y sus aplicaciones. |
| PCT/ES2003/000624 WO2004052092A1 (es) | 2002-12-09 | 2003-12-09 | Mamíferos no humanos mutantes deficientes en receptores sigma y sus aplicaciones |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| CY1106675T1 true CY1106675T1 (el) | 2012-05-23 |
Family
ID=32480022
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CY20071100839T CY1106675T1 (el) | 2002-12-09 | 2007-06-25 | Μεταλλαγμενα, μη ανθρωπινα θηλαστικα με ελλειψη σιγμα υποδοχεα και εφαρμογες αυτων |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US8003847B2 (el) |
| EP (2) | EP1584232B1 (el) |
| JP (1) | JP4515915B2 (el) |
| AR (1) | AR042300A1 (el) |
| AT (1) | ATE360362T1 (el) |
| AU (1) | AU2003285369C1 (el) |
| CA (1) | CA2508697A1 (el) |
| CY (1) | CY1106675T1 (el) |
| DE (1) | DE60313499T2 (el) |
| DK (1) | DK1584232T3 (el) |
| ES (2) | ES2209650B2 (el) |
| HK (1) | HK1083987A1 (el) |
| NO (1) | NO20053367L (el) |
| PT (1) | PT1584232E (el) |
| WO (1) | WO2004052092A1 (el) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2625153A1 (en) | 2005-10-21 | 2007-04-26 | Braincells, Inc. | Modulation of neurogenesis by pde inhibition |
| US20070112017A1 (en) | 2005-10-31 | 2007-05-17 | Braincells, Inc. | Gaba receptor mediated modulation of neurogenesis |
| US20100216734A1 (en) | 2006-03-08 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis by nootropic agents |
| EP2377531A2 (en) | 2006-05-09 | 2011-10-19 | Braincells, Inc. | Neurogenesis by modulating angiotensin |
| US7678808B2 (en) | 2006-05-09 | 2010-03-16 | Braincells, Inc. | 5 HT receptor mediated neurogenesis |
| WO2008030651A1 (en) | 2006-09-08 | 2008-03-13 | Braincells, Inc. | Combinations containing a 4-acylaminopyridine derivative |
| US20100184806A1 (en) | 2006-09-19 | 2010-07-22 | Braincells, Inc. | Modulation of neurogenesis by ppar agents |
| US20100216805A1 (en) | 2009-02-25 | 2010-08-26 | Braincells, Inc. | Modulation of neurogenesis using d-cycloserine combinations |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5464764A (en) * | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| AU5431098A (en) | 1996-11-07 | 1998-05-29 | Wistar Institute Of Anatomy And Biology, The | Sparc-deficient transgenic mice |
| US6194633B1 (en) | 1998-01-26 | 2001-02-27 | University Of Iowa Research Foundation | Non-human animal having a functionally disrupted SLP-76 gene |
| US6207876B1 (en) | 1998-04-28 | 2001-03-27 | Board Of Regents, The University Of Texas System | Adenosine deaminase deficient transgenic mice and methods for the use thereof |
| US6252132B1 (en) | 1998-11-02 | 2001-06-26 | Institut Pasteur | Mutant mouse containing a knockout mutation in DNA encoding an endogenous alpha 4 subunit of nicotinic acetylcholine receptor |
| US6245965B1 (en) | 1999-01-29 | 2001-06-12 | St. Jude Children's Research Hospital | Knockout mice and cells that lack p19INK4d and p27KIP1 activity and methods of use thereof |
| US6245963B1 (en) | 1999-05-28 | 2001-06-12 | Academia Sinica | Knockout-transgenic mouse model of spinal muscular atrophy |
| JP4470077B2 (ja) * | 1999-11-16 | 2010-06-02 | 和男 鈴木 | 好中球走化性因子ｌｅｃｔ２遺伝子の機能が欠損したマウス |
-
2002
- 2002-12-09 ES ES200202815A patent/ES2209650B2/es not_active Expired - Fee Related
-
2003
- 2003-12-04 AR ARP030104478A patent/AR042300A1/es not_active Application Discontinuation
- 2003-12-09 US US10/731,379 patent/US8003847B2/en not_active Expired - Fee Related
- 2003-12-09 DE DE60313499T patent/DE60313499T2/de not_active Expired - Lifetime
- 2003-12-09 EP EP03778357A patent/EP1584232B1/en not_active Expired - Lifetime
- 2003-12-09 ES ES03778357T patent/ES2286484T3/es not_active Expired - Lifetime
- 2003-12-09 DK DK03778357T patent/DK1584232T3/da active
- 2003-12-09 AT AT03778357T patent/ATE360362T1/de active
- 2003-12-09 WO PCT/ES2003/000624 patent/WO2004052092A1/es active IP Right Grant
- 2003-12-09 JP JP2004558125A patent/JP4515915B2/ja not_active Expired - Fee Related
- 2003-12-09 AU AU2003285369A patent/AU2003285369C1/en not_active Ceased
- 2003-12-09 PT PT03778357T patent/PT1584232E/pt unknown
- 2003-12-09 CA CA002508697A patent/CA2508697A1/en not_active Abandoned
- 2003-12-09 EP EP06120550A patent/EP1752540A3/en not_active Withdrawn
-
2005
- 2005-07-11 NO NO20053367A patent/NO20053367L/no not_active Application Discontinuation
-
2006
- 2006-04-11 HK HK06104406A patent/HK1083987A1/xx not_active IP Right Cessation
-
2007
- 2007-06-25 CY CY20071100839T patent/CY1106675T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP1752540A3 (en) | 2007-11-21 |
| AU2003285369A1 (en) | 2004-06-30 |
| DE60313499T2 (de) | 2008-01-03 |
| HK1083987A1 (en) | 2006-07-21 |
| AU2003285369B2 (en) | 2009-09-10 |
| EP1584232B1 (en) | 2007-04-25 |
| US8003847B2 (en) | 2011-08-23 |
| EP1752540A2 (en) | 2007-02-14 |
| JP2006508673A (ja) | 2006-03-16 |
| ES2209650B2 (es) | 2006-11-01 |
| DE60313499D1 (de) | 2007-06-06 |
| DK1584232T3 (da) | 2007-07-30 |
| NO20053367D0 (no) | 2005-07-11 |
| US20050132429A1 (en) | 2005-06-16 |
| AR042300A1 (es) | 2005-06-15 |
| ES2209650A1 (es) | 2004-06-16 |
| NO20053367L (no) | 2005-07-11 |
| WO2004052092A1 (es) | 2004-06-24 |
| JP4515915B2 (ja) | 2010-08-04 |
| ATE360362T1 (de) | 2007-05-15 |
| ES2286484T3 (es) | 2007-12-01 |
| EP1584232A1 (en) | 2005-10-12 |
| CA2508697A1 (en) | 2004-06-24 |
| AU2003285369C1 (en) | 2010-02-18 |
| PT1584232E (pt) | 2007-07-24 |
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